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Update README.md
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anna-grim authored Jan 8, 2025
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The objective of this step is to generate initial proposals for potential soma locations by detecting blob-like structures in the image. Our proposal detection algorithm includes the following steps:

<blockquote>
a. Smooth image with Gaussian filter to reduce false positives.

b. Laplacian of Gaussian (LoG) to enhance regions where the gradient changes dramatically, then apply a maximum filter.

c. Generate initial set of proposals by detecting local maximas in LoG image that lie outside of the image margins.

d. Shift each proposal to the brightest voxel in its neighborhood. If the brightness is below a threshold, reject the proposal.
<p>a. Smooth image with Gaussian filter to reduce false positives.</p>
<p>b. Laplacian of Gaussian (LoG) to enhance regions where the gradient changes dramatically, then apply a maximum filter.</p>
<p>c. Generate initial set of proposals by detecting local maximas in LoG image that lie outside of the image margins.</p>
<p>d. Shift each proposal to the brightest voxel in its neighborhood. If the brightness is below a threshold, reject the proposal.</p>
</blockquote>

<p>
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