HYENA (Hijacking of Enhancer Activity) is a computational tool to detect genes activated by nearby somatic structural variations (SVs), a phenomenon known as enhancer hijacking. It takes somatic SVs and gene expression data as inputs and outputs enhancer hijacking candidate genes.
Please refer to User-manual_0_5_4.pdf for instructions.
Cite HYENA: Yu A, Yesilkanal AE, Thakur A, Wang F, Yang Y, Phillips W, Wu X, Muir A, He X, Spitz F, Yang L. HYENA detects oncogenes activated by distal enhancers in cancer. Nucleic Acids Res. 2024. https://pubmed.ncbi.nlm.nih.gov/39051548/