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SyntheVAEiser: Synthetic gene expression sample generation Codebase corresponding to 'Augmenting traditional ML with VAE-based gene expression sample generation for improved prediction of cancer molecular subtypes' Data structure for input to model: Categorically labeled, tabular gene expression Samples as rows, features as columns Description of paths in code files: data/ The file set of samples for encoding and generating sythetic samples. One file per cancer type for this experiment. v/ This is 'version' - the parent directory in which the individual output dirs will be written. decoded_objs/ The original sample expression values after encoding and re-coding by the VAE. latent_objs/ The latent feature representations of the original samples. Input to the HLVS and RNLVS fuctions at runtime. take-off_points/ The subset of samples randomly selected within each experimental validation replicate. Corresponds to the four data phases shown in Figure 1 - original, blend, re-coded, and latent-phase synthetic. synthetic_sample_sets/ The generated syntetic samples decoded back to the original feature dimension of the input gene expression values. rfe_out/ Optional output directory for directly incorporating recursive feature elimination on the synthetic samples in-line.
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