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mdeluci authored Jun 13, 2024
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Expand Up @@ -119,23 +119,6 @@ @article{deLucio2
abstract = {Subcutaneous injection for self-administration of biotherapeutics, such as monoclonal antibodies, has emerged as a fast-growing field in the pharmaceutical industry. Effective drug delivery in the subcutaneous tissue critically depends on the coupled mechanical and transport processes occurring in the tissue during and after the injection. The details of these processes, however, remain poorly understood; and this explains the growing interest in computational approaches. Notably, there are very few computational studies on subcutaneous injection into three-dimensional porous media that account for tissue deformability. Here, we leverage a poroelastic model to analyze the response of subcutaneous tissue under the flow of a pressurized fluid. We propose a computational method based on Isogeometric Analysis that exploits the global continuity of splines. Our model shows the importance of considering tissue deformation and permeability changes in order to obtain more realistic results in terms of fluid pressure and velocity, during and after the injection.}
}

@article{deLucio,
author = {{de Lucio}, Mario and Fernandez Garcia, Marcos and Diaz Garcia, Jacobo and Romera Rodriguez, Luis E. and Alvarez Marcos, Francisco},
title = {On the importance of tunica intima in the aging aorta: a three-layered in silico model for computing wall stresses in abdominal aortic aneurysms},
journal = {Computer Methods in Biomechanics and Biomedical Engineering},
volume = {24},
number = {5},
pages = {467--484},
preview = {deLucio1.jpg},
bibtex_show = {true},
year = {2021},
publisher = {Taylor \& Francis},
doi = {10.1080/10255842.2020.1836167},
note = {PMID: 33090043},
url = {https://doi.org/10.1080/10255842.2020.1836167},
abstract = {Layer-specific experimental data for human aortic tissue suggest that, in aged arteries and arteries with non-atherosclerotic intimal thickening, the innermost layer of the aorta increases significantly its stiffness and thickness, becoming load-bearing. However, there are very few computational studies of abdominal aortic aneurysms (AAAs) that take into account the mechanical contribution of the three layers that comprise the aneurysmal tissue. In this paper, a three-layered finite element model is proposed from the simplest uniaxial stress state to geometrically parametrized models of AAAs with different asymmetry values. Comparisons are made between a three-layered artery wall and a mono-layered intact artery, which represents the complex behavior of the aggregate adventitia-media-intima in a single layer with averaged mechanical properties. Likewise, the response of our idealized geometries is compared with similar experimental and numerical models. Finally, the mechanical contributions of adventitia, media and intima are analyzed for the three-layered aneurysms through the evaluation of the mean stress absorption percentage. Results show the relevance and necessity of considering the inclusion of tunica intima in multi-layered models of AAAs for getting accurate results in terms of peak wall stresses and displacements.},
}

@article{COSTAS2020103966,
title = {Testing and simulation of additively manufactured AlSi10Mg components under quasi-static loading},
journal = {European Journal of Mechanics - A/Solids},
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