Update papers.bib

_bibliography/papers.bib

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 @string{aps = {American Physical Society,}}
 
 % Add new ones to the top of the list
+@article{WANG2024108543,
+title = {A MPET2-mPBPK model for subcutaneous injection of biotherapeutics with different molecular weights: From local scale to whole-body scale},
+journal = {Computer Methods and Programs in Biomedicine},
+pages = {108543},
+year = {2024},
+issn = {0169-2607},
+doi = {https://doi.org/10.1016/j.cmpb.2024.108543},
+url = {https://www.sciencedirect.com/science/article/pii/S0169260724005364},
+author = {Hao Wang and Mario {de Lucio} and Tianyi Hu and Yu Leng and Hector Gomez},
+bibtex_show={true},
+selected={true},
+preview={MPET2_PK.JPG},
+keywords = {Multi-network poroelastic and transport model (MPET), Physiologically-based pharmacokinetics, Subcutaneous injection, Drug absorption, Molecular weight effect},
+abstract = {Background and Objective:
+Subcutaneous injection of biotherapeutics has attracted considerable attention in the pharmaceutical industry. However, there is limited understanding of the mechanisms underlying the absorption of drugs with different molecular weights and the delivery of drugs from the injection site to the targeted tissue.
+Methods:
+We propose the MPET2-mPBPK model to address this issue. This multiscale model couples the MPET2 model, which describes subcutaneous injection at the local tissue scale from a biomechanical view, with a post-injection absorption model at injection site and a minimal physiologically-based pharmacokinetic (mPBPK) model at whole-body scale. Utilizing the principles of tissue biomechanics and fluid dynamics, the local MPET2 model provides solutions that account for tissue deformation and drug absorption in local blood vessels and initial lymphatic vessels during injection. Additionally, we introduce a model accounting for the molecular weight effect on the absorption by blood vessels, and a nonlinear model accounting for the absorption in lymphatic vessels. The post-injection model predicts drug absorption in local blood vessels and initial lymphatic vessels, which are integrated into the whole-body mPBPK model to describe the pharmacokinetic behaviors of the absorbed drug in the circulatory and lymphatic system.
+Results:
+We establish a numerical model which links the biomechanical process of subcutaneous injection at local tissue scale and the pharmacokinetic behaviors of injected biotherapeutics at whole-body scale. With the help of the model, we propose an explicit relationship between the reflection coefficient and the molecular weight and predict the bioavalibility of biotherapeutics with varying molecular weights via subcutaneous injection.
+Conclusion:
+The considered drug absorption mechanisms enable us to study the differences in local drug absorption and whole-body drug distribution with varying molecular weights. This model enhances the understanding of drug absorption mechanisms and transport routes in the circulatory system for drugs of different molecular weights, and holds the potential to facilitate the application of computational modeling to drug formulation.}
+}
+
 @article{deLucio5,
   title = {Modeling drug transport and absorption in subcutaneous injection of monoclonal antibodies: Impact of tissue deformation, devices, and physiology},
   journal = {International Journal of Pharmaceutics},