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mdeluci authored Jun 13, 2024
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Expand Up @@ -166,3 +166,14 @@ @article{delucio2020puente
url = {https://dialnet.unirioja.es/servlet/articulo?codigo=7486537},
bibtex_show={true},
}

@mastersthesis{deLucio2018,
title = {A multi-layered in-silico model for rupture risk assessment of abdominal aortic aneurysms with non-atherosclerotic intimal thickening},
author = {de Lucio, Mario},
year = {2018},
school = {Universidade da Coruna},
bibtex_show={true},
preview={MSc_thesis.jpg},
abstract = {An abdominal aortic aneurysm is a localized bulge or swelling in the lower part of the aorta, the main blood vessel of the human body that goes from the left ventricle of the heart down through the chest and the tummy, where it splits in two smaller vessels called iliac arteries. They usually remain asymptomatic until rupture, which makes them a life-threatening disease with an overall mortality of more than 80%. Layer-specific experimental data for human aortic tissue suggest that, in aged arteries and arteries with non-atherosclerotic intimal thickening, the innermost layer of the aorta increases significantly its stiffness and thickness, becoming load-bearing. However, there are very few computational studies of aortic abdominal aneurysms (AAAs) that take into account the mechanical contribution of the three layers that make up the aneurysmal tissue. In this technical project, a three-layered finite element model is proposed from the simplest (uniaxial) stress state, to geometrically parametrized models of AAAs with different asymmetry values. Comparisons are made between a three-layered artery wall, and a mono-layered intact artery, whose constitutive parameters stand for the mean mechanical behavior of the three layers. Likewise, the response of our idealized geometries is compared with similar models. The mechanical contributions of adventitia, media and intima, are also analyzed for the three-layered aneurysms through the evaluation of the mean stress absorption percentage. Results show the relevance of considering the inclusion of tunica intima in multi-layered models of AAAs for getting more accurate results in terms of peak wall stresses and displacements. The last part of this investigation contains a Fluid-Structure Interaction study in parametrized abdominal aortic aneurysms, considering a hyperelastic anisotropic constitutive law for the aneurysmal wall. Because of the high computational cost that it would attain to model a full cardiac cycle in a three-layered aneurysm considering the Fluid-Structure Interaction, only a mono-layered aneurysm is simulated within this final part of the project. As in the previous section, comparisons are made between elastic, hyperelastic isotropic and hyperelastic anisotropic artery walls in terms of stresses and displacements.},
}

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