Updated docs to commit 9891e2ab47330e902bab7258d5603e71472ec286.

seminar/index.html

@@ -124,16 +124,30 @@ <h4>How to apply as a speaker</h4>
         <p>The seminar is a great opportunity to present your recent work to a large international audience.
             If you want to apply as a speaker, please use the contact in the registration confirmation email.</p>
         <h4>Next seminar</h4>
-        <h6> Title: TBD </h6> 4 September 2024 5:30 p.m. - 6:30 p.m. Central European Time
-        <p>Speaker: <strong><a href="">TBD</a></strong>, TBD</p>
+        <h6> Title: Single-cell multi-scale footprinting reveals the organization of cis-regulatory elements </h6> 4 September 2024 5:30 p.m. - 6:30 p.m. Central European Time
+        <p>Speaker: <strong><a href="https://www.buenrostrolab.com/">Max Horlbeck and Ruochi Zhang (Buenrostro lab)</a></strong>, Harvard University and Broad Institute</p>
         <strong>Abstract:</strong>
         <p align="justify">
-            TBD
+            Cis-regulatory elements (CREs) control gene expression and are dynamic in their structure and function,
+reflecting changes to the composition of diverse effector proteins over time1–3. However, methods for
+measuring the organization of effector proteins at CREs across the genome are limited, hampering efforts to
+connect CRE structure to their function in cell fate and disease. Here, we developed PRINT, a computational
+method that identifies footprints of DNA-protein interactions from bulk and single-cell chromatin accessibility
+data across multiple scales of protein sizes. Using these multi-scale footprints, we created the seq2PRINT
+framework, which employs deep-learning to allow precise inference of transcription factor and nucleosome
+binding and interprets regulatory logic at CREs. Applying seq2PRINT to single-cell chromatin accessibility
+data from human bone marrow, we observe sequential establishment and widening of CREs centered on
+pioneer factors across hematopoiesis. We further discover age-associated alterations in the structure of
+CREs in murine hematopoietic stem cells, including widespread loss of nucleosomes and gain of de
+novo-identified Ets composite motifs. Collectively, we establish a method for obtaining rich insights into
+DNA-binding protein dynamics from chromatin accessibility data and reveal the architecture of regulatory
+elements across differentiation and aging.
         </p>
 
         <h4>Upcoming speakers</h4>
         <div class="container-fluid">
             <ul class="list-unstyled">
+                <li>2 October 2024 - <a href="https://avantikalal.github.io/">Avantika Lal</a>, Genentech</li>
 
             </ul>
         </div>