added FunctionConstraint to cat-vrs-source.yaml

schema/cat-vrs/cat-vrs-source.yaml

@@ -207,4 +207,34 @@ $defs:
           - EFO:0030071
           - EFO:0030072
     required:
-      - copyChange
+      - copyChange
+
+  FunctionConstraint:
+    maturity: trial use
+    inherits: Constraint
+    type: object
+    description: >-
+        A categorical label of the function change that members of this categorical variant satisfies.
+    properties:
+      type:
+        extends: type
+        const: FunctionConstraint
+        default: FunctionConstraint
+        description: 'MUST be "FunctionConstraint"'
+      functionConsequence:
+        description: >-
+          A categorical label of the function change that members of this categorical variant satisfies, using ontology terms from [The Sequence Ontology](http://www.sequenceontology.org). ``SO:0002052`` refers to a [dominant negative variant](http://www.sequenceontology.org/browser/current_release/term/SO:0002052), a variant where the mutated gene product adversely affects the other (wild type) gene product. ``SO:0002054`` refers to a [loss of function variant](http://www.sequenceontology.org/browser/current_release/term/SO:0002054), a sequence variant whereby the gene product has diminished or abolished function. ``SO:0001561`` refers to a [polypeptide partial loss of function](http://www.sequenceontology.org/browser/current_release/term/SO:0001561), a sequence variant that causes some but not all loss of polypeptide function with respect to a reference sequence. ``SO:0002219`` refers to a [functionally normal](http://www.sequenceontology.org/browser/current_release/term/SO:0002219) variant, a sequence variant in which the function of a gene product is retained with respect to a reference. ``SO:0001557`` refers to a [polypeptide gain of function variant](http://www.sequenceontology.org/browser/current_release/term/SO:0001557), a sequence variant which causes gain of polypeptide function with respect to a reference sequence. ``SO:0002053`` refers to a [gain of function variant](http://www.sequenceontology.org/browser/current_release/term/SO:0002053), a sequence variant whereby new or enhanced function is conferred on the gene product.
+        type: string
+        enum:
+          - SO:0002052
+          - SO:0002054
+          - SO:0001561
+          - SO:0002219
+          - SO:0001557
+          - SO:0002053
+      description:
+        description: >-
+          A free-text description of the function change.
+        type: string
+    required:
+      - functionConsequence