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drizopoulos committed Oct 15, 2023
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Expand Up @@ -20,7 +20,7 @@ library("JMbayes2")
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# Non Proportional Hazards
The basic definition of the joint model assumes the the coefficients that quantify the association between the versions of the longitudinal outcomes and the hazard of the event are time-constant (i.e., the proportional hazards assumption). We can relax this assumption by specifying time-varying coefficients via the `functional_forms` argument of function `jm()`.
The basic definition of the joint model assumes the coefficients that quantify the association between the versions of the longitudinal outcomes and the hazard of the event are time-constant (i.e., the proportional hazards assumption). We can relax this assumption by specifying time-varying coefficients via the `functional_forms` argument of function `jm()`.

We will illustrate this capability using the PBC dataset. We start by fitting a Cox model for the composite event transplantation or death, including sex as a baseline covariate:
```{r}
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