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Figure out why percent replicating is apparently insensitive to number of replicates #60

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shntnu opened this issue Aug 20, 2021 · 1 comment
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shntnu commented Aug 20, 2021

@gwaygenomics reported this in https://github.com/broadinstitute/lincs-profiling-complementarity

Additionally, because we had 5 replicates of Cell Painting and 3 replicates of L1000 per treatment, we performed a subsampling experiment with Cell Painting to match the number of L1000 replicates. We actually observed slightly increased percent replicating scores in the subsampled Cell Painting data with fewer replicates indicating that the two additional Cell Painting replicates did not artificially inflate percent replicating scores (Supplementary Figure 3).

supfigure3

@shntnu shntnu added the question Further information is requested label Aug 20, 2021
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shntnu commented Aug 20, 2021

cc'ing @AnneCarpenter to keep her posted on the thread whenever we get to it

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