Skip to content

Commit

Permalink
Add full taxonomy text.
Browse files Browse the repository at this point in the history
  • Loading branch information
morriscb committed Nov 13, 2024
1 parent 05544a5 commit 911b267
Showing 1 changed file with 8 additions and 3 deletions.
11 changes: 8 additions & 3 deletions descriptions/Zeng_Aging_Mouse_taxonomy.md
Original file line number Diff line number Diff line change
Expand Up @@ -3,9 +3,14 @@
The Mouse Aging dataset [Jin et al] is a comprehensive single-cell RNA
sequencing (scRNA-seq) dataset containing ~1.2 million high-quality single-cell
transcriptomes of brain cells from young adult and aged mice of both sexes,
from regions spanning the forebrain, midbrain, and hindbrain. The 847 clusters
identified in this dataset are presented here with mappings into the [Whole
Mouse Brain Taxonomy](WMB-taxonomy.md).
from regions spanning the forebrain, midbrain, and hindbrain. High-resolution
de novo clustering of all cells results in 847 cell clusters and reveals at
least 12 age-biased clusters that are mostly glial types. Clusters in the study
were mapped to the Whole Mouse Brain taxonomy ([WMB-taxonomy](WMB-taxonomy.md))
to provided class, subclass and supertype annotations. At the broader cell
subclass and supertype levels, age-associated gene expression signatures were
analyzed resulting in a list of 2,449 differentially expressed genes (age-DE
genes) for many neuronal and non-neuronal cell types.

The associated metadata is hosted on AWS S3 bucket as a AWS Public Dataset:

Expand Down

0 comments on commit 911b267

Please sign in to comment.