diff --git a/Kconfig.zephyr b/Kconfig.zephyr
index 829deac2a9c549..5ad2fb2bf85c0b 100644
--- a/Kconfig.zephyr
+++ b/Kconfig.zephyr
@@ -430,7 +430,7 @@ endchoice
 
 config LTO
 	bool "Link Time Optimization [EXPERIMENTAL]"
-	depends on !(GEN_ISR_TABLES || GEN_IRQ_VECTOR_TABLE) || ISR_TABLES_LOCAL_DECLARATION
+	depends on (!(GEN_ISR_TABLES || GEN_IRQ_VECTOR_TABLE) || ISR_TABLES_LOCAL_DECLARATION) && !NATIVE_LIBRARY
 	select EXPERIMENTAL
 	help
 	  This option enables Link Time Optimization.