diff --git a/modules/trusted-firmware-m/CMakeLists.txt b/modules/trusted-firmware-m/CMakeLists.txt
index 464832a885ec12..f647e385dcf101 100644
--- a/modules/trusted-firmware-m/CMakeLists.txt
+++ b/modules/trusted-firmware-m/CMakeLists.txt
@@ -228,6 +228,8 @@ if (CONFIG_BUILD_WITH_TFM)
     message(FATAL_ERROR "Unsupported ZEPHYR_TOOLCHAIN_VARIANT: ${ZEPHYR_TOOLCHAIN_VARIANT}")
   endif()
 
+  string(REPLACE "toolchain" "toolchain_ns" TFM_TOOLCHAIN_NS_FILE ${TFM_TOOLCHAIN_FILE})
+
   if (CONFIG_TFM_QCBOR_PATH STREQUAL "DOWNLOAD")
     # Change CMake cache type to string to avoid QCBOR_PATH=/absolute/path/DOWNLOAD being set.
     set(QCBOR_PATH_TYPE ":STRING")
@@ -318,6 +320,11 @@ if (CONFIG_BUILD_WITH_TFM)
   # This is the root of all TFM build artifacts.
   set_target_properties(tfm PROPERTIES TFM_BINARY_DIR ${TFM_BINARY_DIR})
 
+  # Set TFM toolchain properties on 'tfm'
+  set_target_properties(tfm PROPERTIES TFM_TOOLCHAIN_NS_FILE ${TFM_TOOLCHAIN_NS_FILE})
+  set_target_properties(tfm PROPERTIES TFM_TOOLCHAIN_PREFIX  ${TFM_TOOLCHAIN_PREFIX})
+  set_target_properties(tfm PROPERTIES TFM_TOOLCHAIN_PATH    ${TFM_TOOLCHAIN_PATH})
+
   # Set BL2 (MCUboot) executable file paths as target properties on 'tfm'
   # These files are produced by the TFM build system.
   if(CONFIG_TFM_BL2)
diff --git a/samples/tfm_integration/tfm_regression_test/CMakeLists.txt b/samples/tfm_integration/tfm_regression_test/CMakeLists.txt
index 571bf986206a19..b86eebc4a81e74 100644
--- a/samples/tfm_integration/tfm_regression_test/CMakeLists.txt
+++ b/samples/tfm_integration/tfm_regression_test/CMakeLists.txt
@@ -17,6 +17,10 @@ get_target_property(TFM_NS_BIN_FILE          tfm TFM_NS_BIN_FILE)
 get_target_property(TFM_NS_HEX_FILE          tfm TFM_NS_HEX_FILE)
 get_target_property(TFM_NS_SIGNED_BIN_FILE   tfm TFM_NS_SIGNED_BIN_FILE)
 
+get_target_property(TFM_TOOLCHAIN_PATH       tfm TFM_TOOLCHAIN_PATH)
+get_target_property(TFM_TOOLCHAIN_PREFIX     tfm TFM_TOOLCHAIN_PREFIX)
+get_target_property(TFM_TOOLCHAIN_NS_FILE    tfm TFM_TOOLCHAIN_NS_FILE)
+
 set(TFM_TEST_REPO_PATH ${ZEPHYR_TRUSTED_FIRMWARE_M_MODULE_DIR}/../tf-m-tests)
 
 set(TFM_TEST_DIR         "${TFM_TEST_REPO_PATH}/tests_reg/test/secure_regression")
@@ -43,7 +47,8 @@ ExternalProject_Add(tfm_regression_test_app
                 -S ${TFM_TEST_REPO_PATH}/tests_reg
                 -B ${PROJECT_BINARY_DIR}/tfm_ns
                 -DCONFIG_SPE_PATH=${TFM_BINARY_DIR}/api_ns
-                -DTFM_TOOLCHAIN_FILE=cmake/toolchain_ns_GNUARM.cmake
+                -DTFM_TOOLCHAIN_FILE=cmake/${TFM_TOOLCHAIN_NS_FILE}
+                -DCROSS_COMPILE=${TFM_TOOLCHAIN_PATH}/${TFM_TOOLCHAIN_PREFIX}
                 -DQCBOR_PATH${QCBOR_PATH_TYPE}=${CONFIG_TFM_QCBOR_PATH}
                 -DCMAKE_BUILD_TYPE=RelWithDebInfo
     BUILD_COMMAND ${CMAKE_COMMAND} --build .