diff --git a/python-example/requirements.txt b/python-example/requirements.txt
index f1202ae..f5464ce 100644
--- a/python-example/requirements.txt
+++ b/python-example/requirements.txt
@@ -1,6 +1,6 @@
 Flask
 opentelemetry-distro==0.41b0
 opentelemetry-exporter-otlp==1.20.0
-opentelemetry-instrumentation==0.41b0
+opentelemetry-instrumentation==0.46b0
 opentelemetry-instrumentation-flask==0.41b0