diff --git a/metagraph/integration_tests/test_transform_anno.py b/metagraph/integration_tests/test_transform_anno.py
index 9e71b5b73f..a1887db9e0 100644
--- a/metagraph/integration_tests/test_transform_anno.py
+++ b/metagraph/integration_tests/test_transform_anno.py
@@ -18,6 +18,7 @@
 
 NUM_THREADS = 4
 
+
 class TestColumnOperations(TestingBase):
     @classmethod
     def setUpClass(cls):
@@ -70,6 +71,74 @@ def test_overlap(self):
         self.assertEqual(res.returncode, 0)
         self.assertEqual(156421, len(res.stdout.decode()))
 
+    def _check_aggregation_min(self, min_count, expected_density):
+        command = f'{METAGRAPH} transform_anno {self.annotation} -p {NUM_THREADS} \
+            --aggregate-columns --min-count {min_count} -o aggregated'
+
+        res = subprocess.run(command.split(), stdout=PIPE)
+        self.assertEqual(res.returncode, 0)
+
+        res = self._get_stats(f'-a aggregated{anno_file_extension[self.anno_repr]}')
+        self.assertEqual(res.returncode, 0)
+        out = res.stdout.decode().split('\n')[2:]
+        self.assertEqual('labels:  1', out[0])
+        self.assertEqual('objects: 46960', out[1])
+        self.assertEqual(f'density: {expected_density}', out[2])
+        self.assertEqual(f'representation: {self.anno_repr}', out[3])
+
+    def test_aggregate_columns(self):
+        self._check_aggregation_min(0, 1)
+        self._check_aggregation_min(1, 1)
+        self._check_aggregation_min(5, 0.0715077)
+        self._check_aggregation_min(10, 0.00344974)
+        self._check_aggregation_min(20, 0)
+
+    def _check_aggregation_min_max_value(self, min_count, max_value, expected_density):
+        command = f'{METAGRAPH} transform_anno {self.annotation} -p {NUM_THREADS} \
+            --aggregate-columns --min-count {min_count} --max-value {max_value} -o aggregated'
+
+        res = subprocess.run(command.split(), stdout=PIPE)
+        self.assertEqual(res.returncode, 0)
+
+        res = self._get_stats(f'-a aggregated{anno_file_extension[self.anno_repr]}')
+        self.assertEqual(res.returncode, 0)
+        out = res.stdout.decode().split('\n')[2:]
+        self.assertEqual('labels:  1', out[0])
+        self.assertEqual('objects: 46960', out[1])
+        self.assertEqual(f'density: {expected_density}', out[2])
+        self.assertEqual(f'representation: {self.anno_repr}', out[3])
+
+    def test_aggregate_columns_filtered(self):
+        self._check_aggregation_min_max_value(0, 0, 0)
+        self._check_aggregation_min_max_value(1, 0, 0)
+        self._check_aggregation_min_max_value(2, 0, 0)
+        self._check_aggregation_min_max_value(3, 0, 0)
+        self._check_aggregation_min_max_value(5, 0, 0)
+
+        self._check_aggregation_min_max_value(0, 1, 0.99704)
+        self._check_aggregation_min_max_value(1, 1, 0.99704)
+        self._check_aggregation_min_max_value(2, 1, 0.392994)
+        self._check_aggregation_min_max_value(3, 1, 0.183305)
+        self._check_aggregation_min_max_value(5, 1, 0.0715077)
+
+        self._check_aggregation_min_max_value(0, 2, 0.998807)
+        self._check_aggregation_min_max_value(1, 2, 0.998807)
+        self._check_aggregation_min_max_value(2, 2, 0.394825)
+        self._check_aggregation_min_max_value(3, 2, 0.183986)
+        self._check_aggregation_min_max_value(5, 2, 0.0715077)
+
+        self._check_aggregation_min_max_value(0, 5, 0.998999)
+        self._check_aggregation_min_max_value(1, 5, 0.998999)
+        self._check_aggregation_min_max_value(2, 5, 0.395315)
+        self._check_aggregation_min_max_value(3, 5, 0.184817)
+        self._check_aggregation_min_max_value(5, 5, 0.0715077)
+
+        self._check_aggregation_min_max_value(0, 1000, 1)
+        self._check_aggregation_min_max_value(1, 1000, 1)
+        self._check_aggregation_min_max_value(2, 1000, 0.395336)
+        self._check_aggregation_min_max_value(3, 1000, 0.184817)
+        self._check_aggregation_min_max_value(5, 1000, 0.0715077)
+
 
 if __name__ == '__main__':
     unittest.main()
diff --git a/metagraph/src/annotation/representation/column_compressed/annotate_column_compressed.cpp b/metagraph/src/annotation/representation/column_compressed/annotate_column_compressed.cpp
index 5473cdcb7e..75514bfd4c 100644
--- a/metagraph/src/annotation/representation/column_compressed/annotate_column_compressed.cpp
+++ b/metagraph/src/annotation/representation/column_compressed/annotate_column_compressed.cpp
@@ -589,6 +589,97 @@ ::load_column_values(const std::vector<std::string> &filenames,
         exit(1);
 }
 
+template <typename Label>
+void ColumnCompressed<Label>
+::load_columns_and_values(const std::vector<std::string> &filenames,
+                          const ColumnsValuesCallback &callback,
+                          size_t num_threads) {
+    std::atomic<bool> error_occurred = false;
+
+    std::vector<uint64_t> offsets(filenames.size(), 0);
+
+    // load labels
+    #pragma omp parallel for num_threads(num_threads) schedule(dynamic)
+    for (size_t i = 1; i < filenames.size(); ++i) {
+        auto fname = make_suffix(filenames[i - 1], kExtension);
+        try {
+            offsets[i] = read_num_labels(fname);
+        } catch (...) {
+            logger->error("Can't load label encoder from {}", fname);
+            error_occurred = true;
+        }
+    }
+
+    if (error_occurred)
+        exit(1);
+
+    // compute global offsets (partial sums)
+    std::partial_sum(offsets.begin(), offsets.end(), offsets.begin());
+
+    // load annotations
+    #pragma omp parallel for num_threads(num_threads) schedule(dynamic)
+    for (size_t i = 0; i < filenames.size(); ++i) {
+        const auto &filename = make_suffix(filenames[i], kExtension);
+        logger->trace("Loading columns from {}", filename);
+        try {
+            std::ifstream in(filename, std::ios::binary);
+            if (!in)
+                throw std::ifstream::failure("can't open file");
+
+            std::ignore = load_number(in);
+
+            LabelEncoder<Label> label_encoder_load;
+            if (!label_encoder_load.load(in))
+                throw std::ifstream::failure("can't load label encoder");
+
+            if (!label_encoder_load.size()) {
+                logger->warn("No columns in {}", filename);
+                continue;
+            }
+
+            const auto &values_fname
+                = utils::remove_suffix(filename, ColumnCompressed<>::kExtension)
+                                                + ColumnCompressed<>::kCountExtension;
+
+            std::ifstream values_in(values_fname, std::ios::binary);
+            if (!values_in)
+                throw std::ifstream::failure("can't open file " + values_fname);
+
+            for (size_t c = 0; c < label_encoder_load.size(); ++c) {
+                auto column = std::make_unique<bit_vector_smart>();
+
+                if (!column->load(in))
+                    throw std::ifstream::failure("can't load next column");
+
+                sdsl::int_vector<> column_values;
+                try {
+                    column_values.load(values_in);
+                } catch (...) {
+                    logger->error("Can't load column values from {} for column {}",
+                                  values_fname, c);
+                    throw;
+                }
+                if (column_values.size() != column->num_set_bits())
+                    throw std::ifstream::failure("inconsistent size of the value vector");
+
+                callback(offsets[i] + c,
+                         label_encoder_load.decode(c),
+                         std::move(column), std::move(column_values));
+            }
+
+        } catch (const std::exception &e) {
+            logger->error("Caught exception when loading values for {}: {}", filename, e.what());
+            error_occurred = true;
+        } catch (...) {
+            logger->error("Unknown exception when loading values for {}", filename);
+            error_occurred = true;
+        }
+    }
+
+    if (error_occurred)
+        exit(1);
+}
+
 template <typename Label>
 void ColumnCompressed<Label>::insert_rows(const std::vector<Index> &rows) {
     assert(std::is_sorted(rows.begin(), rows.end()));
diff --git a/metagraph/src/annotation/representation/column_compressed/annotate_column_compressed.hpp b/metagraph/src/annotation/representation/column_compressed/annotate_column_compressed.hpp
index c4713acc0a..ebcaac6c10 100644
--- a/metagraph/src/annotation/representation/column_compressed/annotate_column_compressed.hpp
+++ b/metagraph/src/annotation/representation/column_compressed/annotate_column_compressed.hpp
@@ -92,6 +92,14 @@ class ColumnCompressed : public MultiLabelEncoded<Label> {
                                    const ValuesCallback &callback,
                                    size_t num_threads = 1);
 
+    using ColumnsValuesCallback = std::function<void(uint64_t offset,
+                                                     const Label &,
+                                                     std::unique_ptr<bit_vector>&&,
+                                                     sdsl::int_vector<>&&)>;
+    static void load_columns_and_values(const std::vector<std::string> &filenames,
+                                        const ColumnsValuesCallback &callback,
+                                        size_t num_threads = 1);
+
     // Dump columns to separate files in human-readable format
     bool dump_columns(const std::string &prefix, size_t num_threads = 1) const;
 
diff --git a/metagraph/src/cli/config/config.cpp b/metagraph/src/cli/config/config.cpp
index 4e2f6f838d..c732383e0c 100644
--- a/metagraph/src/cli/config/config.cpp
+++ b/metagraph/src/cli/config/config.cpp
@@ -196,6 +196,10 @@ Config::Config(int argc, char *argv[]) {
             min_fraction = std::stod(get_value(i++));
         } else if (!strcmp(argv[i], "--max-fraction")) {
             max_fraction = std::stod(get_value(i++));
+        } else if (!strcmp(argv[i], "--min-value")) {
+            min_value = atoi(get_value(i++));
+        } else if (!strcmp(argv[i], "--max-value")) {
+            max_value = atoi(get_value(i++));
         } else if (!strcmp(argv[i], "--mem-cap-gb")) {
             memory_available = atof(get_value(i++));
         } else if (!strcmp(argv[i], "--dump-text-anno")) {
@@ -1145,9 +1149,12 @@ void Config::print_usage(const std::string &prog_name, IdentityType identity) {
 
             // fprintf(stderr, "\t-o --outfile-base [STR] basename of output file []\n");
             fprintf(stderr, "\t   --aggregate-columns \t\taggregate annotation columns into a bitmask (new column) [off]\n");
+            fprintf(stderr, "\t                       \t\t\tFormula: min-count <= \\sum_i 1{min-value <= c_i <= max-value} <= max-count\n");
             fprintf(stderr, "\t   --anno-label [STR]\t\tname of the aggregated output column [mask]\n");
+            fprintf(stderr, "\t   --min-value [INT] \t\tmin value for filtering [1]\n");
             fprintf(stderr, "\t   --min-count [INT] \t\texclude k-mers appearing in fewer than this number of columns [1]\n");
             fprintf(stderr, "\t   --min-fraction [FLOAT] \texclude k-mers appearing in fewer than this fraction of columns [0.0]\n");
+            fprintf(stderr, "\t   --max-value [INT] \t\tmax value for filtering [inf]\n");
             fprintf(stderr, "\t   --max-count [INT] \t\texclude k-mers appearing in more than this number of columns [inf]\n");
             fprintf(stderr, "\t   --max-fraction [FLOAT] \texclude k-mers appearing in more than this fraction of columns [1.0]\n");
             fprintf(stderr, "\t   --compute-overlap [STR] \tcompute the number of shared bits in columns of this annotation and ANNOTATOR [off]\n");
diff --git a/metagraph/src/cli/config/config.hpp b/metagraph/src/cli/config/config.hpp
index 5692595e4d..523cf077f6 100644
--- a/metagraph/src/cli/config/config.hpp
+++ b/metagraph/src/cli/config/config.hpp
@@ -81,6 +81,8 @@ class Config {
     double memory_available = 1;
     unsigned int min_count = 1;
     unsigned int max_count = std::numeric_limits<unsigned int>::max();
+    unsigned int min_value = 1;
+    unsigned int max_value = std::numeric_limits<unsigned int>::max();
     unsigned int num_top_labels = -1;
     unsigned int genome_binsize_anno = 1000;
     unsigned int arity_brwt = 2;
diff --git a/metagraph/src/cli/transform_annotation.cpp b/metagraph/src/cli/transform_annotation.cpp
index 59d9e0d2c8..dcbcca2f1a 100644
--- a/metagraph/src/cli/transform_annotation.cpp
+++ b/metagraph/src/cli/transform_annotation.cpp
@@ -503,6 +503,9 @@ int transform_annotation(Config *config) {
             exit(1);
         }
 
+        const bool filter_values = config->min_value > 1
+                                    || config->max_value
+                                        < std::numeric_limits<unsigned int>::max();
         const uint64_t min_cols
             = std::max((uint64_t)std::ceil(num_columns * config->min_fraction),
                        (uint64_t)config->min_count);
@@ -511,36 +514,67 @@ int transform_annotation(Config *config) {
                        (uint64_t)config->max_count);
 
         // TODO: set width to log2(max_cols + 1) but make sure atomic
-        //       increments can't lead to overflow
+        //       increments don't overflow
         sdsl::int_vector<> sum(0, 0, sdsl::bits::hi(num_columns) + 1);
-        ProgressBar progress_bar(num_columns, "Intersect columns",
-                                 std::cerr, !get_verbose());
+        ProgressBar progress_bar(num_columns, "Intersect columns", std::cerr, !get_verbose());
         ThreadPool thread_pool(get_num_threads(), 1);
         std::mutex mu_sum;
         std::mutex mu;
-        auto on_column = [&](uint64_t, const auto &, auto&& col) {
-            std::lock_guard<std::mutex> lock(mu);
 
-            if (!sum.size()) {
-                sum.resize(col->size());
-            } else if (sum.size() != col->size()) {
-                logger->error("Input columns have inconsistent size ({} != {})",
-                              sum.size(), col->size());
-                exit(1);
-            }
+        if (filter_values) {
+            auto on_column = [&](uint64_t, const std::string &,
+                                 std::unique_ptr<bit_vector>&& col,
+                                 sdsl::int_vector<>&& values) {
+                std::lock_guard<std::mutex> lock(mu);
 
-            thread_pool.enqueue([&,col{std::move(col)}]() {
-                col->call_ones([&](uint64_t i) {
-                    atomic_fetch_and_add(sum, i, 1, mu_sum, __ATOMIC_RELAXED);
+                if (!sum.size()) {
+                    sum.resize(col->size());
+                    sdsl::util::set_to_value(sum, 0);
+                } else if (sum.size() != col->size()) {
+                    logger->error("Input columns have inconsistent size ({} != {})",
+                                  sum.size(), col->size());
+                    exit(1);
+                }
+
+                thread_pool.enqueue([&,col(std::move(col)),values(std::move(values))]() {
+                    assert(col->num_set_bits() == values.size());
+                    for (uint64_t r = 0; r < values.size(); ++r) {
+                        if (values[r] >= config->min_value && values[r] <= config->max_value)
+                            atomic_fetch_and_add(sum, col->select1(r + 1), 1, mu_sum, __ATOMIC_RELAXED);
+                    }
+                    ++progress_bar;
                 });
-                ++progress_bar;
-            });
-        };
+            };
 
-        if (!ColumnCompressed<>::merge_load(files, on_column, get_num_threads())) {
-            logger->error("Couldn't load annotations");
-            exit(1);
+            ColumnCompressed<>::load_columns_and_values(files, on_column, get_num_threads());
+
+        } else {
+            auto on_column = [&](uint64_t, const auto &, auto&& col) {
+                std::lock_guard<std::mutex> lock(mu);
+
+                if (!sum.size()) {
+                    sum.resize(col->size());
+                    sdsl::util::set_to_value(sum, 0);
+                } else if (sum.size() != col->size()) {
+                    logger->error("Input columns have inconsistent size ({} != {})",
+                                  sum.size(), col->size());
+                    exit(1);
+                }
+
+                thread_pool.enqueue([&,col{std::move(col)}]() {
+                    col->call_ones([&](uint64_t i) {
+                        atomic_fetch_and_add(sum, i, 1, mu_sum, __ATOMIC_RELAXED);
+                    });
+                    ++progress_bar;
+                });
+            };
+
+            if (!ColumnCompressed<>::merge_load(files, on_column, get_num_threads())) {
+                logger->error("Couldn't load annotations");
+                exit(1);
+            }
         }
+
         thread_pool.join();
         std::atomic_thread_fence(std::memory_order_acquire);