diff --git a/phys2denoise/metrics/cardiac.py b/phys2denoise/metrics/cardiac.py index 52df119..40ebc47 100644 --- a/phys2denoise/metrics/cardiac.py +++ b/phys2denoise/metrics/cardiac.py @@ -15,6 +15,10 @@ def _cardiac_metrics(card, peaks, samplerate, metric, window=6, central_measure= Computes the average heart beats interval (HBI) or the average heart rate variability (HRV) in a sliding window. + We refer to HEART RATE (variability), however note that if using a PPG + recorded signal, it is more accurate to talk about PULSE RATE (variability). + See [3]_ for the differences and similarities between the two measures. + Parameters ---------- card : list or 1D numpy.ndarray @@ -23,14 +27,15 @@ def _cardiac_metrics(card, peaks, samplerate, metric, window=6, central_measure= array of peak indexes for card. samplerate : float Sampling rate for card, in Hertz. - metrics : "hbi", "hrv", string + metrics : "hbi", "hr", "hrv", string Cardiac metric(s) to calculate. window : float, optional Size of the sliding window, in seconds. Default is 6. - central_measure : "mean","average", "avg", "median", "mdn", string, optional + central_measure : "mean","average", "avg", "median", "mdn", "stdev", "std", string, optional Measure of the center used (mean or median). Default is "mean". + Returns ------- card_met : 2D numpy.ndarray @@ -62,6 +67,9 @@ def _cardiac_metrics(card, peaks, samplerate, metric, window=6, central_measure= vol. 213, pp. 116707, 2020. .. [2] C. Chang, J. P. Cunningham, & G. H. Glover, "Influence of heart rate on the BOLD signal: The cardiac response function", NeuroImage, vol. 44, 2009 + .. [3] N. Pinheiro et al., "Can PPG be used for HRV analysis?," 2016 38th + Annual International Conference of the IEEE Engineering in Medicine and + Biology Society (EMBC), doi: 10.1109/EMBC.2016.7591347. """ # Convert window to samples, but halves it. halfwindow_samples = int(round(window * samplerate / 2)) @@ -70,6 +78,8 @@ def _cardiac_metrics(card, peaks, samplerate, metric, window=6, central_measure= central_measure_operator = np.mean elif central_measure in ["median", "mdn"]: central_measure_operator = np.median + elif central_measure in ["stdev", "std"]: + central_measure_operator = np.std else: raise NotImplementedError( f" {central_measure} is not a supported metric of centrality." @@ -86,7 +96,10 @@ def _cardiac_metrics(card, peaks, samplerate, metric, window=6, central_measure= ) if metric == "hbi": card_met[n] = central_measure_operator(diff) if diff.size > 0 else 0 + elif metric == "hr": + card_met[n] = central_measure_operator(1 / diff) if diff.size > 0 else 0 elif metric == "hrv": + central_measure_operator = np.std card_met[n] = central_measure_operator(1 / diff) if diff.size > 0 else 0 else: raise NotImplementedError( @@ -102,9 +115,13 @@ def _cardiac_metrics(card, peaks, samplerate, metric, window=6, central_measure= @due.dcite(references.CHANG_CUNNINGHAM_GLOVER_2009) -def heart_rate_variability(card, peaks, samplerate, window=6, central_measure="mean"): +def heart_rate(card, peaks, samplerate, window=6, central_measure="mean"): """ - Compute average heart rate variability (HRV) in a sliding window. + Compute average heart rate (HR) in a sliding window. + + We call this function HEART RATE, however note that if using a PPG + recorded signal, it is more accurate to talk about PULSE RATE. + See [2]_ for the differences and similarities between the two measures. Parameters ---------- @@ -130,7 +147,7 @@ def heart_rate_variability(card, peaks, samplerate, window=6, central_measure="m Notes ----- - Heart rate variability (HRV) is taken from [1]_, and computed as the amounts of + Heart rate (HR) is taken from [1]_, and computed as the amounts of beats per minute. However, operationally, it is the average of the inverse of the time interval between two heart beats. @@ -146,12 +163,71 @@ def heart_rate_variability(card, peaks, samplerate, window=6, central_measure="m ---------- .. [1] C. Chang, J. P. Cunningham, & G. H. Glover, "Influence of heart rate on the BOLD signal: The cardiac response function", NeuroImage, vol. 44, 2009 + .. [2] N. Pinheiro et al., "Can PPG be used for HRV analysis?," 2016 38th + Annual International Conference of the IEEE Engineering in Medicine and + Biology Society (EMBC), doi: 10.1109/EMBC.2016.7591347. """ return _cardiac_metrics( card, peaks, samplerate, metric="hrv", window=6, central_measure="mean" ) +@due.dcite(references.PINHERO_ET_AL_2016) +def heart_rate_variability(card, peaks, samplerate, window=6, central_measure="mean"): + """ + Compute average heart rate variability (HRV) in a sliding window. + + We call this function HEART RATE variability, however note that if using a PPG + recorded signal, it is more accurate to talk about PULSE RATE variability. + See [1]_ for the differences and similarities between the two measures. + + Parameters + ---------- + card : list or 1D numpy.ndarray + Timeseries of recorded cardiac signal + peaks : list or 1D numpy.ndarray + array of peak indexes for card. + samplerate : float + Sampling rate for card, in Hertz. + window : float, optional + Size of the sliding window, in seconds. + Default is 6. + central_measure : "mean","average", "avg", "median", "mdn", string, optional + Measure of the center used (mean or median). + Default is "mean". + Returns + ------- + card_met : 2D numpy.ndarray + Heart Beats Interval or Heart Rate Variability timeseries. + The first column is the raw metric, in Hertz. + The second column is the metric convolved with the CRF, cut to the length + of the raw metric. + + Notes + ----- + Heart rate variability (HRV) is taken from [1]_, and computed as the amounts of + beats per minute. + However, operationally, it is the average of the inverse of the time interval + between two heart beats. + This metric should be convolved with the cardiac response function + before being included in a GLM. + + IMPORTANT : The unit of measure has a meaning, since they it's based on Hertz. + Hence, zscoring might remove important quantifiable information. + + See `_cardiac_metrics` for full implementation. + + References + ---------- + .. [1] N. Pinheiro et al., "Can PPG be used for HRV analysis?," 2016 38th + Annual International Conference of the IEEE Engineering in Medicine and + Biology Society (EMBC), doi: 10.1109/EMBC.2016.7591347. + """ + return _cardiac_metrics( + card, peaks, samplerate, metric="hrv", window=6, central_measure="std" + ) + + @due.dcite(references.CHEN_2020) def heart_beat_interval(card, peaks, samplerate, window=6, central_measure="mean"): """ diff --git a/phys2denoise/references.py b/phys2denoise/references.py index e39a7dd..cb01db5 100644 --- a/phys2denoise/references.py +++ b/phys2denoise/references.py @@ -11,6 +11,8 @@ GLOVER_2000 = Doi("10.1002/1522-2594(200007)44:1<162::AID-MRM23>3.0.CO;2-E") +PINHERO_ET_AL_2016 = Doi("10.1109/EMBC.2016.7591347") + POWER_2018 = Doi("10.1073/pnas.1720985115") POWER_2020 = Doi("10.1016/j.neuroimage.2019.116234")