diff --git a/requirements/constraints.txt b/requirements/constraints.txt
index e65e19a574fc..a2c90429c5b0 100644
--- a/requirements/constraints.txt
+++ b/requirements/constraints.txt
@@ -60,12 +60,12 @@ django-webpack-loader==0.7.0
 # Adding pin to avoid any major upgrade
 djangorestframework<3.15.0
 
-# Date: 2023-07-19
-# The version of django-stubs we can use depends on which Django release we're using
-# 1.16.0 works with Django 3.2 through 4.1
-# Issue for unpinning: https://github.com/openedx/edx-platform/issues/35275
-django-stubs==1.16.0
-djangorestframework-stubs==3.14.0  # Pinned to match django-stubs. Remove this when we can remove the above pin.
+# Date: 2024-07-19
+# Generally speaking, the major version of django-stubs should match the major version of django.
+# Specifically, we need to perpetually constrain django-stubs to a compatible version based on:
+# https://github.com/typeddjango/django-stubs?tab=readme-ov-file#version-compatibility
+# Issue: https://github.com/openedx/edx-platform/issues/35275
+django-stubs<5
 
 # Date: 2024-07-23
 # django-storages==1.14.4 breaks course imports
diff --git a/requirements/edx/development.txt b/requirements/edx/development.txt
index e32139843ed6..296619c98db7 100644
--- a/requirements/edx/development.txt
+++ b/requirements/edx/development.txt
@@ -577,7 +577,7 @@ django-storages==1.14.3
     #   -r requirements/edx/doc.txt
     #   -r requirements/edx/testing.txt
     #   edxval
-django-stubs==1.16.0
+django-stubs==4.2.7
     # via
     #   -c requirements/edx/../constraints.txt
     #   -r requirements/edx/development.in
@@ -625,10 +625,8 @@ djangorestframework==3.14.0
     #   openedx-learning
     #   ora2
     #   super-csv
-djangorestframework-stubs==3.14.0
-    # via
-    #   -c requirements/edx/../constraints.txt
-    #   -r requirements/edx/development.in
+djangorestframework-stubs==3.14.5
+    # via -r requirements/edx/development.in
 djangorestframework-xml==2.0.0
     # via
     #   -r requirements/edx/doc.txt
@@ -1301,8 +1299,6 @@ mypy==1.11.2
     # via
     #   -c requirements/edx/../constraints.txt
     #   -r requirements/edx/development.in
-    #   django-stubs
-    #   djangorestframework-stubs
 mypy-extensions==1.0.0
     # via mypy
 mysqlclient==2.2.6
@@ -2121,8 +2117,6 @@ tinycss2==1.4.0
     #   -r requirements/edx/doc.txt
     #   -r requirements/edx/testing.txt
     #   bleach
-tomli==2.2.1
-    # via django-stubs
 tomlkit==0.13.2
     # via
     #   -r requirements/edx/doc.txt