diff --git a/CHANGELOG_NEXT.md b/CHANGELOG_NEXT.md
index f40795aede..1ecdcaf9eb 100644
--- a/CHANGELOG_NEXT.md
+++ b/CHANGELOG_NEXT.md
@@ -8,4 +8,6 @@
 
 ### :house: (Internal)
 
+* chore: remove checks for unsupported node versions [#4341](https://github.com/open-telemetry/opentelemetry-js/pull/4341) @dyladan
+
 ### :bug: (Bug Fix)
diff --git a/experimental/packages/opentelemetry-instrumentation-grpc/package.json b/experimental/packages/opentelemetry-instrumentation-grpc/package.json
index 1387d81d55..807efaa2ab 100644
--- a/experimental/packages/opentelemetry-instrumentation-grpc/package.json
+++ b/experimental/packages/opentelemetry-instrumentation-grpc/package.json
@@ -59,14 +59,12 @@
     "@protobuf-ts/runtime-rpc": "2.9.3",
     "@types/mocha": "10.0.6",
     "@types/node": "18.6.5",
-    "@types/semver": "7.5.6",
     "@types/sinon": "10.0.20",
     "codecov": "3.8.3",
     "cross-var": "1.1.0",
     "lerna": "6.6.2",
     "mocha": "10.2.0",
     "nyc": "15.1.0",
-    "semver": "7.5.4",
     "sinon": "15.1.2",
     "ts-mocha": "10.0.0",
     "typescript": "4.4.4"
diff --git a/experimental/packages/opentelemetry-instrumentation-http/package.json b/experimental/packages/opentelemetry-instrumentation-http/package.json
index 4bd2cb71b1..c3ea3de7e8 100644
--- a/experimental/packages/opentelemetry-instrumentation-http/package.json
+++ b/experimental/packages/opentelemetry-instrumentation-http/package.json
@@ -53,7 +53,6 @@
     "@types/mocha": "10.0.6",
     "@types/node": "18.6.5",
     "@types/request-promise-native": "1.0.21",
-    "@types/semver": "7.5.6",
     "@types/sinon": "10.0.20",
     "@types/superagent": "4.1.24",
     "axios": "1.5.1",
@@ -76,8 +75,7 @@
   "dependencies": {
     "@opentelemetry/core": "1.18.1",
     "@opentelemetry/instrumentation": "0.45.1",
-    "@opentelemetry/semantic-conventions": "1.18.1",
-    "semver": "^7.5.2"
+    "@opentelemetry/semantic-conventions": "1.18.1"
   },
   "homepage": "https://github.com/open-telemetry/opentelemetry-js/tree/main/experimental/packages/opentelemetry-instrumentation-http",
   "sideEffects": false
diff --git a/experimental/packages/opentelemetry-instrumentation-http/src/http.ts b/experimental/packages/opentelemetry-instrumentation-http/src/http.ts
index 337d058033..959eb5de96 100644
--- a/experimental/packages/opentelemetry-instrumentation-http/src/http.ts
+++ b/experimental/packages/opentelemetry-instrumentation-http/src/http.ts
@@ -38,7 +38,6 @@ import {
 import type * as http from 'http';
 import type * as https from 'https';
 import { Socket } from 'net';
-import * as semver from 'semver';
 import * as url from 'url';
 import {
   Err,
@@ -398,10 +397,6 @@ export class HttpInstrumentation extends InstrumentationBase<Http> {
         };
 
         response.on('end', endHandler);
-        // See https://github.com/open-telemetry/opentelemetry-js/pull/3625#issuecomment-1475673533
-        if (semver.lt(process.version, '16.0.0')) {
-          response.on('close', endHandler);
-        }
         response.on(errorMonitor, (error: Err) => {
           this._diag.debug('outgoingRequest on error()', error);
           if (responseFinished) {
@@ -609,18 +604,6 @@ export class HttpInstrumentation extends InstrumentationBase<Http> {
         options,
         extraOptions
       );
-      /**
-       * Node 8's https module directly call the http one so to avoid creating
-       * 2 span for the same request we need to check that the protocol is correct
-       * See: https://github.com/nodejs/node/blob/v8.17.0/lib/https.js#L245
-       */
-      if (
-        component === 'http' &&
-        semver.lt(process.version, '9.0.0') &&
-        optionsParsed.protocol === 'https:'
-      ) {
-        return original.apply(this, [optionsParsed, ...args]);
-      }
 
       if (
         utils.isIgnored(
diff --git a/experimental/packages/opentelemetry-instrumentation-http/test/functionals/http-package.test.ts b/experimental/packages/opentelemetry-instrumentation-http/test/functionals/http-package.test.ts
index c07039f290..62ad4ccebc 100644
--- a/experimental/packages/opentelemetry-instrumentation-http/test/functionals/http-package.test.ts
+++ b/experimental/packages/opentelemetry-instrumentation-http/test/functionals/http-package.test.ts
@@ -88,15 +88,7 @@ describe('Packages', () => {
       },
     ].forEach(({ name, httpPackage }) => {
       it(`should create a span for GET requests and add propagation headers by using ${name} package`, async () => {
-        if (process.versions.node.startsWith('12') && name === 'got') {
-          // got complains with nock and node version 12+
-          // > RequestError: The first argument must be one of type string, Buffer, ArrayBuffer, Array, or Array-like Object. Received type function
-          // so let's make a real call
-          nock.cleanAll();
-          nock.enableNetConnect();
-        } else {
-          nock.load(path.join(__dirname, '../', '/fixtures/google-http.json'));
-        }
+        nock.load(path.join(__dirname, '../', '/fixtures/google-http.json'));
 
         const urlparsed = url.parse(
           `${protocol}://www.google.com/search?q=axios&oq=axios&aqs=chrome.0.69i59l2j0l3j69i60.811j0j7&sourceid=chrome&ie=UTF-8`
diff --git a/experimental/packages/opentelemetry-instrumentation-http/test/functionals/https-package.test.ts b/experimental/packages/opentelemetry-instrumentation-http/test/functionals/https-package.test.ts
index a7c5972a6a..80a003f535 100644
--- a/experimental/packages/opentelemetry-instrumentation-http/test/functionals/https-package.test.ts
+++ b/experimental/packages/opentelemetry-instrumentation-http/test/functionals/https-package.test.ts
@@ -88,24 +88,10 @@ describe('Packages', () => {
       },
     ].forEach(({ name, httpPackage }) => {
       it(`should create a span for GET requests and add propagation headers by using ${name} package`, async () => {
-        if (process.versions.node.startsWith('12') && name === 'got') {
-          // got complains with nock and node version 12+
-          // > RequestError: The first argument must be one of type string, Buffer, ArrayBuffer, Array, or Array-like Object. Received type function
-          // so let's make a real call
-          nock.cleanAll();
-          nock.enableNetConnect();
-        } else {
-          nock.load(path.join(__dirname, '../', '/fixtures/google-https.json'));
-        }
+        nock.load(path.join(__dirname, '../', '/fixtures/google-https.json'));
 
         const urlparsed = url.parse(
-          name === 'got' && process.versions.node.startsWith('12')
-            ? // there is an issue with got 9.6 version and node 12 when redirecting so url above will not work
-              // https://github.com/nock/nock/pull/1551
-              // https://github.com/sindresorhus/got/commit/bf1aa5492ae2bc78cbbec6b7d764906fb156e6c2#diff-707a4781d57c42085155dcb27edb9ccbR258
-              // TODO: check if this is still the case when new version
-              'https://www.google.com'
-            : 'https://www.google.com/search?q=axios&oq=axios&aqs=chrome.0.69i59l2j0l3j69i60.811j0j7&sourceid=chrome&ie=UTF-8'
+          'https://www.google.com/search?q=axios&oq=axios&aqs=chrome.0.69i59l2j0l3j69i60.811j0j7&sourceid=chrome&ie=UTF-8'
         );
         const result = await httpPackage.get(urlparsed.href!);
         if (!resHeaders) {
diff --git a/experimental/packages/opentelemetry-sdk-node/package.json b/experimental/packages/opentelemetry-sdk-node/package.json
index 1bbca9ddb8..eeabe76225 100644
--- a/experimental/packages/opentelemetry-sdk-node/package.json
+++ b/experimental/packages/opentelemetry-sdk-node/package.json
@@ -67,14 +67,12 @@
     "@opentelemetry/exporter-jaeger": "1.18.1",
     "@types/mocha": "10.0.6",
     "@types/node": "18.6.5",
-    "@types/semver": "7.5.6",
     "@types/sinon": "10.0.20",
     "codecov": "3.8.3",
     "cross-var": "1.1.0",
     "lerna": "6.6.2",
     "mocha": "10.2.0",
     "nyc": "15.1.0",
-    "semver": "7.5.4",
     "sinon": "15.1.2",
     "ts-loader": "8.4.0",
     "ts-mocha": "10.0.0",
diff --git a/experimental/packages/opentelemetry-sdk-node/test/sdk.test.ts b/experimental/packages/opentelemetry-sdk-node/test/sdk.test.ts
index 6fb76f3dad..512d65bc65 100644
--- a/experimental/packages/opentelemetry-sdk-node/test/sdk.test.ts
+++ b/experimental/packages/opentelemetry-sdk-node/test/sdk.test.ts
@@ -24,10 +24,7 @@ import {
   metrics,
   DiagConsoleLogger,
 } from '@opentelemetry/api';
-import {
-  AsyncHooksContextManager,
-  AsyncLocalStorageContextManager,
-} from '@opentelemetry/context-async-hooks';
+import { AsyncLocalStorageContextManager } from '@opentelemetry/context-async-hooks';
 import { CompositePropagator } from '@opentelemetry/core';
 import {
   AggregationTemporality,
@@ -48,7 +45,6 @@ import {
   IdGenerator,
 } from '@opentelemetry/sdk-trace-base';
 import * as assert from 'assert';
-import * as semver from 'semver';
 import * as Sinon from 'sinon';
 import { NodeSDK } from '../src';
 import { env } from 'process';
@@ -66,10 +62,6 @@ import {
   LoggerProvider,
 } from '@opentelemetry/sdk-logs';
 
-const DefaultContextManager = semver.gte(process.version, '14.8.0')
-  ? AsyncLocalStorageContextManager
-  : AsyncHooksContextManager;
-
 describe('Node SDK', () => {
   let ctxManager: any;
   let propagator: any;
@@ -166,7 +158,7 @@ describe('Node SDK', () => {
 
       assert.ok(
         context['_getContextManager']().constructor.name ===
-          DefaultContextManager.name
+          AsyncLocalStorageContextManager.name
       );
       assert.ok(
         propagation['_getGlobalPropagator']() instanceof CompositePropagator
@@ -191,7 +183,7 @@ describe('Node SDK', () => {
 
       assert.ok(
         context['_getContextManager']().constructor.name ===
-          DefaultContextManager.name
+          AsyncLocalStorageContextManager.name
       );
       assert.ok(
         propagation['_getGlobalPropagator']() instanceof CompositePropagator
diff --git a/experimental/packages/otlp-exporter-base/src/platform/node/util.ts b/experimental/packages/otlp-exporter-base/src/platform/node/util.ts
index fd40981e85..18e90f2a3e 100644
--- a/experimental/packages/otlp-exporter-base/src/platform/node/util.ts
+++ b/experimental/packages/otlp-exporter-base/src/platform/node/util.ts
@@ -50,7 +50,6 @@ export function sendWithHttp<ExportItem, ServiceRequest>(
 ): void {
   const exporterTimeout = collector.timeoutMillis;
   const parsedUrl = new url.URL(collector.url);
-  const nodeVersion = Number(process.versions.node.split('.')[0]);
   let retryTimer: ReturnType<typeof setTimeout>;
   let req: http.ClientRequest;
   let reqIsDestroyed = false;
@@ -63,8 +62,7 @@ export function sendWithHttp<ExportItem, ServiceRequest>(
       const err = new OTLPExporterError('Request Timeout');
       onError(err);
     } else {
-      // req.abort() was deprecated since v14
-      nodeVersion >= 14 ? req.destroy() : req.abort();
+      req.destroy();
     }
   }, exporterTimeout);
 
diff --git a/experimental/packages/shim-opencensus/package.json b/experimental/packages/shim-opencensus/package.json
index 58f1444e65..26836364c3 100644
--- a/experimental/packages/shim-opencensus/package.json
+++ b/experimental/packages/shim-opencensus/package.json
@@ -72,8 +72,7 @@
     "@opentelemetry/core": "1.18.1",
     "@opentelemetry/resources": "1.18.1",
     "@opentelemetry/sdk-metrics": "1.18.1",
-    "require-in-the-middle": "^7.1.1",
-    "semver": "^7.5.2"
+    "require-in-the-middle": "^7.1.1"
   },
   "homepage": "https://github.com/open-telemetry/opentelemetry-js/tree/main/packages/shim-opencensus",
   "sideEffects": false
diff --git a/experimental/packages/shim-opencensus/test/util.ts b/experimental/packages/shim-opencensus/test/util.ts
index 842525ea0c..0d34bd3cca 100644
--- a/experimental/packages/shim-opencensus/test/util.ts
+++ b/experimental/packages/shim-opencensus/test/util.ts
@@ -22,11 +22,7 @@ import {
   SimpleSpanProcessor,
 } from '@opentelemetry/sdk-trace-base';
 import { ShimTracer } from '../src/ShimTracer';
-import * as semver from 'semver';
-import {
-  AsyncHooksContextManager,
-  AsyncLocalStorageContextManager,
-} from '@opentelemetry/context-async-hooks';
+import { AsyncLocalStorageContextManager } from '@opentelemetry/context-async-hooks';
 import { Tracer, TracerProvider, context } from '@opentelemetry/api';
 
 export async function withTestTracer(
@@ -61,10 +57,7 @@ export function setupNodeContextManager(
   before: Mocha.HookFunction,
   after: Mocha.HookFunction
 ) {
-  const ContextManager = semver.gte(process.version, '14.8.0')
-    ? AsyncLocalStorageContextManager
-    : AsyncHooksContextManager;
-  const instance = new ContextManager();
+  const instance = new AsyncLocalStorageContextManager();
   instance.enable();
   before(() => context.setGlobalContextManager(instance));
   after(() => context.disable());
diff --git a/packages/opentelemetry-sdk-trace-node/package.json b/packages/opentelemetry-sdk-trace-node/package.json
index 1a2791bf00..a6b5a7927e 100644
--- a/packages/opentelemetry-sdk-trace-node/package.json
+++ b/packages/opentelemetry-sdk-trace-node/package.json
@@ -50,7 +50,6 @@
     "@opentelemetry/semantic-conventions": "1.18.1",
     "@types/mocha": "10.0.6",
     "@types/node": "18.6.5",
-    "@types/semver": "7.5.6",
     "@types/sinon": "10.0.20",
     "codecov": "3.8.3",
     "cross-var": "1.1.0",
@@ -69,8 +68,7 @@
     "@opentelemetry/core": "1.18.1",
     "@opentelemetry/propagator-b3": "1.18.1",
     "@opentelemetry/propagator-jaeger": "1.18.1",
-    "@opentelemetry/sdk-trace-base": "1.18.1",
-    "semver": "^7.5.2"
+    "@opentelemetry/sdk-trace-base": "1.18.1"
   },
   "homepage": "https://github.com/open-telemetry/opentelemetry-js/tree/main/packages/opentelemetry-sdk-trace-node",
   "sideEffects": false
diff --git a/packages/opentelemetry-sdk-trace-node/src/NodeTracerProvider.ts b/packages/opentelemetry-sdk-trace-node/src/NodeTracerProvider.ts
index 9d552162f6..abb25f4db9 100644
--- a/packages/opentelemetry-sdk-trace-node/src/NodeTracerProvider.ts
+++ b/packages/opentelemetry-sdk-trace-node/src/NodeTracerProvider.ts
@@ -13,17 +13,13 @@
  * See the License for the specific language governing permissions and
  * limitations under the License.
  */
-import {
-  AsyncHooksContextManager,
-  AsyncLocalStorageContextManager,
-} from '@opentelemetry/context-async-hooks';
+import { AsyncLocalStorageContextManager } from '@opentelemetry/context-async-hooks';
 import { B3Propagator, B3InjectEncoding } from '@opentelemetry/propagator-b3';
 import {
   BasicTracerProvider,
   PROPAGATOR_FACTORY,
   SDKRegistrationConfig,
 } from '@opentelemetry/sdk-trace-base';
-import * as semver from 'semver';
 import { NodeTracerConfig } from './config';
 import { JaegerPropagator } from '@opentelemetry/propagator-jaeger';
 
@@ -58,10 +54,7 @@ export class NodeTracerProvider extends BasicTracerProvider {
 
   override register(config: SDKRegistrationConfig = {}): void {
     if (config.contextManager === undefined) {
-      const ContextManager = semver.gte(process.version, '14.8.0')
-        ? AsyncLocalStorageContextManager
-        : AsyncHooksContextManager;
-      config.contextManager = new ContextManager();
+      config.contextManager = new AsyncLocalStorageContextManager();
       config.contextManager.enable();
     }
 
diff --git a/packages/opentelemetry-sdk-trace-node/test/registration.test.ts b/packages/opentelemetry-sdk-trace-node/test/registration.test.ts
index 5c35f8de97..2b1466b179 100644
--- a/packages/opentelemetry-sdk-trace-node/test/registration.test.ts
+++ b/packages/opentelemetry-sdk-trace-node/test/registration.test.ts
@@ -23,13 +23,9 @@ import {
   trace,
   ProxyTracerProvider,
 } from '@opentelemetry/api';
-import {
-  AsyncHooksContextManager,
-  AsyncLocalStorageContextManager,
-} from '@opentelemetry/context-async-hooks';
+import { AsyncLocalStorageContextManager } from '@opentelemetry/context-async-hooks';
 import { CompositePropagator } from '@opentelemetry/core';
 import { NodeTracerProvider } from '../src';
-import * as semver from 'semver';
 
 const assertInstanceOf = (actual: object, ExpectedInstance: Function) => {
   assert.ok(
@@ -38,10 +34,6 @@ const assertInstanceOf = (actual: object, ExpectedInstance: Function) => {
   );
 };
 
-const DefaultContextManager = semver.gte(process.version, '14.8.0')
-  ? AsyncLocalStorageContextManager
-  : AsyncHooksContextManager;
-
 describe('API registration', () => {
   beforeEach(() => {
     context.disable();
@@ -53,7 +45,10 @@ describe('API registration', () => {
     const tracerProvider = new NodeTracerProvider();
     tracerProvider.register();
 
-    assertInstanceOf(context['_getContextManager'](), DefaultContextManager);
+    assertInstanceOf(
+      context['_getContextManager'](),
+      AsyncLocalStorageContextManager
+    );
     assertInstanceOf(
       propagation['_getGlobalPropagator'](),
       CompositePropagator
@@ -113,7 +108,10 @@ describe('API registration', () => {
 
     assert.strictEqual(propagation['_getGlobalPropagator'](), propagator);
 
-    assertInstanceOf(context['_getContextManager'](), DefaultContextManager);
+    assertInstanceOf(
+      context['_getContextManager'](),
+      AsyncLocalStorageContextManager
+    );
 
     const apiTracerProvider = trace.getTracerProvider() as ProxyTracerProvider;
     assert.ok(apiTracerProvider.getDelegate() === tracerProvider);