nmrCV-full.obo

format-version: 1.2
data-version: nmrCV/releases/2023-11-23/nmrCV-full.owl
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_gocam ""
subsetdef: ro-eco ""
subsetdef: RO:0002259 ""
synonymtypedef: OMO:0003000 "abbreviation"
synonymtypedef: OMO:0003001 "ambiguous synonym"
synonymtypedef: OMO:0003002 "dubious synonym"
synonymtypedef: OMO:0003003 "layperson synonym"
synonymtypedef: OMO:0003004 "plural form"
synonymtypedef: OMO:0003005 "UK spelling synonym"
synonymtypedef: OMO:0003006 "misspelling"
synonymtypedef: OMO:0003007 "misnomer"
synonymtypedef: OMO:0003008 "previous name"
synonymtypedef: OMO:0003009 "legal name"
synonymtypedef: OMO:0003010 "International Nonproprietary Name"
synonymtypedef: OMO:0003011 "latin term"
synonymtypedef: OMO:0003012 "acronym"
ontology: nmrCV/nmrCV-full
property_value: http://purl.org/dc/terms/description "This artefact is an MSI-approved controlled vocabulary primarily developed under COSMOS EU and PhenoMeNal EU governance. The nmrCV is supporting the nmrML XML format with standardized terms. nmrML is a vendor agnostic open access NMR raw data standard. Its primaly role is analogous to the mzCV for the PSI-approved mzML XML format. It uses BFO2.0 as its Top level. This CV was derived from two predecessors (The NMR CV from the David Wishart Group, developed by Joseph Cruz) and the MSI nmr CV developed by Daniel Schober at the EBI. This simple taxonomy of terms (no DL semantics used) serves the nuclear magnetic resonance markup language (nmrML) with meaningful descriptors to amend the nmrML xml file with CV terms. Metabolomics scientists are encouraged to use this CV to annotrate their raw and experimental context data, i.e. within nmrML. The approach to have an exchange syntax mixed of an xsd and CV stems from the PSI mzML effort. The reason to branch out from an xsd into a CV is, that in areas where the terminology is likely to change faster than the nmrML xsd could be updated and aligned, an externally and decentrallised maintained CV can accompensate for such dynamics in a more flexible way. A second reason for this set-up is that semantic validity of CV terms used in an nmrML XML instance (allowed CV terms, position/relation to each other, cardinality) can be validated by rule-based proprietary validators: By means of cardinality specifications and XPath expressions defined in an XML mapping file (an instances of the CvMappingRules.xsd ), one can define what ontology terms are allowed in a specific location of the data model." xsd:string
property_value: http://purl.org/dc/terms/license https://creativecommons.org/publicdomain/mark/1.0/
property_value: http://purl.org/dc/terms/title "nuclear magnetic resonance CV" xsd:string
property_value: owl:versionInfo "2023-11-23" xsd:string

[Term]
id: BFO:0000001
name: entity
property_value: BFO:0000179 "entity" xsd:string
property_value: BFO:0000180 "Entity" xsd:string
property_value: IAO:0000112 "Julius Caesar" xsd:string
property_value: IAO:0000112 "the Second World War" xsd:string
property_value: IAO:0000112 "Verdi’s Requiem" xsd:string
property_value: IAO:0000112 "your body mass index" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81" xsd:string
property_value: IAO:0000116 "Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000004", comment="per discussion with Barry Smith", seeAlso="http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf"}
property_value: IAO:0000600 "An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/001-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000002
name: continuant
def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." []
is_a: BFO:0000001 ! entity
disjoint_from: BFO:0000003 ! occurrent
relationship: BFO:0000050 BFO:0000002 {all_only="true"} ! part of continuant
property_value: BFO:0000179 "continuant" xsd:string
property_value: BFO:0000180 "Continuant" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240" xsd:string
property_value: IAO:0000116 "Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000007"}
property_value: IAO:0000600 "A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/008-002"}
property_value: IAO:0000601 "if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/126-001"}
property_value: IAO:0000601 "if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/009-002"}
property_value: IAO:0000601 "if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/011-002"}
property_value: IAO:0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/009-002"}
property_value: IAO:0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/126-001"}
property_value: IAO:0000602 "(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/008-002"}
property_value: IAO:0000602 "(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/011-002"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000003
name: occurrent
def: "An entity that has temporal parts and that happens, unfolds or develops through time." []
is_a: BFO:0000001 ! entity
relationship: BFO:0000050 BFO:0000003 {all_only="true"} ! part of occurrent
property_value: BFO:0000179 "occurrent" xsd:string
property_value: BFO:0000180 "Occurrent" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players." xsd:string
property_value: IAO:0000116 "Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process." xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000006", comment="per discussion with Barry Smith"}
property_value: IAO:0000116 "Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame." xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000012"}
property_value: IAO:0000600 "An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/077-002"}
property_value: IAO:0000601 "b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/079-001"}
property_value: IAO:0000601 "Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/108-001"}
property_value: IAO:0000602 "(forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/108-001"}
property_value: IAO:0000602 "(forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/079-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000004
name: independent continuant
def: "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])" [] {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/017-002"}
comment: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
is_a: BFO:0000002 ! continuant
disjoint_from: BFO:0000020 ! specifically dependent continuant
disjoint_from: BFO:0000031 ! generically dependent continuant
relationship: BFO:0000050 BFO:0000004 {all_only="true"} ! part of independent continuant
property_value: BFO:0000179 "ic" xsd:string
property_value: BFO:0000180 "IndependentContinuant" xsd:string
property_value: IAO:0000112 "a chair" xsd:string
property_value: IAO:0000112 "a heart" xsd:string
property_value: IAO:0000112 "a leg" xsd:string
property_value: IAO:0000112 "a molecule" xsd:string
property_value: IAO:0000112 "a spatial region" xsd:string
property_value: IAO:0000112 "an atom" xsd:string
property_value: IAO:0000112 "an orchestra." xsd:string
property_value: IAO:0000112 "an organism" xsd:string
property_value: IAO:0000112 "the bottom right portion of a human torso" xsd:string
property_value: IAO:0000112 "the interior of your mouth" xsd:string
property_value: IAO:0000601 "For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/134-001"}
property_value: IAO:0000601 "For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/018-002"}
property_value: IAO:0000602 "(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/018-002"}
property_value: IAO:0000602 "(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/134-001"}
property_value: IAO:0000602 "(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/017-002"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000006
name: spatial region
is_a: BFO:0000141 ! immaterial entity
disjoint_from: BFO:0000029 ! site
disjoint_from: BFO:0000140 ! continuant fiat boundary
property_value: BFO:0000179 "s-region" xsd:string
property_value: BFO:0000180 "SpatialRegion" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: Spatial regions do not participate in processes." xsd:string
property_value: IAO:0000116 "Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional." xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000002", comment="per discussion with Barry Smith"}
property_value: IAO:0000600 "A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/035-001"}
property_value: IAO:0000601 "All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/036-001"}
property_value: IAO:0000602 "(forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/036-001"}
property_value: IAO:0000602 "(forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/035-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000008
name: temporal region
is_a: BFO:0000003 ! occurrent
disjoint_from: BFO:0000011 ! spatiotemporal region
disjoint_from: BFO:0000015 ! process
disjoint_from: BFO:0000035 ! process boundary
property_value: BFO:0000179 "t-region" xsd:string
property_value: BFO:0000180 "TemporalRegion" xsd:string
property_value: IAO:0000116 "Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000003", comment="per discussion with Barry Smith"}
property_value: IAO:0000600 "A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/100-001"}
property_value: IAO:0000601 "All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/101-001"}
property_value: IAO:0000601 "Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/119-002"}
property_value: IAO:0000602 "(forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/119-002"}
property_value: IAO:0000602 "(forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/101-001"}
property_value: IAO:0000602 "(forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/100-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000009
name: two-dimensional spatial region
is_a: BFO:0000006 ! spatial region
disjoint_from: BFO:0000028 ! three-dimensional spatial region
property_value: BFO:0000179 "2d-s-region" xsd:string
property_value: BFO:0000180 "TwoDimensionalSpatialRegion" xsd:string
property_value: IAO:0000112 "an infinitely thin plane in space." xsd:string
property_value: IAO:0000112 "the surface of a sphere-shaped part of space" xsd:string
property_value: IAO:0000600 "A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/039-001"}
property_value: IAO:0000602 "(forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/039-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000011
name: spatiotemporal region
is_a: BFO:0000003 ! occurrent
property_value: BFO:0000179 "st-region" xsd:string
property_value: BFO:0000180 "SpatiotemporalRegion" xsd:string
property_value: IAO:0000112 "the spatiotemporal region occupied by a human life" xsd:string
property_value: IAO:0000112 "the spatiotemporal region occupied by a process of cellular meiosis." xsd:string
property_value: IAO:0000112 "the spatiotemporal region occupied by the development of a cancer tumor" xsd:string
property_value: IAO:0000600 "A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/095-001"}
property_value: IAO:0000601 "All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/096-001"}
property_value: IAO:0000601 "Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/099-001"}
property_value: IAO:0000601 "Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/098-001"}
property_value: IAO:0000601 "Every spatiotemporal region occupies_spatiotemporal_region itself." xsd:string
property_value: IAO:0000601 "Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/107-002"}
property_value: IAO:0000602 "(forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/107-002"}
property_value: IAO:0000602 "(forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/099-001"}
property_value: IAO:0000602 "(forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/096-001"}
property_value: IAO:0000602 "(forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/098-001"}
property_value: IAO:0000602 "(forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/095-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000015
name: process
def: "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])" [] {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/083-003"}
comment: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
is_a: BFO:0000003 ! occurrent
property_value: BFO:0000179 "process" xsd:string
property_value: BFO:0000180 "Process" xsd:string
property_value: IAO:0000112 "a process of cell-division, \\ a beating of the heart" xsd:string
property_value: IAO:0000112 "a process of meiosis" xsd:string
property_value: IAO:0000112 "a process of sleeping" xsd:string
property_value: IAO:0000112 "the course of a disease" xsd:string
property_value: IAO:0000112 "the flight of a bird" xsd:string
property_value: IAO:0000112 "the life of an organism" xsd:string
property_value: IAO:0000112 "your process of aging." xsd:string
property_value: IAO:0000116 "BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)" xsd:string
property_value: IAO:0000602 "(iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/083-003"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000016
name: disposition
is_a: BFO:0000017 ! realizable entity
disjoint_from: BFO:0000023 ! role
property_value: BFO:0000179 "disposition" xsd:string
property_value: BFO:0000180 "Disposition" xsd:string
property_value: IAO:0000112 "an atom of element X has the disposition to decay to an atom of element Y" xsd:string
property_value: IAO:0000112 "certain people have a predisposition to colon cancer" xsd:string
property_value: IAO:0000112 "children are innately disposed to categorize objects in certain ways." xsd:string
property_value: IAO:0000112 "the cell wall is disposed to filter chemicals in endocytosis and exocytosis" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type." xsd:string
property_value: IAO:0000600 "b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/062-002"}
property_value: IAO:0000601 "If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/063-002"}
property_value: IAO:0000602 "(forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/063-002"}
property_value: IAO:0000602 "(forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/062-002"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000017
name: realizable entity
def: "A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances." []
is_a: BFO:0000020 ! specifically dependent continuant
disjoint_from: BFO:0000019 ! quality
relationship: BFO:0000050 BFO:0000017 {all_only="true"} ! part of realizable entity
property_value: BFO:0000179 "realizable" xsd:string
property_value: BFO:0000180 "RealizableEntity" xsd:string
property_value: IAO:0000112 "the disposition of this piece of metal to conduct electricity." xsd:string
property_value: IAO:0000112 "the disposition of your blood to coagulate" xsd:string
property_value: IAO:0000112 "the function of your reproductive organs" xsd:string
property_value: IAO:0000112 "the role of being a doctor" xsd:string
property_value: IAO:0000112 "the role of this boundary to delineate where Utah and Colorado meet" xsd:string
property_value: IAO:0000600 "To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/058-002"}
property_value: IAO:0000601 "All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/060-002"}
property_value: IAO:0000602 "(forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/060-002"}
property_value: IAO:0000602 "(forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/058-002"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000018
name: zero-dimensional spatial region
is_a: BFO:0000006 ! spatial region
disjoint_from: BFO:0000028 ! three-dimensional spatial region
property_value: BFO:0000179 "0d-s-region" xsd:string
property_value: BFO:0000180 "ZeroDimensionalSpatialRegion" xsd:string
property_value: IAO:0000600 "A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/037-001"}
property_value: IAO:0000602 "(forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/037-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000019
name: quality
is_a: BFO:0000020 ! specifically dependent continuant
relationship: BFO:0000050 BFO:0000019 {all_only="true"} ! part of quality
property_value: BFO:0000179 "quality" xsd:string
property_value: BFO:0000180 "Quality" xsd:string
property_value: IAO:0000112 "the ambient temperature of this portion of air" xsd:string
property_value: IAO:0000112 "the color of a tomato" xsd:string
property_value: IAO:0000112 "the length of the circumference of your waist" xsd:string
property_value: IAO:0000112 "the mass of this piece of gold." xsd:string
property_value: IAO:0000112 "the shape of your nose" xsd:string
property_value: IAO:0000112 "the shape of your nostril" xsd:string
property_value: IAO:0000600 "a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/055-001"}
property_value: IAO:0000601 "If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/105-001"}
property_value: IAO:0000602 "(forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/105-001"}
property_value: IAO:0000602 "(forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/055-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000020
name: specifically dependent continuant
def: "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])" [] {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/050-003"}
comment: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
is_a: BFO:0000002 ! continuant
disjoint_from: BFO:0000031 ! generically dependent continuant
relationship: BFO:0000050 BFO:0000020 {all_only="true"} ! part of specifically dependent continuant
property_value: BFO:0000179 "sdc" xsd:string
property_value: BFO:0000180 "SpecificallyDependentContinuant" xsd:string
property_value: IAO:0000112 "of one-sided specifically dependent continuants: the mass of this tomato" xsd:string
property_value: IAO:0000112 "of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates." xsd:string
property_value: IAO:0000112 "Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key" xsd:string
property_value: IAO:0000112 "the disposition of this fish to decay" xsd:string
property_value: IAO:0000112 "the function of this heart: to pump blood" xsd:string
property_value: IAO:0000112 "the mutual dependence of proton donors and acceptors in chemical reactions [79" xsd:string
property_value: IAO:0000112 "the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction" xsd:string
property_value: IAO:0000112 "the pink color of a medium rare piece of grilled filet mignon at its center" xsd:string
property_value: IAO:0000112 "the role of being a doctor" xsd:string
property_value: IAO:0000112 "the shape of this hole." xsd:string
property_value: IAO:0000112 "the smell of this portion of mozzarella" xsd:string
property_value: IAO:0000116 "Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc." xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000005", comment="per discussion with Barry Smith"}
property_value: IAO:0000602 "(iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/050-003"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000023
name: role
def: "A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts." []
is_a: BFO:0000017 ! realizable entity
property_value: BFO:0000179 "role" xsd:string
property_value: BFO:0000180 "Role" xsd:string
property_value: IAO:0000112 "John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married." xsd:string
property_value: IAO:0000112 "the priest role" xsd:string
property_value: IAO:0000112 "the role of a boundary to demarcate two neighboring administrative territories" xsd:string
property_value: IAO:0000112 "the role of a building in serving as a military target" xsd:string
property_value: IAO:0000112 "the role of a stone in marking a property boundary" xsd:string
property_value: IAO:0000112 "the role of subject in a clinical trial" xsd:string
property_value: IAO:0000112 "the student role" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals –  professor, sergeant, nurse – only during certain phases in their lives." xsd:string
property_value: IAO:0000600 "b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/061-001"}
property_value: IAO:0000602 "(forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/061-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000024
name: fiat object part
is_a: BFO:0000040 ! material entity
property_value: BFO:0000179 "fiat-object-part" xsd:string
property_value: BFO:0000180 "FiatObjectPart" xsd:string
property_value: IAO:0000112 "or with divisions drawn by cognitive subjects for practical reasons, such as the division of a cake (before slicing) into (what will become) slices (and thus member parts of an object aggregate). However, this does not mean that fiat object parts are dependent for their existence on divisions or delineations effected by cognitive subjects. If, for example, it is correct to conceive geological layers of the Earth as fiat object parts of the Earth, then even though these layers were first delineated in recent times, still existed long before such delineation and what holds of these layers (for example that the oldest layers are also the lowest layers) did not begin to hold because of our acts of delineation.Treatment of material entity in BFOExamples viewed by some as problematic cases for the trichotomy of fiat object part, object, and object aggregate include: a mussel on (and attached to) a rock, a slime mold, a pizza, a cloud, a galaxy, a railway train with engine and multiple carriages, a clonal stand of quaking aspen, a bacterial community (biofilm), a broken femur. Note that, as Aristotle already clearly recognized, such problematic cases – which lie at or near the penumbra of instances defined by the categories in question – need not invalidate these categories. The existence of grey objects does not prove that there are not objects which are black and objects which are white; the existence of mules does not prove that there are not objects which are donkeys and objects which are horses. It does, however, show that the examples in question need to be addressed carefully in order to show how they can be fitted into the proposed scheme, for example by recognizing additional subdivisions [29" xsd:string
property_value: IAO:0000112 "the division of the brain into regions" xsd:string
property_value: IAO:0000112 "the division of the planet into hemispheres" xsd:string
property_value: IAO:0000112 "the dorsal and ventral surfaces of the body" xsd:string
property_value: IAO:0000112 "the FMA:regional parts of an intact human body." xsd:string
property_value: IAO:0000112 "the upper and lower lobes of the left lung" xsd:string
property_value: IAO:0000112 "the Western hemisphere of the Earth" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: Most examples of fiat object parts are associated with theoretically drawn divisions" xsd:string
property_value: IAO:0000600 "b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of  c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/027-004"}
property_value: IAO:0000602 "(forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/027-004"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000026
name: one-dimensional spatial region
is_a: BFO:0000006 ! spatial region
disjoint_from: BFO:0000028 ! three-dimensional spatial region
property_value: BFO:0000179 "1d-s-region" xsd:string
property_value: BFO:0000180 "OneDimensionalSpatialRegion" xsd:string
property_value: IAO:0000112 "an edge of a cube-shaped portion of space." xsd:string
property_value: IAO:0000600 "A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/038-001"}
property_value: IAO:0000602 "(forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/038-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000027
name: object aggregate
is_a: BFO:0000040 ! material entity
property_value: BFO:0000179 "object-aggregate" xsd:string
property_value: BFO:0000180 "ObjectAggregate" xsd:string
property_value: IAO:0000112 "a collection of cells in a blood biobank." xsd:string
property_value: IAO:0000112 "a swarm of bees is an aggregate of members who are linked together through natural bonds" xsd:string
property_value: IAO:0000112 "a symphony orchestra" xsd:string
property_value: IAO:0000112 "an organization is an aggregate whose member parts have roles of specific types (for example in a jazz band, a chess club, a football team)" xsd:string
property_value: IAO:0000112 "defined by fiat: the aggregate of members of an organization" xsd:string
property_value: IAO:0000112 "defined through physical attachment: the aggregate of atoms in a lump of granite" xsd:string
property_value: IAO:0000112 "defined through physical containment: the aggregate of molecules of carbon dioxide in a sealed container" xsd:string
property_value: IAO:0000112 "defined via attributive delimitations such as: the patients in this hospital" xsd:string
property_value: IAO:0000112 "the aggregate of bearings in a constant velocity axle joint" xsd:string
property_value: IAO:0000112 "the aggregate of blood cells in your body" xsd:string
property_value: IAO:0000112 "the nitrogen atoms in the atmosphere" xsd:string
property_value: IAO:0000112 "the restaurants in Palo Alto" xsd:string
property_value: IAO:0000112 "your collection of Meissen ceramic plates." xsd:string
property_value: IAO:0000116 "An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000301"}
property_value: IAO:0000116 "An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000011"}
property_value: IAO:0000116 "BFO 2 Reference: object aggregates may gain and lose parts while remaining numerically identical (one and the same individual) over time. This holds both for aggregates whose membership is determined naturally (the aggregate of cells in your body) and aggregates determined by fiat (a baseball team, a congressional committee)." xsd:string
property_value: IAO:0000119 "ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158." xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000300"}
property_value: IAO:0000600 "b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/025-004"}
property_value: IAO:0000602 "(forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/025-004"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000028
name: three-dimensional spatial region
is_a: BFO:0000006 ! spatial region
property_value: BFO:0000179 "3d-s-region" xsd:string
property_value: BFO:0000180 "ThreeDimensionalSpatialRegion" xsd:string
property_value: IAO:0000112 "a cube-shaped region of space" xsd:string
property_value: IAO:0000112 "a sphere-shaped region of space," xsd:string
property_value: IAO:0000600 "A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/040-001"}
property_value: IAO:0000602 "(forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/040-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000029
name: site
is_a: BFO:0000141 ! immaterial entity
property_value: BFO:0000179 "site" xsd:string
property_value: BFO:0000180 "Site" xsd:string
property_value: IAO:0000112 "a hole in the interior of a portion of cheese" xsd:string
property_value: IAO:0000112 "a rabbit hole" xsd:string
property_value: IAO:0000112 "an air traffic control region defined in the airspace above an airport" xsd:string
property_value: IAO:0000112 "Manhattan Canyon)" xsd:string
property_value: IAO:0000112 "the cockpit of an aircraft" xsd:string
property_value: IAO:0000112 "the Grand Canyon" xsd:string
property_value: IAO:0000112 "the hold of a ship" xsd:string
property_value: IAO:0000112 "the interior of a kangaroo pouch" xsd:string
property_value: IAO:0000112 "the interior of the trunk of your car" xsd:string
property_value: IAO:0000112 "the interior of your bedroom" xsd:string
property_value: IAO:0000112 "the interior of your office" xsd:string
property_value: IAO:0000112 "the interior of your refrigerator" xsd:string
property_value: IAO:0000112 "the lumen of your gut" xsd:string
property_value: IAO:0000112 "the Piazza San Marco" xsd:string
property_value: IAO:0000112 "your left nostril (a fiat part – the opening – of your left nasal cavity)" xsd:string
property_value: IAO:0000600 "b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/034-002"}
property_value: IAO:0000602 "(forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/034-002"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000030
name: object
is_a: BFO:0000040 ! material entity
property_value: BFO:0000179 "object" xsd:string
property_value: BFO:0000180 "Object" xsd:string
property_value: IAO:0000112 "atom" xsd:string
property_value: IAO:0000112 "cell" xsd:string
property_value: IAO:0000112 "cells and organisms" xsd:string
property_value: IAO:0000112 "engineered artifacts" xsd:string
property_value: IAO:0000112 "grain of sand" xsd:string
property_value: IAO:0000112 "molecule" xsd:string
property_value: IAO:0000112 "organelle" xsd:string
property_value: IAO:0000112 "organism" xsd:string
property_value: IAO:0000112 "planet" xsd:string
property_value: IAO:0000112 "solid portions of matter" xsd:string
property_value: IAO:0000112 "star" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: an object is a maximal causally unified material entity" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: BFO rests on the presupposition that at multiple micro-, meso- and macroscopic scales reality exhibits certain stable, spatially separated or separable material units, combined or combinable into aggregates of various sorts (for example organisms into what are called ‘populations’). Such units play a central role in almost all domains of natural science from particle physics to cosmology. Many scientific laws govern the units in question, employing general terms (such as ‘molecule’ or ‘planet’) referring to the types and subtypes of units, and also to the types and subtypes of the processes through which such units develop and interact. The division of reality into such natural units is at the heart of biological science, as also is the fact that these units may form higher-level units (as cells form multicellular organisms) and that they may also form aggregates of units, for example as cells form portions of tissue and organs form families, herds, breeds, species, and so on. At the same time, the division of certain portions of reality into engineered units (manufactured artifacts) is the basis of modern industrial technology, which rests on the distributed mass production of engineered parts through division of labor and on their assembly into larger, compound units such as cars and laptops. The division of portions of reality into units is one starting point for the phenomenon of counting." xsd:string
property_value: IAO:0000116 "BFO 2 Reference: Each object is such that there are entities of which we can assert unproblematically that they lie in its interior, and other entities of which we can assert unproblematically that they lie in its exterior. This may not be so for entities lying at or near the boundary between the interior and exterior. This means that two objects – for example the two cells depicted in Figure 3 – may be such that there are material entities crossing their boundaries which belong determinately to neither cell. Something similar obtains in certain cases of conjoined twins (see below)." xsd:string
property_value: IAO:0000116 "BFO 2 Reference: To say that b is causally unified means: b is a material entity which is such that its material parts are tied together in such a way that, in environments typical for entities of the type in question,if c, a continuant part of b that is in the interior of b at t, is larger than a certain threshold size (which will be determined differently from case to case, depending on factors such as porosity of external cover) and is moved in space to be at t at a location on the exterior of the spatial region that had been occupied by b at t, then either b’s other parts will be moved in coordinated fashion or b will be damaged (be affected, for example, by breakage or tearing) in the interval between t and t.causal changes in one part of b can have consequences for other parts of b without the mediation of any entity that lies on the exterior of b. Material entities with no proper material parts would satisfy these conditions trivially. Candidate examples of types of causal unity for material entities of more complex sorts are as follows (this is not intended to be an exhaustive list):CU1: Causal unity via physical coveringHere the parts in the interior of the unified entity are combined together causally through a common membrane or other physical covering\\. The latter points outwards toward and may serve a protective function in relation to what lies on the exterior of the entity [13, 47" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: ‘objects’ are sometimes referred to as ‘grains’ [74" xsd:string
property_value: IAO:0000600 "b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/024-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000031
name: generically dependent continuant
def: "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])" [] {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/074-001"}
is_a: BFO:0000002 ! continuant
property_value: BFO:0000179 "gdc" xsd:string
property_value: BFO:0000180 "GenericallyDependentContinuant" xsd:string
property_value: IAO:0000112 "The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity." xsd:string
property_value: IAO:0000112 "the pdf file on your laptop, the pdf file that is a copy thereof on my laptop" xsd:string
property_value: IAO:0000112 "the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule." xsd:string
property_value: IAO:0000602 "(iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/074-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000034
name: function
is_a: BFO:0000016 ! disposition
property_value: BFO:0000179 "function" xsd:string
property_value: BFO:0000180 "Function" xsd:string
property_value: IAO:0000112 "the function of a hammer to drive in nails" xsd:string
property_value: IAO:0000112 "the function of a heart pacemaker to regulate the beating of a heart through electricity" xsd:string
property_value: IAO:0000112 "the function of amylase in saliva to break down starch into sugar" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc." xsd:string
property_value: IAO:0000600 "A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/064-001"}
property_value: IAO:0000602 "(forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/064-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000035
name: process boundary
def: "p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])" [] {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/084-001"}
is_a: BFO:0000003 ! occurrent
property_value: BFO:0000179 "p-boundary" xsd:string
property_value: BFO:0000180 "ProcessBoundary" xsd:string
property_value: IAO:0000112 "the boundary between the 2nd and 3rd year of your life." xsd:string
property_value: IAO:0000601 "Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/085-002"}
property_value: IAO:0000602 "(forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/085-002"}
property_value: IAO:0000602 "(iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/084-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000038
name: one-dimensional temporal region
is_a: BFO:0000008 ! temporal region
disjoint_from: BFO:0000148 ! zero-dimensional temporal region
property_value: BFO:0000179 "1d-t-region" xsd:string
property_value: BFO:0000180 "OneDimensionalTemporalRegion" xsd:string
property_value: IAO:0000112 "the temporal region during which a process occurs." xsd:string
property_value: IAO:0000116 "BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks)." xsd:string
property_value: IAO:0000600 "A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/103-001"}
property_value: IAO:0000602 "(forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/103-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000040
name: material entity
def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." []
is_a: BFO:0000004 ! independent continuant
disjoint_from: BFO:0000141 ! immaterial entity
property_value: BFO:0000179 "material" xsd:string
property_value: BFO:0000180 "MaterialEntity" xsd:string
property_value: IAO:0000112 "a flame" xsd:string
property_value: IAO:0000112 "a forest fire" xsd:string
property_value: IAO:0000112 "a human being" xsd:string
property_value: IAO:0000112 "a hurricane" xsd:string
property_value: IAO:0000112 "a photon" xsd:string
property_value: IAO:0000112 "a puff of smoke" xsd:string
property_value: IAO:0000112 "a sea wave" xsd:string
property_value: IAO:0000112 "a tornado" xsd:string
property_value: IAO:0000112 "an aggregate of human beings." xsd:string
property_value: IAO:0000112 "an energy wave" xsd:string
property_value: IAO:0000112 "an epidemic" xsd:string
property_value: IAO:0000112 "the undetached arm of a human being" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity." xsd:string
property_value: IAO:0000116 "BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here." xsd:string
property_value: IAO:0000600 "A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/019-002"}
property_value: IAO:0000601 "every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/021-002"}
property_value: IAO:0000601 "Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/020-002"}
property_value: IAO:0000602 "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/021-002"}
property_value: IAO:0000602 "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/020-002"}
property_value: IAO:0000602 "(forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/019-002"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000140
name: continuant fiat boundary
def: "b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001])" [] {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/029-001"}
is_a: BFO:0000141 ! immaterial entity
property_value: BFO:0000179 "cf-boundary" xsd:string
property_value: BFO:0000180 "ContinuantFiatBoundary" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: a continuant fiat boundary is a boundary of some material entity (for example: the plane separating the Northern and Southern hemispheres; the North Pole), or it is a boundary of some immaterial entity (for example of some portion of airspace). Three basic kinds of continuant fiat boundary can be distinguished (together with various combination kinds [29" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: In BFO 1.1 the assumption was made that the external surface of a material entity such as a cell could be treated as if it were a boundary in the mathematical sense. The new document propounds the view that when we talk about external surfaces of material objects in this way then we are talking about something fiat. To be dealt with in a future version: fiat boundaries at different levels of granularity.More generally, the focus in discussion of boundaries in BFO 2.0 is now on fiat boundaries, which means: boundaries for which there is no assumption that they coincide with physical discontinuities. The ontology of boundaries becomes more closely allied with the ontology of regions." xsd:string
property_value: IAO:0000116 "Continuant fiat boundary doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the mereological sum of two-dimensional continuant fiat boundary and a one dimensional continuant fiat boundary that doesn't overlap it. The situation is analogous to temporal and spatial regions." xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000008"}
property_value: IAO:0000601 "Every continuant fiat boundary is located at some spatial region at every time at which it exists" xsd:string
property_value: IAO:0000602 "(iff (ContinuantFiatBoundary a) (and (ImmaterialEntity a) (exists (b) (and (or (ZeroDimensionalSpatialRegion b) (OneDimensionalSpatialRegion b) (TwoDimensionalSpatialRegion b)) (forall (t) (locatedInAt a b t)))) (not (exists (c t) (and (SpatialRegion c) (continuantPartOfAt c a t)))))) // axiom label in BFO2 CLIF: [029-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/029-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000141
name: immaterial entity
is_a: BFO:0000004 ! independent continuant
property_value: BFO:0000179 "immaterial" xsd:string
property_value: BFO:0000180 "ImmaterialEntity" xsd:string
property_value: IAO:0000116 "BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10" xsd:string
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000142
name: one-dimensional continuant fiat boundary
is_a: BFO:0000140 ! continuant fiat boundary
disjoint_from: BFO:0000146 ! two-dimensional continuant fiat boundary
disjoint_from: BFO:0000147 ! zero-dimensional continuant fiat boundary
property_value: BFO:0000179 "1d-cf-boundary" xsd:string
property_value: BFO:0000180 "OneDimensionalContinuantFiatBoundary" xsd:string
property_value: IAO:0000112 "all geopolitical boundaries" xsd:string
property_value: IAO:0000112 "all lines of latitude and longitude" xsd:string
property_value: IAO:0000112 "The Equator" xsd:string
property_value: IAO:0000112 "the line separating the outer surface of the mucosa of the lower lip from the outer surface of the skin of the chin." xsd:string
property_value: IAO:0000112 "the median sulcus of your tongue" xsd:string
property_value: IAO:0000600 "a one-dimensional continuant fiat boundary is a continuous fiat line whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [032-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/032-001"}
property_value: IAO:0000602 "(iff (OneDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (OneDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [032-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/032-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000144
name: process profile
def: "b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])" [] {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/093-002"}
is_a: BFO:0000015 ! process
disjoint_from: BFO:0000182 ! history
property_value: BFO:0000179 "process-profile" xsd:string
property_value: BFO:0000180 "ProcessProfile" xsd:string
property_value: IAO:0000112 "On a somewhat higher level of complexity are what we shall call rate process profiles, which are the targets of selective abstraction focused not on determinate quality magnitudes plotted over time, but rather on certain ratios between these magnitudes and elapsed times. A speed process profile, for example, is represented by a graph plotting against time the ratio of distance covered per unit of time. Since rates may change, and since such changes, too, may have rates of change, we have to deal here with a hierarchy of process profile universals at successive levels" xsd:string
property_value: IAO:0000112 "One important sub-family of rate process profiles is illustrated by the beat or frequency profiles of cyclical processes, illustrated by the 60 beats per minute beating process of John’s heart, or the 120 beats per minute drumming process involved in one of John’s performances in a rock band, and so on. Each such process includes what we shall call a beat process profile instance as part, a subtype of rate process profile in which the salient ratio is not distance covered but rather number of beat cycles per unit of time. Each beat process profile instance instantiates the determinable universal beat process profile. But it also instantiates multiple more specialized universals at lower levels of generality, selected from   rate process profilebeat process profileregular beat process profile3 bpm beat process profile4 bpm beat process profileirregular beat process profileincreasing beat process profileand so on.In the case of a regular beat process profile, a rate can be assigned in the simplest possible fashion by dividing the number of cycles by the length of the temporal region occupied by the beating process profile as a whole. Irregular process profiles of this sort, for example as identified in the clinic, or in the readings on an aircraft instrument panel, are often of diagnostic significance." xsd:string
property_value: IAO:0000112 "The simplest type of process profiles are what we shall call ‘quality process profiles’, which are the process profiles which serve as the foci of the sort of selective abstraction that is involved when measurements are made of changes in single qualities, as illustrated, for example, by process profiles of mass, temperature, aortic pressure, and so on." xsd:string
property_value: IAO:0000600 "b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/094-005"}
property_value: IAO:0000602 "(forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/094-005"}
property_value: IAO:0000602 "(iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/093-002"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000145
name: relational quality
def: "b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001])" [] {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/057-001"}
is_a: BFO:0000019 ! quality
property_value: BFO:0000179 "r-quality" xsd:string
property_value: BFO:0000180 "RelationalQuality" xsd:string
property_value: IAO:0000112 "a marriage bond, an instance of requited love, an obligation between one person and another." xsd:string
property_value: IAO:0000112 "John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married." xsd:string
property_value: IAO:0000602 "(iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/057-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000146
name: two-dimensional continuant fiat boundary
is_a: BFO:0000140 ! continuant fiat boundary
property_value: BFO:0000179 "2d-cf-boundary" xsd:string
property_value: BFO:0000180 "TwoDimensionalContinuantFiatBoundary" xsd:string
property_value: IAO:0000600 "a two-dimensional continuant fiat boundary (surface) is a self-connected fiat surface whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [033-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/033-001"}
property_value: IAO:0000602 "(iff (TwoDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (TwoDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [033-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/033-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000147
name: zero-dimensional continuant fiat boundary
is_a: BFO:0000140 ! continuant fiat boundary
property_value: BFO:0000179 "0d-cf-boundary" xsd:string
property_value: BFO:0000180 "ZeroDimensionalContinuantFiatBoundary" xsd:string
property_value: IAO:0000112 "the geographic North Pole" xsd:string
property_value: IAO:0000112 "the point of origin of some spatial coordinate system." xsd:string
property_value: IAO:0000112 "the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet" xsd:string
property_value: IAO:0000116 "zero dimension continuant fiat boundaries are not spatial points. Considering the example 'the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet' : There are many frames in which that point is zooming through many points in space. Whereas, no matter what the frame, the quadripoint is always in the same relation to the boundaries of Colorado, Utah, New Mexico, and Arizona." xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000001", comment="requested by Melanie Courtot", seeAlso="ZDRnpiIi:TUJ"}
property_value: IAO:0000600 "a zero-dimensional continuant fiat boundary is a fiat point whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [031-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/031-001"}
property_value: IAO:0000602 "(iff (ZeroDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (ZeroDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [031-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/031-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000148
name: zero-dimensional temporal region
is_a: BFO:0000008 ! temporal region
property_value: BFO:0000179 "0d-t-region" xsd:string
property_value: BFO:0000180 "ZeroDimensionalTemporalRegion" xsd:string
property_value: IAO:0000112 "a temporal region that is occupied by a process boundary" xsd:string
property_value: IAO:0000112 "right now" xsd:string
property_value: IAO:0000112 "the moment at which a child is born" xsd:string
property_value: IAO:0000112 "the moment at which a finger is detached in an industrial accident" xsd:string
property_value: IAO:0000112 "the moment of death." xsd:string
property_value: IAO:0000118 "temporal instant." xsd:string
property_value: IAO:0000600 "A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/102-001"}
property_value: IAO:0000602 "(forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/102-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000182
name: history
is_a: BFO:0000015 ! process
property_value: BFO:0000179 "history" xsd:string
property_value: BFO:0000180 "History" xsd:string
property_value: IAO:0000600 "A history is a process that is the sum of the totality of processes taking place in the spatiotemporal region occupied by a material entity or site, including processes on the surface of the entity or within the cavities to which it serves as host. (axiom label in BFO2 Reference: [138-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/138-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: GO:0016301

[Term]
id: IAO:0000027
name: data item
def: "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements." []
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000111 "data item" xsd:string
property_value: IAO:0000112 "Data items include counts of things, analyte concentrations, and statistical summaries." xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000116 "2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers." xsd:string
property_value: IAO:0000116 "2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum." xsd:string
property_value: IAO:0000116 "2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym." xsd:string
property_value: IAO:0000116 "2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/" xsd:string
property_value: IAO:0000116 "JAR: datum     -- well, this will be very tricky to define, but maybe some \ninformation-like stuff that might be put into a computer and that is \nmeant, by someone, to denote and/or to be interpreted by some \nprocess... I would include lists, tables, sentences... I think I might \ndefer to Barry, or to Brian Cantwell Smith\n\nJAR: A data item is an approximately justified approximately true approximate belief" xsd:string
property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string
property_value: IAO:0000117 "PERSON: Chris Stoeckert" xsd:string
property_value: IAO:0000117 "PERSON: Jonathan Rees" xsd:string
property_value: IAO:0000118 "data" xsd:string

[Term]
id: IAO:0000030
name: information content entity
def: "A generically dependent continuant that is about some thing." []
is_a: BFO:0000031 ! generically dependent continuant
relationship: IAO:0000136 BFO:0000001 ! is about entity
property_value: IAO:0000111 "information content entity" xsd:string
property_value: IAO:0000112 "Examples of information content entites include journal articles, data, graphical layouts, and graphs." xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000116 "2014-03-10: The use of \"thing\" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ)." xsd:string
property_value: IAO:0000116 "information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907).\n\nPrevious. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity." xsd:string
property_value: IAO:0000117 "PERSON: Chris Stoeckert" xsd:string
property_value: IAO:0000119 "OBI_0000142" xsd:string

[Term]
id: IAO:0000078
name: curation status specification
def: "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." []
is_a: IAO:0000102 ! data about an ontology part
property_value: IAO:0000111 "curation status specification" xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000116 "Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)" xsd:string
property_value: IAO:0000117 "PERSON:Bill Bug" xsd:string
property_value: IAO:0000119 "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>" xsd:string
property_value: IAO:0000119 "OBI_0000266" xsd:string

[Term]
id: IAO:0000102
name: data about an ontology part
def: "Data about an ontology part is a data item about a part of an ontology, for example a term" []
is_a: IAO:0000027 ! data item
property_value: IAO:0000111 "data about an ontology part" xsd:string
property_value: IAO:0000117 "Person:Alan Ruttenberg" xsd:string

[Term]
id: IAO:0000225
name: obsolescence reason specification
def: "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." []
is_a: IAO:0000102 ! data about an ontology part
property_value: IAO:0000111 "obsolescence reason specification" xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000116 "The creation of this class has been inspired in part by Werner Ceusters' paper, Applying evolutionary terminology auditing to the Gene Ontology." xsd:string
property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string
property_value: IAO:0000117 "PERSON: Melanie Courtot" xsd:string

[Term]
id: IAO:0000409
name: denotator type
def: "A denotator type indicates how a term should be interpreted from an ontological perspective." []
is_a: IAO:0000102 ! data about an ontology part
property_value: IAO:0000111 "denotator type" xsd:string
property_value: IAO:0000112 "The Basic Formal Ontology ontology makes a distinction between Universals and defined classes, where the formal are \"natural kinds\" and the latter arbitrary collections of entities." xsd:string
property_value: IAO:0000117 "Alan Ruttenberg" xsd:string
property_value: IAO:0000119 "Barry Smith, Werner Ceusters" xsd:string

[Term]
id: IAO:8000000
name: ontology module
is_a: IAO:0000102 ! data about an ontology part
property_value: IAO:0000111 "ontology module" xsd:string
property_value: IAO:0000116 "I have placed this under 'data about an ontology part', but this can be discussed. I think this is OK if 'part' is interpreted reflexively, as an ontology module is the whole ontology rather than part of it." xsd:string
property_value: IAO:0000118 "ontology file" xsd:string
property_value: IAO:0000232 "This class and it's subclasses are applied to OWL ontologies. Using an rdf:type triple will result in problems with OWL-DL. I propose that dcterms:type is instead used to connect an ontology URI with a class from this hierarchy. The class hierarchy is not disjoint, so multiple assertions can be made about a single ontology." xsd:string

[Term]
id: IAO:8000001
name: base ontology module
def: "An ontology module that comprises only of asserted axioms local to the ontology, excludes import directives, and excludes axioms or declarations from external ontologies." []
is_a: IAO:8000000 ! ontology module
property_value: IAO:0000111 "base ontology module" xsd:string
property_value: seeAlso https://github.com/INCATools/ontology-starter-kit/issues/50

[Term]
id: IAO:8000002
name: editors ontology module
def: "An ontology module that is intended to be directly edited, typically managed in source control, and typically not intended for direct consumption by end-users." []
is_a: IAO:8000000 ! ontology module
property_value: IAO:0000111 "editors ontology module" xsd:string
property_value: IAO:0000118 "source ontology module" xsd:string

[Term]
id: IAO:8000003
name: main release ontology module
def: "An ontology module that is intended to be the primary release product and the one consumed by the majority of tools." []
is_a: IAO:8000000 ! ontology module
property_value: IAO:0000111 "main release ontology module" xsd:string
property_value: IAO:0000116 "TODO: Add logical axioms that state that a main release ontology module is derived from (directly or indirectly) an editors module" xsd:string

[Term]
id: IAO:8000004
name: bridge ontology module
def: "An ontology module that consists entirely of axioms that connect or bridge two distinct ontology modules. For example, the Uberon-to-ZFA bridge module." []
is_a: IAO:8000000 ! ontology module
property_value: IAO:0000111 "bridge ontology module" xsd:string
property_value: seeAlso https://github.com/obophenotype/uberon/wiki/inter-anatomy-ontology-bridge-ontologies

[Term]
id: IAO:8000005
name: import ontology module
def: "A subset ontology module that is intended to be imported from another ontology." []
is_a: IAO:8000006 ! subset ontology module
property_value: IAO:0000111 "import ontology module" xsd:string
property_value: IAO:0000116 "TODO: add axioms that indicate this is the output of a module extraction process." xsd:string
property_value: IAO:0000118 "import file" xsd:string
property_value: seeAlso http://robot.obolibrary.org/extract

[Term]
id: IAO:8000006
name: subset ontology module
def: "An ontology module that is extracted from a main ontology module and includes only a subset of entities or axioms." []
is_a: IAO:8000000 ! ontology module
property_value: IAO:0000111 "subset ontology module" xsd:string
property_value: IAO:0000118 "ontology slim" xsd:string
property_value: IAO:0000118 "subset ontology" xsd:string
property_value: seeAlso http://robot.obolibrary.org/filter
property_value: seeAlso http://www.geneontology.org/page/go-slim-and-subset-guide

[Term]
id: IAO:8000007
name: curation subset ontology module
def: "A subset ontology that is intended as a whitelist for curators using the ontology. Such a subset will exclude classes that curators should not use for curation." []
is_a: IAO:8000006 ! subset ontology module
property_value: IAO:0000111 "curation subset ontology module" xsd:string

[Term]
id: IAO:8000008
name: analysis subset ontology module
def: "An ontology module that is intended for usage in analysis or discovery applications." []
is_a: IAO:8000006 ! subset ontology module
property_value: IAO:0000111 "analysis ontology module" xsd:string

[Term]
id: IAO:8000009
name: single layer subset ontology module
def: "A subset ontology that is largely comprised of a single layer or strata in an ontology class hierarchy. The purpose is typically for rolling up for visualization. The classes in the layer need not be disjoint." []
is_a: IAO:8000006 ! subset ontology module
property_value: IAO:0000111 "single layer ontology module" xsd:string
property_value: IAO:0000118 "ribbon subset" xsd:string

[Term]
id: IAO:8000010
name: exclusion subset ontology module
def: "A subset of an ontology that is intended to be excluded for some purpose. For example, a blacklist of classes." []
is_a: IAO:8000006 ! subset ontology module
property_value: IAO:0000111 "exclusion subset ontology module" xsd:string
property_value: IAO:0000118 "antislim" xsd:string

[Term]
id: IAO:8000011
name: external import ontology module
def: "An imported ontology module that is derived from an external ontology. Derivation methods include the OWLAPI SLME approach." []
is_a: IAO:8000005 ! import ontology module
property_value: IAO:0000111 "external import ontology module" xsd:string
property_value: IAO:0000118 "external import" xsd:string

[Term]
id: IAO:8000012
name: species subset ontology module
def: "A subset ontology that is crafted to either include or exclude a taxonomic grouping of species." []
is_a: IAO:8000006 ! subset ontology module
property_value: IAO:0000111 "species subset ontology module" xsd:string
property_value: IAO:0000118 "taxon subset" xsd:string
property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Taxon-constraints

[Term]
id: IAO:8000013
name: reasoned ontology module
def: "An ontology module that contains axioms generated by a reasoner. The generated axioms are typically direct SubClassOf axioms, but other possibilities are available." []
is_a: IAO:8000000 ! ontology module
property_value: IAO:0000111 "reasoned ontology module" xsd:string
property_value: seeAlso http://robot.obolibrary.org/reason

[Term]
id: IAO:8000014
name: generated ontology module
def: "An ontology module that is automatically generated, for example via a SPARQL query or via template and a CSV." []
is_a: IAO:8000000 ! ontology module
property_value: IAO:0000111 "generated ontology module" xsd:string
property_value: IAO:0000116 "TODO: Add axioms (using PROV-O?) that indicate this is the output-of some reasoning process" xsd:string

[Term]
id: IAO:8000015
name: template generated ontology module
def: "An ontology module that is automatically generated from a template specification and fillers for slots in that template." []
is_a: IAO:8000014 ! generated ontology module
property_value: IAO:0000111 "template generated ontology module" xsd:string
property_value: seeAlso http://robot.obolibrary.org/template
property_value: seeAlso https://doi.org/10.1186/s13326-017-0126-0
property_value: seeAlso https://github.com/dosumis/dead_simple_owl_design_patterns/

[Term]
id: IAO:8000016
name: taxonomic bridge ontology module
is_a: IAO:8000004 ! bridge ontology module
property_value: IAO:0000111 "taxonomic bridge ontology module" xsd:string

[Term]
id: IAO:8000017
name: ontology module subsetted by expressivity
is_a: IAO:8000006 ! subset ontology module
property_value: IAO:0000111 "ontology module subsetted by expressivity" xsd:string

[Term]
id: IAO:8000018
name: obo basic subset ontology module
def: "A subset ontology that is designed for basic applications to continue to make certain simplifying assumptions; many of these simplifying assumptions were based on the initial version of the Gene Ontology, and have become enshrined in many popular and useful tools such as term enrichment tools.\n\nExamples of such assumptions include: traversing the ontology graph ignoring relationship types using a naive algorithm will not lead to cycles (i.e. the ontology is a DAG); every referenced term is declared in the ontology (i.e. there are no dangling clauses).\n\nAn ontology is OBO Basic if and only if it has the following characteristics:\nDAG\nUnidirectional\nNo Dangling Clauses\nFully Asserted\nFully Labeled\nNo equivalence axioms\nSingly labeled edges\nNo qualifier lists\nNo disjointness axioms\nNo owl-axioms header\nNo imports" []
is_a: IAO:8000017 ! ontology module subsetted by expressivity
property_value: IAO:0000111 "obo basic subset ontology module" xsd:string
property_value: seeAlso 6.2

[Term]
id: IAO:8000019
name: ontology module subsetted by OWL profile
is_a: IAO:8000017 ! ontology module subsetted by expressivity
property_value: IAO:0000111 "ontology module subsetted by OWL profile" xsd:string

[Term]
id: IAO:8000020
name: EL++ ontology module
is_a: IAO:8000019 ! ontology module subsetted by OWL profile
property_value: IAO:0000111 "EL++ ontology module" xsd:string

[Term]
id: NMRCV:0000000
name: root node

[Term]
id: OBI:0000011
name: planned process
def: "A process that realizes a plan which is the concretization of a plan specification." []
is_a: BFO:0000015 ! process
property_value: IAO:0000111 "planned process" xsd:string
property_value: IAO:0000111 "planned process" xsd:string
property_value: IAO:0000112 "Injecting mice with a vaccine in order to test its efficacy" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000116 "'Plan' includes a future direction sense. That can be problematic if plans are changed during their execution. There are however implicit contingencies for protocols that an agent has in his mind that can be considered part of the plan, even if the agent didn't have them in mind before. Therefore, a planned process can diverge from what the agent would have said the plan was before executing it, by adjusting to problems encountered during execution (e.g. choosing another reagent with equivalent properties, if the originally planned one has run out.)" xsd:string
property_value: IAO:0000116 "We are only considering successfully completed planned processes. A plan may be modified, and details added during execution. For a given planned process, the associated realized plan specification is the one encompassing all changes made during execution. This means that all processes in which an agent acts towards achieving some \nobjectives is a planned process." xsd:string
property_value: IAO:0000117 "Bjoern Peters" xsd:string
property_value: IAO:0000119 "branch derived" xsd:string
property_value: IAO:0000232 "6/11/9: Edited at workshop. Used to include: is initiated by an agent" xsd:string
property_value: IAO:0000232 "This class merges the previously separated objective driven process and planned process, as they the separation proved hard to maintain. (1/22/09, branch call)" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0000014
name: regulator role
def: "a regulatory role involved with making and/or enforcing relevant legislation and governmental orders" []
is_a: OBI:0000017 ! regulatory role
property_value: IAO:0000111 "regulator role" xsd:string
property_value: IAO:0000112 "Fact sheet - Regulating the companies The role of the regulator. Ofwat is the economic regulator of the water and sewerage industry in England and Wales.  http://www.ofwat.gov.uk/aptrix/ofwat/publish.nsf/Content/roleofregulator_factsheet170805" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Person:Jennifer Fostel" xsd:string
property_value: IAO:0000118 "regulator" xsd:string
property_value: IAO:0000119 "OBI" xsd:string

[Term]
id: OBI:0000017
name: regulatory role
def: "a role which inheres in material entities and is realized in the processes of making, enforcing or being defined by legislation or orders issued by a governmental body." []
is_a: BFO:0000023 ! role
property_value: IAO:0000111 "regulatory role" xsd:string
property_value: IAO:0000112 "Regulatory agency, Ethics committee, Approval letter; example:  Browse these EPA Regulatory Role subtopics  http://www.epa.gov/ebtpages/enviregulatoryrole.html  Feb 29, 2008" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "GROUP:  Role branch" xsd:string
property_value: IAO:0000119 "OBI, CDISC" xsd:string
property_value: IAO:0000232 "govt agents responsible for creating regulations; proxies for enforcing regulations.  CDISC definition:  regulatory authorities. Bodies having the power to regulate. NOTE: In the ICH GCP guideline the term includes the authorities that review submitted clinical data and those that conduct inspections. These bodies are sometimes referred to as competent" xsd:string

[Term]
id: OBI:0000018
name: material supplier role
def: "a role realized through the process of supplying materials such as animal subjects, reagents or other materials used in an investigation." []
is_a: OBI:0000947 ! service provider role
property_value: IAO:0000111 "material supplier role" xsd:string
property_value: IAO:0000112 "Jackson Labs is an organization which provide mice as experimental material" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000116 "Supplier role is a special kind of service, e.g. biobank" xsd:string
property_value: IAO:0000117 "PERSON:Jennifer Fostel" xsd:string
property_value: IAO:0000118 "material provider role" xsd:string
property_value: IAO:0000118 "supplier" xsd:string

[Term]
id: OBI:0000023
name: classified data set
def: "A data set that is produced as the output of a class prediction data transformation and consists of a data set with assigned class labels." []
is_a: BFO:0000002 ! continuant
is_a: IAO:0000100
relationship: OBI:0000312 OBI:0000663 ! is_specified_output_of class prediction data transformation
property_value: IAO:0000111 "classified data set" xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 "PERSON: James Malone" xsd:string
property_value: IAO:0000117 "PERSON: Monnie McGee" xsd:string
property_value: IAO:0000118 "data set with assigned class labels" xsd:string

[Term]
id: OBI:0000112
name: specimen role
def: "a role borne by a material entity that is gained during a specimen collection process and that can be realized by use of the specimen in an investigation" []
is_a: BFO:0000023 ! role
property_value: IAO:0000111 "specimen role" xsd:string
property_value: IAO:0000112 "liver section; a portion of a culture of cells; a nemotode or other animal once no longer a subject (generally killed); portion of blood from a patient." xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000116 "22Jun09.  The definition includes whole organisms, and can include a human.  The link between specimen role and study subject role has been removed.  A specimen taken as part of a case study is not considered to be a population representative, while a specimen taken as representing a population, e.g. person taken from a cohort, blood specimen taken from an animal) would be considered a population representative and would also bear material sample role." xsd:string
property_value: IAO:0000116 "blood taken from animal: animal continues in study, whereas blood has role specimen.\nsomething taken from study subject, leaves the study and becomes the specimen." xsd:string
property_value: IAO:0000116 "Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation." xsd:string
property_value: IAO:0000116 "parasite example\n- when parasite in people we study people, people are subjects and parasites are specimen\n- when parasite extracted, they become subject in the following study\nspecimen can later be subject." xsd:string
property_value: IAO:0000117 "GROUP:  Role Branch" xsd:string
property_value: IAO:0000119 "OBI" xsd:string
property_value: IAO:0000233 https://github.com/obi-ontology/obi/issues/1013

[Term]
id: OBI:0000245
name: organization
def: "An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members." []
is_a: BFO:0000040 ! material entity
property_value: IAO:0000111 "organization" xsd:string
property_value: IAO:0000112 "PMID: 16353909.AAPS J. 2005 Sep 22;7(2):E274-80. Review. The joint food and agriculture organization of the United Nations/World Health Organization Expert Committee on Food Additives and its role in the evaluation of the safety of veterinary drug residues in foods." xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000116 "BP: The definition summarizes long email discussions on the OBI developer, roles, biomaterial and denrie branches. It leaves open if an organization is a material entity or a dependent continuant, as no consensus was reached on that.  The current placement as material is therefore temporary, in order to move forward with development. Here is the entire email summary, on which the definition is based:\n\n1) there are organization_member_roles (president, treasurer, branch\neditor), with individual persons as bearers\n\n2) there are organization_roles (employer, owner, vendor, patent holder)\n\n3) an organization has a charter / rules / bylaws, which specify what roles\nthere are, how they should be realized, and how to modify the\ncharter/rules/bylaws themselves.\n\nIt is debatable what the organization itself is (some kind of dependent\ncontinuant or an aggregate of people). This also determines who/what the\nbearer of organization_roles' are. My personal favorite is still to define\norganization as a kind of 'legal entity', but thinking it through leads to\nall kinds of questions that are clearly outside the scope of OBI.\n\nInterestingly enough, it does not seem to matter much where we place\norganization itself, as long as we can subclass it (University, Corporation,\nGovernment Agency, Hospital), instantiate it (Affymetrix, NCBI, NIH, ISO,\nW3C, University of Oklahoma), and have it play roles.\n\nThis leads to my proposal: We define organization through the statements 1 -\n3 above, but without an 'is a' statement for now. We can leave it in its\ncurrent place in the is_a hierarchy (material entity) or move it up to\n'continuant'. We leave further clarifications to BFO, and close this issue\nfor now." xsd:string
property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string
property_value: IAO:0000117 "PERSON: Bjoern Peters" xsd:string
property_value: IAO:0000117 "PERSON: Philippe Rocca-Serra" xsd:string
property_value: IAO:0000117 "PERSON: Susanna Sansone" xsd:string
property_value: IAO:0000119 "GROUP: OBI" xsd:string

[Term]
id: OBI:0000450
name: regulatory agency
def: "A regulatory agency is a organization that has responsibility over or for  the legislation (acts and regulations) for a given sector of the government." []
is_a: OBI:0000245 ! organization
intersection_of: OBI:0000245 ! organization
intersection_of: RO:0000087 OBI:0000014 ! has role regulator role
relationship: RO:0000087 OBI:0000014 ! has role regulator role
property_value: IAO:0000111 "regulatory agency" xsd:string
property_value: IAO:0000112 "The US Environmental Protection Agency" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "GROUP: OBI Biomaterial Branch" xsd:string
property_value: IAO:0000119 "WEB: en.wikipedia.org/wiki/Regulator" xsd:string

[Term]
id: OBI:0000571
name: manufacturer role
def: "Manufacturer role is a role which inheres in a person or organization and which is realized by a manufacturing process." []
is_a: BFO:0000023 ! role
property_value: IAO:0000111 "manufacturer role" xsd:string
property_value: IAO:0000112 "With respect to The Accuri C6 Flow Cytometer System, the organization Accuri bears the role manufacturer role.  With respect to a transformed line of tissue culture cells derived by a specific lab, the lab whose personnel isolated the cll line bears the role manufacturer role.  With respect to a specific antibody produced by an individual scientist, the scientist who purifies, characterizes and distributes the anitbody bears the role manufacturer role." xsd:string
property_value: IAO:0000114 IAO:0000123
property_value: IAO:0000117 "GROUP:  Role Branch" xsd:string
property_value: IAO:0000119 "OBI" xsd:string

[Term]
id: OBI:0000648
name: clustered data set
def: "A data set that is produced as the output of a class discovery data transformation and consists of a data set with assigned discovered class labels." []
is_a: BFO:0000002 ! continuant
is_a: IAO:0000100
relationship: OBI:0000312 OBI:0200175 ! is_specified_output_of class discovery data transformation
property_value: IAO:0000111 "clustered data set" xsd:string
property_value: IAO:0000112 "A clustered data set is the output of a K means clustering data transformation" xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 "PERSON: James Malone" xsd:string
property_value: IAO:0000117 "PERSON: Monnie McGee" xsd:string
property_value: IAO:0000118 "data set with assigned discovered class labels" xsd:string
property_value: IAO:0000232 "AR thinks could be a data item instead" xsd:string

[Term]
id: OBI:0000659
name: specimen collection process
def: "A planned process with the objective of collecting a specimen." []
is_a: OBI:0000011 ! planned process
intersection_of: OBI:0000011 ! planned process
intersection_of: OBI:0000417 OBI:0000684 ! achieves_planned_objective specimen collection objective
relationship: OBI:0000293 BFO:0000040 ! has_specified_input material entity
relationship: OBI:0000299 OBI:0100051 ! has_specified_output specimen
relationship: OBI:0000417 OBI:0000684 ! achieves_planned_objective specimen collection objective
property_value: IAO:0000111 "specimen collection process" xsd:string
property_value: IAO:0000112 "drawing blood from a patient for analysis, collecting a piece of a plant for depositing in a herbarium, buying meat from a butcher in order to measure its protein content in an investigation" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000116 "label  changed to 'specimen collection process' on 10/27/2014, details see tracker:\nhttp://sourceforge.net/p/obi/obi-terms/716/" xsd:string
property_value: IAO:0000116 "Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation." xsd:string
property_value: IAO:0000116 "Philly2013: A specimen collection can have as part a material entity acquisition, such as ordering from a bank. The distinction is that specimen collection necessarily involves the creation of a specimen role. However ordering cell lines cells from ATCC for use in an investigation is NOT a specimen collection, because the cell lines already have a specimen role." xsd:string
property_value: IAO:0000116 "Philly2013: The specimen_role for the specimen is created during the specimen collection process." xsd:string
property_value: IAO:0000117 "Bjoern Peters" xsd:string
property_value: IAO:0000118 "specimen collection" xsd:string
property_value: IAO:0000232 "5/31/2012: This process is not necessarily an acquisition, as specimens may be collected from materials already in posession" xsd:string
property_value: IAO:0000232 "6/9/09: used at workshop" xsd:string

[Term]
id: OBI:0000663
name: class prediction data transformation
def: "A class prediction data transformation (sometimes called supervised classification) is a data transformation that has objective class prediction." []
is_a: OBI:0200000 ! data transformation
property_value: IAO:0000111 "class prediction data transformation" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000118 "supervised classification data transformation" xsd:string
property_value: IAO:0000119 "PERSON: James Malone" xsd:string

[Term]
id: OBI:0000684
name: specimen collection objective
def: "A objective specification to obtain a material entity for potential use as an input during an investigation." []
is_a: IAO:0000005
property_value: IAO:0000111 "specimen collection objective" xsd:string
property_value: IAO:0000112 "The objective to collect bits of excrement in the rainforest. The objective to obtain a blood sample from a patient." xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "Bjoern Peters" xsd:string
property_value: IAO:0000119 "Bjoern Peters" xsd:string

[Term]
id: OBI:0000700
name: support vector machine
def: "A support vector machine is a data transformation with a class prediction objective based on the construction of a separating hyperplane that maximizes the margin between two data sets of vectors in n-dimensional space." []
is_a: OBI:0000663 ! class prediction data transformation
relationship: OBI:0000417 OBI:0200179 ! achieves_planned_objective class prediction objective
property_value: IAO:0000111 "support vector machine" xsd:string
property_value: IAO:0000114 IAO:0000123
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000117 "Ryan Brinkman" xsd:string
property_value: IAO:0000118 "SVM" xsd:string
property_value: IAO:0000119 "PERSON: Ryan Brinkman" xsd:string

[Term]
id: OBI:0000704
name: decision tree induction objective
def: "A decision tree induction objective is a data transformation objective in which a tree-like graph of edges and nodes is created and from which the selection of each branch requires that some type of logical decision is made." []
is_a: OBI:0200166 ! data transformation objective
property_value: IAO:0000111 "decision tree induction objective" xsd:string
property_value: IAO:0000114 IAO:0000123
property_value: IAO:0000117 "James Malone" xsd:string

[Term]
id: OBI:0000707
name: decision tree building data transformation
def: "A decision tree building data transformation is a data transformation that has objective decision tree induction." []
is_a: OBI:0200000 ! data transformation
relationship: OBI:0000417 OBI:0000704 ! achieves_planned_objective decision tree induction objective
property_value: IAO:0000111 "decision tree building data transformation" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000119 "PERSON: James Malone" xsd:string

[Term]
id: OBI:0000713
name: GenePattern software
def: "a software that provides access to more than 100 tools for gene expression analysis, proteomics, SNP analysis and common data processing tasks." []
is_a: IAO:0000010
property_value: IAO:0000111 "GenePattern software" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000117 "Person:Helen Parkinson" xsd:string
property_value: IAO:0000119 "WEB: http://www.broadinstitute.org/cancer/software/genepattern/" xsd:string

[Term]
id: OBI:0000726
name: peak matching
def: "Peak matching is a data transformation performed on a dataset of a graph of ordered data points (e.g. a spectrum) with the objective of pattern matching local maxima above a noise threshold" []
is_a: OBI:0200000 ! data transformation
property_value: IAO:0000111 "peak matching" xsd:string
property_value: IAO:0000114 IAO:0000123
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000117 "Ryan Brinkman" xsd:string
property_value: IAO:0000119 "PERSON: Ryan Brinkman" xsd:string

[Term]
id: OBI:0000727
name: k-nearest neighbors
def: "A k-nearest neighbors is a data transformation which achieves a class discovery or partitioning objective, in which an input data object with vector y is assigned to a class label based upon the k closest training data set points to y; where k is the largest value that class label is assigned." []
is_a: APOLLO_SV:00000796
is_a: OBI:0200171 ! partitioning data transformation
is_a: OBI:0200175 ! class discovery data transformation
relationship: OBI:0000299 OBI:0000648 ! has_specified_output clustered data set
relationship: OBI:0000417 OBI:0200178 ! achieves_planned_objective class discovery objective
property_value: IAO:0000111 "k-nearest neighbors" xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000118 "k-NN" xsd:string
property_value: IAO:0000119 "PERSON: James Malone" xsd:string

[Term]
id: OBI:0000749
name: CART
def: "A CART (classification and regression trees) is a data transformation method for producing a classification or regression model with a tree-based structure." []
is_a: OBI:0000707 ! decision tree building data transformation
property_value: IAO:0000111 "CART" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000118 "classification and regression trees" xsd:string
property_value: IAO:0000119 "BOOK: David J. Hand, Heikki Mannila and Padhraic Smyth (2001) Principles of Data Mining." xsd:string

[Term]
id: OBI:0000792
name: statistical model validation
def: "A data transformation which assesses how the results of a statistical analysis will generalize to an independent data set." []
is_a: OBI:0200171 ! partitioning data transformation
relationship: OBI:0000417 OBI:0200188 ! achieves_planned_objective cross validation objective
property_value: IAO:0000111 "statistical model validation" xsd:string
property_value: IAO:0000112 "Using the expression levels of 20 proteins to predict whether a cancer patient will respond to a drug. A practical goal would be to determine which subset of the 20 features should be used to produce the best predictive model. - wikipedia" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Helen Parkinson" xsd:string
property_value: IAO:0000119 "http://en.wikipedia.org/wiki/Cross-validation_%28statistics%29" xsd:string

[Term]
id: OBI:0000835
name: manufacturer
def: "A person or organization that has a manufacturer role." []
is_a: BFO:0000040 ! material entity
relationship: RO:0000087 OBI:0000571 ! has role manufacturer role
property_value: IAO:0000111 "manufacturer" xsd:string
property_value: IAO:0000114 IAO:0000123

[Term]
id: OBI:0000947
name: service provider role
def: "is a role which inheres in a person or organization and is realized in in a planned process which provides access to training, materials or execution of protocols for an organization or person" []
is_a: BFO:0000023 ! role
property_value: IAO:0000111 "service provider role" xsd:string
property_value: IAO:0000112 "Jackson Lab provides experimental animals, EBI provides training on databases, a core facility provides access to a DNA sequencer." xsd:string
property_value: IAO:0000114 IAO:0000123
property_value: IAO:0000117 "PERSON:Helen Parkinson" xsd:string

[Term]
id: OBI:0000963
name: categorical label
def: "A label that is part of a categorical datum and that indicates the value of the data item on the categorical scale." []
is_a: IAO:0000009
property_value: IAO:0000111 "categorical label" xsd:string
property_value: IAO:0000112 "The labels 'positive' vs. 'negative', or 'left handed', 'right handed', 'ambidexterous', or 'strongly binding', 'weakly binding' , 'not binding', or '+++', '++', '+', '-' etc. form scales of categorical labels." xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Bjoern Peters" xsd:string
property_value: IAO:0000119 "Bjoern Peters" xsd:string

[Term]
id: OBI:0001000
name: questionnaire
def: "A document with a set of printed or written questions with a choice of answers, devised for the purposes of a survey or statistical study." []
is_a: IAO:0000310
property_value: IAO:0000111 "questionnaire" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000116 "JT: It plays a role in collecting data that could be fleshed out more; but I'm thinking it is, in itself, an edited document. \nJZ: based on textual definition of edited document, it can be defined as N&S. I prefer to leave questionnaire as a document now. We can add more restrictions in the future and use that to determine it is an edited document or not." xsd:string
property_value: IAO:0000116 "Need to clarify if this is a document or a directive information entity (or what their connection is))" xsd:string
property_value: IAO:0000117 "PERSON: Jessica Turner" xsd:string
property_value: IAO:0000119 "Merriam-Webster" xsd:string

[Term]
id: OBI:0001930
name: categorical value specification
def: "A value specification that is specifies one category out of a fixed number of nominal categories" []
is_a: OBI:0001933 ! value specification
property_value: IAO:0000111 "categorical value specification" xsd:string
property_value: IAO:0000114 IAO:0000123
property_value: IAO:0000117 "PERSON:Bjoern Peters" xsd:string

[Term]
id: OBI:0001933
name: value specification
def: "An information content entity that specifies a value within a classification scheme or on a quantitative scale." []
is_a: IAO:0000030 ! information content entity
property_value: IAO:0000111 "value specification" xsd:string
property_value: IAO:0000112 "The value of 'positive' in a classification scheme of \"positive or negative\"; the value of '20g' on the quantitative scale of mass." xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000116 "This term is currently a descendant of 'information content entity', which requires that it 'is about' something. A value specification of '20g' for a measurement data item of the mass of a particular mouse 'is about' the mass of that mouse. However there are cases where a value specification is not clearly about any particular. In the future we may change 'value specification' to remove the 'is about' requirement." xsd:string
property_value: IAO:0000117 "PERSON:Bjoern Peters" xsd:string

[Term]
id: OBI:0002076
name: collection of specimens
def: "A material entity that has two or more specimens as its parts." []
is_a: BFO:0000040 ! material entity
intersection_of: BFO:0000040 ! material entity
intersection_of: RO:0002351 OBI:0100051 {all_only="true"} ! specimen
property_value: http://purl.org/dc/elements/1.1/source "Biobank" xsd:string
property_value: IAO:0000111 "collection of specimens" xsd:string
property_value: IAO:0000112 "Blood cells collected from multiple donors over the course of a study." xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000116 "Details see tracker: https://sourceforge.net/p/obi/obi-terms/778/" xsd:string
property_value: IAO:0000117 "Person: Chris Stoeckert, Jie Zheng" xsd:string
property_value: IAO:0000119 "OBIB, OBI" xsd:string

[Term]
id: OBI:0002205
name: histologic grade according to AJCC 7th edition
def: "A categorical value specification that is a histologic grade assigned to a tumor slide specimen according to the American Joint Committee on Cancer (AJCC) 7th Edition grading system." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "histologic grade according to AJCC 7th edition" xsd:string
property_value: IAO:0000112 "G1:Well differentiated" xsd:string
property_value: IAO:0000112 "G4: Undifferentiated" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002210
name: histologic grade according to the Fuhrman Nuclear Grading System
def: "A categorical value specification that is a histologic grade assigned to a tumor slide specimen according to the Fuhrman Nuclear Grading System." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "histologic grade according to the Fuhrman Nuclear Grading System" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "Histologic Grade (Fuhrman Nuclear Grading System)" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002215
name: histologic grade for ovarian tumor
def: "A categorical value specification that is a histologic grade assigned to a ovarian tumor." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "histologic grade for ovarian tumor" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002216
name: histologic grade for ovarian tumor according to a two-tier grading system
def: "A histologic grade for ovarian tumor that is from a two-tier histological classification of tumors." []
is_a: OBI:0002215 ! histologic grade for ovarian tumor
property_value: IAO:0000111 "histologic grade for ovarian tumor according to a two-tier grading system" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002219
name: histologic grade for ovarian tumor according to the World Health Organization
def: "A histologic grade for ovarian tumor that is from a histological classification by the World Health Organization (WHO)." []
is_a: OBI:0002215 ! histologic grade for ovarian tumor
property_value: IAO:0000111 "histologic grade for ovarian tumor according to the World Health Organization" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002224
name: pathologic primary tumor stage for colon and rectum according to AJCC 7th edition
def: "A categorical value specification that is a pathologic finding about one or more characteristics of colorectal cancer following the rules of the TNM American Joint Committee on Cancer (AJCC) version 7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "pathologic primary tumor stage for colon and rectum according to AJCC 7th edition" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "pT: Pathologic spread colorectal primary tumor (AJCC 7th Edition)" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002232
name: pathologic primary tumor stage for lung according to AJCC 7th edition
def: "A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM American Joint Committee on Cancer (AJCC) version 7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "pathologic primary tumor stage for lung according to AJCC 7th edition" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "pT: Pathologic spread lung primary tumor (AJCC 7th Edition)" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002243
name: pathologic primary tumor stage for kidney according to AJCC 7th edition
def: "A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "pathologic primary tumor stage for kidney according to AJCC 7th edition" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "pT: Pathologic spread kidney primary tumor (AJCC 7th Edition)" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002256
name: pathologic primary tumor stage for ovary according to AJCC 7th edition
def: "A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "pathologic primary tumor stage for ovary according to AJCC 7th edition" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "pT: Pathologic spread ovarian primary tumor (AJCC 7th Edition)" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002270
name: pathologic lymph node stage for colon and rectum according to AJCC 7th edition
def: "A categorical value specification that is a pathologic finding about one or more characteristics of colorectal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "pathologic lymph node stage for colon and rectum according to AJCC 7th edition" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "pN: Pathologic spread colon lymph nodes (AJCC 7th Edition)" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002279
name: pathologic lymph node stage for lung according to AJCC 7th edition
def: "A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "pathologic lymph node stage for lung according to AJCC 7th edition" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "pN: Pathologic spread colon lymph nodes (AJCC 7th Edition)" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002284
name: pathologic lymph node stage for kidney according to AJCC 7th edition
def: "A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "pathologic lymph node stage for kidney according to AJCC 7th edition" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "pN: Pathologic spread kidney lymph nodes (AJCC 7th Edition)" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002287
name: pathologic lymph node stage for ovary according to AJCC 7th edition
def: "A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "pathologic lymph node stage for ovary according to AJCC 7th edition" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "pN: Pathologic spread ovarian lymph nodes (AJCC 7th Edition)" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002290
name: pathologic distant metastases stage for colon according to AJCC 7th edition
def: "A categorical value specification that is a pathologic finding about one or more characteristics of colon cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "pathologic distant metastases stage for colon according to AJCC 7th edition" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "M: colon distant metastases (AJCC 7th Edition)" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002298
name: pathologic distant metastases stage for lung according to AJCC 7th edition
def: "A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "pathologic distant metastases stage for lung according to AJCC 7th edition" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "M: lung distant metastases (AJCC 7th Edition)" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002306
name: pathologic distant metastases stage for kidney according to AJCC 7th edition
def: "A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "pathologic distant metastases stage for kidney according to AJCC 7th edition" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "M: kidney distant Metastases (AJCC 7th Edition)" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002310
name: pathologic distant metastases stage for ovary according to AJCC 7th edition
def: "A categorical value specification that is a  pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "pathologic distant metastases stage for ovary according to AJCC 7th edition" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "M: ovarian distant metastases (AJCC 7th Edition)" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002314
name: clinical tumor stage group according to AJCC 7th edition
def: "A categorical value specification that is an assessment of the stage of a cancer according to the American Joint Committee on Cancer (AJCC) v7 staging systems." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "clinical tumor stage group according to AJCC 7th edition" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "Clinical tumor stage group (AJCC 7th Edition)" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002326
name: International Federation of Gynecology and Obstetrics cervical cancer stage value specification
def: "A categorical value specification that is an assessment of the stage of a gynecologic cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging systems." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "International Federation of Gynecology and Obstetrics cervical cancer stage value specification" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "Clinical FIGO stage" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002341
name: International Federation of Gynecology and Obstetrics ovarian cancer stage value specification
def: "A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the FIGO classification system." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "International Federation of Gynecology and Obstetrics ovarian cancer stage value specification" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "Pathologic Tumor Stage Grouping for ovarian cancer (FIGO)" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002356
name: performance status value specification
def: "A categorical value specification that is an assessment of a participant's performance status (general well-being and activities of daily life)." []
is_a: OBI:0001930 ! categorical value specification
property_value: IAO:0000111 "performance status value specification" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "Performance Status Scale" xsd:string
property_value: IAO:0000119 "https://en.wikipedia.org/wiki/Performance_status" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002357
name: Eastern Cooperative Oncology Group score value specification
def: "A performance status value specification designed by the Eastern Cooperative Oncology Group to assess disease progression and its affect on the daily living abilities of the patient." []
is_a: OBI:0002356 ! performance status value specification
property_value: IAO:0000111 "Eastern Cooperative Oncology Group score value specification" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "ECOG score" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002363
name: Karnofsky score vaue specification
def: "A performance status value specification designed for classifying patients 16 years of age or older by their functional impairment." []
is_a: OBI:0002356 ! performance status value specification
property_value: IAO:0000111 "Karnofsky score vaue specification" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Chris Stoeckert, Helena Ellis" xsd:string
property_value: IAO:0000118 "Karnofsky Score" xsd:string
property_value: IAO:0000119 "NCI BBRB, OBI" xsd:string
property_value: IAO:0000234 "NCI BBRB" xsd:string

[Term]
id: OBI:0002989
name: material supplier
def: "A person or organization that provides material supplies to other people or organizations." []
is_a: BFO:0000040 ! material entity
relationship: RO:0000087 OBI:0000018 ! has role material supplier role
property_value: IAO:0000111 "material supplier" xsd:string
property_value: IAO:0000114 IAO:0000123
property_value: IAO:0000117 "Rebecca Jackson" xsd:string
property_value: IAO:0000233 "https://github.com/obi-ontology/obi/issues/1289" xsd:string

[Term]
id: OBI:0100051
name: specimen
def: "A material entity that has the specimen role." []
is_a: BFO:0000040 ! material entity
intersection_of: BFO:0000040 ! material entity
intersection_of: RO:0000087 OBI:0000112 ! has role specimen role
relationship: RO:0000087 OBI:0000112 ! has role specimen role
property_value: IAO:0000111 "specimen" xsd:string
property_value: IAO:0000112 "Biobanking of blood taken and stored in a freezer for potential future investigations stores specimen." xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000116 "Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation." xsd:string
property_value: IAO:0000117 "PERSON: James Malone" xsd:string
property_value: IAO:0000117 "PERSON: Philippe Rocca-Serra" xsd:string
property_value: IAO:0000119 "GROUP: OBI Biomaterial Branch" xsd:string
property_value: IAO:0000233 https://github.com/obi-ontology/obi/issues/1013

[Term]
id: OBI:0200000
name: data transformation
def: "A planned process that produces output data from input data." []
is_a: OBI:0000011 ! planned process
relationship: OBI:0000293 IAO:0000027 {all_only="true"} ! has_specified_input data item
relationship: OBI:0000417 OBI:0200166 ! achieves_planned_objective data transformation objective
property_value: IAO:0000111 "data transformation" xsd:string
property_value: IAO:0000112 "The application of a clustering protocol to microarray data or the application of a statistical testing method on a primary data set to determine a p-value." xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "Elisabetta Manduchi" xsd:string
property_value: IAO:0000117 "Helen Parkinson" xsd:string
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000117 "Melanie Courtot" xsd:string
property_value: IAO:0000117 "Philippe Rocca-Serra" xsd:string
property_value: IAO:0000117 "Richard Scheuermann" xsd:string
property_value: IAO:0000117 "Ryan Brinkman" xsd:string
property_value: IAO:0000117 "Tina Hernandez-Boussard" xsd:string
property_value: IAO:0000118 "data analysis" xsd:string
property_value: IAO:0000118 "data processing" xsd:string
property_value: IAO:0000119 "Branch editors" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0200033
name: leave one out cross validation method
def: "is a data transformation :  leave-one-out cross-validation (LOOCV) involves using a single observation from the original sample as the validation data, and the remaining observations as the training data. This is repeated such that each observation in the sample is used once as the validation data" []
is_a: OBI:0000792 ! statistical model validation
property_value: IAO:0000111 "leave one out cross validation method" xsd:string
property_value: IAO:0000112 "The authors conducted  leave-one-out cross validation to estimate the strength and accuracy of the differentially expressed filtered genes. http://bioinformatics.oxfordjournals.org/cgi/content/abstract/19/3/368" xsd:string
property_value: IAO:0000114 IAO:0000123
property_value: IAO:0000116 "2009-11-10. Tracker: https://sourceforge.net/tracker/?func=detail&aid=2893049&group_id=177891&atid=886178" xsd:string
property_value: IAO:0000117 "Person:Helen Parkinson" xsd:string

[Term]
id: OBI:0200041
name: k-means clustering
def: "A k-means clustering is a data transformation which achieves a class discovery or partitioning objective, which takes as input a collection of objects (represented as points in multidimensional space) and which partitions them into a specified number k of clusters. The algorithm attempts to find the centers of natural clusters in the data. The most common form of the algorithm starts by partitioning the input points into k initial sets, either at random or using some heuristic data. It then calculates the mean point, or centroid, of each set. It constructs a new partition by associating each point with the closest centroid. Then the centroids are recalculated for the new clusters, and the algorithm repeated by alternate applications of these two steps until convergence, which is obtained when the points no longer switch clusters (or alternatively centroids are no longer changed)." []
is_a: APOLLO_SV:00000796
is_a: OBI:0200171 ! partitioning data transformation
is_a: OBI:0200175 ! class discovery data transformation
relationship: OBI:0000299 OBI:0000648 ! has_specified_output clustered data set
relationship: OBI:0000417 OBI:0200178 ! achieves_planned_objective class discovery objective
property_value: IAO:0000111 "k-means clustering" xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 "Elisabetta Manduchi" xsd:string
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000117 "Philippe Rocca-Serra" xsd:string
property_value: IAO:0000119 "WEB: http://en.wikipedia.org/wiki/K-means" xsd:string

[Term]
id: OBI:0200042
name: hierarchical clustering
def: "A hierarchical clustering is a data transformation which achieves a class discovery objective, which takes as input data item and builds a hierarchy of clusters. The traditional representation of this hierarchy is a tree (visualized by a dendrogram), with the individual input objects at one end (leaves) and a single cluster containing every object at the other (root)." []
is_a: APOLLO_SV:00000796
is_a: OBI:0200175 ! class discovery data transformation
relationship: OBI:0000299 OBI:0000648 ! has_specified_output clustered data set
relationship: OBI:0000417 OBI:0200178 ! achieves_planned_objective class discovery objective
property_value: IAO:0000111 "hierarchical clustering" xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000119 "WEB: http://en.wikipedia.org/wiki/Data_clustering#Hierarchical_clustering" xsd:string

[Term]
id: OBI:0200050
name: dimensionality reduction
def: "A dimensionality reduction is data partitioning which transforms each input m-dimensional vector (x_1, x_2, ..., x_m) into an output n-dimensional vector (y_1, y_2, ..., y_n), where n is smaller than m." []
is_a: APOLLO_SV:00000796
is_a: OBI:0200175 ! class discovery data transformation
relationship: OBI:0000299 OBI:0000648 ! has_specified_output clustered data set
relationship: OBI:0000417 OBI:0200178 ! achieves_planned_objective class discovery objective
property_value: IAO:0000111 "dimensionality reduction" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "Elisabetta Manduchi" xsd:string
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000117 "Melanie Courtot" xsd:string
property_value: IAO:0000117 "Philippe Rocca-Serra" xsd:string
property_value: IAO:0000118 "data projection" xsd:string
property_value: IAO:0000119 "PERSON: Elisabetta Manduchi" xsd:string
property_value: IAO:0000119 "PERSON: James Malone" xsd:string
property_value: IAO:0000119 "PERSON: Melanie Courtot" xsd:string

[Term]
id: OBI:0200051
name: principal components analysis dimensionality reduction
def: "A principal components analysis dimensionality reduction is a dimensionality reduction achieved by applying principal components analysis and by keeping low-order principal components and excluding higher-order ones." []
is_a: OBI:0200050 ! dimensionality reduction
property_value: IAO:0000111 "principal components analysis dimensionality reduction" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "Elisabetta Manduchi" xsd:string
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000117 "Melanie Courtot" xsd:string
property_value: IAO:0000117 "Philippe Rocca-Serra" xsd:string
property_value: IAO:0000118 "pca data reduction" xsd:string
property_value: IAO:0000119 "PERSON: Elisabetta Manduchi" xsd:string
property_value: IAO:0000119 "PERSON: James Malone" xsd:string
property_value: IAO:0000119 "PERSON: Melanie Courtot" xsd:string

[Term]
id: OBI:0200111
name: data visualization
def: "A planned process with the objective to graphically represent some data by inputing the data and outputting images, diagrams or animations." []
is_a: OBI:0000011 ! planned process
relationship: OBI:0000293 IAO:0000027 ! has_specified_input data item
relationship: OBI:0000293 IAO:0000027 {all_only="true"} ! has_specified_input data item
property_value: IAO:0000111 "data visualization" xsd:string
property_value: IAO:0000112 "Generation of a heatmap from a microarray dataset" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "Elisabetta Manduchi" xsd:string
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000117 "Melanie Courtot" xsd:string
property_value: IAO:0000117 "Tina Boussard" xsd:string
property_value: IAO:0000118 "data encoding as image" xsd:string
property_value: IAO:0000118 "visualization" xsd:string
property_value: IAO:0000119 "PERSON: Elisabetta Manduchi" xsd:string
property_value: IAO:0000119 "PERSON: James Malone" xsd:string
property_value: IAO:0000119 "PERSON: Melanie Courtot" xsd:string
property_value: IAO:0000119 "PERSON: Tina Boussard" xsd:string
property_value: IAO:0000232 "Possible future hierarchy might include this:\ninformation_encoding\n>data_encoding\n>>image_encoding" xsd:string

[Term]
id: OBI:0200166
name: data transformation objective
def: "An objective specification to transformation input data into output data" []
is_a: IAO:0000005
property_value: IAO:0000111 "data transformation objective" xsd:string
property_value: IAO:0000112 "normalize objective" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000116 "Modified definition in 2013 Philly OBI workshop" xsd:string
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000119 "PERSON: James Malone" xsd:string

[Term]
id: OBI:0200171
name: partitioning data transformation
def: "A partitioning data transformation is a data transformation that has objective partitioning." []
is_a: OBI:0200000 ! data transformation
relationship: OBI:0000417 OBI:0200172 ! achieves_planned_objective partitioning objective
property_value: IAO:0000111 "partitioning data transformation" xsd:string
property_value: IAO:0000114 IAO:0000123
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000119 "PERSON: James Malone" xsd:string

[Term]
id: OBI:0200172
name: partitioning objective
def: "A partitioning objective is a data transformation objective where the aim is to generate a collection of disjoint non-empty subsets whose union equals a non-empty input set." []
is_a: OBI:0200166 ! data transformation objective
property_value: IAO:0000111 "partitioning objective" xsd:string
property_value: IAO:0000112 "A k-means clustering which has partitioning objective is a data transformation in which the input data is partitioned into k output sets." xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "Elisabetta Manduchi" xsd:string
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000119 "PERSON: Elisabetta Manduchi" xsd:string

[Term]
id: OBI:0200175
name: class discovery data transformation
def: "A class discovery data transformation (sometimes called unsupervised classification) is a data transformation that has objective class discovery." []
is_a: OBI:0200000 ! data transformation
property_value: IAO:0000111 "class discovery data transformation" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000118 "clustering data transformation" xsd:string
property_value: IAO:0000118 "unsupervised classification data transformation" xsd:string
property_value: IAO:0000119 "PERSON: James Malone" xsd:string

[Term]
id: OBI:0200178
name: class discovery objective
def: "A class discovery objective (sometimes called unsupervised classification) is a data transformation objective where the aim is to organize input data  (typically vectors of attributes) into classes, where the number of classes and their specifications are not known a priori. Depending on usage, the class assignment can be definite or probabilistic." []
is_a: OBI:0200166 ! data transformation objective
property_value: IAO:0000111 "class discovery objective" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000118 "clustering objective" xsd:string
property_value: IAO:0000118 "discriminant analysis objective" xsd:string
property_value: IAO:0000118 "unsupervised classification objective" xsd:string
property_value: IAO:0000119 "PERSON: Elisabetta Manduchi" xsd:string
property_value: IAO:0000119 "PERSON: James Malone" xsd:string

[Term]
id: OBI:0200179
name: class prediction objective
def: "A class prediction objective (sometimes called supervised classification) is a data transformation objective where the aim is to create a predictor from training data through a machine learning technique. The training data consist of pairs of objects (typically vectors of attributes) and\nclass labels for these objects. The resulting predictor can be used to attach class labels to any valid novel input object. Depending on usage, the prediction can be definite or probabilistic. A classification is learned from the training data and can then be tested on test data." []
is_a: OBI:0200166 ! data transformation objective
property_value: IAO:0000111 "class prediction objective" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000118 "classification objective" xsd:string
property_value: IAO:0000118 "supervised classification objective" xsd:string
property_value: IAO:0000119 "PERSON: Elisabetta Manduchi" xsd:string
property_value: IAO:0000119 "PERSON: James Malone" xsd:string

[Term]
id: OBI:0200188
name: cross validation objective
def: "A cross validation objective is a data transformation objective in which the aim is to partition a sample of data into subsets such that the analysis is initially performed on a single subset, while the other subset(s) are retained for subsequent use in confirming and validating the initial analysis." []
is_a: OBI:0200172 ! partitioning objective
property_value: IAO:0000111 "cross validation objective" xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 "James Malone" xsd:string
property_value: IAO:0000118 "rotation estimation objective" xsd:string
property_value: IAO:0000119 "WEB: http://en.wikipedia.org/wiki/Cross_validation" xsd:string

[Term]
id: OBI:0200190
name: clustered data visualization
def: "A data visualization which has input of a clustered data set and produces an output of a report graph which is capable of rendering data of this type." []
is_a: OBI:0200111 ! data visualization
relationship: OBI:0000293 OBI:0000648 {all_only="true"} ! has_specified_input clustered data set
property_value: IAO:0000111 "clustered data visualization" xsd:string
property_value: IAO:0000114 IAO:0000123
property_value: IAO:0000117 "James Malone" xsd:string

[Typedef]
id: BFO:0000050
name: part of
def: "a core relation that holds between a part and its whole" []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000111 "is part of" xsd:string
property_value: IAO:0000112 "my brain is part of my body (continuant parthood, two material entities)" xsd:string
property_value: IAO:0000112 "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)" xsd:string
property_value: IAO:0000112 "this day is part of this year (occurrent parthood)" xsd:string
property_value: IAO:0000116 "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other." xsd:string
property_value: IAO:0000116 "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string
property_value: IAO:0000116 "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'." xsd:string
property_value: IAO:0000118 "part_of" xsd:string
property_value: RO:0001900 RO:0001901
property_value: RO:0040042 BFO:0000002
property_value: RO:0040042 BFO:0000003
property_value: RO:0040042 BFO:0000004
property_value: RO:0040042 BFO:0000017
property_value: RO:0040042 BFO:0000019
property_value: RO:0040042 BFO:0000020
property_value: RO:0040042 BFO:0000031
property_value: seeAlso http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections
property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:PartOf
property_value: seeAlso "http://www.obofoundry.org/ro/#OBO_REL:part_of" xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Part_of" xsd:anyURI
is_transitive: true
is_a: RO:0002131 ! overlaps
inverse_of: BFO:0000051 ! has part

[Typedef]
id: BFO:0000051
name: has part
def: "a core relation that holds between a whole and its part" []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000111 "has part" xsd:string
property_value: IAO:0000112 "my body has part my brain (continuant parthood, two material entities)" xsd:string
property_value: IAO:0000112 "my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)" xsd:string
property_value: IAO:0000112 "this year has part this day (occurrent parthood)" xsd:string
property_value: IAO:0000116 "Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part." xsd:string
property_value: IAO:0000116 "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string
property_value: IAO:0000116 "Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)\n\nA continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'." xsd:string
property_value: IAO:0000118 "has_part" xsd:string
property_value: RO:0001900 RO:0001901
is_transitive: true
is_a: RO:0002131 ! overlaps

[Typedef]
id: BFO:0000062
name: preceded by
def: "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." []
subset: ro-eco
property_value: http://purl.org/dc/terms/source "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" xsd:string
property_value: IAO:0000111 "preceded by" xsd:string
property_value: IAO:0000116 "An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C.    The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other." xsd:string
property_value: IAO:0000118 "is preceded by" xsd:string
property_value: IAO:0000118 "preceded_by" xsd:string
domain: BFO:0000003 ! occurrent
range: BFO:0000003 ! occurrent
holds_over_chain: BFO:0000050 BFO:0000062
is_transitive: true
is_a: RO:0002086 ! ends after
inverse_of: BFO:0000063 ! precedes

[Typedef]
id: BFO:0000063
name: precedes
def: "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." []
subset: ro-eco
property_value: IAO:0000111 "precedes" xsd:string
domain: BFO:0000003 ! occurrent
range: BFO:0000003 ! occurrent
holds_over_chain: BFO:0000050 BFO:0000063
is_transitive: true
is_a: RO:0002222 ! temporally related to

[Typedef]
id: IAO:0000136
name: is about
def: "A (currently) primitive relation that relates an information artifact to an entity." []
property_value: IAO:0000112 "This document is about information artifacts and their representations" xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000116 "7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of \"mentions\" relation. Weaken the is_about relationship to be primitive. \n\nWe will try to build it back up by elaborating the various subproperties that are more precisely defined.\n\nSome currently missing phenomena that should be considered \"about\" are predications - \"The only person who knows the answer is sitting beside me\" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic." xsd:string
property_value: IAO:0000117 "person:Alan Ruttenberg" xsd:string
property_value: IAO:0000119 "Smith, Ceusters, Ruttenberg, 2000 years of philosophy" xsd:string

[Typedef]
id: OBI:0000293
name: has_specified_input
def: "The inverse property of is_specified_input_of" []
property_value: IAO:0000111 "has_specified_input" xsd:string
property_value: IAO:0000111 "has_specified_input" xsd:string
property_value: IAO:0000112 "see is_input_of example_of_usage" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000116 "8/17/09: specified inputs of one process are not necessarily specified inputs of a larger process that it is part of. This is in contrast to how 'has participant' works." xsd:string
property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string
property_value: IAO:0000117 "PERSON: Bjoern Peters" xsd:string
property_value: IAO:0000117 "PERSON: Larry Hunter" xsd:string
property_value: IAO:0000117 "PERSON: Melanie Coutot" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl
is_a: RO:0000057 ! has participant

[Typedef]
id: OBI:0000295
name: is_specified_input_of
def: "A relation between a planned process and a continuant participating in that process that is not created during  the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of." []
property_value: IAO:0000111 "is_specified_input_of" xsd:string
property_value: IAO:0000112 "some Autologous EBV(Epstein-Barr virus)-transformed B-LCL (B lymphocyte cell line) is_input_for instance of Chromum Release Assay described at https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "Alan Ruttenberg" xsd:string
property_value: IAO:0000117 "PERSON:Bjoern Peters" xsd:string
is_a: RO:0000056 ! participates in

[Typedef]
id: OBI:0000299
name: has_specified_output
def: "The inverse property of is_specified_output_of" []
property_value: IAO:0000111 "has_specified_output" xsd:string
property_value: IAO:0000111 "has_specified_output" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string
property_value: IAO:0000117 "PERSON: Bjoern Peters" xsd:string
property_value: IAO:0000117 "PERSON: Larry Hunter" xsd:string
property_value: IAO:0000117 "PERSON: Melanie Courtot" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl
is_a: RO:0000057 ! has participant

[Typedef]
id: OBI:0000312
name: is_specified_output_of
def: "A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of." []
property_value: IAO:0000111 "is_specified_output_of" xsd:string
property_value: IAO:0000111 "is_specified_output_of" xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "Alan Ruttenberg" xsd:string
property_value: IAO:0000117 "PERSON:Bjoern Peters" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl
is_a: RO:0000056 ! participates in

[Typedef]
id: OBI:0000417
name: achieves_planned_objective
def: "This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process." []
property_value: IAO:0000111 "achieves_planned_objective" xsd:string
property_value: IAO:0000112 "A cell sorting process achieves the objective specification 'material separation objective'" xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "BP, AR, PPPB branch" xsd:string
property_value: IAO:0000119 "PPPB branch derived" xsd:string
property_value: IAO:0000232 "modified according to email thread from 1/23/09 in accordince with DT and PPPB branch" xsd:string

[Typedef]
id: RO:0000052
name: characteristic of
def: "a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence." []
comment: Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing.
property_value: IAO:0000111 "inheres in" xsd:string
property_value: IAO:0000112 "this fragility is a characteristic of this vase" xsd:string
property_value: IAO:0000112 "this red color is a characteristic of this apple" xsd:string
property_value: IAO:0000118 "inheres_in" xsd:string
property_value: RO:0001900 RO:0001901
is_functional: true
is_a: RO:0002314 ! characteristic of part of
inverse_of: RO:0000053 ! has characteristic

[Typedef]
id: RO:0000053
name: has characteristic
def: "Inverse of characteristic_of" []
property_value: IAO:0000111 "bearer of" xsd:string
property_value: IAO:0000112 "this apple is bearer of this red color" xsd:string
property_value: IAO:0000112 "this vase is bearer of this fragility" xsd:string
property_value: IAO:0000116 "A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist." xsd:string
property_value: IAO:0000118 "bearer_of" xsd:string
property_value: IAO:0000118 "is bearer of" xsd:string
property_value: RO:0001900 RO:0001901
range: BFO:0000020 ! specifically dependent continuant
is_inverse_functional: true

[Typedef]
id: RO:0000056
name: participates in
def: "a relation between a continuant and a process, in which the continuant is somehow involved in the process" []
property_value: IAO:0000111 "participates in" xsd:string
property_value: IAO:0000112 "this blood clot participates in this blood coagulation" xsd:string
property_value: IAO:0000112 "this input material (or this output material) participates in this process" xsd:string
property_value: IAO:0000112 "this investigator participates in this investigation" xsd:string
property_value: IAO:0000118 "participates_in" xsd:string
domain: BFO:0000002 ! continuant
range: BFO:0000003 ! occurrent
inverse_of: RO:0000057 ! has participant

[Typedef]
id: RO:0000057
name: has participant
def: "a relation between a process and a continuant, in which the continuant is somehow involved in the process" []
property_value: http://purl.org/dc/terms/source "http://www.obofoundry.org/ro/#OBO_REL:has_participant" xsd:string
property_value: IAO:0000111 "has participant" xsd:string
property_value: IAO:0000112 "this blood coagulation has participant this blood clot" xsd:string
property_value: IAO:0000112 "this investigation has participant this investigator" xsd:string
property_value: IAO:0000112 "this process has participant this input material (or this output material)" xsd:string
property_value: IAO:0000116 "Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time." xsd:string
property_value: IAO:0000118 "has_participant" xsd:string
domain: BFO:0000003 ! occurrent
range: BFO:0000002 ! continuant
holds_over_chain: BFO:0000051 RO:0000057

[Typedef]
id: RO:0000079
name: function of
def: "a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence" []
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.
property_value: IAO:0000112 "this catalysis function is a function of this enzyme" xsd:string
property_value: IAO:0000116 "A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists." xsd:string
property_value: IAO:0000118 "function_of" xsd:string
property_value: IAO:0000118 "is function of" xsd:string
domain: BFO:0000034 ! function
is_a: RO:0000052 ! characteristic of
inverse_of: RO:0000085 ! has function

[Typedef]
id: RO:0000080
name: quality of
def: "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence" []
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.
property_value: IAO:0000112 "this red color is a quality of this apple" xsd:string
property_value: IAO:0000116 "A quality inheres in its bearer at all times for which the quality exists." xsd:string
property_value: IAO:0000118 "is quality of" xsd:string
property_value: IAO:0000118 "quality_of" xsd:string
is_a: RO:0000052 ! characteristic of
inverse_of: RO:0000086 ! has quality

[Typedef]
id: RO:0000081
name: role of
def: "a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence" []
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.
property_value: IAO:0000112 "this investigator role is a role of this person" xsd:string
property_value: IAO:0000116 "A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists." xsd:string
property_value: IAO:0000118 "is role of" xsd:string
property_value: IAO:0000118 "role_of" xsd:string
is_a: RO:0000052 ! characteristic of
inverse_of: RO:0000087 ! has role

[Typedef]
id: RO:0000085
name: has function
def: "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence" []
property_value: IAO:0000112 "this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function)" xsd:string
property_value: IAO:0000116 "A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists." xsd:string
property_value: IAO:0000118 "has_function" xsd:string
domain: BFO:0000004 ! independent continuant
range: BFO:0000034 ! function
is_a: RO:0000053 ! has characteristic

[Typedef]
id: RO:0000086
name: has quality
def: "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence" []
property_value: IAO:0000112 "this apple has quality this red color" xsd:string
property_value: IAO:0000116 "A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist." xsd:string
property_value: IAO:0000118 "has_quality" xsd:string
range: BFO:0000019 ! quality
is_a: RO:0000053 ! has characteristic

[Typedef]
id: RO:0000087
name: has role
def: "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence" []
property_value: IAO:0000112 "this person has role this investigator role (more colloquially: this person has this role of investigator)" xsd:string
property_value: IAO:0000116 "A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists." xsd:string
property_value: IAO:0000118 "has_role" xsd:string
domain: BFO:0000004 ! independent continuant
range: BFO:0000023 ! role
is_a: RO:0000053 ! has characteristic

[Typedef]
id: RO:0000091
name: has disposition
def: "a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence" []
domain: BFO:0000004 ! independent continuant
range: BFO:0000016 ! disposition
is_a: RO:0000053 ! has characteristic
inverse_of: RO:0000092 ! disposition of

[Typedef]
id: RO:0000092
name: disposition of
def: "inverse of has disposition" []
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.
subset: RO:0002259
is_a: RO:0000052 ! characteristic of

[Typedef]
id: RO:0002013
name: has regulatory component activity
def: "A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B." []
is_a: RO:0002017 ! has component activity
is_a: RO:0002334 ! regulated by
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:30:46Z

[Typedef]
id: RO:0002014
name: has negative regulatory component activity
def: "A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B." []
comment: By convention GO molecular functions are classified by their effector function.  Internal regulatory functions are treated as components.  For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'.
is_a: RO:0002013 ! has regulatory component activity
is_a: RO:0002335 ! negatively regulated by
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:31:01Z

[Typedef]
id: RO:0002015
name: has positive regulatory component activity
def: "A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B." []
comment: By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components.  So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'.
is_a: RO:0002013 ! has regulatory component activity
is_a: RO:0002336 ! positively regulated by
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:31:17Z

[Typedef]
id: RO:0002017
name: has component activity
comment: A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.
is_a: RO:0002018 ! has component process
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:44:33Z

[Typedef]
id: RO:0002018
name: has component process
def: "w 'has process component' p if p and w are processes,  w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." []
domain: BFO:0000015 ! process
range: BFO:0000015 ! process
is_a: RO:0002180 ! has component
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:49:21Z

[Typedef]
id: RO:0002022
name: directly regulated by
comment: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2. {xref="https://orcid.org/0000-0002-7073-9172"}
is_a: RO:0002334 ! regulated by
inverse_of: RO:0002578 ! directly regulates
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-17T13:52:24Z

[Typedef]
id: RO:0002023
name: directly negatively regulated by
def: "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." [https://orcid.org/0000-0002-7073-9172]
is_a: RO:0002022 ! directly regulated by
inverse_of: RO:0002630 ! directly negatively regulates
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-17T13:52:38Z

[Typedef]
id: RO:0002024
name: directly positively regulated by
def: "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." [https://orcid.org/0000-0002-7073-9172]
is_a: RO:0002022 ! directly regulated by
inverse_of: RO:0002629 ! directly positively regulates
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-17T13:52:47Z

[Typedef]
id: RO:0002025
name: has effector activity
def: "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674),  A 'has component activity' B and B is the effector (output function) of B.  Each compound function has only one effector activity." [https://orcid.org/0000-0002-7073-9172]
comment: This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.
is_functional: true
is_a: RO:0002017 ! has component activity
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-22T14:14:36Z

[Typedef]
id: RO:0002086
name: ends after
comment: X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)
subset: ro-eco
property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string
is_transitive: true
is_a: RO:0002222 ! temporally related to

[Typedef]
id: RO:0002087
name: immediately preceded by
comment: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string
property_value: IAO:0000118 "starts_at_end_of" xsd:string
is_a: BFO:0000062 ! preceded by
inverse_of: RO:0002090 ! immediately precedes

[Typedef]
id: RO:0002090
name: immediately precedes
comment: X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)
subset: ro-eco
property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: IAO:0000118 "ends_at_start_of" xsd:string
property_value: IAO:0000118 "meets" xsd:string
property_value: RO:0002575 BFO:0000063
is_a: BFO:0000063 ! precedes

[Typedef]
id: RO:0002131
name: overlaps
def: "x overlaps y if and only if there exists some z such that x has part z and z part of y" []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_gocam
subset: ro-eco
property_value: IAO:0000114 IAO:0000125
property_value: RO:0001900 RO:0001901
holds_over_chain: BFO:0000050 BFO:0000050
holds_over_chain: BFO:0000051 BFO:0000050 {RO:0002582="true"}
holds_over_chain: BFO:0000051 RO:0002131
is_symmetric: true
is_a: RO:0002323 ! mereotopologically related to
transitive_over: BFO:0000050 ! part of
expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)" []

[Typedef]
id: RO:0002180
name: has component
def: "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." []
subset: ro-eco
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000116 "The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity." xsd:string
property_value: IAO:0000232 "For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit." xsd:string
property_value: RO:0001900 RO:0001901
property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:Componency
is_a: BFO:0000051 ! has part

[Typedef]
id: RO:0002211
name: regulates
def: "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000117 https://orcid.org/0000-0001-7476-6306
property_value: IAO:0000117 https://orcid.org/0000-0002-3837-8864
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "GO" xsd:string
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000232 "Regulation precludes parthood; the regulatory process may not be within the regulated process." xsd:string
property_value: IAO:0000589 "regulates (processual)" xsd:string
property_value: IAO:0000600 "false" xsd:boolean
domain: BFO:0000015 ! process
range: BFO:0000015 ! process
holds_over_chain: RO:0002578 RO:0002578
is_transitive: true
is_a: RO:0002411 ! causally upstream of
inverse_of: RO:0002334 ! regulated by
transitive_over: RO:0002025 ! has effector activity

[Typedef]
id: RO:0002212
name: negatively regulates
def: "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "negatively regulates (process to process)" xsd:string
property_value: RO:0004050 RO:0002211
is_a: RO:0002211 ! regulates
is_a: RO:0002305 ! causally upstream of, negative effect
inverse_of: RO:0002335 ! negatively regulated by

[Typedef]
id: RO:0002213
name: positively regulates
def: "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "positively regulates (process to process)" xsd:string
property_value: RO:0004049 RO:0002211
holds_over_chain: RO:0002212 RO:0002212
is_transitive: true
is_a: RO:0002211 ! regulates
is_a: RO:0002304 ! causally upstream of, positive effect
inverse_of: RO:0002336 ! positively regulated by

[Typedef]
id: RO:0002215
name: capable of
def: "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " []
subset: ro-eco
property_value: IAO:0000112 "mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)" xsd:string
property_value: IAO:0000112 "osteoclast SubClassOf 'capable of' some 'bone resorption'" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "has function realized in" xsd:string
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20123131
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/21208450
property_value: IAO:0000232 "For compatibility with BFO, this relation has a shortcut definition in which the expression \"capable of some P\" expands to \"bearer_of (some realized_by only P)\"." xsd:string
domain: BFO:0000004 ! independent continuant
range: BFO:0000015 ! process
is_a: RO:0002216 ! capable of part of

[Typedef]
id: RO:0002216
name: capable of part of
def: "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "has function in" xsd:string
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
holds_over_chain: RO:0002215 BFO:0000050 {RO:0002582="true"}
is_a: RO:0002328 ! functionally related to
is_a: RO:0002500 ! causal agent in process

[Typedef]
id: RO:0002222
name: temporally related to
comment: A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.
subset: ro-eco
property_value: http://purl.org/dc/terms/source "https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1" xsd:anyURI
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 https://en.wikipedia.org/wiki/Allen%27s_interval_algebra
property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends." xsd:string
domain: BFO:0000003 ! occurrent
range: BFO:0000003 ! occurrent

[Typedef]
id: RO:0002233
name: has input
def: "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
subset: ro-eco
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "consumes" xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Has_input" xsd:anyURI
domain: BFO:0000015 ! process
is_a: RO:0000057 ! has participant
inverse_of: RO:0002352 ! input of

[Typedef]
id: RO:0002263
name: acts upstream of
def: "c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes." []
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: IAO:0000112 "A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision." xsd:string
property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of
holds_over_chain: RO:0002327 RO:0002411
is_a: RO:0002264 ! acts upstream of or within

[Typedef]
id: RO:0002264
name: acts upstream of or within
def: "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." []
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
synonym: "affects" RELATED []
property_value: IAO:0000112 "A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway." xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within" xsd:anyURI
holds_over_chain: RO:0002327 RO:0002418
is_a: RO:0002500 ! causal agent in process

[Typedef]
id: RO:0002304
name: causally upstream of, positive effect
def: "p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q." []
comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: http://purl.org/dc/terms/creator https://orcid.org/0000-0002-6601-2165
property_value: RO:0004049 RO:0002411
property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of,_positive_effect
is_a: RO:0002411 ! causally upstream of
is_a: RO:0004047 ! causally upstream of or within, positive effect

[Typedef]
id: RO:0002305
name: causally upstream of, negative effect
def: "p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: http://purl.org/dc/terms/creator https://orcid.org/0000-0002-6601-2165
property_value: RO:0004050 RO:0002411
property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of,_negative_effect
is_a: RO:0002411 ! causally upstream of
is_a: RO:0004046 ! causally upstream of or within, negative effect

[Typedef]
id: RO:0002314
name: characteristic of part of
def: "q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w." []
property_value: IAO:0000116 "Because part_of is transitive, inheres in is a sub-relation of characteristic of part of" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "inheres in part of" xsd:string
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205
property_value: RO:0001900 RO:0001901
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
holds_over_chain: RO:0000052 BFO:0000050 {RO:0002582="true"}
is_a: RO:0002502 ! depends on
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002323
name: mereotopologically related to
def: "A mereological relationship or a topological relationship" []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships" xsd:string
property_value: RO:0001900 RO:0001901

[Typedef]
id: RO:0002327
name: enables
def: "c enables p iff c is capable of p and c acts to execute p." []
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: IAO:0000112 "a particular instances of akt-2 enables some instance of protein kinase activity" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "catalyzes" xsd:string
property_value: IAO:0000118 "executes" xsd:string
property_value: IAO:0000118 "has" xsd:string
property_value: IAO:0000118 "is catalyzing" xsd:string
property_value: IAO:0000118 "is executing" xsd:string
property_value: IAO:0000232 "This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized." xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Enables" xsd:anyURI
is_a: RO:0002215 ! capable of
inverse_of: RO:0002333 ! enabled by
transitive_over: BFO:0000051 ! has part
transitive_over: RO:0002017 ! has component activity

[Typedef]
id: RO:0002328
name: functionally related to
def: "A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000232 "This is a grouping relation that collects relations used for the purpose of connecting structure and function" xsd:string

[Typedef]
id: RO:0002329
name: part of structure that is capable of
def: "this relation holds between c and p when c is part of some c', and c' is capable of p." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "false" xsd:boolean
holds_over_chain: BFO:0000050 RO:0002215 {RO:0002581="true"}
is_a: RO:0002328 ! functionally related to

[Typedef]
id: RO:0002331
name: involved in
def: "c involved_in p if and only if c enables some process p', and p' is part of p" []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "actively involved in" xsd:string
property_value: IAO:0000118 "enables part of" xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Involved_in" xsd:anyURI
holds_over_chain: RO:0002327 BFO:0000050
is_a: RO:0000056 ! participates in
is_a: RO:0002431 ! involved in or involved in regulation of
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002333
name: enabled by
def: "inverse of enables" []
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: seeAlso "https://wiki.geneontology.org/Enabled_by" xsd:anyURI
is_a: RO:0000057 ! has participant
is_a: RO:0002328 ! functionally related to

[Typedef]
id: RO:0002334
name: regulated by
def: "inverse of regulates" []
subset: RO:0002259
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000589 "regulated by (processual)" xsd:string
domain: BFO:0000015 ! process
range: BFO:0000015 ! process
is_transitive: true
is_a: RO:0002427 ! causally downstream of or within

[Typedef]
id: RO:0002335
name: negatively regulated by
def: "inverse of negatively regulates" []
subset: RO:0002259
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0002334 ! regulated by

[Typedef]
id: RO:0002336
name: positively regulated by
def: "inverse of positively regulates" []
subset: RO:0002259
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0002334 ! regulated by

[Typedef]
id: RO:0002352
name: input of
def: "inverse of has input" []
subset: ro-eco
subset: RO:0002259
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0000056 ! participates in
is_a: RO:0002328 ! functionally related to

[Typedef]
id: RO:0002404
name: causally downstream of
def: "inverse of upstream of" []
property_value: IAO:0000114 IAO:0000428
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: BFO:0000062 ! preceded by
is_a: RO:0002427 ! causally downstream of or within
inverse_of: RO:0002411 ! causally upstream of

[Typedef]
id: RO:0002405
name: immediately causally downstream of
property_value: IAO:0000114 IAO:0000428
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0002087 ! immediately preceded by
is_a: RO:0002404 ! causally downstream of
inverse_of: RO:0002412 ! immediately causally upstream of

[Typedef]
id: RO:0002407
name: indirectly positively regulates
def: "p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "indirectly activates" xsd:string
property_value: RO:0002579 RO:0002213
property_value: seeAlso "https://wiki.geneontology.org/Indirectly_positively_regulates" xsd:anyURI
holds_over_chain: RO:0002409 RO:0002409
holds_over_chain: RO:0002629 RO:0002407
holds_over_chain: RO:0002629 RO:0002629
is_transitive: true
is_a: RO:0002213 ! positively regulates
is_a: RO:0012012 ! indirectly regulates
transitive_over: RO:0002629 ! directly positively regulates

[Typedef]
id: RO:0002409
name: indirectly negatively regulates
def: "p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "indirectly inhibits" xsd:string
property_value: RO:0002579 RO:0002212
property_value: seeAlso "https://wiki.geneontology.org/Indirectly_negatively_regulates" xsd:anyURI
holds_over_chain: RO:0002630 RO:0002409
holds_over_chain: RO:0002630 RO:0002630
is_transitive: true
is_a: RO:0002212 ! negatively regulates
is_a: RO:0012012 ! indirectly regulates
transitive_over: RO:0002630 ! directly negatively regulates

[Typedef]
id: RO:0002410
name: causally related to
def: "relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause." [https://en.wikipedia.org/wiki/Causality]
property_value: IAO:0000116 "This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents.\n\nTo define causal relations in an activity-flow type network, we make use of 3 primitives:\n\n * Temporal: how do the intervals of the two occurrents relate? \n * Is the causal relation regulatory?\n * Is the influence positive or negative?\n\nThe first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified.\n\nFor the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule.\n\nFor the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral.\n\nEach of these 3 primitives can be composed to yield a cross-product of different relation types." xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string

[Typedef]
id: RO:0002411
name: causally upstream of
def: "p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_transitive: true
is_a: BFO:0000063 ! precedes
is_a: RO:0002418 ! causally upstream of or within

[Typedef]
id: RO:0002412
name: immediately causally upstream of
def: "p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: RO:0002575 RO:0002411
is_a: RO:0002090 ! immediately precedes
is_a: RO:0002411 ! causally upstream of

[Typedef]
id: RO:0002418
name: causally upstream of or within
def: "p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q." []
synonym: "affects" RELATED []
property_value: IAO:0000116 "We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "influences (processual)" xsd:string
is_transitive: true
is_a: RO:0002501 ! causal relation between processes
inverse_of: RO:0002427 ! causally downstream of or within

[Typedef]
id: RO:0002427
name: causally downstream of or within
def: "inverse of causally upstream of or within" []
subset: RO:0002259
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
is_transitive: true
is_a: RO:0002501 ! causal relation between processes

[Typedef]
id: RO:0002428
name: involved in regulation of
def: "c involved in regulation of p if c is involved in some p' and p' regulates some p" []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
holds_over_chain: RO:0002327 RO:0002211
holds_over_chain: RO:0002331 RO:0002211
is_a: RO:0002263 ! acts upstream of
is_a: RO:0002431 ! involved in or involved in regulation of

[Typedef]
id: RO:0002429
name: involved in positive regulation of
def: "c involved in regulation of p if c is involved in some p' and p' positively regulates some p" []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: RO:0004049 RO:0002428
holds_over_chain: RO:0002327 RO:0002213
holds_over_chain: RO:0002331 RO:0002213
is_a: RO:0002428 ! involved in regulation of

[Typedef]
id: RO:0002430
name: involved in negative regulation of
def: "c involved in regulation of p if c is involved in some p' and p' negatively regulates some p" []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: RO:0004050 RO:0002428
holds_over_chain: RO:0002327 RO:0002212
holds_over_chain: RO:0002331 RO:0002212
is_a: RO:0002428 ! involved in regulation of

[Typedef]
id: RO:0002431
name: involved in or involved in regulation of
def: "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" []
property_value: IAO:0000116 "OWL does not allow defining object properties via a Union" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "involved in or reguates" xsd:string
is_a: RO:0002264 ! acts upstream of or within
is_a: RO:0002328 ! functionally related to
is_a: RO:0002500 ! causal agent in process

[Typedef]
id: RO:0002434
name: interacts with
def: "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." []
subset: ro-eco
synonym: "in pairwise interaction with" EXACT []
property_value: closeMatch "http://purl.obolibrary.org/obo/MI_0914" xsd:anyURI
property_value: IAO:0000116 "Considering relabeling as 'pairwise interacts with'" xsd:anyURI
property_value: IAO:0000116 "This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact." xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000232 "Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules." xsd:string
property_value: seeAlso "http://purl.obolibrary.org/obo/ro/docs/interaction-relations/" xsd:anyURI
domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_symmetric: true

[Typedef]
id: RO:0002436
name: molecularly interacts with
def: "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other." []
property_value: closeMatch "http://purl.obolibrary.org/obo/MI_0915" xsd:anyURI
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "binds" xsd:string
property_value: IAO:0000118 "molecularly binds with" xsd:string
property_value: seeAlso ECO:0000353
is_symmetric: true
is_a: RO:0002434 ! interacts with

[Typedef]
id: RO:0002447
name: phosphorylates
property_value: IAO:0000116 "Axiomatization to GO to be added later" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y." xsd:string
is_a: RO:0002436 ! molecularly interacts with

[Typedef]
id: RO:0002448
name: directly regulates activity of
def: "The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B.\n\nA and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B." []
synonym: "molecularly controls" EXACT []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0003-4639-4431
domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_a: RO:0002436 ! molecularly interacts with
is_a: RO:0011002 ! regulates activity of

[Typedef]
id: RO:0002449
name: directly negatively regulates activity of
def: "The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. \nFor example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B." []
synonym: "molecularly decreases activity of" EXACT []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0003-4639-4431
property_value: IAO:0000118 "directly inhibits" xsd:string
domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_a: RO:0002448 ! directly regulates activity of

[Typedef]
id: RO:0002450
name: directly positively regulates activity of
def: "The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. \nFor example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B." []
synonym: "molecularly increases activity of" EXACT []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0003-4639-4431
property_value: IAO:0000118 "directly activates" xsd:string
domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_a: RO:0002448 ! directly regulates activity of

[Typedef]
id: RO:0002464
name: helper property (not for use in curation)
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000232 "This property or its subproperties is not to be used directly. These properties exist as helper properties that are used to support OWL reasoning." xsd:string

[Typedef]
id: RO:0002481
name: is kinase activity
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0002564 ! molecular interaction relation helper property

[Typedef]
id: RO:0002500
name: causal agent in process
def: "A relationship between a material entity and a process where the material entity has some causal role that influences the process" []
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
is_a: RO:0002595 ! causal relation between material entity and a process
inverse_of: RO:0002608 ! process has causal agent

[Typedef]
id: RO:0002501
name: causal relation between processes
def: "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string
domain: BFO:0000003 ! occurrent
range: BFO:0000003 ! occurrent
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0002502
name: depends on
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: seeAlso BFO:0000169

[Typedef]
id: RO:0002506
name: causal relation between entities
property_value: IAO:0000116 "The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string
domain: BFO:0000002 ! continuant
range: BFO:0000002 ! continuant
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0002559
name: causally influenced by
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "causally influenced by (entity-centric)" xsd:string
is_a: RO:0002506 ! causal relation between entities
inverse_of: RO:0002566 ! causally influences

[Typedef]
id: RO:0002563
name: interaction relation helper property
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:N-Ary_Relation_Pattern_%28OWL_2%29
property_value: seeAlso "http://purl.obolibrary.org/obo/ro/docs/interaction-relations/" xsd:anyURI
is_a: RO:0002464 ! helper property (not for use in curation)

[Typedef]
id: RO:0002564
name: molecular interaction relation helper property
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0002563 ! interaction relation helper property

[Typedef]
id: RO:0002566
name: causally influences
def: "The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size)." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0003-4639-4431
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "causally influences (entity-centric)" xsd:string
domain: BFO:0000002 ! continuant
range: BFO:0000002 ! continuant
is_a: RO:0002506 ! causal relation between entities

[Typedef]
id: RO:0002578
name: directly regulates
def: "p directly regulates q iff p is immediately causally upstream of q and p regulates q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "directly regulates (processual)" xsd:string
property_value: RO:0002575 RO:0002211
is_a: RO:0002211 ! regulates
is_a: RO:0002412 ! immediately causally upstream of

[Typedef]
id: RO:0002584
name: has part structure that is capable of
def: "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" []
property_value: IAO:0000112 "gland SubClassOf 'has part structure that is capable of' some 'secretion by cell'" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
holds_over_chain: BFO:0000051 RO:0002215
is_a: RO:0002328 ! functionally related to
is_a: RO:0002595 ! causal relation between material entity and a process

[Typedef]
id: RO:0002595
name: causal relation between material entity and a process
def: "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." []
property_value: IAO:0000116 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
domain: BFO:0000040 ! material entity
range: BFO:0000015 ! process
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0002596
name: capable of regulating
def: "Holds between c and p if and only if c is capable of some activity a, and a regulates p." []
property_value: IAO:0000112 "pyrethroid -> growth" xsd:string
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
holds_over_chain: RO:0002215 RO:0002211
is_a: RO:0002500 ! causal agent in process

[Typedef]
id: RO:0002597
name: capable of negatively regulating
def: "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." []
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
holds_over_chain: RO:0002215 RO:0002212
is_a: RO:0002596 ! capable of regulating

[Typedef]
id: RO:0002598
name: capable of positively regulating
def: "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." []
property_value: IAO:0000112 "renin -> arteriolar smooth muscle contraction" xsd:string
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
holds_over_chain: RO:0002215 RO:0002213
is_a: RO:0002596 ! capable of regulating

[Typedef]
id: RO:0002608
name: process has causal agent
def: "Inverse of 'causal agent in process'" []
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0002629
name: directly positively regulates
def: "p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "directly positively regulates (process to process)" xsd:string
property_value: RO:0004049 RO:0002578
property_value: seeAlso "https://wiki.geneontology.org/Directly_positively_regulates" xsd:anyURI
is_a: RO:0002213 ! positively regulates
is_a: RO:0002578 ! directly regulates

[Typedef]
id: RO:0002630
name: directly negatively regulates
def: "p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "directly negatively regulates (process to process)" xsd:string
property_value: RO:0004050 RO:0002578
property_value: seeAlso "https://wiki.geneontology.org/Directly_negatively_regulates" xsd:anyURI
is_a: RO:0002212 ! negatively regulates
is_a: RO:0002578 ! directly regulates

[Typedef]
id: RO:0004031
name: enables subfunction
def: "Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P." []
holds_over_chain: RO:0002327 BFO:0000051
is_a: RO:0002328 ! functionally related to
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-01-25T23:20:13Z

[Typedef]
id: RO:0004032
name: acts upstream of or within, positive effect
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004049 RO:0002264
property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect" xsd:anyURI
holds_over_chain: RO:0002327 RO:0004047
is_a: RO:0002264 ! acts upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-01-26T23:49:30Z

[Typedef]
id: RO:0004033
name: acts upstream of or within, negative effect
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004050 RO:0002264
property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect" xsd:anyURI
holds_over_chain: RO:0002327 RO:0004046
is_a: RO:0002264 ! acts upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-01-26T23:49:51Z

[Typedef]
id: RO:0004034
name: acts upstream of, positive effect
def: "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" []
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004049 RO:0002263
property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of,_positive_effect" xsd:anyURI
holds_over_chain: RO:0002327 RO:0002304
is_a: RO:0002263 ! acts upstream of
is_a: RO:0004032 ! acts upstream of or within, positive effect
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-01-26T23:53:14Z

[Typedef]
id: RO:0004035
name: acts upstream of, negative effect
def: "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" []
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004050 RO:0002263
property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of,_negative_effect" xsd:anyURI
holds_over_chain: RO:0002327 RO:0002305
is_a: RO:0002263 ! acts upstream of
is_a: RO:0004033 ! acts upstream of or within, negative effect
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-01-26T23:53:22Z

[Typedef]
id: RO:0004046
name: causally upstream of or within, negative effect
property_value: RO:0004050 RO:0002418
property_value: seeAlso "https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect" xsd:anyURI
is_a: RO:0002418 ! causally upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-03-13T23:55:05Z

[Typedef]
id: RO:0004047
name: causally upstream of or within, positive effect
property_value: RO:0004049 RO:0002418
property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of_or_within,_positive_effect
is_a: RO:0002418 ! causally upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-03-13T23:55:19Z

[Typedef]
id: RO:0011002
name: regulates activity of
def: "The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B." []
property_value: IAO:0000117 https://orcid.org/0000-0003-4639-4431
domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_a: RO:0002566 ! causally influences

[Typedef]
id: RO:0012011
name: indirectly causally upstream of
def: "p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q." []
is_a: RO:0002411 ! causally upstream of
created_by: https://orcid.org/0000-0003-1813-6857
creation_date: 2022-09-26T06:07:17Z

[Typedef]
id: RO:0012012
name: indirectly regulates
def: "p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q." []
is_a: RO:0002211 ! regulates
is_a: RO:0012011 ! indirectly causally upstream of
created_by: https://orcid.org/0000-0003-1813-6857
creation_date: 2022-09-26T06:08:01Z

[Typedef]
id: RO:0017001
name: device utilizes material
def: "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y." []
synonym: "utilizes" BROAD []
property_value: IAO:0000112 "A diagnostic testing device utilizes a specimen." xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0001-9625-1899
property_value: IAO:0000117 https://orcid.org/0000-0003-2620-0345
property_value: IAO:0000232 "A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input." xsd:string
property_value: IAO:0000232 "See github ticket https://github.com/oborel/obo-relations/issues/497" xsd:string
holds_over_chain: RO:0002215 RO:0002233
creation_date: 2021-11-08T12:00:00Z

[Typedef]
id: RO:0019000
name: regulates characteristic
def: "A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C." []
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-8688-6599
domain: BFO:0000015 ! process
range: PATO:0000001
holds_over_chain: RO:0002211 RO:0019000
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0019001
name: positively regulates characteristic
def: "A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C." []
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-8688-6599
holds_over_chain: RO:0002213 RO:0019001
is_a: RO:0019000 ! regulates characteristic

[Typedef]
id: RO:0019002
name: negatively regulates characteristic
def: "A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C." []
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-8688-6599
holds_over_chain: RO:0002212 RO:0019001
holds_over_chain: RO:0002213 RO:0019002
is_a: RO:0019000 ! regulates characteristic