diff --git a/assets/index-pvyZ93tw.js b/assets/index-BpgbaWPX.js
similarity index 99%
rename from assets/index-pvyZ93tw.js
rename to assets/index-BpgbaWPX.js
index db11530..7374306 100644
--- a/assets/index-pvyZ93tw.js
+++ b/assets/index-BpgbaWPX.js
@@ -1825,4 +1825,4 @@ void main(void) {
             <\/script>
           </body>
         </html>`}async saveHTML(u="untitled.html",h="gl1",g){const S=await this.generateHTML(h,g);return NVUtilities.download(S,u,"application/html")}json(){return this.document.opts=this.opts,this.document.scene=this.scene,this.document.volumes=this.volumes,this.document.meshes=this.meshes,this.drawScene(),this.document.previewImageDataURL=this.canvas.toDataURL(),this.document.json()}async saveDocument(u="untitled.nvd",h=!0){return this.document.title=u,log.debug("saveDocument",this.volumes[0]),this.drawScene(),this.document.previewImageDataURL=this.canvas.toDataURL(),this.document.volumes=this.volumes,this.document.meshes=this.meshes,this.document.download(u,h)}async loadImages(u){const h=[],g=[];for(const S of u)if("url"in S){const v=this.getFileExt(S.url);if(this.loaders[v]){const C=this.loaders[v].toExt.toUpperCase();MESH_EXTENSIONS.includes(C)?g.push(S):h.push(S);continue}MESH_EXTENSIONS.includes(v.toUpperCase())?g.push(S):h.push(S)}return h.length>0&&await this.loadVolumes(h),g.length>0&&await this.loadMeshes(g),this}async loadVolumes(u){return this.loadingText="loading...",this.drawScene(),this.thumbnailVisible?(this.deferredVolumes=u,this):(this.volumes=[],this.gl.clearColor(0,0,0,1),this.gl.clear(this.gl.COLOR_BUFFER_BIT),await this.addVolumesFromUrl(u),this)}async addMeshFromUrl(u){const h=this.getFileExt(u.url);if(h==="JCON"||h==="JSON"){const v=await(await fetch(u.url,{})).json(),C=this.loadConnectomeAsMesh(v);return this.mediaUrlMap.set(C,u.url),this.onMeshAddedFromUrl(u,C),this.addMesh(C),C}const g=await NVMesh2.loadFromUrl({...u,gl:this.gl});return this.mediaUrlMap.set(g,u.url),this.onMeshAddedFromUrl(u,g),this.addMesh(g),g}async addMeshesFromUrl(u){const h=u.map(async S=>{const v=this.getFileExt(S.name||S.url);if(this.loaders[v]){let D=S.url;const _=this.loaders[v].toExt;let P=S.name||S.url;if(P=P.split("/").pop(),typeof S.url=="string"){const e=S.url;try{const O=await fetch(e);if(!O.ok)throw new Error(`Failed to load file: ${O.statusText}`);D=await O.arrayBuffer()}catch(O){throw new Error(`Failed to load url ${e}: ${O}`)}}const{positions:L,indices:m}=await this.loaders[v].loader(D);S.name=`${P}.${_}`;const k=NVMeshUtilities.createMZ3(L,m,!1);S.buffer=k}if(v==="JCON"||v==="JSON"){const _=await(await fetch(S.url,{})).json(),P=this.loadConnectomeAsMesh(_);return this.mediaUrlMap.set(P,S.url),this.onMeshAddedFromUrl(S,P),P}const C=await NVMesh2.loadFromUrl({...S,gl:this.gl});return this.mediaUrlMap.set(C,S.url),this.onMeshAddedFromUrl(S,C),C}),g=await Promise.all(h);for(let S=0;S<g.length;S++)this.addMesh(g[S]);return g}async loadMeshes(u){return this.loadingText="loading...",this.drawScene(),this.thumbnailVisible?(this.deferredMeshes=u,this):(this.initialized,this.meshes=[],this.gl.clearColor(0,0,0,1),this.gl.clear(this.gl.COLOR_BUFFER_BIT),await this.addMeshesFromUrl(u),this.updateGLVolume(),this.drawScene(),this)}async loadConnectomeFromUrl(u,h={}){const S=await(await fetch(u,{headers:h})).json();return this.loadConnectome(S)}async loadFreeSurferConnectomeFromUrl(u,h={}){const S=await(await fetch(u,{headers:h})).json();return this.loadFreeSurferConnectome(S)}async loadFreeSurferConnectome(u){const h=NVConnectome.convertFreeSurferConnectome(u);return this.loadConnectome(h)}handleNodeAdded(u){const h=u.detail.node,g=[1,1,1,1];this.addLabel(h.name,{textColor:g,bulletScale:1,bulletColor:g,lineWidth:0,lineColor:g,lineTerminator:"none",textScale:1},[h.x,h.y,h.z]),this.drawScene()}loadConnectomeAsMesh(u){let h=u;if("data_type"in u&&u.data_type==="fs_pointset")h=NVConnectome.convertFreeSurferConnectome(u),log.warn("converted FreeSurfer connectome",h);else if("nodes"in u){const g=u.nodes;"names"in g&&"X"in g&&"Y"in g&&"Z"in g&&"Color"in g&&"Size"in g&&(h=NVConnectome.convertLegacyConnectome(u),log.warn("converted legacy connectome",h))}else throw new Error("not a known connectome format");return new NVConnectome(this.gl,h)}loadConnectome(u){this.loadingText="loading...",this.drawScene(),this.meshes=[],this.gl.clearColor(0,0,0,1),this.gl.clear(this.gl.COLOR_BUFFER_BIT);const h=this.loadConnectomeAsMesh(u);return this.addMesh(h),this.drawScene(),this}createEmptyDrawing(){if(this.back===null||!this.back.dims||Math.min(Math.min(this.back.dims[1],this.back.dims[2]),this.back.dims[3])<1)return;const h=this.back.dims[1]*this.back.dims[2]*this.back.dims[3];this.drawBitmap=new Uint8Array(h),this.drawClearAllUndoBitmaps(),this.drawAddUndoBitmap(),this.drawTexture=this.r8Tex(this.drawTexture,TEXTURE7_DRAW,this.back.dims,!0),this.refreshDrawing(!1)}r16Tex(u,h,g,S){u&&this.gl.deleteTexture(u),u=this.gl.createTexture(),this.gl.activeTexture(h),this.gl.bindTexture(this.gl.TEXTURE_3D,u),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R16I,g[1],g[2],g[3]);const v=g[1]*g[2]*g[3];return S.length!==v&&(S=new Int16Array(v)),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g[1],g[2],g[3],this.gl.RED_INTEGER,this.gl.SHORT,S),u}drawGrowCut(){if(!this.back||!this.back.dims)throw new Error("back not defined");const u=this.back.hdr,h=this.gl,g=u.dims[1]*u.dims[2]*u.dims[3];if(!this.drawBitmap||this.drawBitmap.length!==g){log.debug("bitmap dims are wrong");return}const S=h.createFramebuffer();h.bindFramebuffer(h.FRAMEBUFFER,S),h.disable(h.CULL_FACE),h.viewport(0,0,this.back.dims[1],this.back.dims[2]),h.disable(h.BLEND);let v=img2ras16(this.back);const C=this.r16Tex(null,TEXTURE11_GC_BACK,this.back.dims,v);for(let H=1;H<g;H++)v[H]=this.drawBitmap[H];const D=this.r16Tex(null,TEXTURE14_GC_LABEL0,this.back.dims,v),_=this.r16Tex(null,TEXTURE15_GC_LABEL1,this.back.dims,v),P=1e4;for(let H=1;H<g;H++)v[H]>0&&(v[H]=P);const L=this.r16Tex(null,TEXTURE12_GC_STRENGTH0,this.back.dims,v),m=this.r16Tex(null,TEXTURE13_GC_STRENGTH1,this.back.dims,v);h.bindVertexArray(this.genericVAO);const k=this.growCutShader;k.use(h);const e=128;h.uniform1i(k.uniforms.finalPass,0),h.uniform1i(k.uniforms.backTex,11);for(let H=0;H<e;H++){h.uniform1i(k.uniforms.labelTex,14),h.uniform1i(k.uniforms.strengthTex,12);for(let G=0;G<this.back.dims[3];G++){const K=1/this.back.dims[3]*(G+.5);h.uniform1f(k.uniforms.coordZ,K),h.framebufferTextureLayer(h.FRAMEBUFFER,h.COLOR_ATTACHMENT0,_,0,G),h.framebufferTextureLayer(h.FRAMEBUFFER,h.COLOR_ATTACHMENT1,m,0,G),h.drawBuffers([h.COLOR_ATTACHMENT0,h.COLOR_ATTACHMENT1]),h.checkFramebufferStatus(h.FRAMEBUFFER)!==h.FRAMEBUFFER_COMPLETE&&log.error("Incomplete framebuffer"),h.drawArrays(h.TRIANGLE_STRIP,0,4)}H===e-1&&h.uniform1i(k.uniforms.finalPass,1),h.uniform1i(k.uniforms.labelTex,15),h.uniform1i(k.uniforms.strengthTex,13);for(let G=0;G<this.back.dims[3];G++){const K=1/this.back.dims[3]*(G+.5);h.uniform1f(k.uniforms.coordZ,K),h.framebufferTextureLayer(h.FRAMEBUFFER,h.COLOR_ATTACHMENT0,D,0,G),h.framebufferTextureLayer(h.FRAMEBUFFER,h.COLOR_ATTACHMENT1,L,0,G),h.drawBuffers([h.COLOR_ATTACHMENT0,h.COLOR_ATTACHMENT1]),h.checkFramebufferStatus(h.FRAMEBUFFER)!==h.FRAMEBUFFER_COMPLETE&&log.error("Incomplete framebuffer"),h.drawArrays(h.TRIANGLE_STRIP,0,4)}}h.drawBuffers([h.COLOR_ATTACHMENT0]);const O=h.COLOR_ATTACHMENT1,q=D;h.readBuffer(O);const Q=h.getParameter(h.IMPLEMENTATION_COLOR_READ_FORMAT),i0=h.getParameter(h.IMPLEMENTATION_COLOR_READ_TYPE);(Q!==h.RED_INTEGER||i0!==h.SHORT)&&log.debug("readPixels will fail."),v=new Int16Array;const j=this.back.dims[1]*this.back.dims[2],Y=new Int16Array(j);for(let H=0;H<this.back.dims[3];H++)h.framebufferTextureLayer(h.FRAMEBUFFER,O,q,0,H),h.readPixels(0,0,this.back.dims[1],this.back.dims[2],Q,i0,Y),v=Int16Array.from([...v,...Y]);let T=v[0];for(let H=0;H<v.length;H++)T=Math.max(T,v[H]);for(let H=1;H<g;H++)this.drawBitmap[H]=v[H];h.deleteTexture(C),h.deleteTexture(L),h.deleteTexture(m),h.deleteTexture(D),h.deleteTexture(_),h.bindVertexArray(this.unusedVAO),h.viewport(0,0,h.canvas.width,h.canvas.height),h.bindFramebuffer(h.FRAMEBUFFER,null),h.deleteFramebuffer(S),this.drawAddUndoBitmap(),this.refreshDrawing(!0)}drawPt(u,h,g,S){var _;if(!((_=this.back)!=null&&_.dims))throw new Error("back.dims not set");const v=this.back.dims[1],C=this.back.dims[2],D=this.back.dims[3];u=Math.min(Math.max(u,0),v-1),h=Math.min(Math.max(h,0),C-1),g=Math.min(Math.max(g,0),D-1),this.drawBitmap[u+h*v+g*v*C]=S}drawPenLine(u,h,g){const S=Math.abs(u[0]-h[0]),v=Math.abs(u[1]-h[1]),C=Math.abs(u[2]-h[2]);let D=-1,_=-1,P=-1;h[0]>u[0]&&(D=1),h[1]>u[1]&&(_=1),h[2]>u[2]&&(P=1);let L=u[0],m=u[1],k=u[2];const e=h[0],O=h[1],q=h[2];if(S>=v&&S>=C){let Q=2*v-S,i0=2*C-S;for(;L!==e;)L+=D,Q>=0&&(m+=_,Q-=2*S),i0>=0&&(k+=P,i0-=2*S),Q+=2*v,i0+=2*C,this.drawPt(L,m,k,g)}else if(v>=S&&v>=C){let Q=2*S-v,i0=2*C-v;for(;m!==O;)m+=_,Q>=0&&(L+=D,Q-=2*v),i0>=0&&(k+=P,i0-=2*v),Q+=2*S,i0+=2*C,this.drawPt(L,m,k,g)}else{let Q=2*v-C,i0=2*S-C;for(;k!==q;)k+=P,Q>=0&&(m+=_,Q-=2*C),i0>=0&&(L+=D,i0-=2*C),Q+=2*v,i0+=2*S,this.drawPt(L,m,k,g)}}drawFloodFillCore(u,h,g=6){var L;if(!((L=this.back)!=null&&L.dims))throw new Error("back.dims undefined");const S=[this.back.dims[1],this.back.dims[2],this.back.dims[3]],v=S[0],C=v*S[1];function D(m){return m[0]+m[1]*v+m[2]*C}function _(m){const k=Math.floor(m/C),e=Math.floor((m-k*C)/v);return[Math.floor(m%v),e,k]}const P=[];for(P.push(h),u[h]=2;P.length>0;){let m=function(O){const q=e.slice();if(q[0]+=O[0],q[1]+=O[1],q[2]+=O[2],q[0]<0||q[1]<0||q[2]<0||q[0]>=S[0]||q[1]>=S[1]||q[2]>=S[2])return;const Q=D(q);u[Q]===1&&(u[Q]=2,P.push(Q))};const k=P[0];P.shift();const e=_(k);m([0,0,-1]),m([0,0,1]),m([0,-1,0]),m([0,1,0]),m([-1,0,0]),m([1,0,0]),!(g<=6)&&(m([-1,-1,0]),m([1,1,0]),m([-1,1,0]),m([1,1,0]),m([0,-1,-1]),m([0,1,-1]),m([-1,0,-1]),m([1,0,-1]),m([0,-1,1]),m([0,1,1]),m([-1,0,1]),m([1,0,1]),!(g<=18)&&(m([-1,-1,-1]),m([1,-1,-1]),m([-1,1,-1]),m([1,1,-1]),m([-1,-1,1]),m([1,-1,1]),m([-1,1,1]),m([1,1,1])))}}drawFloodFill(u,h=0,g=0,S=NaN,v=NaN,C=6){var q;if(!this.drawBitmap)throw new Error("drawBitmap undefined");if(!((q=this.back)!=null&&q.dims))throw new Error("back.dims undefined");h=Math.abs(h);const D=[this.back.dims[1],this.back.dims[2],this.back.dims[3]];if(u[0]<0||u[1]<0||u[2]<0||u[0]>=D[0]||u[1]>=D[1]||u[2]>=D[2])return;const _=D[0],P=_*D[1],L=P*D[2],m=this.drawBitmap.slice();if(m.length!==P*D[2])return;function k(Q){return Q[0]+Q[1]*_+Q[2]*P}const e=k(u),O=m[e];if(O===h){g!==0?log.debug("drawFloodFill selected voxel is not part of a drawing"):log.debug("drawFloodFill selected voxel is already desired color");return}for(let Q=1;Q<L;Q++)m[Q]=0,this.drawBitmap[Q]===O&&(m[Q]=1);if(this.drawFloodFillCore(m,e,C),g!==0){const Q=this.volumes[0].img2RAS();let i0=Q[e],j=i0;if(isFinite(v)&&isFinite(S))i0=v,j=S;else{for(let Y=1;Y<L;Y++)m[Y]===2&&(i0=Math.max(i0,Q[Y]),j=Math.min(j,Q[Y]));g===Number.POSITIVE_INFINITY&&(i0=g),g===Number.NEGATIVE_INFINITY&&(j=g)}log.debug("Intensity range of selected cluster :",j,i0);for(let Y=1;Y<L;Y++)m[Y]=0,Q[Y]>=j&&Q[Y]<=i0&&(m[Y]=1);this.drawFloodFillCore(m,e,C),h=O}for(let Q=1;Q<L;Q++)m[Q]===2&&(this.drawBitmap[Q]=h);this.drawAddUndoBitmap(),this.refreshDrawing(!1)}drawPenFilled(){var O;const u=this.drawPenFillPts.length;if(u<2){this.drawPenFillPts=[];return}const h=this.drawPenAxCorSag;let g=0,S=1;if(h===1&&(S=2),h===2&&(g=1,S=2),!((O=this.back)!=null&&O.dims))throw new Error("back.dims undefined");const v=[this.back.dims[g+1],this.back.dims[S+1]],C=new Uint8Array(v[0]*v[1]);let D=1;function _(q,Q){const i0=Math.abs(q[0]-Q[0]),j=Math.abs(q[1]-Q[1]);C[q[0]+q[1]*v[0]]=D,C[Q[0]+Q[1]*v[0]]=D;let Y=-1,T=-1;Q[0]>q[0]&&(Y=1),Q[1]>q[1]&&(T=1);let H=q[0],G=q[1];const K=Q[0],e0=Q[1];if(i0>=j){let z=2*j-i0;for(;H!==K;)H+=Y,z>=0&&(G+=T,z-=2*i0),z+=2*j,C[H+G*v[0]]=D}else{let z=2*i0-j;for(;G!==e0;)G+=T,z>=0&&(H+=Y,z-=2*j),z+=2*i0,C[H+G*v[0]]=D}}const P=[this.drawPenFillPts[0][g],this.drawPenFillPts[0][S]];let L=P;for(let q=1;q<u;q++){const Q=[this.drawPenFillPts[q][g],this.drawPenFillPts[q][S]];_(L,Q),L=Q}_(P,L);const m=[];function k(q){if(q[0]<0||q[1]<0||q[0]>=v[0]||q[1]>=v[1])return;const Q=q[0]+q[1]*v[0];C[Q]===0&&(m.push(q),C[Q]=2)}for(let q=0;q<v[0];q++)k([q,0]);for(let q=0;q<v[0];q++)k([q,v[1]-1]);for(let q=0;q<v[1];q++)k([0,q]);for(let q=0;q<v[1];q++)k([v[0]-1,q]);for(;m.length>0;){const q=m.shift();k([q[0]-1,q[1]]),k([q[0]+1,q[1]]),k([q[0],q[1]-1]),k([q[0],q[1]+1])}D=this.opts.penValue;const e=this.drawPenFillPts[0][3-(g+S)];if(!this.drawBitmap)throw new Error("drawBitmap undefined");if(h===0){const q=e*v[0]*v[1];for(let Q=0;Q<v[0]*v[1];Q++)C[Q]!==2&&(this.drawBitmap[Q+q]=D)}else{let q=1;const Q=this.back.dims[1]*this.back.dims[2];let i0=e*this.back.dims[1];h===2&&(q=this.back.dims[1],i0=e);let j=0;for(let Y=0;Y<v[1];Y++)for(let T=0;T<v[0];T++)C[j]!==2&&(this.drawBitmap[T*q+Y*Q+i0]=D),j++}if(!this.drawFillOverwrites&&this.drawUndoBitmaps[this.currentDrawUndoBitmap].length>0){const q=this.drawBitmap.length,Q=decodeRLE(this.drawUndoBitmaps[this.currentDrawUndoBitmap],q);for(let i0=0;i0<q;i0++)Q[i0]!==0&&(this.drawBitmap[i0]=Q[i0])}this.drawPenFillPts=[],this.drawAddUndoBitmap(),this.refreshDrawing(!1)}closeDrawing(){this.drawClearAllUndoBitmaps(),this.rgbaTex(this.drawTexture,TEXTURE7_DRAW,[2,2,2,2],!0),this.drawBitmap=null,this.drawScene()}refreshDrawing(u=!0){var S;if(!((S=this.back)!=null&&S.dims))throw new Error("back.dims undefined");if(!this.drawBitmap)throw new Error("drawBitmap undefined");const h=this.back.dims.slice(),g=this.back.dims[1]*this.back.dims[2]*this.back.dims[3];this.drawBitmap.length===8?(h[1]=2,h[2]=2,h[3]=2):g!==this.drawBitmap.length&&log.warn("Drawing bitmap must match the background image"),this.gl.activeTexture(TEXTURE7_DRAW),this.gl.bindTexture(this.gl.TEXTURE_3D,this.drawTexture),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,h[1],h[2],h[3],this.gl.RED,this.gl.UNSIGNED_BYTE,this.drawBitmap),u&&this.drawScene()}r8Tex(u,h,g,S=!1){if(u&&this.gl.deleteTexture(u),u=this.gl.createTexture(),this.gl.activeTexture(h),this.gl.bindTexture(this.gl.TEXTURE_3D,u),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R8,g[1],g[2],g[3]),S){const v=new Uint8Array(g[1]*g[2]*g[3]);this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g[1],g[2],g[3],this.gl.RED,this.gl.UNSIGNED_BYTE,v)}return u}rgbaTex(u,h,g,S=!1){if(u&&this.gl.deleteTexture(u),u=this.gl.createTexture(),this.gl.activeTexture(h),this.gl.bindTexture(this.gl.TEXTURE_3D,u),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.RGBA8,g[1],g[2],g[3]),S){const v=new Uint8Array(g[1]*g[2]*g[3]*4);this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g[1],g[2],g[3],this.gl.RGBA,this.gl.UNSIGNED_BYTE,v)}return u}requestCORSIfNotSameOrigin(u,h){new URL(h,window.location.href).origin!==window.location.origin&&(u.crossOrigin="")}async loadPngAsTexture(u,h){return new Promise((g,S)=>{const v=new Image;v.onload=()=>{if(!this.bmpShader)return;let C;h===4?(this.bmpTexture!==null&&this.gl.deleteTexture(this.bmpTexture),this.bmpTexture=this.gl.createTexture(),C=this.bmpTexture,this.bmpTextureWH=v.width/v.height,this.gl.activeTexture(TEXTURE4_THUMBNAIL),this.bmpShader.use(this.gl),this.gl.uniform1i(this.bmpShader.uniforms.bmpTexture,4)):h===5?(this.gl.activeTexture(TEXTURE5_MATCAP),this.matCapTexture!==null&&this.gl.deleteTexture(this.matCapTexture),this.matCapTexture=this.gl.createTexture(),C=this.matCapTexture):(this.fontShader.use(this.gl),this.gl.activeTexture(TEXTURE3_FONT),this.gl.uniform1i(this.fontShader.uniforms.fontTexture,3),this.fontTexture!==null&&this.gl.deleteTexture(this.fontTexture),this.fontTexture=this.gl.createTexture(),C=this.fontTexture),this.gl.bindTexture(this.gl.TEXTURE_2D,C),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR),this.gl.texImage2D(this.gl.TEXTURE_2D,0,this.gl.RGBA,this.gl.RGBA,this.gl.UNSIGNED_BYTE,v),g(C),h!==4&&this.drawScene()},v.onerror=S,this.requestCORSIfNotSameOrigin(v,u),v.src=u})}async loadFontTexture(u){return this.loadPngAsTexture(u,3)}async loadBmpTexture(u){return this.loadPngAsTexture(u,4)}async loadMatCapTexture(u){return this.loadPngAsTexture(u,5)}initFontMets(){if(!this.fontMetrics)throw new Error("fontMetrics undefined");this.fontMets={distanceRange:this.fontMetrics.atlas.distanceRange,size:this.fontMetrics.atlas.size,mets:{}};for(let g=0;g<256;g++)this.fontMets.mets[g]={xadv:0,uv_lbwh:[0,0,0,0],lbwh:[0,0,0,0]};const u=this.fontMetrics.atlas.width,h=this.fontMetrics.atlas.height;for(let g=0;g<this.fontMetrics.glyphs.length;g++){const S=this.fontMetrics.glyphs[g],v=S.unicode;if(this.fontMets.mets[v].xadv=S.advance,S.planeBounds===void 0)continue;let C=S.atlasBounds.left/u,D=(h-S.atlasBounds.top)/h,_=(S.atlasBounds.right-S.atlasBounds.left)/u,P=(S.atlasBounds.top-S.atlasBounds.bottom)/h;this.fontMets.mets[v].uv_lbwh=[C,D,_,P],C=S.planeBounds.left,D=S.planeBounds.bottom,_=S.planeBounds.right-S.planeBounds.left,P=S.planeBounds.top-S.planeBounds.bottom,this.fontMets.mets[v].lbwh=[C,D,_,P]}}async loadFont(u=Roboto_Regular_default,h=Roboto_Regular_default2){await this.loadFontTexture(u);const g=await fetch(h);if(!g.ok)throw Error(g.statusText);const S=await g.text();this.fontMetrics=JSON.parse(S),this.initFontMets(),this.fontShader.use(this.gl),this.drawScene()}async loadDefaultMatCap(){return this.loadMatCapTexture(Shiny_default)}async loadDefaultFont(){await this.loadFontTexture(this.DEFAULT_FONT_GLYPH_SHEET),this.fontMetrics=this.DEFAULT_FONT_METRICS,this.initFontMets()}async initText(){this.fontShader=new Shader(this.gl,vertFontShader,fragFontShader),this.fontShader.use(this.gl),await this.loadDefaultFont(),await this.loadDefaultMatCap(),this.drawLoadingText(this.loadingText)}meshShaderNameToNumber(u="Phong"){const h=u.toLowerCase();for(let g=0;g<this.meshShaders.length;g++)if(this.meshShaders[g].Name.toLowerCase()===h)return g}setMeshShader(u,h=2){let g=0;if(typeof h=="number"?g=h:g=this.meshShaderNameToNumber(h),g===void 0)throw new Error("shaderIndex undefined");g=Math.min(g,this.meshShaders.length-1),g=Math.max(g,0);const S=this.getMeshIndexByID(u);if(S>=this.meshes.length){log.debug("Unable to change shader until mesh is loaded (maybe you need async)");return}this.meshes[S].meshShaderIndex=g,this.updateGLVolume(),this.onMeshShaderChanged(S,g)}createCustomMeshShader(u,h="Custom"){if(!u)throw new Error("Need fragment shader");const g=this.meshShaderNameToNumber(h);g>=0&&(this.gl.deleteProgram(this.meshShaders[g].shader.program),this.meshShaders.splice(g,1));const S=new Shader(this.gl,vertMeshShader,u);return S.use(this.gl),{Name:h,Frag:u,shader:S}}setCustomMeshShader(u="",h="Custom"){const g=this.createCustomMeshShader(u,h);return this.meshShaders.push(g),this.onCustomMeshShaderAdded(u,h),this.meshShaders.length-1}meshShaderNames(u=!0){const h=[];for(let g=0;g<this.meshShaders.length;g++)h.push(this.meshShaders[g].Name);return u===!0?h.sort():h}initRenderShader(u,h=0){u.use(this.gl),this.gl.uniform1i(u.uniforms.volume,0),this.gl.uniform1i(u.uniforms.colormap,1),this.gl.uniform1i(u.uniforms.overlay,2),this.gl.uniform1i(u.uniforms.drawing,7),this.gl.uniform1fv(u.uniforms.renderDrawAmbientOcclusion,[this.renderDrawAmbientOcclusion,1]),this.gl.uniform1f(u.uniforms.gradientAmount,h)}async init(){const u=this.gl.getExtension("WEBGL_debug_renderer_info");if(u){const C=this.gl.getParameter(u.UNMASKED_VENDOR_WEBGL),D=this.gl.getParameter(u.UNMASKED_RENDERER_WEBGL);log.info("renderer vendor: ",C),log.info("renderer: ",D)}else log.info("debug_renderer_info unavailable");const h=this.gl.getParameter(this.gl.RENDERER);log.info("firefox renderer: ",h),this.gl.clearDepth(0),this.gl.enable(this.gl.CULL_FACE),this.gl.cullFace(this.gl.FRONT),this.gl.enable(this.gl.BLEND),this.gl.blendFunc(this.gl.SRC_ALPHA,this.gl.ONE_MINUS_SRC_ALPHA),this.volumeTexture=this.rgbaTex(this.volumeTexture,TEXTURE0_BACK_VOL,[2,2,2,2],!0),this.overlayTexture=this.rgbaTex(this.overlayTexture,TEXTURE2_OVERLAY_VOL,[2,2,2,2],!0),this.drawTexture=this.r8Tex(this.drawTexture,TEXTURE7_DRAW,[2,2,2,2],!0);const g=[1,1,0,1,0,0,0,1,0,0,0,0],S=this.gl;this.cuboidVertexBuffer=S.createBuffer(),S.bindBuffer(S.ARRAY_BUFFER,this.cuboidVertexBuffer),S.bufferData(S.ARRAY_BUFFER,new Float32Array(g),S.STATIC_DRAW),this.genericVAO=S.createVertexArray(),S.bindVertexArray(this.genericVAO),S.bindBuffer(S.ARRAY_BUFFER,this.cuboidVertexBuffer),S.enableVertexAttribArray(0),S.vertexAttribPointer(0,3,S.FLOAT,!1,0,0),S.bindVertexArray(this.unusedVAO),this.pickingMeshShader=new Shader(S,vertMeshShader,fragMeshDepthShader),this.pickingMeshShader.use(S),this.pickingImageShader=new Shader(S,vertRenderShader,fragVolumePickingShader),this.pickingImageShader.use(S),S.uniform1i(this.pickingImageShader.uniforms.volume,0),S.uniform1i(this.pickingImageShader.uniforms.colormap,1),S.uniform1i(this.pickingImageShader.uniforms.overlay,2),S.uniform1i(this.pickingImageShader.uniforms.drawing,7),this.sliceMMShader=new Shader(S,vertSliceMMShader,fragSliceMMShader),this.sliceMMShader.use(S),S.uniform1i(this.sliceMMShader.uniforms.volume,0),S.uniform1i(this.sliceMMShader.uniforms.colormap,1),S.uniform1i(this.sliceMMShader.uniforms.overlay,2),S.uniform1i(this.sliceMMShader.uniforms.drawing,7),S.uniform1f(this.sliceMMShader.uniforms.drawOpacity,this.drawOpacity),this.sliceV1Shader=new Shader(S,vertSliceMMShader,fragSliceV1Shader),this.sliceV1Shader.use(S),S.uniform1i(this.sliceV1Shader.uniforms.volume,0),S.uniform1i(this.sliceV1Shader.uniforms.colormap,1),S.uniform1i(this.sliceV1Shader.uniforms.overlay,2),S.uniform1i(this.sliceV1Shader.uniforms.drawing,7),S.uniform1f(this.sliceV1Shader.uniforms.drawOpacity,this.drawOpacity),this.orientCubeShader=new Shader(S,vertOrientCubeShader,fragOrientCubeShader),this.orientCubeShaderVAO=S.createVertexArray(),S.bindVertexArray(this.orientCubeShaderVAO);const v=S.createBuffer();S.enableVertexAttribArray(0),S.enableVertexAttribArray(1),S.bindBuffer(S.ARRAY_BUFFER,v),S.bufferData(S.ARRAY_BUFFER,orientCube,S.STATIC_DRAW),S.vertexAttribPointer(0,3,S.FLOAT,!1,24,0),S.enableVertexAttribArray(1),S.vertexAttribPointer(1,3,S.FLOAT,!1,24,12),S.bindVertexArray(this.unusedVAO),this.rectShader=new Shader(S,vertRectShader,fragRectShader),this.rectShader.use(S),this.lineShader=new Shader(S,vertLineShader,fragRectShader),this.lineShader.use(S),this.line3DShader=new Shader(S,vertLine3DShader,fragRectShader),this.line3DShader.use(S),this.circleShader=new Shader(S,vertCircleShader,fragCircleShader),this.circleShader.use(S),this.renderVolumeShader=new Shader(S,vertRenderShader,fragRenderShader),this.initRenderShader(this.renderVolumeShader),this.renderSliceShader=new Shader(S,vertRenderShader,fragRenderSliceShader),this.initRenderShader(this.renderSliceShader),this.renderGradientShader=new Shader(S,vertRenderShader,fragRenderGradientShader),this.initRenderShader(this.renderGradientShader,.3),S.uniform1i(this.renderGradientShader.uniforms.matCap,5),S.uniform1i(this.renderGradientShader.uniforms.gradient,6),this.renderShader=this.renderVolumeShader,this.colorbarShader=new Shader(S,vertColorbarShader,fragColorbarShader),this.colorbarShader.use(S),S.uniform1i(this.colorbarShader.uniforms.colormap,1),this.blurShader=new Shader(S,blurVertShader,blurFragShader),this.sobelShader=new Shader(S,blurVertShader,sobelFragShader),this.growCutShader=new Shader(S,vertGrowCutShader,fragGrowCutShader),this.passThroughShader=new Shader(S,vertPassThroughShader,fragPassThroughShader),this.orientShaderAtlasU=new Shader(S,vertOrientShader,fragOrientShaderU.concat(fragOrientShaderAtlas)),this.orientShaderAtlasI=new Shader(S,vertOrientShader,fragOrientShaderI.concat(fragOrientShaderAtlas)),this.orientShaderU=new Shader(S,vertOrientShader,fragOrientShaderU.concat(fragOrientShader)),this.orientShaderI=new Shader(S,vertOrientShader,fragOrientShaderI.concat(fragOrientShader)),this.orientShaderF=new Shader(S,vertOrientShader,fragOrientShaderF.concat(fragOrientShader)),this.orientShaderRGBU=new Shader(S,vertOrientShader,fragOrientShaderU.concat(fragRGBOrientShader)),this.surfaceShader=new Shader(S,vertSurfaceShader,fragSurfaceShader),this.surfaceShader.use(S),this.fiberShader=new Shader(S,vertFiberShader,fragFiberShader),this.pickingImageShader.use(S);for(let C=0;C<this.meshShaders.length;C++){const D=this.meshShaders[C];D.Name==="Flat"?D.shader=new Shader(S,vertFlatMeshShader,fragFlatMeshShader):D.shader=new Shader(S,vertMeshShader,D.Frag),D.shader.use(S),D.shader.isMatcap=D.Name==="Matcap",D.shader.isMatcap&&S.uniform1i(D.shader.uniforms.matCap,5)}return this.bmpShader=new Shader(S,vertBmpShader,fragBmpShader),await this.initText(),this.opts.thumbnail.length>0&&(await this.loadBmpTexture(this.opts.thumbnail),this.thumbnailVisible=!0),this.updateGLVolume(),this.initialized=!0,this.resizeListener(),this.drawScene(),this}gradientGL(u){const h=this.gl,g=[0,0,0,0,1,0,1,0,0,1,1,0],S=h.createVertexArray();h.bindVertexArray(S);const v=h.createBuffer();h.bindBuffer(h.ARRAY_BUFFER,v),h.bufferData(h.ARRAY_BUFFER,new Float32Array(g),h.STATIC_DRAW),h.enableVertexAttribArray(0),h.vertexAttribPointer(0,3,h.FLOAT,!1,0,0);const C=h.createFramebuffer();h.bindFramebuffer(h.FRAMEBUFFER,C),h.disable(h.CULL_FACE),h.viewport(0,0,u.dims[1],u.dims[2]),h.disable(h.BLEND);const D=this.rgbaTex(null,TEXTURE8_GRADIENT_TEMP,u.dims),_=this.blurShader;_.use(h),h.activeTexture(TEXTURE0_BACK_VOL),h.bindTexture(h.TEXTURE_3D,this.volumeTexture);const P=.7;h.uniform1i(_.uniforms.intensityVol,0),h.uniform1f(_.uniforms.dX,P/u.dims[1]),h.uniform1f(_.uniforms.dY,P/u.dims[2]),h.uniform1f(_.uniforms.dZ,P/u.dims[3]),h.bindVertexArray(S);for(let k=0;k<u.dims[3]-1;k++){const e=1/u.dims[3]*(k+.5);h.uniform1f(_.uniforms.coordZ,e),h.framebufferTextureLayer(h.FRAMEBUFFER,h.COLOR_ATTACHMENT0,D,0,k),h.clear(h.DEPTH_BUFFER_BIT),h.drawArrays(h.TRIANGLE_STRIP,0,g.length/3)}const L=this.sobelShader;L.use(h),h.activeTexture(TEXTURE8_GRADIENT_TEMP),h.bindTexture(h.TEXTURE_3D,D),h.uniform1i(L.uniforms.intensityVol,8);const m=.7;h.uniform1f(L.uniforms.dX,m/u.dims[1]),h.uniform1f(L.uniforms.dY,m/u.dims[2]),h.uniform1f(L.uniforms.dZ,m/u.dims[3]),h.uniform1f(L.uniforms.coordZ,.5),h.bindVertexArray(S),h.activeTexture(TEXTURE0_BACK_VOL),this.gradientTexture!==null&&h.deleteTexture(this.gradientTexture),this.gradientTexture=this.rgbaTex(this.gradientTexture,TEXTURE6_GRADIENT,u.dims);for(let k=0;k<u.dims[3]-1;k++){const e=1/u.dims[3]*(k+.5);h.uniform1f(L.uniforms.coordZ,e),h.framebufferTextureLayer(h.FRAMEBUFFER,h.COLOR_ATTACHMENT0,this.gradientTexture,0,k),h.clear(h.DEPTH_BUFFER_BIT),h.drawArrays(h.TRIANGLE_STRIP,0,g.length/3)}h.deleteFramebuffer(C),h.deleteTexture(D),h.deleteBuffer(v),h.bindFramebuffer(h.FRAMEBUFFER,null)}updateGLVolume(){let u=0;const h=this.volumes.length;this.refreshColormaps();for(let g=0;g<h;g++)this.volumes[g].toRAS&&(this.refreshLayers(this.volumes[g],u),u++);if(this.furthestVertexFromOrigin=0,h>0&&(this.furthestVertexFromOrigin=this.volumeObject3D.furthestVertexFromOrigin),this.meshes)for(let g=0;g<this.meshes.length;g++)this.furthestVertexFromOrigin=Math.max(this.furthestVertexFromOrigin,this.meshes[g].furthestVertexFromOrigin);this.onVolumeUpdated&&this.onVolumeUpdated(),this.drawScene()}getDescriptives(u=0,h=[],g=!1){const S=this.volumes[u].hdr;let v=S.scl_slope;isNaN(v)&&(v=1);let C=S.scl_inter;isNaN(C)&&(C=1);const D=this.volumes[u].img,_=D.length,P=new Float32Array(_);for(let K=0;K<_;K++)P[K]=D[K]*v+C;const L=new Uint8Array(_);for(let K=0;K<_;K++)L[K]=1;if(h.length>0)for(let K=0;K<h.length;K++){const e0=this.volumes[h[K]].img;if(e0.length!==_){log.debug("Mask resolution does not match image. Skipping masking layer "+h[K]);continue}for(let z=0;z<_;z++)(e0[z]===0||isNaN(e0[z]))&&(L[z]=0)}else if(h.length<1&&g)for(let K=0;K<_;K++)(this.drawBitmap[K]===0||isNaN(this.drawBitmap[K]))&&(L[K]=0);let m=0,k=0,e=0,O=Number.NEGATIVE_INFINITY,q=Number.POSITIVE_INFINITY,Q=0,i0=0,j=0;for(let K=0;K<_;K++){if(L[K]<1)continue;const e0=P[K];m++;let z=k+(e0-k)/m;e=e+(e0-k)*(e0-z),k=z,e0!==0&&(Q++,z=i0+(e0-i0)/Q,j=j+(e0-i0)*(e0-z),i0=z,q=Math.min(e0,O),O=Math.max(e0,O))}const Y=Math.sqrt(e/(m-1)),T=Math.sqrt(j/(Q-1)),H=q,G=O;return m!==Q&&(q=Math.min(0,O),O=Math.max(0,O)),{mean:k,stdev:Y,nvox:m,volumeMM3:m*S.pixDims[1]*S.pixDims[2]*S.pixDims[3],volumeML:m*S.pixDims[1]*S.pixDims[2]*S.pixDims[3]*.001,min:q,max:O,meanNot0:i0,stdevNot0:T,nvoxNot0:Q,minNot0:H,maxNot0:G,cal_min:this.volumes[u].cal_min,cal_max:this.volumes[u].cal_max,robust_min:this.volumes[u].robust_min,robust_max:this.volumes[u].robust_max}}refreshLayers(u,h){var H;if(this.refreshColormaps(),this.volumes.length<1)return;const g=u.hdr;let S=u.img;u.frame4D>0&&u.frame4D<u.nFrame4D&&(S=u.img.slice(u.frame4D*u.nVox3D,(u.frame4D+1)*u.nVox3D));const v=u.opacity;if(h>1&&v===0)return;let C=null;if(!this.back)throw new Error("back undefined");this.gl.bindVertexArray(this.unusedVAO),this.crosshairs3D&&(this.crosshairs3D.mm[0]=NaN);let D=clone$2(u.toRAS);if(h===0){this.volumeObject3D=u.toNiivueObject3D(this.VOLUME_ID,this.gl),invert(D,D),this.back.matRAS=u.matRAS,this.back.dims=u.dimsRAS,this.back.pixDims=u.pixDimsRAS,C=this.rgbaTex(this.volumeTexture,TEXTURE0_BACK_VOL,u.dimsRAS);const{volScale:G,vox:K}=this.sliceScale(!0);if(this.volScale=G,this.vox=K,this.volumeObject3D.scale=G,!this.renderShader)throw new Error("renderShader undefined");this.renderShader.use(this.gl),this.gl.uniform3fv(this.renderShader.uniforms.texVox,K),this.gl.uniform3fv(this.renderShader.uniforms.volScale,G);const e0=this.pickingImageShader;e0.use(this.gl),this.gl.uniform1i(e0.uniforms.volume,0),this.gl.uniform1i(e0.uniforms.colormap,1),this.gl.uniform1i(e0.uniforms.overlay,2),this.gl.uniform3fv(e0.uniforms.volScale,G),log.debug(this.volumeObject3D)}else{((H=this.back)==null?void 0:H.dims)===void 0&&log.error("Fatal error: Unable to render overlay: background dimensions not defined!");const G=this.mm2frac(u.mm000,0,!0);let K=this.mm2frac(u.mm100,0,!0),e0=this.mm2frac(u.mm010,0,!0),z=this.mm2frac(u.mm001,0,!0);K=subtract$1(K,K,G),e0=subtract$1(e0,e0,G),z=subtract$1(z,z,G),D=fromValues$3(K[0],e0[0],z[0],G[0],K[1],e0[1],z[1],G[1],K[2],e0[2],z[2],G[2],0,0,0,1),invert(D,D),h===1?(C=this.rgbaTex(this.overlayTexture,TEXTURE2_OVERLAY_VOL,this.back.dims),this.overlayTexture=C,this.overlayTextureID=C):C=this.overlayTextureID}const _=this.gl.createFramebuffer();this.gl.bindFramebuffer(this.gl.FRAMEBUFFER,_),this.gl.disable(this.gl.CULL_FACE),this.gl.viewport(0,0,this.back.dims[1],this.back.dims[2]),this.gl.disable(this.gl.BLEND);const P=this.gl.createTexture();this.gl.activeTexture(TEXTURE9_ORIENT),this.gl.bindTexture(this.gl.TEXTURE_3D,P),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1);let L=this.orientShaderU;if(!g)throw new Error("hdr undefined");if(!S)throw new Error("img undefined");if(g.datatypeCode===2)g.intent_code===1002&&(L=this.orientShaderAtlasU),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R8UI,g.dims[1],g.dims[2],g.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RED_INTEGER,this.gl.UNSIGNED_BYTE,S);else if(g.datatypeCode===4)L=this.orientShaderI,g.intent_code===1002&&(L=this.orientShaderAtlasI),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R16I,g.dims[1],g.dims[2],g.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RED_INTEGER,this.gl.SHORT,S);else if(g.datatypeCode===16)this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R32F,g.dims[1],g.dims[2],g.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RED,this.gl.FLOAT,S),L=this.orientShaderF;else if(g.datatypeCode===64){let G=new Float32Array;G=Float32Array.from(S),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R32F,g.dims[1],g.dims[2],g.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RED,this.gl.FLOAT,G),L=this.orientShaderF}else g.datatypeCode===128?(L=this.orientShaderRGBU,L.use(this.gl),this.gl.uniform1i(L.uniforms.hasAlpha,0),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.RGB8UI,g.dims[1],g.dims[2],g.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RGB_INTEGER,this.gl.UNSIGNED_BYTE,S)):g.datatypeCode===512?(g.intent_code===1002&&(L=this.orientShaderAtlasU),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R16UI,g.dims[1],g.dims[2],g.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RED_INTEGER,this.gl.UNSIGNED_SHORT,S)):g.datatypeCode===2304&&(L=this.orientShaderRGBU,L.use(this.gl),this.gl.uniform1i(L.uniforms.hasAlpha,1),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.RGBA8UI,g.dims[1],g.dims[2],g.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RGBA_INTEGER,this.gl.UNSIGNED_BYTE,S));u.global_min===void 0&&u.calMinMax();let m=null;if(this.gl.bindVertexArray(this.genericVAO),h>1){if(!this.back.dims)throw new Error("back.dims undefined");m=this.rgbaTex(m,TEXTURE10_BLEND,this.back.dims),this.gl.bindTexture(this.gl.TEXTURE_3D,m);const G=this.passThroughShader;G.use(this.gl),this.gl.uniform1i(G.uniforms.in3D,2);for(let K=0;K<this.back.dims[3];K++){const e0=1/this.back.dims[3]*(K+.5);this.gl.uniform1f(G.uniforms.coordZ,e0),this.gl.framebufferTextureLayer(this.gl.FRAMEBUFFER,this.gl.COLOR_ATTACHMENT0,m,0,K),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4)}}else m=this.rgbaTex(m,TEXTURE10_BLEND,[2,2,2,2]);L.use(this.gl),this.gl.activeTexture(TEXTURE1_COLORMAPS);let k=null;if(u.colormapLabel!==null&&u.colormapLabel.lut.length>7){const G=u.colormapLabel.max-u.colormapLabel.min+1;k=this.createColormapTexture(k,1,G),this.gl.texSubImage2D(this.gl.TEXTURE_2D,0,0,0,G,1,this.gl.RGBA,this.gl.UNSIGNED_BYTE,u.colormapLabel.lut),this.gl.uniform1f(L.uniforms.cal_min,u.colormapLabel.min-.5),this.gl.uniform1f(L.uniforms.cal_max,u.colormapLabel.max+.5),this.gl.bindTexture(this.gl.TEXTURE_2D,k)}else this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture),this.gl.uniform1f(L.uniforms.cal_min,u.cal_min),this.gl.uniform1f(L.uniforms.cal_max,u.cal_max);this.gl.uniform1i(L.uniforms.isAlphaThreshold,u.alphaThreshold),this.gl.uniform1i(L.uniforms.isAdditiveBlend,this.opts.isAdditiveBlend?1:0);let e=Number.POSITIVE_INFINITY,O=Number.NEGATIVE_INFINITY;if(u.colormapNegative.length>0&&(e=Math.min(-u.cal_min,-u.cal_max),O=Math.max(-u.cal_min,-u.cal_max),isFinite(u.cal_minNeg)&&isFinite(u.cal_maxNeg)&&(e=Math.min(u.cal_minNeg,u.cal_maxNeg),O=Math.max(u.cal_minNeg,u.cal_maxNeg))),!L)throw new Error("orientShader undefined");this.gl.uniform1f(L.uniforms.layer??null,h),this.gl.uniform1f(L.uniforms.cal_minNeg??null,e),this.gl.uniform1f(L.uniforms.cal_maxNeg??null,O),this.gl.bindTexture(this.gl.TEXTURE_3D,P),this.gl.uniform1i(L.uniforms.intensityVol??null,9),this.gl.uniform1i(L.uniforms.blend3D??null,10),this.gl.uniform1i(L.uniforms.colormap??null,1),this.gl.uniform1f(L.uniforms.scl_inter??null,g.scl_inter),this.gl.uniform1f(L.uniforms.scl_slope??null,g.scl_slope),this.gl.uniform1f(L.uniforms.opacity??null,v),this.gl.uniform1i(L.uniforms.modulationVol??null,7);let q=null;if(u.modulationImage!==null&&u.modulationImage>=0&&u.modulationImage<this.volumes.length){log.debug("modulating",this.volumes);const G=this.volumes[u.modulationImage].hdr;if(G.dims[1]===g.dims[1]&&G.dims[2]===g.dims[2]&&G.dims[3]===g.dims[3]){u.modulateAlpha?(this.gl.uniform1i(L.uniforms.modulation,2),this.gl.uniform1f(L.uniforms.opacity,1)):this.gl.uniform1i(L.uniforms.modulation,1),q=this.r8Tex(q,this.gl.TEXTURE7,g.dims,!0),this.gl.activeTexture(this.gl.TEXTURE7),this.gl.bindTexture(this.gl.TEXTURE_3D,q);const K=g.dims[1]*g.dims[2]*g.dims[3],e0=new Uint8Array(K),z=this.volumes[u.modulationImage].cal_min,f=1/(this.volumes[u.modulationImage].cal_max-z),f0=this.volumes[u.modulationImage].img.buffer;let o0=new Uint8Array(f0);switch(G.datatypeCode){case 4:o0=new Int16Array(f0);break;case 16:o0=new Float32Array(f0);break;case 64:o0=new Float64Array(f0);break;case 128:o0=new Uint8Array(f0);break;case 512:o0=new Uint16Array(f0);break}log.debug(this.volumes[u.modulationImage]);const c0=this.volumes[u.modulationImage].colormapNegative.length>0;let d0=this.volumes[u.modulationImage].cal_min,v0=this.volumes[u.modulationImage].cal_max;isFinite(this.volumes[u.modulationImage].cal_minNeg)&&isFinite(this.volumes[u.modulationImage].cal_maxNeg)&&(d0=this.volumes[u.modulationImage].cal_minNeg,v0=this.volumes[u.modulationImage].cal_minNeg),d0=Math.abs(d0),v0=Math.abs(v0),d0>v0&&([d0,v0]=[v0,d0]);const g0=1/(v0-d0);let C0=Math.abs(u.modulateAlpha);C0=Math.max(C0,1);const x0=this.volumes[u.modulationImage].frame4D*K;for(let M0=0;M0<K;M0++){const ee=o0[M0+x0]*G.scl_slope+G.scl_inter;let re=(ee-z)*f;c0&&ee<0&&(re=(Math.abs(ee)-d0)*g0),re=Math.min(Math.max(re,0),1),re=Math.pow(re,C0)*255,e0[M0]=re}this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,g.dims[1],g.dims[2],g.dims[3],this.gl.RED,this.gl.UNSIGNED_BYTE,e0)}else log.debug("Modulation image dimensions do not match target")}else this.gl.uniform1i(L.uniforms.modulation,0);if(this.gl.uniformMatrix4fv(L.uniforms.mtx,!1,D),!this.back.dims)throw new Error("back.dims undefined");let Q=0;g.intent_code===1002&&(Q=this.opts.atlasOutline),this.gl.uniform4fv(L.uniforms.xyzaFrac,[1/this.back.dims[1],1/this.back.dims[2],1/this.back.dims[3],Q]),log.debug("back dims: ",this.back.dims);for(let G=0;G<this.back.dims[3];G++){const K=1/this.back.dims[3]*(G+.5);this.gl.uniform1f(L.uniforms.coordZ,K),this.gl.framebufferTextureLayer(this.gl.FRAMEBUFFER,this.gl.COLOR_ATTACHMENT0,C,0,G),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4)}if(this.gl.bindVertexArray(this.unusedVAO),this.gl.deleteTexture(P),this.gl.deleteTexture(q),this.gl.deleteTexture(m),this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.gl.bindFramebuffer(this.gl.FRAMEBUFFER,null),this.gl.deleteFramebuffer(_),h===0&&(this.volumeTexture=C,this.gradientTextureAmount>0?this.gradientGL(g):(this.gradientTexture!==null&&this.gl.deleteTexture(this.gradientTexture),this.gradientTexture=null)),!this.renderShader)throw new Error("renderShader undefined");this.renderShader.use(this.gl);const i0=this.sliceScale(!0),j=i0.vox,Y=i0.volScale;if(this.gl.uniform1f(this.renderShader.uniforms.overlays,this.overlays),this.gl.uniform4fv(this.renderShader.uniforms.clipPlaneColor,this.opts.clipPlaneColor),this.gl.uniform1f(this.renderShader.uniforms.clipThick,this.opts.clipThick),this.gl.uniform3fv(this.renderShader.uniforms.clipLo,this.opts.clipVolumeLow),this.gl.uniform3fv(this.renderShader.uniforms.clipHi,this.opts.clipVolumeHigh),this.gl.uniform1f(this.renderShader.uniforms.backOpacity,this.volumes[0].opacity),this.gl.uniform1f(this.renderShader.uniforms.renderOverlayBlend,this.opts.renderOverlayBlend),this.gl.uniform4fv(this.renderShader.uniforms.clipPlane,this.scene.clipPlane),this.gl.uniform3fv(this.renderShader.uniforms.texVox,j),this.gl.uniform3fv(this.renderShader.uniforms.volScale,Y),!this.pickingImageShader)throw new Error("pickingImageShader undefined");this.pickingImageShader.use(this.gl),this.gl.uniform1f(this.pickingImageShader.uniforms.overlays,this.overlays.length),this.gl.uniform3fv(this.pickingImageShader.uniforms.texVox,j),this.gl.uniform3fv(this.pickingImageShader.uniforms.clipLo,this.opts.clipVolumeLow),this.gl.uniform3fv(this.pickingImageShader.uniforms.clipHi,this.opts.clipVolumeHigh);let T=this.sliceMMShader;if(this.opts.isV1SliceShader&&(T=this.sliceV1Shader),!T)throw new Error("slice shader undefined");T.use(this.gl),this.gl.uniform1f(T.uniforms.overlays,this.overlays.length),this.gl.uniform1f(T.uniforms.drawOpacity,this.drawOpacity),k!==null&&(this.gl.deleteTexture(k),this.gl.activeTexture(TEXTURE1_COLORMAPS),this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture)),this.gl.uniform1i(T.uniforms.drawing,7),this.gl.activeTexture(TEXTURE7_DRAW),this.gl.bindTexture(this.gl.TEXTURE_3D,this.drawTexture),this.updateInterpolation(h)}colormaps(){return cmapper.colormaps()}addColormap(u,h){cmapper.addColormap(u,h)}setColormap(u,h){const g=this.getVolumeIndexByID(u);this.volumes[g].colormap=h,this.updateGLVolume()}idx(u,h,g,S){return g*S[0]*S[1]+h*S[0]+u}check_previous_slice(u,h,g,S,v,C,D,_){const P=new Uint32Array(27);let L=0;if(!v)return 0;const m=u[this.idx(g,S,v,C)];if(D>=6){const k=this.idx(g,S,v-1,C);m===u[k]&&(P[L++]=h[k])}if(D>=18){if(g){const k=this.idx(g-1,S,v-1,C);m===u[k]&&(P[L++]=h[k])}if(S){const k=this.idx(g,S-1,v-1,C);m===u[k]&&(P[L++]=h[k])}if(g<C[0]-1){const k=this.idx(g+1,S,v-1,C);m===u[k]&&(P[L++]=h[k])}if(S<C[1]-1){const k=this.idx(g,S+1,v-1,C);m===u[k]&&(P[L++]=h[k])}}if(D===26){if(g&&S){const k=this.idx(g-1,S-1,v-1,C);m===u[k]&&(P[L++]=h[k])}if(g<C[0]-1&&S){const k=this.idx(g+1,S-1,v-1,C);m===u[k]&&(P[L++]=h[k])}if(g&&S<C[1]-1){const k=this.idx(g-1,S+1,v-1,C);m===u[k]&&(P[L++]=h[k])}if(g<C[0]-1&&S<C[1]-1){const k=this.idx(g+1,S+1,v-1,C);m===u[k]&&(P[L++]=h[k])}}return L?(this.fill_tratab(_,P,L),P[0]):0}do_initial_labelling(u,h,g){let S=1;const v=8192;let C=v,D=new Uint32Array(C).fill(0);const _=new Uint32Array(h[0]*h[1]*h[2]).fill(0),P=new Uint32Array(27);for(let L=0;L<h[2];L++)for(let m=0;m<h[1];m++)for(let k=0;k<h[0];k++){let e=0;const O=u[this.idx(k,m,L,h)];if(O!==0){if(P[0]=this.check_previous_slice(u,_,k,m,L,h,g,D),P[0]&&(e+=1),g>=6){if(k){const q=this.idx(k-1,m,L,h);O===u[q]&&(P[e++]=_[q])}if(m){const q=this.idx(k,m-1,L,h);O===u[q]&&(P[e++]=_[q])}}if(g>=18){if(m&&k){const q=this.idx(k-1,m-1,L,h);O===u[q]&&(P[e++]=_[q])}if(m&&k<h[0]-1){const q=this.idx(k+1,m-1,L,h);O===u[q]&&(P[e++]=_[q])}}if(e)_[this.idx(k,m,L,h)]=P[0],this.fill_tratab(D,P,e);else{if(_[this.idx(k,m,L,h)]=S,S>=C){C+=v;const q=new Uint32Array(C);q.set(D),D=q}D[S-1]=S,S++}}}for(let L=0;L<S-1;L++){let m=L;for(;D[m]!==m+1;)m=D[m]-1;D[L]=m+1}return[S-1,D,_]}fill_tratab(u,h,g){let S=0;const v=new Uint32Array(g+5).fill(0);let D=2147483647;for(let _=0;_<g;_++){let P=h[_];for(S=0;u[P-1]!==P;)if(P=u[P-1],S++,S>100){log.info(`
-Ooh no!!`);break}v[_]=P,D=Math.min(D,P)}for(let _=0;_<g;_++)u[v[_]-1]=D}translate_labels(u,h,g,S){const v=h[0]*h[1]*h[2];let C=0;const D=new Uint32Array(v).fill(0);for(let L=0;L<S;L++)C=Math.max(C,g[L]);const _=new Uint32Array(C).fill(0);let P=0;for(let L=0;L<v;L++)u[L]&&(_[g[u[L]-1]-1]||(P+=1,_[g[u[L]-1]-1]=P),D[L]=_[g[u[L]-1]-1]);return[P,D]}largest_original_cluster_labels(u,h,g){const S=u.length,v=new Uint32Array(h+1).fill(0),C=new Uint32Array(h+1).fill(0);for(let P=0;P<S;P++){const L=u[P],m=g[P];v[m]=L,C[m]++}let D=0;for(let P=0;P<h+1;P++){const L=v[P];D=Math.max(D,L);for(let m=0;m<h+1;m++)m!==P&&L===v[m]&&(C[P]<C[m]||C[P]===C[m]&&P<m)&&(v[P]=0)}const _=new Uint32Array(S).fill(0);for(let P=0;P<S;P++)_[P]=v[g[P]];return[D,_]}bwlabel(u,h,g=26,S=!1,v=!1){const C=Date.now(),D=h[0]*h[1]*h[2],_=new Uint32Array(D).fill(0);if(![6,18,26].includes(g))return log.info("bwlabel: conn must be 6, 18 or 26."),[0,_];if(h[0]<2||h[1]<2||h[2]<1)return log.info("bwlabel: img must be 2 or 3-dimensional"),[0,_];if(S)for(let O=0;O<D;O++)u[O]!==0&&(_[O]=1);else _.set(u);let[P,L,m]=this.do_initial_labelling(_,h,g);L===void 0&&(L=new Uint32Array);const[k,e]=this.translate_labels(m,h,L,P);if(log.info(g+" neighbor clustering into "+k+" regions in "+(Date.now()-C)+"ms"),v){const[O,q]=this.largest_original_cluster_labels(_,k,e);return[O,q]}return[k,e]}async createConnectedLabelImage(u,h=26,g=!1,S=!1){var m,k;const v=this.getVolumeIndexByID(u),C=Uint32Array.from(((m=this.volumes[v].dims)==null?void 0:m.slice(1,4))??[]),D=Uint32Array.from(((k=this.volumes[v].img)==null?void 0:k.slice())??[]),[_,P]=this.bwlabel(D,C,h,g,S),L=this.volumes[v].clone();L.opacity=.5,L.colormap="random";for(let e=0;e<L.img.length;e++)L.img[e]=P[e];return L.cal_min=0,L.cal_max=_,L}async scalecropUint8(u,h=0,g=255,S,v){const C=u.length,D=new Uint8Array(C);for(let _=0;_<C;_++){let P=u[_];P=h+v*(P-S),P=Math.max(P,h),P=Math.min(P,g),D[_]=P}return D}async scalecropFloat32(u,h=0,g=1,S,v){const C=u.length,D=new Float32Array(C);for(let _=0;_<C;_++){let P=u[_];P=h+v*(P-S),P=Math.max(P,h),P=Math.min(P,g),D[_]=P}return D}getScale(u,h=0,g=255,S=0,v=.999){let C=u.global_min,D=u.global_max;if(u.hdr.datatypeCode===2)return[C,1];if((!isFinite(S)||!isFinite(v))&&isFinite(u.cal_min)&&isFinite(u.cal_max)&&u.cal_max>u.cal_min){C=u.cal_min,D=u.cal_max;const Y=(g-h)/(D-C);return log.info(" Robust Rescale:  min: "+C+"  max: "+D+" scale: "+Y),console.log("Robust Rescale:  min: "+C+"  max: "+D+" scale: "+Y),[C,Y]}const _=u.img,P=u.hdr.dims[1]*u.hdr.dims[2]*u.hdr.dims[3];if(u.hdr.scl_slope!==1||u.hdr.scl_inter!==0){const Y=u.img,T=new Float32Array(u.img.length);for(let H=0;H<P;H++)T[H]=Y[H]*u.hdr.scl_slope+u.hdr.scl_inter}if(C<0&&log.warn("WARNING: Input image has value(s) below 0.0 !"),log.info(" Input:    min: "+C+"  max: "+D),S===0&&v===1)return[C,1];let L=0;for(let Y=0;Y<P;Y++)Math.abs(_[Y])>=1e-15&&L++;const m=1e3,k=(D-C)/m,e=new Array(m).fill(0);for(let Y=0;Y<P;Y++){const T=_[Y];let H=Math.floor((T-C)/k);H=Math.min(H,m-1),e[H]++}const O=new Array(m).fill(0);O[0]=e[0];for(let Y=1;Y<m;Y++)O[Y]=O[Y-1]+e[Y];let q=Math.floor(S*P),Q=0;for(;Q<m&&!(O[Q]>=q);)Q++;const i0=C;for(C=Q*k+i0,q=P-Math.floor((1-v)*L),Q=0;Q<m-1&&!(O[Q+1]>=q);)Q++;D=Q*k+i0;let j=1;return C!==D&&(j=(g-h)/(D-C)),log.info(" Rescale:  min: "+C+"  max: "+D+" scale: "+j),[C,j]}conformVox2Vox(u,h,g=256,S=1,v=!1){const C=h.flat(),D=fromValues$3(C[0],C[1],C[2],C[3],C[4],C[5],C[6],C[7],C[8],C[9],C[10],C[11],C[12],C[13],C[14],C[15]),_=fromValues$1(u[1]/2,u[2]/2,u[3]/2,1),P=create$1(),L=create$3();transpose(L,D),transformMat4(P,_,L);const m=fromValues$2(P[0],P[1],P[2]),k=fromValues$2(S,S,S);let e=fromValues$3(-1,0,0,0,0,0,1,0,0,-1,0,0,0,0,0,1);v&&(e=fromValues$3(1,0,0,0,0,1,0,0,0,0,1,0,0,0,0,1)),transpose(e,e);const O=fromValues$1(g,g,g,1),q=create$3();scale$3(q,e,k);const Q=fromValues$1(O[0],O[1],O[2],1);transformMat4(Q,Q,q),scale$1(Q,Q,.5);const i0=create$2();subtract$1(i0,m,fromValues$2(Q[0],Q[1],Q[2]));const j=create$3();transpose(j,q),j[3]=i0[0],j[7]=i0[1],j[11]=i0[2];const Y=create$3();invert(Y,j);const T=create$3();mul(T,D,Y);const H=create$3();return invert(H,T),[j,T,H]}async createNiftiArray(u=[256,256,256],h=[1,1,1],g=[1,0,0,-128,0,1,0,-128,0,0,1,-128,0,0,0,1],S=2,v=new Uint8Array){return await NVImage.createNiftiArray(u,h,g,S,v)}async niftiArray2NVImage(u=new Uint8Array){return await NVImage.loadFromUrl({url:u})}async loadFromUrl(u){return await NVImage.loadFromUrl({url:u})}async conform(u,h=!1,g=!0,S=!1,v=!1){const _=this.conformVox2Vox(u.hdr.dims,u.hdr.affine.flat(),256,1,h),P=_[0],L=_[2],m=256*256*256,k=new Float32Array(m),e=new Float32Array(u.img),O=u.hdr.dims[1]*u.hdr.dims[2]*u.hdr.dims[3];if(u.hdr.scl_slope!==1||u.hdr.scl_inter!==0)for(let f0=0;f0<O;f0++)e[f0]=e[f0]*u.hdr.scl_slope+u.hdr.scl_inter;const q=u.hdr.dims[1],Q=u.hdr.dims[2],i0=u.hdr.dims[3],j=q*Q;let Y=-1;function T(f0,o0,c0){return f0+o0*q+c0*j}const H=L[0],G=L[4],K=L[8];if(g)for(let f0=0;f0<256;f0++)for(let o0=0;o0<256;o0++){const c0=o0*L[1]+f0*L[2]+L[3],d0=o0*L[5]+f0*L[6]+L[7],v0=o0*L[9]+f0*L[10]+L[11];for(let g0=0;g0<256;g0++){const C0=g0*H+c0,x0=g0*G+d0,M0=g0*K+v0,ee=Math.floor(C0),re=Math.floor(x0),Fe=Math.floor(M0);if(Y++,ee<0||re<0||Fe<0)continue;const Ne=Math.ceil(C0),ke=Math.ceil(x0),D0=Math.ceil(M0);if(Ne>=q||ke>=Q||D0>=i0)continue;const Be=C0-ee,Ge=x0-re,ti=M0-Fe,ai=1-Be,ri=1-Ge,qe=1-ti,be=T(ee,re,Fe);let J0=0;J0+=e[be]*ai*ri*qe,J0+=e[be+j]*ai*ri*ti,J0+=e[be+q]*ai*Ge*qe,J0+=e[be+q+j]*ai*Ge*ti,J0+=e[be+1]*Be*ri*qe,J0+=e[be+1+j]*Be*ri*ti,J0+=e[be+1+q]*Be*Ge*qe,J0+=e[be+1+q+j]*Be*Ge*ti,k[Y]=J0}}else for(let f0=0;f0<256;f0++)for(let o0=0;o0<256;o0++){const c0=o0*L[1]+f0*L[2]+L[3],d0=o0*L[5]+f0*L[6]+L[7],v0=o0*L[9]+f0*L[10]+L[11];for(let g0=0;g0<256;g0++){const C0=Math.round(g0*H+c0),x0=Math.round(g0*G+d0),M0=Math.round(g0*K+v0);Y++,!(C0<0||x0<0||M0<0)&&(C0>=q||x0>=Q||M0>=i0||(k[Y]=e[T(C0,x0,M0)]))}}let e0=0;v&&(e0=NaN);let z=new Uint8Array;if(S){const f0=await this.getScale(u,0,1,e0),o0=await this.scalecropFloat32(k,0,1,f0[0],f0[1]);z=await this.createNiftiArray([256,256,256],[1,1,1],Array.from(P),16,new Uint8Array(o0.buffer))}else{const f0=await this.getScale(u,0,255,e0),o0=await this.scalecropUint8(k,0,255,f0[0],f0[1]);z=await this.createNiftiArray([256,256,256],[1,1,1],Array.from(P),2,o0)}return await this.niftiArray2NVImage(z)}setRenderDrawAmbientOcclusion(u){if(!this.renderShader)throw new Error("renderShader undefined");this.renderDrawAmbientOcclusion=u,this.renderShader.use(this.gl),this.gl.uniform1fv(this.renderShader.uniforms.renderDrawAmbientOcclusion,[this.renderDrawAmbientOcclusion,1]),this.drawScene()}setColorMap(u,h){this.setColormap(u,h)}setColormapNegative(u,h){const g=this.getVolumeIndexByID(u);this.volumes[g].colormapNegative=h,this.updateGLVolume()}setModulationImage(u,h,g=0){const S=this.getVolumeIndexByID(u);let v=null;h.length>0&&(v=this.getVolumeIndexByID(h)),this.volumes[S].modulationImage=v,this.volumes[S].modulateAlpha=g,this.updateGLVolume()}setGamma(u=1){this.scene.gamma=u,cmapper.gamma=u,this.updateGLVolume()}async loadDeferred4DVolumes(u){const h=this.getVolumeIndexByID(u),g=this.volumes[h];if(g.nTotalFrame4D<=g.nFrame4D)return;let S;g.fileObject?S=await NVImage.loadFromFile({file:g.fileObject}):S=await NVImage.loadFromUrl({url:g.url}),S&&(g.img=S.img.slice(),g.nTotalFrame4D=S.nTotalFrame4D,g.nFrame4D=S.nFrame4D,this.updateGLVolume())}setFrame4D(u,h){const g=this.getVolumeIndexByID(u),S=this.volumes[g];h>S.nFrame4D-1&&(h=S.nFrame4D-1),h<0&&(h=0),h!==S.frame4D&&(S.frame4D=h,this.updateGLVolume(),this.onFrameChange(S,h),this.createOnLocationChange())}getFrame4D(u){const h=this.getVolumeIndexByID(u);return this.volumes[h].frame4D}colormapFromKey(u){return cmapper.colormapFromKey(u)}colormap(u="",h=!1){return cmapper.colormap(u,h)}createColormapTexture(u=null,h=0,g=256){return u!==null&&this.gl.deleteTexture(u),h<1||g<1?null:(u=this.gl.createTexture(),this.gl.activeTexture(TEXTURE1_COLORMAPS),this.gl.bindTexture(this.gl.TEXTURE_2D,u),this.gl.texStorage2D(this.gl.TEXTURE_2D,1,this.gl.RGBA8,g,h),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),u)}addColormapList(u="",h=NaN,g=NaN,S=!1,v=!1,C=!0,D=!1){u.length<1&&(C=!1),this.colormapLists.push({name:u,min:h,max:g,alphaThreshold:S,negative:v,visible:C,invert:D})}refreshColormaps(){if(this.colormapLists=[],this.volumes.length<1&&this.meshes.length<1)return;const u=this.volumes.length;if(u>0)for(let C=0;C<u;C++){const D=this.volumes[C],_=negMinMax(D.cal_min,D.cal_max,D.cal_minNeg,D.cal_maxNeg);this.addColormapList(D.colormapNegative,_[0],_[1],D.alphaThreshold!==void 0,!0,D.colorbarVisible,D.colormapInvert),this.addColormapList(D.colormap,D.cal_min,D.cal_max,D.alphaThreshold!==void 0,!1,D.colorbarVisible,D.colormapInvert)}const h=this.meshes.length;if(h>0)for(let C=0;C<h;C++){const D=this.meshes[C];if(!D.colorbarVisible)continue;const _=D.layers.length;if("edgeColormap"in D&&"edges"in D&&D.edges!==void 0){const P=negMinMax(D.edgeMin,D.edgeMax,NaN,NaN);this.addColormapList(D.edgeColormapNegative,P[0],P[1],!1,!0,!0,D.colormapInvert),this.addColormapList(D.edgeColormap,D.edgeMin,D.edgeMax,!1,!1,!0,D.colormapInvert)}if(!(_<1))for(let P=0;P<_;P++){const L=this.meshes[C].layers[P];if(!L.colorbarVisible||L.colormap.length<1)continue;const m=negMinMax(L.cal_min,L.cal_max,L.cal_minNeg,L.cal_maxNeg);this.addColormapList(L.colormapNegative,m[0],m[1],L.alphaThreshold,!0,!0,L.colormapInvert),this.addColormapList(L.colormap,L.cal_min,L.cal_max,L.alphaThreshold,!1,!0,L.colormapInvert)}}const g=this.colormapLists.length;if(g<1)return;this.colormapTexture=this.createColormapTexture(this.colormapTexture,g+1);let S=new Uint8ClampedArray;function v(C){const D=new Uint8ClampedArray(S.length+C.length);D.set(S),D.set(C,S.length),S=D}for(let C=0;C<g;C++)v(Array.from(this.colormap(this.colormapLists[C].name,this.colormapLists[C].invert)));return v(Array.from(this.drawLut.lut)),this.gl.texSubImage2D(this.gl.TEXTURE_2D,0,0,0,256,g+1,this.gl.RGBA,this.gl.UNSIGNED_BYTE,S),this}sliceScale(u=!1){var C;let h=this.screenFieldOfViewMM(0);u&&(h=this.screenFieldOfViewVox(0));const g=Math.max(h[0],Math.max(h[1],h[2])),S=[h[0]/g,h[1]/g,h[2]/g];if(!((C=this.back)!=null&&C.dims))throw new Error("back.dims undefined");const v=[this.back.dims[1],this.back.dims[2],this.back.dims[3]];return{volScale:S,vox:v,longestAxis:g,dimsMM:h}}tileIndex(u,h){for(let g=0;g<this.screenSlices.length;g++){const S=this.screenSlices[g].leftTopWidthHeight;if(u>S[0]&&h>S[1]&&u<S[0]+S[2]&&h<S[1]+S[3])return g}return-1}inRenderTile(u,h){const g=this.tileIndex(u,h);return g>=0&&this.screenSlices[g].axCorSag===4?g:-1}sliceScroll3D(u=0){if(u!==0){if(this.volumes.length>0&&this.scene.clipPlaneDepthAziElev[0]<1.8){const h=this.scene.clipPlaneDepthAziElev.slice();return u>0&&(h[0]=Math.min(1.5,h[0]+.025)),u<0&&(h[0]=Math.max(-1.5,h[0]-.025)),h[0]!==this.scene.clipPlaneDepthAziElev[0]?(this.scene.clipPlaneDepthAziElev=h,this.setClipPlane(this.scene.clipPlaneDepthAziElev)):void 0}u>0&&(this.scene.volScaleMultiplier=Math.min(2,this.scene.volScaleMultiplier*1.1)),u<0&&(this.scene.volScaleMultiplier=Math.max(.5,this.scene.volScaleMultiplier*.9)),this.drawScene()}}deleteThumbnail(){this.bmpTexture&&(this.gl.deleteTexture(this.bmpTexture),this.bmpTexture=null,this.thumbnailVisible=!1)}inGraphTile(u,h){if(this.graph.opacity<=0||this.volumes.length<1||this.volumes[0].nFrame4D<1||!this.graph.plotLTWH||this.graph.plotLTWH[2]<1||this.graph.plotLTWH[3]<1)return!1;const g=[(u-this.graph.LTWH[0])/this.graph.LTWH[2],(h-this.graph.LTWH[1])/this.graph.LTWH[3]];return g[0]>0&&g[1]>0&&g[0]<=1&&g[1]<=1}mouseClick(u,h,g=0,S=!0){if(u*=this.uiData.dpr,h*=this.uiData.dpr,this.canvas.focus(),this.thumbnailVisible){this.thumbnailVisible=!1,Promise.all([this.loadVolumes(this.deferredVolumes),this.loadMeshes(this.deferredMeshes)]).catch(v=>{throw v});return}if(this.inGraphTile(u,h)){if(!this.graph.plotLTWH)throw new Error("plotLTWH undefined");const v=[(u-this.graph.plotLTWH[0])/this.graph.plotLTWH[2],(h-this.graph.plotLTWH[1])/this.graph.plotLTWH[3]];if(v[0]>0&&v[1]>0&&v[0]<=1&&v[1]<=1){const C=Math.round(v[0]*(this.volumes[0].nFrame4D-1));this.setFrame4D(this.volumes[0].id,C);return}v[0]>.5&&v[1]>1&&this.loadDeferred4DVolumes(this.volumes[0].id).catch(C=>{throw C});return}if(this.inRenderTile(u,h)>=0){this.sliceScroll3D(g),this.drawScene();return}if(!(this.screenSlices.length<1||this.gl.canvas.height<1||this.gl.canvas.width<1))for(let v=0;v<this.screenSlices.length;v++){const C=this.screenSlices[v].axCorSag;if(this.drawPenAxCorSag>=0&&this.drawPenAxCorSag!==C||C>2)continue;const D=this.screenXY2TextureFrac(u,h,v,!1);if(!(D[0]<0)){if(!S){this.scene.crosshairPos[2-C]=g,this.drawScene();return}if(g!==0){let _=1;g<0&&(_=-1);const P=[0,0,0];P[2-C]=_,this.moveCrosshairInVox(P[0],P[1],P[2]),this.drawScene(),this.createOnLocationChange(C);return}if(this.opts.isForceMouseClickToVoxelCenters?this.scene.crosshairPos=clone$1(this.vox2frac(this.frac2vox(D))):this.scene.crosshairPos=clone$1(D),this.opts.drawingEnabled){const _=this.frac2vox(this.scene.crosshairPos),P=this.frac2mm(this.scene.crosshairPos);if(this.opts.clickToSegment){const L=this.opts.clickToSegmentRadius,m=this.opts.clickToSegmentSteps,k=this.opts.clickToSegmentBright?Number.POSITIVE_INFINITY:Number.NEGATIVE_INFINITY;this.drawPenFillPts=[],this.drawPenAxCorSag=C;for(let O=1;O<=m;O++){const q=O/m*2*Math.PI,Q=P[0]+L*Math.cos(q),i0=P[1]+L*Math.sin(q),j=P[2],Y=this.back.mm2vox([Q,i0,j])[0],T=this.back.mm2vox([Q,i0,j])[1],H=this.back.mm2vox([Q,i0,j])[2];this.drawPt(Y,T,H,this.opts.penValue),this.drawPenFillPts.push([Y,T,_[2]]),O===m&&this.drawFloodFill([Y,T,_[2]],0,k,NaN,NaN,this.opts.floodFillNeighbors)}this.drawScene(),this.createOnLocationChange(C);const e=this.getDescriptives(0,[],!0);this.onClickToSegment({mL:e.volumeML,mm3:e.volumeMM3});return}if(!isFinite(this.opts.penValue)||this.opts.penValue<0||Object.is(this.opts.penValue,-0)){isFinite(this.opts.penValue)?this.drawFloodFill(_,Math.abs(this.opts.penValue),this.opts.penValue,NaN,NaN,this.opts.floodFillNeighbors):this.drawFloodFill(_,0,this.opts.penValue,NaN,NaN,this.opts.floodFillNeighbors);return}if(isNaN(this.drawPenLocation[0]))this.drawPenAxCorSag=C,this.drawPenFillPts=[],this.drawPt(..._,this.opts.penValue);else{if(_[0]===this.drawPenLocation[0]&&_[1]===this.drawPenLocation[1]&&_[2]===this.drawPenLocation[2])return;this.drawPenLine(_,this.drawPenLocation,this.opts.penValue)}this.drawPenLocation=_,this.opts.isFilledPen&&this.drawPenFillPts.push(_),this.refreshDrawing(!1)}this.drawScene(),this.createOnLocationChange(C);return}}}drawRuler(){let u=[],h=[];for(let _=0;_<this.screenSlices.length;_++)if(this.screenSlices[_].axCorSag!==4&&this.screenSlices[_].fovMM.length>1){h=this.screenSlices[_].leftTopWidthHeight,u=this.screenSlices[_].fovMM;break}if(h.length<4)return;const S=100/u[0]*h[2],v=h[0]+.5*h[2]-.5*S,C=h[1]+h[3]-2*this.opts.rulerWidth,D=[v,C,v+S,C];this.drawRuler10cm(D)}drawRuler10cm(u){if(!this.lineShader)throw new Error("lineShader undefined");this.gl.bindVertexArray(this.genericVAO),this.lineShader.use(this.gl),this.gl.uniform4fv(this.lineShader.uniforms.lineColor,this.opts.rulerColor),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,this.opts.rulerWidth),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,u),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4);const h=-.1*(u[0]-u[2]),g=u[1],S=g-2*this.opts.rulerWidth,v=g-4*this.opts.rulerWidth;for(let C=0;C<11;C++){const D=u[0]+C*h,_=[D,g,D,S];C%5===0&&(_[3]=v),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,_),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4)}this.gl.bindVertexArray(this.unusedVAO)}screenXY2mm(u,h,g=-1){let S;for(let v=0;v<this.screenSlices.length;v++){let C=v;if(g>=0&&(C=g),this.screenSlices[C].axCorSag>2)continue;const _=this.screenSlices[C].leftTopWidthHeight;if(u<_[0]||h<_[1]||u>_[0]+_[2]||h>_[1]+_[3]||(S=this.screenXY2TextureFrac(u,h,C,!1),S[0]<0))continue;const P=this.frac2mm(S);return fromValues$1(P[0],P[1],P[2],C)}return fromValues$1(NaN,NaN,NaN,NaN)}dragForPanZoom(u){const h=this.screenXY2mm(u[2],u[3]);if(isNaN(h[0]))return;const g=this.screenXY2mm(u[0],u[1],h[3]);if(isNaN(g[0])||isNaN(h[0])||isNaN(h[3]))return;const S=create$1(),v=this.uiData.pan2DxyzmmAtMouseDown[3];sub(S,h,g),this.scene.pan2Dxyzmm[0]=this.uiData.pan2DxyzmmAtMouseDown[0]+v*S[0],this.scene.pan2Dxyzmm[1]=this.uiData.pan2DxyzmmAtMouseDown[1]+v*S[1],this.scene.pan2Dxyzmm[2]=this.uiData.pan2DxyzmmAtMouseDown[2]+v*S[2],this.canvas.focus()}dragForCenterButton(u){this.dragForPanZoom(u)}dragForSlicer3D(u){let h=this.uiData.pan2DxyzmmAtMouseDown[3];const g=u[3]-u[1];h+=g*.01,h=Math.max(h,.1),h=Math.min(h,10);const v=this.scene.pan2Dxyzmm[3]-h;this.opts.yoke3Dto2DZoom&&(this.scene.volScaleMultiplier=h),this.scene.pan2Dxyzmm[3]=h;const C=this.frac2mm(this.scene.crosshairPos);this.scene.pan2Dxyzmm[0]+=v*C[0],this.scene.pan2Dxyzmm[1]+=v*C[1],this.scene.pan2Dxyzmm[2]+=v*C[2]}drawMeasurementTool(u){const h=this.gl;if(h.bindVertexArray(this.genericVAO),h.depthFunc(h.ALWAYS),h.enable(h.BLEND),h.blendFunc(h.SRC_ALPHA,h.ONE_MINUS_SRC_ALPHA),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl),h.uniform4fv(this.lineShader.uniforms.lineColor,this.opts.rulerColor),h.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[h.canvas.width,h.canvas.height]),h.uniform1f(this.lineShader.uniforms.thickness,this.opts.rulerWidth),h.uniform4fv(this.lineShader.uniforms.startXYendXY,u),h.drawArrays(h.TRIANGLE_STRIP,0,4);const g=this.opts.rulerColor;g[3]=1,h.uniform4fv(this.lineShader.uniforms.lineColor,g);const S=this.opts.rulerWidth;h.uniform1f(this.lineShader.uniforms.thickness,S*2);let v=[u[0],u[1]-S,u[0],u[1]+S];h.uniform4fv(this.lineShader.uniforms.startXYendXY,v),h.drawArrays(h.TRIANGLE_STRIP,0,4),v=[u[2],u[3]-S,u[2],u[3]+S],h.uniform4fv(this.lineShader.uniforms.startXYendXY,v),h.drawArrays(h.TRIANGLE_STRIP,0,4);let C=this.canvasPos2frac([u[0],u[1]]),D=this.canvasPos2frac([u[2],u[3]]);if(C[0]>=0&&D[0]>=0){const _=this.frac2mm(C);C=fromValues$2(_[0],_[1],_[2]);const P=this.frac2mm(D);D=fromValues$2(P[0],P[1],P[2]);const L=create$2();sub$1(L,C,D);const m=len(L);let k=2;m>9&&(k=1),m>99&&(k=0);const e=m.toFixed(k);this.drawTextBetween(u,e,1,g)}h.bindVertexArray(this.unusedVAO)}drawRect(u,h=[1,0,0,-1]){if(h[3]<0&&(h=this.opts.crosshairColor),!this.rectShader)throw new Error("rectShader undefined");this.rectShader.use(this.gl),this.gl.enable(this.gl.BLEND),this.gl.uniform4fv(this.rectShader.uniforms.lineColor,h),this.gl.uniform2fv(this.rectShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform4f(this.rectShader.uniforms.leftTopWidthHeight,u[0],u[1],u[2],u[3]),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawCircle(u,h=this.opts.fontColor,g=1){if(!this.circleShader)throw new Error("circleShader undefined");this.circleShader.use(this.gl),this.gl.enable(this.gl.BLEND),this.gl.uniform4fv(this.circleShader.uniforms.circleColor,h),this.gl.uniform2fv(this.circleShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform4f(this.circleShader.uniforms.leftTopWidthHeight,u[0],u[1],u[2],u[3]),this.gl.uniform1f(this.circleShader.uniforms.fillPercent,g),this.gl.uniform4fv(this.circleShader.uniforms.circleColor,h),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawSelectionBox(u){this.drawRect(u,this.opts.selectionBoxColor)}effectiveCanvasHeight(){return this.gl.canvas.height-this.colorbarHeight}effectiveCanvasWidth(){return this.gl.canvas.width-this.getLegendPanelWidth()}getAllLabels(){const S=this.meshes.filter(C=>C.type==="connectome").flatMap(C=>C.nodes).map(C=>C.label).filter(C=>C!==void 0);return[...this.document.labels,...S]}getConnectomeLabels(){const S=this.meshes.filter(D=>D.type==="connectome").flatMap(D=>D.nodes).map(D=>D.label).filter(D=>D!==void 0),v=this.document.labels.filter(D=>D.anchor==null||D.anchor===0),C=new Set(S);for(const D of v)C.add(D);return Array.from(C)}getBulletMarginWidth(){let u=0;const h=this.getConnectomeLabels();if(h.length===0)return 0;const g=h.length===1?h[0].style.bulletScale:h.reduce((C,D)=>C.style.bulletScale>D.style.bulletScale?C:D).style.bulletScale,S=h.length===1?h[0]:h.reduce((C,D)=>{const _=this.opts.textHeight*this.gl.canvas.height*C.style.textScale,P=this.opts.textHeight*this.gl.canvas.height*D.style.textScale;return this.textHeight(_,C.text)>this.textHeight(P,D.text)?C:D}),v=this.opts.textHeight*this.gl.canvas.height*S.style.textScale;return u=this.textHeight(v,S.text)*g,u+=v,u}getLegendPanelWidth(){const u=this.getConnectomeLabels();if(!this.opts.showLegend||u.length===0)return 0;const g=this.opts.textHeight*this.gl.canvas.height*1;let S=0;const v=u.reduce((P,L)=>{const m=this.opts.textHeight*this.gl.canvas.height*P.style.textScale,k=this.opts.textHeight*this.gl.canvas.height*L.style.textScale;return this.textWidth(m,P.text)>this.textWidth(k,L.text)?P:L}),C=this.opts.textHeight*this.gl.canvas.height*v.style.textScale,D=this.textWidth(C,v.text),_=this.getBulletMarginWidth();return D&&(S=_+D,S+=g*2),S>=this.gl.canvas.width?0:S}getLegendPanelHeight(){const u=this.getConnectomeLabels();let h=0;const S=this.opts.textHeight*this.gl.canvas.height*1;for(const v of u){const C=this.opts.textHeight*this.gl.canvas.height*v.style.textScale,D=this.textHeight(C,v.text);h+=D}return h&&(h+=S/2*(u.length+1)),h}reserveColorbarPanel(){let u=Math.max(this.opts.textHeight,.01);u=u*Math.min(this.gl.canvas.height,this.gl.canvas.width);const h=3*u,g=[0,this.gl.canvas.height-h,this.gl.canvas.width,h];return this.colorbarHeight=g[3]+1,g}drawColorbarCore(u=0,h=[0,0,0,0],g=!1,S=0,v=1,C){if(h[2]<=0||h[3]<=0)return;let D=Math.max(this.opts.textHeight,.01);D=D*Math.min(this.gl.canvas.height,this.gl.canvas.width);let _=D;const P=3*D;let L=D;if(h[3]<P){if(h[3]<3)return;_=1,L=h[3]-2}this.gl.disable(this.gl.DEPTH_TEST),this.colorbarHeight=h[3]+1;const m=[h[0]+_,h[1],h[2]-2*_,L],k=[m[0]-1,m[1]-1,m[2]+2,m[3]+2];if(this.drawRect(k,this.opts.crosshairColor),!this.colorbarShader)throw new Error("colorbarShader undefined");this.colorbarShader.use(this.gl),this.gl.activeTexture(TEXTURE1_COLORMAPS),this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST);const e=u;if(this.gl.uniform1f(this.colorbarShader.uniforms.layer,e),this.gl.uniform2fv(this.colorbarShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.disable(this.gl.CULL_FACE),g){const K=[m[0]+m[2],m[1],-m[2],m[3]];this.gl.uniform4fv(this.colorbarShader.uniforms.leftTopWidthHeight,K)}else this.gl.uniform4fv(this.colorbarShader.uniforms.leftTopWidthHeight,m);this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR);let O=0;if(C&&v<0&&g?(O=v,v=0):C&&S>0&&(O=S,S=0),S===v||D<1)return;const q=Math.abs(v-S);let[Q,i0]=tickSpacing(S,v);i0<S&&(i0+=Q);function j(K){return K.toFixed(6).replace(/\.?0*$/,"")}let Y=i0;const T=[0,m[1]+m[3]-D*.5,2,D*.75],H=T[1]+T[3],G=1;for(;Y<=v;){T[0]=m[0]+(Y-S)/q*m[2],this.drawRect(T);const K=j(G*Y);this.drawTextBelow([T[0],H],K),Y+=Q}if(O!==0){const K=[m[0]+(O-S)/q*m[2],m[1]-m[3]*.25,2,m[3]*1.5];this.drawRect(K)}}drawColorbar(){const u=this.colormapLists,h=u.length;if(h<1)return;let g=0;for(let _=0;_<h;_++)u[_].visible&&g++;if(g<1)return;let S=this.reserveColorbarPanel(),v=Math.max(this.opts.textHeight,.01);v=v*Math.min(this.gl.canvas.height,this.gl.canvas.width);const C=3*v;let D=S[2]/g;(S[2]<=0||S[3]<=0)&&(D=this.gl.canvas.width/g,S=[0,this.gl.canvas.height-C,D,C]),S[2]=D;for(let _=0;_<h;_++)u[_].visible&&(this.drawColorbarCore(_,S,u[_].negative,u[_].min,u[_].max,u[_].alphaThreshold),S[0]+=D)}textWidth(u,h){if(!h)return 0;let g=0;const S=new TextEncoder().encode(h);for(let v=0;v<h.length;v++)g+=u*this.fontMets.mets[S[v]].xadv;return g}textHeight(u,h){if(!h)return 0;const g=new Set(Array.from(h)),S=new TextEncoder().encode(Array.from(g).join("")),C=Object.values(this.fontMets.mets).filter((D,_)=>S.includes(_)).reduce((D,_)=>D.lbwh[3]>_.lbwh[3]?D:_).lbwh[3];return u*C}drawChar(u,h,g){if(!this.fontShader)throw new Error("fontShader undefined");const S=this.fontMets.mets[g],v=u[0]+h*S.lbwh[0],C=-(h*S.lbwh[1]),D=h*S.lbwh[2],_=h*S.lbwh[3],P=u[1]+(C-_)+h;return this.gl.uniform4f(this.fontShader.uniforms.leftTopWidthHeight,v,P,D,_),this.gl.uniform4fv(this.fontShader.uniforms.uvLeftTopWidthHeight,S.uv_lbwh),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),h*S.xadv}drawLoadingText(u){if(!this.canvas)throw new Error("canvas undefined");this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.gl.enable(this.gl.CULL_FACE),this.gl.enable(this.gl.BLEND),this.drawTextBelow([this.canvas.width/2,this.canvas.height/2],u,3)}drawText(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;if(!this.fontShader)throw new Error("fontShader undefined");this.fontShader.use(this.gl);const v=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*g;this.gl.enable(this.gl.BLEND),this.gl.uniform2f(this.fontShader.uniforms.canvasWidthHeight,this.gl.canvas.width,this.gl.canvas.height),S===null&&(S=this.opts.fontColor),this.gl.uniform4fv(this.fontShader.uniforms.fontColor,S);let C=v/this.fontMets.size*this.fontMets.distanceRange;C=Math.max(C,1),this.gl.uniform1f(this.fontShader.uniforms.screenPxRange,C);const D=new TextEncoder().encode(h);this.gl.bindVertexArray(this.genericVAO);for(let _=0;_<h.length;_++)u[0]+=this.drawChar(u,v,D[_]);this.gl.bindVertexArray(this.unusedVAO)}drawTextRight(u,h,g=1,S=null){this.opts.textHeight<=0||(u[1]-=.5*this.opts.textHeight*this.gl.canvas.height,this.drawText(u,h,g,S))}drawTextLeft(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;const v=this.opts.textHeight*this.gl.canvas.height*g;u[0]-=this.textWidth(v,h),u[1]-=.5*v,this.drawText(u,h,g,S)}drawTextRightBelow(u,h,g=1,S=null){this.opts.textHeight<=0||this.drawText(u,h,g,S)}drawTextBetween(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;const v=[(u[0]+u[2])*.5,(u[1]+u[3])*.5],C=this.opts.textHeight*this.gl.canvas.height*g,D=this.textWidth(C,h);v[0]-=.5*D,v[1]-=.5*C;const _=[v[0]-1,v[1]-1,D+2,C+2];let P=S;P===null&&(P=this.opts.crosshairColor),P&&P[0]+P[1]+P[2]>.8?P=[0,0,0,.5]:P=[1,1,1,.5],this.drawRect(_,P),this.drawText(v,h,g,S)}drawTextBelow(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;if(!this.canvas)throw new Error("canvas undefined");let v=this.opts.textHeight*this.gl.canvas.height*g,C=this.textWidth(v,h);C>this.canvas.width&&(g*=(this.canvas.width-2)/C,v=this.opts.textHeight*this.gl.canvas.height*g,C=this.textWidth(v,h)),u[0]-=.5*this.textWidth(v,h),u[0]=Math.max(u[0],1),u[0]=Math.min(u[0],this.canvas.width-C-1),this.drawText(u,h,g,S)}updateInterpolation(u,h=!1){let g=this.gl.LINEAR;!h&&this.opts.isNearestInterpolation&&(g=this.gl.NEAREST),u===0?this.gl.activeTexture(TEXTURE0_BACK_VOL):this.gl.activeTexture(TEXTURE2_OVERLAY_VOL),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,g),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,g)}setAtlasOutline(u){this.opts.atlasOutline=u,this.updateGLVolume(),this.drawScene()}setInterpolation(u){this.opts.isNearestInterpolation=u;const h=this.volumes.length;if(!(h<1)){for(let g=0;g<h;g++)this.updateInterpolation(g);this.drawScene()}}calculateMvpMatrix2D(u,h,g,S=1/0,v=0,C=0,D=0,_){this.gl.viewport(u[0],this.gl.canvas.height-(u[1]+u[3]),u[2],u[3]);let L=h[0],m=g[0],k=[L,h[1]],e=[m-L,g[1]-h[1]];_&&(k=[g[0],h[1]],e=[h[0]-g[0],g[1]-h[1]],L=-g[0],m=-h[0]);const O=2*Math.max(Math.abs(h[2]),Math.abs(g[2])),q=create$3();let Q=.01,i0=O*8;if(S!==1/0){let K=_;D===0&&(C===0||C===180)&&(K=!K);let e0=O*1.8-v;K||(e0=O*1.8+v),Q=e0-S,i0=e0+S}ortho(q,L,m,h[1],g[1],Q,i0);const j=create$3();j[0]=-1;const Y=fromValues$2(0,0,-O*1.8);translate(j,j,Y),rotateX(j,j,deg2rad(270-D)),rotateZ(j,j,deg2rad(C-180));const T=create$3();invert(T,j);const H=create$3();transpose(H,T);const G=create$3();return multiply(G,q,j),{modelViewProjectionMatrix:G,modelMatrix:j,normalMatrix:H,leftTopMM:k,fovMM:e}}swizzleVec3MM(u,h){return h===1?u=swizzleVec3(u,[0,2,1]):h===2&&(u=swizzleVec3(u,[1,2,0])),u}screenFieldOfViewVox(u=0){const h=clone$1(this.volumeObject3D.fieldOfViewDeObliqueMM);return this.swizzleVec3MM(h,u)}screenFieldOfViewMM(u=0,h=!1){if(!h&&!this.opts.isSliceMM)return this.screenFieldOfViewVox(u);const g=this.volumeObject3D.extentsMin,S=this.volumeObject3D.extentsMax;let v=fromValues$2(g[0],g[1],g[2]),C=fromValues$2(S[0],S[1],S[2]);v=this.swizzleVec3MM(v,u),C=this.swizzleVec3MM(C,u);const D=create$2();return subtract$1(D,C,v),D}screenFieldOfViewExtendedVox(u=0){const h=this.volumes[0].extentsMinOrtho,g=this.volumes[0].extentsMaxOrtho;let S=fromValues$2(h[0],h[1],h[2]),v=fromValues$2(g[0],g[1],g[2]);const C=create$3();S=this.swizzleVec3MM(S,u),v=this.swizzleVec3MM(v,u);const D=create$2();return subtract$1(D,v,S),{mnMM:S,mxMM:v,rotation:C,fovMM:D}}screenFieldOfViewExtendedMM(u=0){if(!this.volumeObject3D)throw new Error("volumeObject3D undefined");const h=this.volumeObject3D.extentsMin,g=this.volumeObject3D.extentsMax;let S=fromValues$2(h[0],h[1],h[2]),v=fromValues$2(g[0],g[1],g[2]);const C=create$3();S=this.swizzleVec3MM(S,u),v=this.swizzleVec3MM(v,u);const D=create$2();return subtract$1(D,v,S),{mnMM:S,mxMM:v,rotation:C,fovMM:D}}drawSliceOrientationText(u,h,g=[NaN,NaN]){this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height);let S="S";h===0&&(S="A");let v=this.opts.isRadiologicalConvention?"R":"L";if(h===2&&(v=this.opts.sagittalNoseLeft?"A":"P"),this.opts.isCornerOrientationText){this.drawTextRightBelow([u[0],u[1]],v+S);return}let C=!0,D=!0;if(!isNaN(g[0])){const _=this.opts.textHeight*this.gl.canvas.height+2;g[1]>_&&(this.drawTextBelow([u[0]+u[2]*.5,u[1]+g[1]-_],S),C=!1);const P=this.textWidth(_,v)+2;g[0]>P&&(this.drawTextRight([u[0]+g[0]-P,u[1]+u[3]*.5],v),D=!1)}C&&this.drawTextBelow([u[0]+u[2]*.5,u[1]],S),D&&this.drawTextRight([u[0],u[1]+u[3]*.5],v)}xyMM2xyzMM(u,h){let g=2;u===1&&(g=1),u===2&&(g=0);let S=[0,0,0],v=[1,1,0],C=[1,0,1];S[g]=h,v[g]=h,C[g]=h,S=this.frac2mm(S),v=this.frac2mm(v),C=this.frac2mm(C),S=this.swizzleVec3MM(fromValues$2(S[0],S[1],S[2]),u),v=this.swizzleVec3MM(fromValues$2(v[0],v[1],v[2]),u),C=this.swizzleVec3MM(fromValues$2(C[0],C[1],C[2]),u);const D=(v[0]-S[0])*(C[1]-S[1])-(C[0]-S[0])*(v[1]-S[1]);let _=(v[0]-S[0])*(C[2]-S[2])-(C[0]-S[0])*(v[2]-S[2]);_/=D;let P=(v[1]-S[1])*(C[2]-S[2])-(C[1]-S[1])*(v[2]-S[2]);P/=D;const L=[0,0,0,0,0];return L[0]=S[0],L[1]=S[1],L[2]=S[2],L[3]=P,L[4]=_,L}draw2DMain(u,h,g=NaN){let S=this.volumes[0].frac2mm.slice(),v=this.screenFieldOfViewExtendedMM(h),C=create$3();this.opts.isSliceMM||(S=this.volumes[0].frac2mmOrtho.slice(),C=clone$2(this.volumes[0].mm2ortho),v=this.screenFieldOfViewExtendedVox(h));let D=this.opts.isRadiologicalConvention&&h<2;g===1/0||g===-1/0?(D=g!==1/0,h===1&&(D=!D)):this.opts.sagittalNoseLeft&&h===2&&(D=!D);let _=0,P=0;h===2?P=D?90:-90:h===1?P=D?180:0:(P=D?180:0,_=D?-90:90);const L=this.gl;let m=!1;if(u[2]===0||u[3]===0){m=!0;const j=L.canvas.width/v.fovMM[0],Y=L.canvas.height/v.fovMM[1],T=Math.min(j,Y),H=j/T,G=Y/T;v.fovMM[0]*=H,v.fovMM[1]*=G;let K=(v.mnMM[0]+v.mxMM[0])*.5;v.mnMM[0]=K-v.fovMM[0]*.5,v.mxMM[0]=K+v.fovMM[0]*.5,K=(v.mnMM[1]+v.mxMM[1])*.5,v.mnMM[1]=K-v.fovMM[1]*.5,v.mxMM[1]=K+v.fovMM[1]*.5,u=[0,0,L.canvas.width,L.canvas.height]}if(isNaN(g)){const j=this.scene.pan2Dxyzmm,Y=this.swizzleVec3MM(fromValues$2(j[0],j[1],j[2]),h),T=this.scene.pan2Dxyzmm[3];v.mnMM[0]-=Y[0],v.mxMM[0]-=Y[0],v.mnMM[1]-=Y[1],v.mxMM[1]-=Y[1],v.mnMM[0]/=T,v.mxMM[0]/=T,v.mnMM[1]/=T,v.mxMM[1]/=T}let k=2;h===1&&(k=1),h===2&&(k=0);let e=this.scene.crosshairPos[k],O=this.frac2mm(this.scene.crosshairPos);!isNaN(g)&&g!==1/0&&g!==-1/0&&(O=this.frac2mm([.5,.5,.5]),O[k]=g,e=this.mm2frac(O)[k]);const q=O[k];L.clear(L.DEPTH_BUFFER_BIT);let Q=this.calculateMvpMatrix2D(u,v.mnMM,v.mxMM,1/0,0,P,_,D);if(g===1/0||g===-1/0){const j=u.slice();this.draw3D(u,Q.modelViewProjectionMatrix,Q.modelMatrix,Q.normalMatrix,P,_);const Y=this.screenSlices[this.screenSlices.length-1];Y.leftTopWidthHeight=j,Y.axCorSag=h,Y.sliceFrac=1/0,Y.AxyzMxy=this.xyMM2xyzMM(h,e),Y.leftTopMM=Q.leftTopMM,Y.fovMM=Q.fovMM;return}L.enable(L.DEPTH_TEST),L.blendFunc(L.SRC_ALPHA,L.ONE_MINUS_SRC_ALPHA),L.disable(L.BLEND),L.depthFunc(L.GREATER),L.disable(L.CULL_FACE);let i0=this.sliceMMShader;if(this.opts.isV1SliceShader&&(i0=this.sliceV1Shader),!i0)throw new Error("slice Shader undefined");if(i0.use(this.gl),L.uniform1f(i0.uniforms.overlayOutlineWidth,this.overlayOutlineWidth),L.uniform1f(i0.uniforms.overlayAlphaShader,this.overlayAlphaShader),L.uniform1i(i0.uniforms.isAlphaClipDark,this.isAlphaClipDark?1:0),L.uniform1i(i0.uniforms.backgroundMasksOverlays,this.backgroundMasksOverlays),L.uniform1f(i0.uniforms.drawOpacity,this.drawOpacity),L.enable(L.BLEND),L.blendFunc(L.SRC_ALPHA,L.ONE_MINUS_SRC_ALPHA),L.uniform1f(i0.uniforms.opacity,this.volumes[0].opacity),L.uniform1i(i0.uniforms.axCorSag,h),L.uniform1f(i0.uniforms.slice,e),L.uniformMatrix4fv(i0.uniforms.frac2mm,!1,S),L.uniformMatrix4fv(i0.uniforms.mvpMtx,!1,Q.modelViewProjectionMatrix.slice()),L.bindVertexArray(this.genericVAO),L.drawArrays(L.TRIANGLE_STRIP,0,4),L.bindVertexArray(this.unusedVAO),this.screenSlices.push({leftTopWidthHeight:u,axCorSag:h,sliceFrac:e,AxyzMxy:this.xyMM2xyzMM(h,e),leftTopMM:Q.leftTopMM,screen2frac:[],fovMM:Q.fovMM}),isNaN(g)&&this.drawCrosshairs3D(!0,1,Q.modelViewProjectionMatrix,!0,this.opts.isSliceMM),this.opts.meshThicknessOn2D>0){this.opts.meshThicknessOn2D!==1/0&&(Q=this.calculateMvpMatrix2D(u,v.mnMM,v.mxMM,this.opts.meshThicknessOn2D,q,P,_,D));const j=clone$2(Q.modelViewProjectionMatrix);multiply(j,j,C),this.drawMesh3D(!0,1,j,Q.modelMatrix,Q.normalMatrix)}isNaN(g)&&this.drawCrosshairs3D(!1,.15,Q.modelViewProjectionMatrix,!0,this.opts.isSliceMM),m&&this.drawSliceOrientationText(u,h),this.readyForSync=!0}draw2D(u,h,g=NaN,S=[NaN,NaN]){const v=[NaN,NaN];if(isNaN(S[0]))this.draw2DMain(u,h,g);else{const C=u.slice();v[0]=Math.floor(.5*(C[2]-S[0])),v[1]=Math.floor(.5*(C[3]-S[1])),C[0]+=v[0],C[1]+=v[1],C[2]=S[0],C[3]=S[1],this.draw2DMain(C,h,g)}g===1/0||g===-1/0||h===4||u[2]!==0&&u[3]!==0&&this.drawSliceOrientationText(u,h,v)}calculateMvpMatrix(u,h=[0,0,0,0],g,S){(h[2]===0||h[3]===0)&&(h=[0,0,this.gl.canvas.width,this.gl.canvas.height]);const v=h[2]/h[3];let C=this.furthestFromPivot;const D=this.pivot3D,_=create$3();C=.8*C/this.scene.volScaleMultiplier,v<1?ortho(_,-C,C,-C/v,C/v,C*.01,C*8):ortho(_,-C*v,C*v,-C,C,C*.01,C*8);const P=create$3();P[0]=-1;const L=fromValues$2(0,0,-C*1.8);translate(P,P,L),this.position&&translate(P,P,this.position),rotateX(P,P,deg2rad(270-S)),rotateZ(P,P,deg2rad(g-180)),translate(P,P,[-D[0],-D[1],-D[2]]);const m=create$3();invert(m,P);const k=create$3();transpose(k,m);const e=create$3();return multiply(e,_,P),[e,P,k]}calculateModelMatrix(u,h){if(!this.back)throw new Error("back undefined");const g=create$3();if(g[0]=-1,rotateX(g,g,deg2rad(270-h)),rotateZ(g,g,deg2rad(u-180)),this.back.obliqueRAS){const S=clone$2(this.back.obliqueRAS);multiply(g,g,S)}return g}calculateRayDirection(u,h){const g=this.calculateModelMatrix(u,h),S=fromValues$3(1,0,0,0,0,-1,0,0,0,0,-1,0,0,0,0,1),v=create$3();multiply(v,S,g);const C=create$3();invert(C,v);const D=fromValues$1(0,0,-1,1);transformMat4(D,D,C);const _=fromValues$2(D[0],D[1],D[2]);normalize$1(_,_);const P=5e-5;return Math.abs(_[0])<P&&(_[0]=P),Math.abs(_[1])<P&&(_[1]=P),Math.abs(_[2])<P&&(_[2]=P),_}sceneExtentsMinMax(u=!0){let h=fromValues$2(0,0,0),g=fromValues$2(0,0,0);if(this.volumes.length>0){if(!this.volumeObject3D)throw new Error("volumeObject3D undefined");h=fromValues$2(this.volumeObject3D.extentsMin[0],this.volumeObject3D.extentsMin[1],this.volumeObject3D.extentsMin[2]),g=fromValues$2(this.volumeObject3D.extentsMax[0],this.volumeObject3D.extentsMax[1],this.volumeObject3D.extentsMax[2]),u||(h=fromValues$2(this.volumes[0].extentsMinOrtho[0],this.volumes[0].extentsMinOrtho[1],this.volumes[0].extentsMinOrtho[2]),g=fromValues$2(this.volumes[0].extentsMaxOrtho[0],this.volumes[0].extentsMaxOrtho[1],this.volumes[0].extentsMaxOrtho[2]))}if(this.meshes.length>0){if(this.volumes.length<1){const v=this.meshes[0].extentsMin,C=this.meshes[0].extentsMax;h=fromValues$2(v[0],v[1],v[2]),g=fromValues$2(C[0],C[1],C[2])}for(let v=0;v<this.meshes.length;v++){const C=this.meshes[v].extentsMin,D=this.meshes[v].extentsMax,_=fromValues$2(C[0],C[1],C[2]);min(h,h,_);const P=fromValues$2(D[0],D[1],D[2]);max$2(g,g,P)}}const S=create$2();return subtract$1(S,g,h),[h,g,S]}setPivot3D(){const[u,h]=this.sceneExtentsMinMax(),g=create$2();add$1(g,u,h),scale$2(g,g,.5),this.pivot3D=[g[0],g[1],g[2]],subtract$1(g,h,u),this.extentsMin=u,this.extentsMax=h,this.furthestFromPivot=length$1(g)*.5}getMaxVols(){if(this.volumes.length<1)return 0;let u=0;for(let h=0;h<this.volumes.length;h++)u=Math.max(u,this.volumes[h].nFrame4D);return u}detectPartialllyLoaded4D(){if(this.volumes.length<1)return!1;for(let u=0;u<this.volumes.length;u++)if(this.volumes[u].nFrame4D<this.volumes[u].hdr.dims[4])return!0;return!1}drawGraph(){if(this.getMaxVols()<2)return;const u=this.graph;let h=0;if(this.graph.autoSizeMultiplanar&&this.opts.sliceType===3)for(let o0=0;o0<this.screenSlices.length;o0++){const c0=this.screenSlices[o0].axCorSag;if(c0===0&&(h=this.screenSlices[o0].leftTopWidthHeight[1]),c0!==2)continue;const d0=this.screenSlices[o0].leftTopWidthHeight.slice();d0[1]===h?(u.LTWH[0]=d0[0]+d0[2],u.LTWH[1]=d0[1]):(u.LTWH[0]=d0[0],u.LTWH[1]=d0[1]+d0[3]),u.LTWH[2]=d0[2],u.LTWH[3]=d0[2]}if(u.opacity<=0||u.LTWH[2]<=5||u.LTWH[3]<=5||u.LTWH[0]+u.LTWH[2]>this.gl.canvas.width||u.LTWH[1]+u.LTWH[3]>this.gl.canvas.height)return;u.backColor=[.15,.15,.15,u.opacity],u.lineColor=[1,1,1,1],this.opts.backColor[0]+this.opts.backColor[1]+this.opts.backColor[2]>1.5&&(u.backColor=[.95,.95,.95,u.opacity],u.lineColor=[0,0,0,1]),u.textColor=u.lineColor.slice(),u.lineThickness=4,u.lineAlpha=1,u.lines=[];const g=[];if(u.vols.length<1)this.volumes[0]!=null&&g.push(0);else for(let o0=0;o0<u.vols.length;o0++){const c0=u.vols[o0];this.volumes[c0]==null||this.volumes[c0].nFrame4D<2||g.push(c0)}if(g.length<1)return;const S=this.volumes[g[0]].nFrame4D;if(this.graph.selectedColumn=this.volumes[g[0]].frame4D,S<2){log.debug("Unable to generate a graph: Selected volume is 3D not 4D");return}for(let o0=0;o0<g.length;o0++){u.lines[o0]=[];const c0=this.frac2vox(this.scene.crosshairPos),d0=this.volumes[g[o0]];let v0=d0.nFrame4D;v0=Math.min(v0,S);for(let g0=0;g0<v0;g0++){const C0=d0.getValue(c0[0],c0[1],c0[2],g0);u.lines[o0].push(C0)}}u.lineRGB=[[1,0,0],[0,.7,0],[0,0,1],[1,1,0],[1,0,1],[0,1,1],[1,1,1],[0,0,0]];let v=u.lines[0][0],C=u.lines[0][0];for(let o0=0;o0<u.lines.length;o0++)for(let c0=0;c0<u.lines[o0].length;c0++){const d0=u.lines[o0][c0];v=Math.min(d0,v),C=Math.max(d0,C)}if(u.normalizeValues&&C>v){const o0=C-v;for(let c0=0;c0<u.lines.length;c0++)for(let d0=0;d0<u.lines[c0].length;d0++){const v0=u.lines[c0][d0];u.lines[c0][d0]=(v0-v)/o0}v=0,C=1}v>=C&&(C=v+1),this.drawRect(u.LTWH,u.backColor);const[D,_,P]=tickSpacing(v,C),L=Math.max(0,-1*Math.floor(Math.log(D)/Math.log(10)));v=Math.min(_,v),C=Math.max(P,C);function m(o0){return o0.toFixed(6).replace(/\.?0*$/,"")}const e=.07*(Math.min(u.LTWH[2],u.LTWH[3])/(this.fontMets.size*this.uiData.dpr));let O=this.opts.textHeight*this.gl.canvas.height*e;O<16&&(O=0);let q=0,Q=_;if(O>0)for(;Q<=C;){const o0=Q.toFixed(L),c0=this.textWidth(O,o0);q=Math.max(c0,q),Q+=D}const i0=.05,j=Math.abs(u.LTWH[2]),Y=Math.abs(u.LTWH[3]),T=[u.LTWH[0]+i0*j+q,u.LTWH[1]+i0*Y,u.LTWH[2]-q-2*i0*j,u.LTWH[3]-O-2*i0*Y];this.graph.LTWH=u.LTWH,this.graph.plotLTWH=T,this.drawRect(T,this.opts.backColor);const H=C-v,G=T[3]/H,K=T[2]/(u.lines[0].length-1),e0=T[1]+T[3];Q=_+.5*D;const z=u.lineColor.slice();for(z[3]=.25*u.lineColor[3];Q<=C;){const o0=e0-(Q-v)*G;this.drawLine([T[0],o0,T[0]+T[2],o0],.5*u.lineThickness,z),Q+=D}Q=_;const f=.5*u.lineThickness;for(;Q<=C;){const o0=e0-(Q-v)*G;this.drawLine([T[0]-f,o0,T[0]+T[2]+u.lineThickness,o0],u.lineThickness,u.lineColor);const c0=Q.toFixed(L);O>0&&this.drawTextLeft([T[0]-6,o0],c0,e,u.textColor),Q+=D}let f0=1;for(;u.lines[0].length/f0>20;)f0*=5;for(let o0=0;o0<u.lines[0].length;o0+=f0){const c0=o0*K+T[0];let d0=u.lineThickness;if(o0%2===1)d0*=.5,this.drawLine([c0,T[1],c0,T[1]+T[3]],d0,z);else{const v0=m(o0);O>0&&this.drawTextBelow([c0,2+T[1]+T[3]],v0,e,u.textColor),this.drawLine([c0,T[1],c0,T[1]+T[3]],d0,u.lineColor)}}for(let o0=0;o0<u.lines.length;o0++){let c0=[1,0,0,u.lineAlpha];o0<u.lineRGB.length&&(c0=[u.lineRGB[o0][0],u.lineRGB[o0][1],u.lineRGB[o0][2],u.lineAlpha]);for(let d0=1;d0<u.lines[o0].length;d0++){const v0=(d0-1)*K,g0=d0*K,C0=(u.lines[o0][d0-1]-v)*G,x0=(u.lines[o0][d0]-v)*G,M0=[T[0]+v0,T[1]+T[3]-C0,T[0]+g0,T[1]+T[3]-x0];this.drawLine(M0,u.lineThickness,c0)}}if(u.selectedColumn>=0&&u.selectedColumn<u.lines[0].length){const o0=u.selectedColumn*K+T[0];this.drawLine([o0,T[1],o0,T[1]+T[3]],u.lineThickness,[u.lineRGB[3][0],u.lineRGB[3][1],u.lineRGB[3][2],1])}this.detectPartialllyLoaded4D()&&this.drawTextBelow([T[0]+T[2],T[1]+T[3]+O*.5],"...",e,u.textColor)}depthPicker(u,h){if(!this.uiData.mouseDepthPicker)return;this.uiData.mouseDepthPicker=!1;const g=this.gl,S=this.mousePos[0]*u[2]/u[2],v=g.canvas.height-this.mousePos[1]*u[3]/u[3]-1,C=new Uint8Array(4);if(g.readPixels(S,v,1,1,g.RGBA,g.UNSIGNED_BYTE,C),this.selectedObjectId=C[3],this.selectedObjectId===this.VOLUME_ID){this.scene.crosshairPos=new Float32Array(C.slice(0,3)).map(k=>k/255);return}const D=unpackFloatFromVec4i(C);if(D>1)return;const _=(this.mousePos[0]-u[0])/u[2],P=(g.canvas.height-this.mousePos[1]-u[1])/u[3],L=unProject(_,P,D,h),m=this.mm2frac(L,0,!0);m[0]<0||m[0]>1||m[1]<0||m[1]>1||m[2]<0||m[2]>1||(this.scene.crosshairPos=this.mm2frac(L,0,!0))}drawImage3D(u,h,g){if(this.volumes.length===0)return;const S=this.gl,v=this.calculateRayDirection(h,g),C=this.volumeObject3D;if(C){S.enable(S.BLEND),S.blendFunc(S.SRC_ALPHA,S.ONE_MINUS_SRC_ALPHA),S.enable(S.CULL_FACE),S.cullFace(S.FRONT);let D=this.renderShader;if(this.uiData.mouseDepthPicker&&(D=this.pickingImageShader),D.use(this.gl),S.uniform1i(D.uniforms.backgroundMasksOverlays,this.backgroundMasksOverlays),this.gradientTextureAmount>0){S.activeTexture(TEXTURE6_GRADIENT),S.bindTexture(S.TEXTURE_3D,this.gradientTexture);const _=this.calculateModelMatrix(h,g),P=create$3();invert(P,_);const L=create$3();transpose(L,P),S.uniformMatrix4fv(D.uniforms.normMtx,!1,L)}this.drawBitmap&&this.drawBitmap.length>8?S.uniform2f(D.uniforms.renderDrawAmbientOcclusionXY,this.renderDrawAmbientOcclusion,this.drawOpacity):S.uniform2f(D.uniforms.renderDrawAmbientOcclusionXY,this.renderDrawAmbientOcclusion,0),S.uniformMatrix4fv(D.uniforms.mvpMtx,!1,u),S.uniformMatrix4fv(D.uniforms.matRAS,!1,this.back.matRAS),S.uniform3fv(D.uniforms.rayDir,v),this.gradientTextureAmount<0?S.uniform4fv(D.uniforms.clipPlane,[this.scene.crosshairPos[0],this.scene.crosshairPos[1],this.scene.crosshairPos[2],30]):S.uniform4fv(D.uniforms.clipPlane,this.scene.clipPlane),S.uniform1f(D.uniforms.drawOpacity,1),S.bindVertexArray(C.vao),S.drawElements(C.mode,C.indexCount,S.UNSIGNED_SHORT,0),S.bindVertexArray(this.unusedVAO)}}drawOrientationCube(u,h=0,g=0){if(!this.opts.isOrientCube)return;const S=.05*Math.min(u[2],u[3]);if(S<5)return;const v=this.gl;v.enable(v.CULL_FACE),v.cullFace(v.BACK),this.orientCubeShader.use(this.gl),v.bindVertexArray(this.orientCubeShaderVAO);const C=create$3(),D=create$3();ortho(D,0,v.canvas.width,0,v.canvas.height,-10*S,10*S);let _=0;u[1]===0&&(_=v.canvas.height-this.effectiveCanvasHeight()),translate(C,C,[1.8*S+u[0],_+1.8*S+u[1],0]),scale$3(C,C,[S,S,S]),rotateX(C,C,deg2rad(270-g)),rotateZ(C,C,deg2rad(-h));const P=create$3();multiply(P,D,C),v.uniformMatrix4fv(this.orientCubeShader.uniforms.u_matrix,!1,P),v.drawArrays(v.TRIANGLE_STRIP,0,168),v.bindVertexArray(this.unusedVAO),this.gl.disable(this.gl.CULL_FACE)}createOnLocationChange(u=NaN){const[h,g,S]=this.sceneExtentsMinMax(!0),v=Math.max(Math.max(S[0],S[1]),S[2]);function C(k){return Math.max(0,-Math.ceil(Math.log10(Math.abs(k))))}let D=C(v*.001);const _=this.frac2mm(this.scene.crosshairPos,0,!0);function P(k,e=0){return parseFloat(k.toFixed(e))}let L=P(_[0],D)+"×"+P(_[1],D)+"×"+P(_[2],D);if(this.volumes.length>0&&this.volumes[0].nFrame4D>0&&(L+="×"+P(this.volumes[0].frame4D)),this.volumes.length>0){let k=" = ";for(let q=0;q<this.volumes.length;q++){const Q=this.volumes[q].mm2vox(_);let i0=this.volumes[q].getValue(Q[0],Q[1],Q[2],this.volumes[q].frame4D);if(D=3,this.volumes[q].colormapLabel!==null){const j=Math.round(i0);j>=0&&j<this.volumes[q].colormapLabel.labels.length?k+=this.volumes[q].colormapLabel.labels[j]:k+="undefined("+P(i0,D)+")"}else k+=P(i0,D);this.volumes[q].imaginary&&(i0=this.volumes[q].getValue(Q[0],Q[1],Q[2],this.volumes[q].frame4D,!0),i0>=0&&(k+="+"),k+=P(i0,D)),k+="   "}L+=k;const e=this.back.dimsRAS,O=e[1]*e[2]*e[3];if(this.drawBitmap&&this.drawBitmap.length===O){const q=this.frac2vox(this.scene.crosshairPos),Q=q[0]+q[1]*e[1]+q[2]*e[1]*e[2];L+=" "+this.drawLut.labels[this.drawBitmap[Q]]}}const m={mm:this.frac2mm(this.scene.crosshairPos,0,!0),axCorSag:u,vox:this.frac2vox(this.scene.crosshairPos),frac:this.scene.crosshairPos,xy:[this.mousePos[0],this.mousePos[1]],values:this.volumes.map(k=>{const e=this.frac2mm(this.scene.crosshairPos,0,!0),O=k.mm2vox(e),q=k.getValue(O[0],O[1],O[2],k.frame4D);return{name:k.name,value:q,id:k.id,mm:e,vox:O}}),string:L};this.onLocationChange(m)}addLabel(u,h,g,S,v){const C={textColor:this.opts.legendTextColor,textScale:1,textAlignment:"left",lineWidth:0,lineColor:this.opts.legendTextColor,lineTerminator:"none",bulletScale:0,bulletColor:this.opts.legendTextColor},D=h?{...C,...h}:{...C},_=new NVLabel3D(u,{...D},g,S,v);return this.document.labels.push(_),_}calculateScreenPoint(u,h,g){const S=create$1();return transformMat4(S,[...u,1],h),S[3]!==0&&(S[0]=(S[0]/S[3]+1)*.5*g[2],S[1]=(1-S[1]/S[3])*.5*g[3],S[2]/=S[3],S[0]+=g[0],S[1]+=g[1]),S}getLabelAtPoint(u){const g=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1,S=this.opts.textHeight*this.gl.canvas.height*1;for(const L of this.document.labels){if(L.anchor==null||L.anchor===0)continue;const m=this.opts.textHeight*this.gl.canvas.height*L.style.textScale,k=this.textHeight(m,L.text),e=this.textWidth(m,L.text);if(!(L.anchor&1&&u[0]>e)&&!(L.anchor&2&&(u[0]<(this.gl.canvas.width-e)/2||u[0]>(this.gl.canvas.width+e)/2))&&!(L.anchor&4&&u[0]<this.gl.canvas.width-e)&&!(L.anchor&8&&(u[1]<S/2||u[1]>k+S/2))&&!(L.anchor&16&&(u[1]<(this.gl.canvas.height-k-S)/2||u[1]>(this.gl.canvas.height+k-S/2)/2))&&!(L.anchor&32&&(u[1]<this.gl.canvas.height-k-S||u[1]>this.gl.canvas.height-S/2)))return L}log.debug("screenPoint",u);const v=this.getLegendPanelHeight(),C=this.getLegendPanelWidth(),D=this.gl.canvas.width-C;let _=(this.canvas.height-v)/2;if(log.debug("panelrect",D,_,D+C,_+v),u[0]<D||u[1]<_||u[0]>D+C||u[1]>_+v)return null;const P=this.getConnectomeLabels();for(const L of P){const m=this.opts.textHeight*this.gl.canvas.height*L.style.textScale,k=this.textHeight(m,L.text);if(u[1]>=_&&u[1]<=_+k+g/2)return L;_+=k,_+=g/2}return null}drawLabelLine(u,h,g,S,v=!1){const C=Array.isArray(u.points)&&Array.isArray(u.points[0])?u.points:[u.points];for(const D of C){const _=this.calculateScreenPoint(D,g,S);v?this.drawDottedLine([...h,_[0],_[1]],u.style.lineWidth,u.style.lineColor):this.draw3DLine(h,[_[0],_[1],_[2]],u.style.lineWidth,u.style.lineColor)}}draw3DLabel(u,h,g,S,v,C,D){const _=u.text,P=h[0],L=h[1],m=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1,k=this.textHeight(u.style.textScale,_)*m;if(u.style.lineWidth>0&&Array.isArray(u.points)&&this.drawLabelLine(u,[P,L+k],g,S,D),u.style.bulletScale){const O=u.style.bulletScale*k,q=k-O,Q=L+q/2+O/2,i0=P+(v-O)/2;this.drawCircle([i0,Q,O,O],u.style.bulletColor)}let e=P;if(C)if(u.style.textAlignment!=="left"){const O=this.textWidth(u.style.textScale,u.text)*m;if(u.style.textAlignment==="right")e=P+C-m*1.5-O;else{const q=C-(v||m);e+=(q-O)/2}}else e+=v;this.drawText([e,L],_,u.style.textScale,u.style.textColor)}draw3DLabels(u,h,g=!1){const S=this.getConnectomeLabels();if(!this.opts.showLegend||S.length===0)return;if(!this.canvas)throw new Error("canvas undefined");const v=this.gl;v.disable(v.CULL_FACE),v.viewport(0,0,this.canvas.width,this.canvas.height);const D=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1,_=this.getBulletMarginWidth(),P=this.getLegendPanelHeight(),L=this.getLegendPanelWidth(),m=v.canvas.width-L;let k=(this.canvas.height-P)/2;this.drawRect([v.canvas.width-L,k,L-D,P],this.opts.legendBackgroundColor);const e=v.getParameter(v.BLEND),O=v.getParameter(v.DEPTH_FUNC);g||(v.disable(v.BLEND),v.depthFunc(v.GREATER));for(const q of S){this.draw3DLabel(q,[m,k],u,h,_,L,g);const Q=this.opts.textHeight*this.gl.canvas.height*q.style.textScale,i0=this.textHeight(Q,q.text);k+=i0,k+=D/2}g||(v.depthFunc(O),e&&v.enable(v.BLEND))}drawAnchoredLabels(){const u=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1,h=this.document.labels.filter(g=>g.anchor!=null&&g.anchor!==0);for(const g of h){const S=g.text,v=this.textHeight(g.style.textScale,S)*u,C=this.textWidth(g.style.textScale,S)*u;let D,_;const L=this.opts.textHeight*this.gl.canvas.height*1,m=L;let k=L/4,e=0,O=0;g.anchor&1&&(D=0),g.anchor&4&&(D=this.canvas.width-C,e-=L/4),g.anchor&2&&(D=(this.canvas.width-C)/2,e-=L/4,k+=L/4),g.anchor&8&&(_=0),g.anchor&16&&(_=(this.canvas.height-v-L)/2,O-=L/4),g.anchor&32&&(_=this.canvas.height-v-L,O-=L/4),this.drawRect([D+e,_+O,C+k,v+m],g.style.backgroundColor),this.draw3DLabel(g,[D,_])}}draw3D(u=[0,0,0,0],h=null,g=null,S=null,v=null,C=0){const D=v!==null;this.setPivot3D(),D||(v=this.scene.renderAzimuth,C=this.scene.renderElevation);const _=this.gl;h===null&&([h,g,S]=this.calculateMvpMatrix(null,u,v,C));let P=[...u];if(u[2]===0||u[3]===0?(u=[0,0,_.canvas.width,_.canvas.height],P=[...u],this.screenSlices.push({leftTopWidthHeight:u,axCorSag:4,sliceFrac:0,AxyzMxy:[],leftTopMM:[],fovMM:[isRadiological(g),0]})):(this.screenSlices.push({leftTopWidthHeight:u.slice(),axCorSag:4,sliceFrac:0,AxyzMxy:[],leftTopMM:[],fovMM:[isRadiological(g),0]}),u[1]=_.canvas.height-u[3]-u[1]),_.enable(_.DEPTH_TEST),_.depthFunc(_.ALWAYS),_.depthMask(!0),_.clearDepth(0),this.draw3DLabels(h,P,!1),_.viewport(u[0],u[1],u[2],u[3]),this.volumes.length>0&&(this.updateInterpolation(0,!0),this.updateInterpolation(1,!0),this.drawImage3D(h,v,C)),this.updateInterpolation(0),this.updateInterpolation(1),D||this.drawCrosshairs3D(!0,1,h),this.drawMesh3D(!0,1,h,g,S),this.uiData.mouseDepthPicker){this.depthPicker(u,h),this.createOnLocationChange(),this.draw3D(u,h,g,S,v,C);return}this.opts.meshXRay>0&&this.drawMesh3D(!1,this.opts.meshXRay,h,g,S),this.draw3DLabels(h,P,!1),_.viewport(u[0],u[1],u[2],u[3]),D||this.drawCrosshairs3D(!1,.15,h),_.viewport(0,0,_.canvas.width,_.canvas.height),this.drawOrientationCube(u,v,C);const L="azimuth: "+this.scene.renderAzimuth.toFixed(0)+" elevation: "+this.scene.renderElevation.toFixed(0);return this.readyForSync=!0,this.sync(),this.draw3DLabels(h,P,!0),L}drawMesh3D(u=!0,h=1,g,S,v){if(this.meshes.length<1)return;const C=this.gl;g||([g,S,v]=this.calculateMvpMatrix(this.volumeObject3D,void 0,this.scene.renderAzimuth,this.scene.renderElevation)),C.enable(C.DEPTH_TEST),C.blendFunc(C.SRC_ALPHA,C.ONE_MINUS_SRC_ALPHA),C.disable(C.BLEND),C.depthFunc(C.GREATER),C.disable(C.CULL_FACE),u?(C.disable(C.BLEND),C.depthFunc(C.GREATER)):(C.enable(C.BLEND),C.depthFunc(C.ALWAYS),C.enable(C.CULL_FACE)),C.cullFace(C.BACK);let D=this.meshShaders[0].shader,_=!1;for(let P=0;P<this.meshes.length;P++)if(this.meshes[P].visible!==!1&&(D=this.meshShaders[this.meshes[P].meshShaderIndex].shader,this.uiData.mouseDepthPicker&&(D=this.pickingMeshShader),D.use(this.gl),C.uniformMatrix4fv(D.uniforms.mvpMtx,!1,g),C.uniformMatrix4fv(D.uniforms.normMtx,!1,v),C.uniform1f(D.uniforms.opacity,h),!(this.meshes[P].indexCount<3))){if(this.meshes[P].offsetPt0&&(this.meshes[P].fiberSides<3||this.meshes[P].fiberRadius<=0)){_=!0;continue}D.isMatcap&&(C.activeTexture(TEXTURE5_MATCAP),C.bindTexture(C.TEXTURE_2D,this.matCapTexture)),C.bindVertexArray(this.meshes[P].vao),C.drawElements(C.TRIANGLES,this.meshes[P].indexCount,C.UNSIGNED_INT,0),C.bindVertexArray(this.unusedVAO)}if(!_){C.enable(C.BLEND),C.depthFunc(C.ALWAYS);return}D=this.fiberShader,D.use(this.gl),C.uniformMatrix4fv(D.uniforms.mvpMtx,!1,g),C.uniform1f(D.uniforms.opacity,h);for(let P=0;P<this.meshes.length;P++)this.meshes[P].indexCount<3||this.meshes[P].offsetPt0&&(this.meshes[P].fiberSides>=3&&this.meshes[P].fiberRadius>0||(C.bindVertexArray(this.meshes[P].vaoFiber),C.drawElements(C.LINE_STRIP,this.meshes[P].indexCount,C.UNSIGNED_INT,0),C.bindVertexArray(this.unusedVAO)));C.enable(C.BLEND),C.depthFunc(C.ALWAYS),this.readyForSync=!0}drawCrosshairs3D(u=!0,h=1,g=null,S=!1,v=!0){if(!this.opts.show3Dcrosshair&&!S||this.opts.crosshairWidth<=0&&S)return;const C=this.gl,D=this.frac2mm(this.scene.crosshairPos,0,v);if(this.crosshairs3D===null||this.crosshairs3D.mm[0]!==D[0]||this.crosshairs3D.mm[1]!==D[1]||this.crosshairs3D.mm[2]!==D[2]){this.crosshairs3D!==null&&(C.deleteBuffer(this.crosshairs3D.indexBuffer),C.deleteBuffer(this.crosshairs3D.vertexBuffer));const[L,m,k]=this.sceneExtentsMinMax(v);let e=1;if(this.volumes.length>0){if(!this.back)throw new Error("back undefined");e=.5*Math.min(Math.min(this.back.pixDims[1],this.back.pixDims[2]),this.back.pixDims[3])}else(k[0]<50||k[0]>1e3)&&(e=k[0]*.02);e*=this.opts.crosshairWidth,this.crosshairs3D=NiivueObject3D.generateCrosshairs(this.gl,1,D,L,m,e,20,this.opts.crosshairGap),this.crosshairs3D.mm=D}if(!this.surfaceShader)throw new Error("surfaceShader undefined");const _=this.surfaceShader;_.use(this.gl),g==null&&([g]=this.calculateMvpMatrix(this.crosshairs3D,void 0,this.scene.renderAzimuth,this.scene.renderElevation)),C.uniformMatrix4fv(_.uniforms.mvpMtx,!1,g),C.bindBuffer(C.ELEMENT_ARRAY_BUFFER,this.crosshairs3D.indexBuffer),C.enable(C.DEPTH_TEST);const P=[...this.opts.crosshairColor];u?(C.disable(C.BLEND),C.depthFunc(C.GREATER)):(C.enable(C.BLEND),C.blendFunc(C.SRC_ALPHA,C.ONE_MINUS_SRC_ALPHA),C.depthFunc(C.ALWAYS)),P[3]=h,C.uniform4fv(_.uniforms.surfaceColor,P),C.bindVertexArray(this.crosshairs3D.vao),C.drawElements(C.TRIANGLES,this.crosshairs3D.indexCount,C.UNSIGNED_INT,0),C.bindVertexArray(this.unusedVAO)}mm2frac(u,h=0,g=!1){if(this.volumes.length<1){const S=fromValues$2(.1,.5,.5),[v,C,D]=this.sceneExtentsMinMax();return S[0]=(u[0]-v[0])/D[0],S[1]=(u[1]-v[1])/D[1],S[2]=(u[2]-v[2])/D[2],isFinite(S)||(isFinite(S[0])||(S[0]=.5),isFinite(S[1])||(S[1]=.5),isFinite(S[2])||(S[2]=.5),this.meshes.length<1&&log.error("mm2frac() not finite: objects not (yet) loaded.")),S}return this.volumes[h].convertMM2Frac(u,g||this.opts.isSliceMM)}vox2frac(u,h=0){return this.volumes[h].convertVox2Frac(u)}frac2vox(u,h=0){return this.volumes.length<=h?[0,0,0]:this.volumes[h].convertFrac2Vox(u)}moveCrosshairInVox(u,h,g){const S=this.frac2vox(this.scene.crosshairPos);S[0]+=u,S[1]+=h,S[2]+=g,S[0]=clamp(S[0],0,this.volumes[0].dimsRAS[1]-1),S[1]=clamp(S[1],0,this.volumes[0].dimsRAS[2]-1),S[2]=clamp(S[2],0,this.volumes[0].dimsRAS[3]-1),this.scene.crosshairPos=this.vox2frac(S),this.createOnLocationChange(),this.drawScene()}frac2mm(u,h=0,g=!1){const S=fromValues$1(u[0],u[1],u[2],1);if(this.volumes.length>0)return this.volumes[h].convertFrac2MM(u,g||this.opts.isSliceMM);{const[v,C]=this.sceneExtentsMinMax(),D=(_,P,L)=>_*(1-L)+P*L;S[0]=D(v[0],C[0],u[0]),S[1]=D(v[1],C[1],u[1]),S[2]=D(v[2],C[2],u[2])}return S}screenXY2TextureFrac(u,h,g,S=!0){const v=fromValues$2(-1,-1,-1),C=this.screenSlices[g].axCorSag;if(C>2)return v;const D=this.screenSlices[g].leftTopWidthHeight.slice();let _=!1;D[2]<0&&(_=!0,D[0]+=D[2],D[2]=-D[2]);let P=(u-D[0])/D[2];_&&(P=1-P);const L=1-(h-D[1])/D[3];if(P<0||P>1||L<0||L>1||this.screenSlices[g].AxyzMxy.length<4)return v;let m=fromValues$2(0,0,0);m[0]=this.screenSlices[g].leftTopMM[0]+P*this.screenSlices[g].fovMM[0],m[1]=this.screenSlices[g].leftTopMM[1]+L*this.screenSlices[g].fovMM[1];const k=this.screenSlices[g].AxyzMxy;m[2]=k[2]+k[4]*(m[1]-k[1])-k[3]*(m[0]-k[0]),C===1&&(m=swizzleVec3(m,[0,2,1])),C===2&&(m=swizzleVec3(m,[2,0,1]));const e=this.mm2frac(m);return S&&(e[0]<0||e[0]>1||e[1]<0||e[1]>1||e[2]<0||e[2]>1)?v:e}canvasPos2frac(u){for(let h=0;h<this.screenSlices.length;h++){const g=this.screenXY2TextureFrac(u[0],u[1],h);if(g[0]>=0)return g}return[-1,-1,-1]}scaleSlice(u,h,g=0,S=0){const v=this.effectiveCanvasWidth()-g,C=this.effectiveCanvasHeight()-S;let D=v/u;h*D>C&&(D=C/h);const _=u*D,P=h*D;return[(v-_)*.5,(C-P)*.5,_,P,D]}drawThumbnail(){if(!this.bmpShader)throw new Error("bmpShader undefined");this.bmpShader.use(this.gl),this.gl.uniform2f(this.bmpShader.uniforms.canvasWidthHeight,this.gl.canvas.width,this.gl.canvas.height);let u=this.gl.canvas.height,h=this.gl.canvas.height*this.bmpTextureWH;h>this.gl.canvas.width&&(u=this.gl.canvas.width/this.bmpTextureWH,h=this.gl.canvas.width),this.gl.uniform4f(this.bmpShader.uniforms.leftTopWidthHeight,0,0,h,u),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawLine(u,h=1,g=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl),g[3]<0&&(g=this.opts.crosshairColor),this.gl.uniform4fv(this.lineShader.uniforms.lineColor,g),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,h),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,u),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}draw3DLine(u,h,g=1,S=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.line3DShader)throw new Error("line3DShader undefined");this.line3DShader.use(this.gl),S[3]<0&&(S=this.opts.crosshairColor),this.gl.uniform4fv(this.line3DShader.uniforms.lineColor,S),this.gl.uniform2fv(this.line3DShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.line3DShader.uniforms.thickness,g),this.gl.uniform2fv(this.line3DShader.uniforms.startXY,u),this.gl.uniform3fv(this.line3DShader.uniforms.endXYZ,h),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawDottedLine(u,h=1,g=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl);const S=g[3]<0?[...this.opts.crosshairColor]:[...g];S[3]=.3;const v=fromValues(u[2]-u[0],u[3]-u[1]),C=length(v);normalize(v,v);const _=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1;scale(v,v,_/2);const P=length(v);let L=Math.floor(C/P);C%P&&L++;const m=[u[0],u[1]];this.gl.uniform4fv(this.lineShader.uniforms.lineColor,S),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,h);for(let k=0;k<L-1;k++){if(k%2){m[0]+=v[0],m[1]+=v[1];continue}const e=[m[0],m[1],m[0]+v[0],m[1]+v[1]];this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,e),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),m[0]+=v[0],m[1]+=v[1]}this.gl.bindVertexArray(this.unusedVAO)}drawGraphLine(u,h=[1,0,0,.5],g=2){this.drawLine(u,g,h)}drawCrossLinesMM(u,h,g,S,v){if(u<0||this.screenSlices.length<=u)return;const C=this.screenSlices[u];let D=C.sliceFrac;D===1/0&&log.warn("Rendering approximate cross lines in world view mode"),D===1/0&&(D=.5);let P=S.slice(),L=v.slice();const m=Math.max(1,this.opts.crosshairWidth);h===1&&(P=g.slice()),h===2&&(P=g.slice(),L=S.slice());function k(e){const O=fromValues(0,0);return O[0]=C.leftTopWidthHeight[0]+(e[0]-C.leftTopMM[0])/C.fovMM[0]*C.leftTopWidthHeight[2],O[1]=C.leftTopWidthHeight[1]+C.leftTopWidthHeight[3]-(e[1]-C.leftTopMM[1])/C.fovMM[1]*C.leftTopWidthHeight[3],O}if(P.length>0&&h===0){const e=D,O=1;for(let q=0;q<P.length;q++){const Q=this.frac2mm([.5,.5,.5]);Q[O]=P[q];let i0=this.mm2frac(Q);i0=i0[O];let j=this.frac2mm([0,i0,e]);j=swizzleVec3(j,[0,1,2]);let Y=this.frac2mm([1,i0,e]);Y=swizzleVec3(Y,[0,1,2]),j=k(j),Y=k(Y),this.drawLine([j[0],j[1],Y[0],Y[1]],m)}}if(P.length>0&&h===1){const e=D,O=2;for(let q=0;q<P.length;q++){const Q=this.frac2mm([.5,.5,.5]);Q[O]=P[q];let i0=this.mm2frac(Q);i0=i0[O];let j=this.frac2mm([0,e,i0]);j=swizzleVec3(j,[0,2,1]);let Y=this.frac2mm([1,e,i0]);Y=swizzleVec3(Y,[0,2,1]),j=k(j),Y=k(Y),this.drawLine([j[0],j[1],Y[0],Y[1]],m)}}if(P.length>0&&h===2){const e=D,O=2;for(let q=0;q<P.length;q++){const Q=this.frac2mm([.5,.5,.5]);Q[O]=P[q];let i0=this.mm2frac(Q);i0=i0[O];let j=this.frac2mm([e,0,i0]);j=swizzleVec3(j,[1,2,0]);let Y=this.frac2mm([e,1,i0]);Y=swizzleVec3(Y,[1,2,0]),j=k(j),Y=k(Y),this.drawLine([j[0],j[1],Y[0],Y[1]],m)}}if(L.length>0&&h===0){const e=D,O=0;for(let q=0;q<L.length;q++){const Q=this.frac2mm([.5,.5,.5]);Q[O]=L[q];let i0=this.mm2frac(Q);i0=i0[O];let j=this.frac2mm([i0,0,e]);j=swizzleVec3(j,[0,1,2]);let Y=this.frac2mm([i0,1,e]);Y=swizzleVec3(Y,[0,1,2]),j=k(j),Y=k(Y),this.drawLine([j[0],j[1],Y[0],Y[1]],m)}}if(L.length>0&&h===1){const e=D,O=0;for(let q=0;q<L.length;q++){const Q=this.frac2mm([.5,.5,.5]);Q[O]=L[q];let i0=this.mm2frac(Q);i0=i0[O];let j=this.frac2mm([i0,e,0]);j=swizzleVec3(j,[0,2,1]);let Y=this.frac2mm([i0,e,1]);Y=swizzleVec3(Y,[0,2,1]),j=k(j),Y=k(Y),this.drawLine([j[0],j[1],Y[0],Y[1]],m)}}if(L.length>0&&h===2){const e=D,O=1;for(let q=0;q<L.length;q++){const Q=this.frac2mm([.5,.5,.5]);Q[O]=L[q];let i0=this.mm2frac(Q);i0=i0[O];let j=this.frac2mm([e,i0,0]);j=swizzleVec3(j,[1,2,0]);let Y=this.frac2mm([e,i0,1]);Y=swizzleVec3(Y,[1,2,0]),j=k(j),Y=k(Y),this.drawLine([j[0],j[1],Y[0],Y[1]],m)}}}drawCrossLines(u,h,g,S,v){if(u<0||this.screenSlices.length<=u)return;if(this.opts.isSliceMM)return this.drawCrossLinesMM(u,h,g,S,v);if(this.screenSlices[u].sliceFrac===1/0)return this.drawCrossLinesMM(u,h,g,S,v);const C=this.screenSlices[u];let D=S.slice(),_=v.slice();if(h===1&&(D=g.slice()),h===2&&(D=g.slice(),_=S.slice()),D.length>0){const P=C.leftTopWidthHeight.slice();let L=2;h===0&&(L=1);const m=this.frac2mm([.5,.5,.5]);for(let k=0;k<D.length;k++){m[L]=D[k];const e=this.mm2frac(m);this.drawRect([P[0],P[1]+P[3]-e[L]*P[3],P[2],1])}}if(_.length>0){const P=C.leftTopWidthHeight.slice(),L=C.fovMM[0]<0;let m=0;h===2&&(m=1);const k=this.frac2mm([.5,.5,.5]);for(let e=0;e<_.length;e++){k[m]=_[e];const O=this.mm2frac(k);L?this.drawRect([P[0]+(P[2]-O[m]*P[2]),P[1],1,P[3]]):this.drawRect([P[0]+O[m]*P[2],P[1],1,P[3]])}}}drawMosaic(u){if(this.volumes.length===0){log.debug("Unable to draw mosaic until voxel-based image is loaded");return}this.screenSlices=[];const h=this.screenFieldOfViewMM(0,!0),g=this.screenFieldOfViewMM(0);u=u.replaceAll(";"," ;").trim();const S=[],v=[],C=[],D=u.split(/\s+/);let _=1;const P=this.opts.textHeight;let L=0,m=0;for(let k=0;k<2;k++){let e=!1,O=!1;e=!1;let q=0,Q=0,i0=0,j=0,Y=!1,T=0;for(let K=0;K<D.length;K++){const e0=D[K];if(e0.includes("X")){O=!0;continue}if(e0.includes("L")){Y=!e0.includes("-");continue}if(e0.includes("V")||e0.includes("H")){K++;continue}e0.includes("A")&&(T=0),e0.includes("C")&&(T=1),e0.includes("S")&&(T=2),e0.includes("R")&&(e=!0),e0.includes(";")&&(i0+=q,j=Math.max(j,Q),q=0,Q=0);const z=parseFloat(e0);if(isNaN(z))continue;let f=0,f0=0,o0=g;if(e&&(o0=h),T===2?f=o0[1]:f=o0[0],T===0?f0=o0[1]:f0=o0[2],k===0)e||(T===0&&S.push(z),T===1&&v.push(z),T===2&&C.push(z));else{const c0=[L+_*Q,m+_*i0,_*f,_*f0];if(this.opts.textHeight=Y?P:0,e){let d0=z<0?-1/0:1/0;Object.is(z,-0)&&(d0=-1/0),this.draw2D(c0,T,d0)}else this.draw2D(c0,T,z);O&&this.drawCrossLines(this.screenSlices.length-1,T,S,v,C),e=!1,O=!1}Q+=f,q=Math.max(q,f0)}if(i0+=q,j=Math.max(j,Q),j<=0||i0<=0)break;const H=this.gl.canvas.width/j,G=this.effectiveCanvasHeight()/i0;_=Math.min(H,G),this.opts.centerMosaic&&(L=Math.floor(.5*(this.gl.canvas.width-j*_)),m=Math.floor(.5*(this.effectiveCanvasHeight()-i0*_)))}this.opts.textHeight=P}drawSceneCore(){if(!this.initialized)return;if(this.colorbarHeight=0,this.gl.clearColor(this.opts.backColor[0],this.opts.backColor[1],this.opts.backColor[2],this.opts.backColor[3]),this.gl.clear(this.gl.COLOR_BUFFER_BIT|this.gl.DEPTH_BUFFER_BIT),this.bmpTexture&&this.thumbnailVisible){this.drawThumbnail();return}let u="";if(this.volumes.length===0||typeof this.volumes[0].dims>"u"){if(this.meshes.length>0){this.screenSlices=[],this.opts.sliceType=4,this.draw3D(),this.opts.isColorbar&&this.drawColorbar();return}this.drawLoadingText(this.loadingText);return}if(this.back===null)return;if(this.uiData.isDragging&&this.scene.clipPlaneDepthAziElev[0]<1.8&&this.inRenderTile(this.uiData.dragStart[0],this.uiData.dragStart[1])>=0){const v=this.uiData.dragStart[0]-this.uiData.dragEnd[0],C=this.uiData.dragStart[1]-this.uiData.dragEnd[1],D=this.uiData.dragClipPlaneStartDepthAziElev.slice();if(D[1]-=v,D[1]=D[1]%360,D[2]+=C,D[1]!==this.scene.clipPlaneDepthAziElev[1]||D[2]!==this.scene.clipPlaneDepthAziElev[2])return this.scene.clipPlaneDepthAziElev=D,this.setClipPlane(this.scene.clipPlaneDepthAziElev)}if(this.sliceMosaicString.length<1&&this.opts.sliceType===4){this.opts.isColorbar&&this.reserveColorbarPanel(),this.screenSlices=[],this.draw3D(),this.opts.isColorbar&&this.drawColorbar();return}this.opts.isColorbar&&this.reserveColorbarPanel();const h=this.getMaxVols(),g=this.opts.sliceType===3&&h>1&&this.graph.autoSizeMultiplanar&&this.graph.opacity>0;if(this.sliceMosaicString.length>0)this.drawMosaic(this.sliceMosaicString);else if(this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.screenSlices=[],this.opts.sliceType===0)this.draw2D([0,0,0,0],0);else if(this.opts.sliceType===1)this.draw2D([0,0,0,0],1);else if(this.opts.sliceType===2)this.draw2D([0,0,0,0],2);else{let v=!1;this.opts.multiplanarForceRender?(v=!0,this.opts.multiplanarForceRender?this.opts.multiplanarShowRender=1:this.opts.multiplanarShowRender=2,delete this.opts.multiplanarForceRender):this.opts.multiplanarShowRender===1&&(v=!0);const C=isFinite(this.drawPenLocation[0])&&this.opts.drawingEnabled,{volScale:D}=this.sliceScale(),_=D.slice();this.opts.multiplanarEqualSize&&(D[0]=1,D[1]=1,D[2]=1),typeof this.opts.multiplanarPadPixels!="number"&&log.debug("multiplanarPadPixels must be numeric");const P=parseFloat(`${this.opts.multiplanarPadPixels}`),L=this.scaleSlice(D[0]+D[1],D[1]+D[2],P*1,P*1),m=Math.max(Math.max(D[1],D[2]),D[0]),k=this.scaleSlice(D[0]+D[0]+D[1],Math.max(D[1],D[2]),P*2),e=this.scaleSlice(D[0]+D[0]+D[1]+m,Math.max(D[1],D[2]),P*3),O=this.scaleSlice(m,D[1]+D[2]+D[2],0,P*2),q=this.scaleSlice(m,D[1]+D[2]+D[2]+m,0,P*3);let Q=!C&&(h<2||!g),i0=!1,j=!1,Y=!1;this.opts.multiplanarLayout===1?i0=!0:this.opts.multiplanarLayout===2?j=!0:this.opts.multiplanarLayout===3?Y=!0:O[4]>k[4]&&O[4]>L[4]?i0=!0:k[4]>L[4]?Y=!0:j=!0;let T=L;i0?(T=O,v||this.opts.multiplanarShowRender===2&&q[4]>=O[4]?T=q:Q=!1):Y&&(T=k,v||this.opts.multiplanarShowRender===2&&e[4]>=k[4]?T=e:Q=!1);const H=D[0]*T[4],G=D[1]*T[4],K=D[2]*T[4],e0=_[0]*T[4],z=_[1]*T[4],f=_[2]*T[4];if(i0){if(this.draw2D([T[0],T[1],H,G],0,NaN,[e0,z]),this.draw2D([T[0],T[1]+G+P,H,K],1,NaN,[e0,f]),this.draw2D([T[0],T[1]+G+P+K+P,G,K],2,NaN,[z,f]),Q){const f0=m*T[4];this.draw3D([T[0],T[1]+G+K+K+P*3,f0,f0])}}else if(Y){if(this.draw2D([T[0],T[1],H,G],0,NaN,[e0,z]),this.draw2D([T[0]+H+P,T[1],H,K],1,NaN,[e0,f]),this.draw2D([T[0]+H+H+P*2,T[1],G,K],2,NaN,[z,f]),Q){const f0=m*T[4];this.draw3D([T[0]+H+H+G+P*3,T[1],f0,f0])}}else j&&(v||(Q=!1),this.opts.multiplanarShowRender===2&&(Q=!0),this.draw2D([T[0],T[1]+K+P,H,G],0,NaN,[e0,z]),this.draw2D([T[0],T[1],H,K],1,NaN,[e0,f]),this.draw2D([T[0]+H+P,T[1],G,K],2,NaN,[z,f]),Q&&this.draw3D([T[0]+H+P,T[1]+K+P,G,G]))}if(this.opts.isRuler&&this.drawRuler(),this.opts.isColorbar&&this.drawColorbar(),g&&this.drawGraph(),this.uiData.isDragging){if(this.uiData.mouseButtonCenterDown){this.dragForCenterButton([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.opts.dragMode===4){this.dragForSlicer3D([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.opts.dragMode===3){this.dragForPanZoom([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.inRenderTile(this.uiData.dragStart[0],this.uiData.dragStart[1])>=0)return;if(this.opts.dragMode===2){this.drawMeasurementTool([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}const v=Math.abs(this.uiData.dragStart[0]-this.uiData.dragEnd[0]),C=Math.abs(this.uiData.dragStart[1]-this.uiData.dragEnd[1]);this.drawSelectionBox([Math.min(this.uiData.dragStart[0],this.uiData.dragEnd[0]),Math.min(this.uiData.dragStart[1],this.uiData.dragEnd[1]),v,C])}if(this.opts.clickToSegment){const v=this.mousePos[0],C=this.mousePos[1],D=this.tileIndex(v,C);if(D>-1){const _=this.screenSlices[D].fovMM,L=this.screenSlices[D].leftTopWidthHeight[2]/_[0],m=this.opts.crosshairColor,k=[m[0],m[1],m[2],.4],e=this.opts.clickToSegmentRadius*L;this.drawCircle([v-e,C-e,e*2,e*2],k,1)}}const S=this.frac2mm([this.scene.crosshairPos[0],this.scene.crosshairPos[1],this.scene.crosshairPos[2]]);return u=S[0].toFixed(2)+"×"+S[1].toFixed(2)+"×"+S[2].toFixed(2),this.readyForSync=!0,this.sync(),this.drawAnchoredLabels(),u}drawScene(){if(this.isBusy){this.needsRefresh=!0;return}this.isBusy=!1,this.needsRefresh=!1;let u=this.drawSceneCore();return this._gl!==null&&this.gl.finish(),this.needsRefresh&&(u=this.drawScene()),u}get gl(){if(!this._gl)throw new Error("unable to get WebGL context. Maybe the browser doesn't support WebGL2.");return this._gl}set gl(u){this._gl=u}},Dcm2niix=class{constructor(){this.worker=null}init(){return this.worker=new Worker(new URL(""+new URL("worker-BxHQgUvF.js",import.meta.url).href,import.meta.url),{type:"module"}),new Promise((w,u)=>{this.worker.onmessage=h=>{h.data&&h.data.type==="ready"&&w(!0)},this.worker.onerror=h=>{u(new Error(`Worker failed to load: ${h.message}`))}})}conformFileList(w){return Array.from(w).map(h=>({file:h,webkitRelativePath:h.webkitRelativePath||h._webkitRelativePath||""}))}input(w){const u=this.conformFileList(w);return new Processor({worker:this.worker,fileList:u})}inputFromWebkitDirectory(w){const u=this.conformFileList(w);return new Processor({worker:this.worker,fileList:u})}inputFromDropItems(w){const u=this.conformFileList(w);return new Processor({worker:this.worker,fileList:u})}},Processor=class{constructor({worker:w,fileList:u}){this.worker=w,this.fileList=u,this.commands=[]}_addCommand(w,...u){return this.commands.push(w,...u.map(String)),this}version(){return this._addCommand("--version")}compressionLevel(w){return this._addCommand(`-${w}`)}a(w){return this._addCommand("-a",w)}adjacent(w){return this.a(w)}b(w){return this._addCommand("-b",w)}bids(w){return this.b(w)}ba(w){return this._addCommand("-ba",w)}bidsAnonymize(w){return this.ba(w)}c(w){return this._addCommand("-c",w)}comment(w){return this.c(w)}d(w){return this._addCommand("-d",w)}directorySearchDepth(w){return this.d(w)}e(w){return this._addCommand("-e",w)}exportFormat(w){return this.e(w)}f(w){return this._addCommand("-f",w)}filenameformat(w){return this.f(w)}i(w){return this._addCommand("-i",w)}ignoreDerived(w){return this.i(w)}l(w){return this._addCommand("-l",w)}losslessScale(w){return this.l(w)}m(w){return this._addCommand("-m",w)}merge2DSlices(w){return this.m(w)}n(w){return this._addCommand("-n",w)}seriesCRC(w){return this.n(w)}p(w){return this._addCommand("-p",w)}philipsPreciseFloat(w){return this.p(w)}q(w){return this._addCommand("-q",w)}searchDirectory(w){return this.q(w)}r(w){return this._addCommand("-r",w)}renameOnly(w){return this.r(w)}s(w){return this._addCommand("-s",w)}singleFileMode(w){return this.s(w)}v(w){return this._addCommand("-v",w)}verbose(w){return this.v(w)}w(w){return this._addCommand("-w",w)}writeBehavior(w){return this.w(w)}x(w){return this._addCommand("-x",w)}crop(w){return this.x(w)}z(w){return this._addCommand("-z",w)}gzip(w){return this.z(w)}bigEndian(w){return this._addCommand("--big-endian",w)}ignoreTriggerTimes(){return this._addCommand("--ignore_trigger_times")}terse(){return this._addCommand("--terse")}xml(){return this._addCommand("--xml")}async run(){return new Promise((w,u)=>{this.worker.onmessage=g=>{if(g.data.type==="error")u(new Error(g.data.message));else{const{convertedFiles:S,exitCode:v}=g.data;v===0||v===3?w(S):u(new Error(`dcm2niix processing failed with exit code ${v}`))}};const h=[...this.commands];this.worker===null&&u(new Error("Worker not initialized. Did you await the init() method?")),this.worker.postMessage({fileList:this.fileList,cmd:h})})}};const nv=new Niivue({dragAndDropEnabled:!1});let resultFileList=[],conversionTime=0;const handleSaveButtonClick=()=>{const w=nv.volumes[0].name;nv.volumes[0].saveToDisk(w)},showSaveButton=()=>{document.getElementById("saveButton").classList.remove("hidden")},hideSaveButton=()=>{document.getElementById("saveButton").classList.add("hidden")},showLoadingCircle=()=>{loadingCircle.classList.remove("hidden")},hideLoadingCircle=()=>{loadingCircle.classList.add("hidden")},hideFileSelect=()=>{fileSelect.classList.add("hidden")},showFileSelect=()=>{fileSelect.classList.remove("hidden")},handleLocationChange=w=>{document.getElementById("intensity").innerHTML=w.string},showText=w=>{document.getElementById("intensity").innerHTML=w},removeAllVolumes=()=>{const w=nv.volumes;for(let u=0;u<w.length;u++)nv.removeVolume(w[u])},handleFileSelectChange=async w=>{if(resultFileList.length===0){console.log("No files to select from");return}const u=parseInt(w.target.value);if(u===-1)return;removeAllVolumes();const h=resultFileList[u];console.log(h);const g=await NVImage.loadFromFile({file:h,name:h.name});await nv.addVolume(g),showSaveButton()},removeSelectItems=()=>{const w=document.getElementById("fileSelect");for(;w.firstChild;)w.removeChild(w.firstChild)},updateSelectItems=w=>{removeSelectItems();const u=document.getElementById("fileSelect");u.innerHTML="";for(let g=0;g<w.length;g++){const S=document.createElement("option");S.value=g,S.text=w[g].name,u.appendChild(S)}const h=document.createElement("option");h.value=-1,h.text="Select a file",h.selected=!0,u.appendChild(h)},runDcm2niix=async w=>{try{hideSaveButton(),showLoadingCircle();const u=new Dcm2niix;await u.init();const h=Date.now();resultFileList=await u.input(w).run(),conversionTime=(Date.now()-h)/1e3,showText(`Conversion time: ${conversionTime} seconds`),resultFileList=resultFileList.filter(v=>v.name.endsWith(".nii")),updateSelectItems(resultFileList),console.log(resultFileList),hideLoadingCircle(),showFileSelect(),fileSelect.value=0;const S=new Event("change");fileSelect.dispatchEvent(S)}catch(u){console.error(u),resultFileList=[],hideLoadingCircle(),hideFileSelect(),showText("Error converting files. Check the console for more information.")}},ensureObjectOfObjects=w=>w.length?w:{0:w};async function handleDrop(w){w.preventDefault();const u=w.dataTransfer.items;try{showLoadingCircle();const h=[];for(let v=0;v<u.length;v++){const C=u[v].webkitGetAsEntry();C&&await traverseFileTree(C,"",h)}const g=new Dcm2niix;await g.init(),resultFileList=await g.inputFromDropItems(h).run(),resultFileList=resultFileList.filter(v=>v.name.endsWith(".nii")),updateSelectItems(resultFileList),console.log(resultFileList),hideLoadingCircle(),showFileSelect(),fileSelect.value=0;const S=new Event("change");fileSelect.dispatchEvent(S),showText("")}catch(h){console.error(h),hideLoadingCircle(),hideFileSelect(),showText("Error converting files. Check the console for more information.")}}async function traverseFileTree(w,u="",h){return new Promise(g=>{if(w.isFile)w.file(S=>{S.fullPath=u+S.name,S._webkitRelativePath=u+S.name,h.push(S),g()});else if(w.isDirectory){const S=w.createReader(),v=()=>{S.readEntries(C=>{if(C.length>0){const D=[];for(const _ of C)D.push(traverseFileTree(_,u+w.name+"/",h));Promise.all(D).then(v)}else g()})};v()}})}async function main(){fileInput.addEventListener("change",async u=>{if(u.target.files.length===0){console.log("No files selected");return}console.log("Selected files:",u.target.files);const h=u.target.files,g=ensureObjectOfObjects(h);await runDcm2niix(g)}),fileSelect.onchange=handleFileSelectChange,dropTarget.ondrop=handleDrop,dropTarget.ondragover=u=>{u.preventDefault()},saveButton.onclick=handleSaveButtonClick,nv.onLocationChange=handleLocationChange;const w=document.getElementById("gl");nv.attachToCanvas(w),nv.opts.yoke3Dto2DZoom=!0,nv.opts.crosshairGap=5,nv.setInterpolation(!0),nv.setMultiplanarLayout(MULTIPLANAR_TYPE.GRID),nv.setSliceType(SLICE_TYPE.MULTIPLANAR),nv.opts.multiplanarShowRender=SHOW_RENDER.ALWAYS,nv.opts.dragMode=DRAG_MODE.slicer3D}main();
+Ooh no!!`);break}v[_]=P,D=Math.min(D,P)}for(let _=0;_<g;_++)u[v[_]-1]=D}translate_labels(u,h,g,S){const v=h[0]*h[1]*h[2];let C=0;const D=new Uint32Array(v).fill(0);for(let L=0;L<S;L++)C=Math.max(C,g[L]);const _=new Uint32Array(C).fill(0);let P=0;for(let L=0;L<v;L++)u[L]&&(_[g[u[L]-1]-1]||(P+=1,_[g[u[L]-1]-1]=P),D[L]=_[g[u[L]-1]-1]);return[P,D]}largest_original_cluster_labels(u,h,g){const S=u.length,v=new Uint32Array(h+1).fill(0),C=new Uint32Array(h+1).fill(0);for(let P=0;P<S;P++){const L=u[P],m=g[P];v[m]=L,C[m]++}let D=0;for(let P=0;P<h+1;P++){const L=v[P];D=Math.max(D,L);for(let m=0;m<h+1;m++)m!==P&&L===v[m]&&(C[P]<C[m]||C[P]===C[m]&&P<m)&&(v[P]=0)}const _=new Uint32Array(S).fill(0);for(let P=0;P<S;P++)_[P]=v[g[P]];return[D,_]}bwlabel(u,h,g=26,S=!1,v=!1){const C=Date.now(),D=h[0]*h[1]*h[2],_=new Uint32Array(D).fill(0);if(![6,18,26].includes(g))return log.info("bwlabel: conn must be 6, 18 or 26."),[0,_];if(h[0]<2||h[1]<2||h[2]<1)return log.info("bwlabel: img must be 2 or 3-dimensional"),[0,_];if(S)for(let O=0;O<D;O++)u[O]!==0&&(_[O]=1);else _.set(u);let[P,L,m]=this.do_initial_labelling(_,h,g);L===void 0&&(L=new Uint32Array);const[k,e]=this.translate_labels(m,h,L,P);if(log.info(g+" neighbor clustering into "+k+" regions in "+(Date.now()-C)+"ms"),v){const[O,q]=this.largest_original_cluster_labels(_,k,e);return[O,q]}return[k,e]}async createConnectedLabelImage(u,h=26,g=!1,S=!1){var m,k;const v=this.getVolumeIndexByID(u),C=Uint32Array.from(((m=this.volumes[v].dims)==null?void 0:m.slice(1,4))??[]),D=Uint32Array.from(((k=this.volumes[v].img)==null?void 0:k.slice())??[]),[_,P]=this.bwlabel(D,C,h,g,S),L=this.volumes[v].clone();L.opacity=.5,L.colormap="random";for(let e=0;e<L.img.length;e++)L.img[e]=P[e];return L.cal_min=0,L.cal_max=_,L}async scalecropUint8(u,h=0,g=255,S,v){const C=u.length,D=new Uint8Array(C);for(let _=0;_<C;_++){let P=u[_];P=h+v*(P-S),P=Math.max(P,h),P=Math.min(P,g),D[_]=P}return D}async scalecropFloat32(u,h=0,g=1,S,v){const C=u.length,D=new Float32Array(C);for(let _=0;_<C;_++){let P=u[_];P=h+v*(P-S),P=Math.max(P,h),P=Math.min(P,g),D[_]=P}return D}getScale(u,h=0,g=255,S=0,v=.999){let C=u.global_min,D=u.global_max;if(u.hdr.datatypeCode===2)return[C,1];if((!isFinite(S)||!isFinite(v))&&isFinite(u.cal_min)&&isFinite(u.cal_max)&&u.cal_max>u.cal_min){C=u.cal_min,D=u.cal_max;const Y=(g-h)/(D-C);return log.info(" Robust Rescale:  min: "+C+"  max: "+D+" scale: "+Y),console.log("Robust Rescale:  min: "+C+"  max: "+D+" scale: "+Y),[C,Y]}const _=u.img,P=u.hdr.dims[1]*u.hdr.dims[2]*u.hdr.dims[3];if(u.hdr.scl_slope!==1||u.hdr.scl_inter!==0){const Y=u.img,T=new Float32Array(u.img.length);for(let H=0;H<P;H++)T[H]=Y[H]*u.hdr.scl_slope+u.hdr.scl_inter}if(C<0&&log.warn("WARNING: Input image has value(s) below 0.0 !"),log.info(" Input:    min: "+C+"  max: "+D),S===0&&v===1)return[C,1];let L=0;for(let Y=0;Y<P;Y++)Math.abs(_[Y])>=1e-15&&L++;const m=1e3,k=(D-C)/m,e=new Array(m).fill(0);for(let Y=0;Y<P;Y++){const T=_[Y];let H=Math.floor((T-C)/k);H=Math.min(H,m-1),e[H]++}const O=new Array(m).fill(0);O[0]=e[0];for(let Y=1;Y<m;Y++)O[Y]=O[Y-1]+e[Y];let q=Math.floor(S*P),Q=0;for(;Q<m&&!(O[Q]>=q);)Q++;const i0=C;for(C=Q*k+i0,q=P-Math.floor((1-v)*L),Q=0;Q<m-1&&!(O[Q+1]>=q);)Q++;D=Q*k+i0;let j=1;return C!==D&&(j=(g-h)/(D-C)),log.info(" Rescale:  min: "+C+"  max: "+D+" scale: "+j),[C,j]}conformVox2Vox(u,h,g=256,S=1,v=!1){const C=h.flat(),D=fromValues$3(C[0],C[1],C[2],C[3],C[4],C[5],C[6],C[7],C[8],C[9],C[10],C[11],C[12],C[13],C[14],C[15]),_=fromValues$1(u[1]/2,u[2]/2,u[3]/2,1),P=create$1(),L=create$3();transpose(L,D),transformMat4(P,_,L);const m=fromValues$2(P[0],P[1],P[2]),k=fromValues$2(S,S,S);let e=fromValues$3(-1,0,0,0,0,0,1,0,0,-1,0,0,0,0,0,1);v&&(e=fromValues$3(1,0,0,0,0,1,0,0,0,0,1,0,0,0,0,1)),transpose(e,e);const O=fromValues$1(g,g,g,1),q=create$3();scale$3(q,e,k);const Q=fromValues$1(O[0],O[1],O[2],1);transformMat4(Q,Q,q),scale$1(Q,Q,.5);const i0=create$2();subtract$1(i0,m,fromValues$2(Q[0],Q[1],Q[2]));const j=create$3();transpose(j,q),j[3]=i0[0],j[7]=i0[1],j[11]=i0[2];const Y=create$3();invert(Y,j);const T=create$3();mul(T,D,Y);const H=create$3();return invert(H,T),[j,T,H]}async createNiftiArray(u=[256,256,256],h=[1,1,1],g=[1,0,0,-128,0,1,0,-128,0,0,1,-128,0,0,0,1],S=2,v=new Uint8Array){return await NVImage.createNiftiArray(u,h,g,S,v)}async niftiArray2NVImage(u=new Uint8Array){return await NVImage.loadFromUrl({url:u})}async loadFromUrl(u){return await NVImage.loadFromUrl({url:u})}async conform(u,h=!1,g=!0,S=!1,v=!1){const _=this.conformVox2Vox(u.hdr.dims,u.hdr.affine.flat(),256,1,h),P=_[0],L=_[2],m=256*256*256,k=new Float32Array(m),e=new Float32Array(u.img),O=u.hdr.dims[1]*u.hdr.dims[2]*u.hdr.dims[3];if(u.hdr.scl_slope!==1||u.hdr.scl_inter!==0)for(let f0=0;f0<O;f0++)e[f0]=e[f0]*u.hdr.scl_slope+u.hdr.scl_inter;const q=u.hdr.dims[1],Q=u.hdr.dims[2],i0=u.hdr.dims[3],j=q*Q;let Y=-1;function T(f0,o0,c0){return f0+o0*q+c0*j}const H=L[0],G=L[4],K=L[8];if(g)for(let f0=0;f0<256;f0++)for(let o0=0;o0<256;o0++){const c0=o0*L[1]+f0*L[2]+L[3],d0=o0*L[5]+f0*L[6]+L[7],v0=o0*L[9]+f0*L[10]+L[11];for(let g0=0;g0<256;g0++){const C0=g0*H+c0,x0=g0*G+d0,M0=g0*K+v0,ee=Math.floor(C0),re=Math.floor(x0),Fe=Math.floor(M0);if(Y++,ee<0||re<0||Fe<0)continue;const Ne=Math.ceil(C0),ke=Math.ceil(x0),D0=Math.ceil(M0);if(Ne>=q||ke>=Q||D0>=i0)continue;const Be=C0-ee,Ge=x0-re,ti=M0-Fe,ai=1-Be,ri=1-Ge,qe=1-ti,be=T(ee,re,Fe);let J0=0;J0+=e[be]*ai*ri*qe,J0+=e[be+j]*ai*ri*ti,J0+=e[be+q]*ai*Ge*qe,J0+=e[be+q+j]*ai*Ge*ti,J0+=e[be+1]*Be*ri*qe,J0+=e[be+1+j]*Be*ri*ti,J0+=e[be+1+q]*Be*Ge*qe,J0+=e[be+1+q+j]*Be*Ge*ti,k[Y]=J0}}else for(let f0=0;f0<256;f0++)for(let o0=0;o0<256;o0++){const c0=o0*L[1]+f0*L[2]+L[3],d0=o0*L[5]+f0*L[6]+L[7],v0=o0*L[9]+f0*L[10]+L[11];for(let g0=0;g0<256;g0++){const C0=Math.round(g0*H+c0),x0=Math.round(g0*G+d0),M0=Math.round(g0*K+v0);Y++,!(C0<0||x0<0||M0<0)&&(C0>=q||x0>=Q||M0>=i0||(k[Y]=e[T(C0,x0,M0)]))}}let e0=0;v&&(e0=NaN);let z=new Uint8Array;if(S){const f0=await this.getScale(u,0,1,e0),o0=await this.scalecropFloat32(k,0,1,f0[0],f0[1]);z=await this.createNiftiArray([256,256,256],[1,1,1],Array.from(P),16,new Uint8Array(o0.buffer))}else{const f0=await this.getScale(u,0,255,e0),o0=await this.scalecropUint8(k,0,255,f0[0],f0[1]);z=await this.createNiftiArray([256,256,256],[1,1,1],Array.from(P),2,o0)}return await this.niftiArray2NVImage(z)}setRenderDrawAmbientOcclusion(u){if(!this.renderShader)throw new Error("renderShader undefined");this.renderDrawAmbientOcclusion=u,this.renderShader.use(this.gl),this.gl.uniform1fv(this.renderShader.uniforms.renderDrawAmbientOcclusion,[this.renderDrawAmbientOcclusion,1]),this.drawScene()}setColorMap(u,h){this.setColormap(u,h)}setColormapNegative(u,h){const g=this.getVolumeIndexByID(u);this.volumes[g].colormapNegative=h,this.updateGLVolume()}setModulationImage(u,h,g=0){const S=this.getVolumeIndexByID(u);let v=null;h.length>0&&(v=this.getVolumeIndexByID(h)),this.volumes[S].modulationImage=v,this.volumes[S].modulateAlpha=g,this.updateGLVolume()}setGamma(u=1){this.scene.gamma=u,cmapper.gamma=u,this.updateGLVolume()}async loadDeferred4DVolumes(u){const h=this.getVolumeIndexByID(u),g=this.volumes[h];if(g.nTotalFrame4D<=g.nFrame4D)return;let S;g.fileObject?S=await NVImage.loadFromFile({file:g.fileObject}):S=await NVImage.loadFromUrl({url:g.url}),S&&(g.img=S.img.slice(),g.nTotalFrame4D=S.nTotalFrame4D,g.nFrame4D=S.nFrame4D,this.updateGLVolume())}setFrame4D(u,h){const g=this.getVolumeIndexByID(u),S=this.volumes[g];h>S.nFrame4D-1&&(h=S.nFrame4D-1),h<0&&(h=0),h!==S.frame4D&&(S.frame4D=h,this.updateGLVolume(),this.onFrameChange(S,h),this.createOnLocationChange())}getFrame4D(u){const h=this.getVolumeIndexByID(u);return this.volumes[h].frame4D}colormapFromKey(u){return cmapper.colormapFromKey(u)}colormap(u="",h=!1){return cmapper.colormap(u,h)}createColormapTexture(u=null,h=0,g=256){return u!==null&&this.gl.deleteTexture(u),h<1||g<1?null:(u=this.gl.createTexture(),this.gl.activeTexture(TEXTURE1_COLORMAPS),this.gl.bindTexture(this.gl.TEXTURE_2D,u),this.gl.texStorage2D(this.gl.TEXTURE_2D,1,this.gl.RGBA8,g,h),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),u)}addColormapList(u="",h=NaN,g=NaN,S=!1,v=!1,C=!0,D=!1){u.length<1&&(C=!1),this.colormapLists.push({name:u,min:h,max:g,alphaThreshold:S,negative:v,visible:C,invert:D})}refreshColormaps(){if(this.colormapLists=[],this.volumes.length<1&&this.meshes.length<1)return;const u=this.volumes.length;if(u>0)for(let C=0;C<u;C++){const D=this.volumes[C],_=negMinMax(D.cal_min,D.cal_max,D.cal_minNeg,D.cal_maxNeg);this.addColormapList(D.colormapNegative,_[0],_[1],D.alphaThreshold!==void 0,!0,D.colorbarVisible,D.colormapInvert),this.addColormapList(D.colormap,D.cal_min,D.cal_max,D.alphaThreshold!==void 0,!1,D.colorbarVisible,D.colormapInvert)}const h=this.meshes.length;if(h>0)for(let C=0;C<h;C++){const D=this.meshes[C];if(!D.colorbarVisible)continue;const _=D.layers.length;if("edgeColormap"in D&&"edges"in D&&D.edges!==void 0){const P=negMinMax(D.edgeMin,D.edgeMax,NaN,NaN);this.addColormapList(D.edgeColormapNegative,P[0],P[1],!1,!0,!0,D.colormapInvert),this.addColormapList(D.edgeColormap,D.edgeMin,D.edgeMax,!1,!1,!0,D.colormapInvert)}if(!(_<1))for(let P=0;P<_;P++){const L=this.meshes[C].layers[P];if(!L.colorbarVisible||L.colormap.length<1)continue;const m=negMinMax(L.cal_min,L.cal_max,L.cal_minNeg,L.cal_maxNeg);this.addColormapList(L.colormapNegative,m[0],m[1],L.alphaThreshold,!0,!0,L.colormapInvert),this.addColormapList(L.colormap,L.cal_min,L.cal_max,L.alphaThreshold,!1,!0,L.colormapInvert)}}const g=this.colormapLists.length;if(g<1)return;this.colormapTexture=this.createColormapTexture(this.colormapTexture,g+1);let S=new Uint8ClampedArray;function v(C){const D=new Uint8ClampedArray(S.length+C.length);D.set(S),D.set(C,S.length),S=D}for(let C=0;C<g;C++)v(Array.from(this.colormap(this.colormapLists[C].name,this.colormapLists[C].invert)));return v(Array.from(this.drawLut.lut)),this.gl.texSubImage2D(this.gl.TEXTURE_2D,0,0,0,256,g+1,this.gl.RGBA,this.gl.UNSIGNED_BYTE,S),this}sliceScale(u=!1){var C;let h=this.screenFieldOfViewMM(0);u&&(h=this.screenFieldOfViewVox(0));const g=Math.max(h[0],Math.max(h[1],h[2])),S=[h[0]/g,h[1]/g,h[2]/g];if(!((C=this.back)!=null&&C.dims))throw new Error("back.dims undefined");const v=[this.back.dims[1],this.back.dims[2],this.back.dims[3]];return{volScale:S,vox:v,longestAxis:g,dimsMM:h}}tileIndex(u,h){for(let g=0;g<this.screenSlices.length;g++){const S=this.screenSlices[g].leftTopWidthHeight;if(u>S[0]&&h>S[1]&&u<S[0]+S[2]&&h<S[1]+S[3])return g}return-1}inRenderTile(u,h){const g=this.tileIndex(u,h);return g>=0&&this.screenSlices[g].axCorSag===4?g:-1}sliceScroll3D(u=0){if(u!==0){if(this.volumes.length>0&&this.scene.clipPlaneDepthAziElev[0]<1.8){const h=this.scene.clipPlaneDepthAziElev.slice();return u>0&&(h[0]=Math.min(1.5,h[0]+.025)),u<0&&(h[0]=Math.max(-1.5,h[0]-.025)),h[0]!==this.scene.clipPlaneDepthAziElev[0]?(this.scene.clipPlaneDepthAziElev=h,this.setClipPlane(this.scene.clipPlaneDepthAziElev)):void 0}u>0&&(this.scene.volScaleMultiplier=Math.min(2,this.scene.volScaleMultiplier*1.1)),u<0&&(this.scene.volScaleMultiplier=Math.max(.5,this.scene.volScaleMultiplier*.9)),this.drawScene()}}deleteThumbnail(){this.bmpTexture&&(this.gl.deleteTexture(this.bmpTexture),this.bmpTexture=null,this.thumbnailVisible=!1)}inGraphTile(u,h){if(this.graph.opacity<=0||this.volumes.length<1||this.volumes[0].nFrame4D<1||!this.graph.plotLTWH||this.graph.plotLTWH[2]<1||this.graph.plotLTWH[3]<1)return!1;const g=[(u-this.graph.LTWH[0])/this.graph.LTWH[2],(h-this.graph.LTWH[1])/this.graph.LTWH[3]];return g[0]>0&&g[1]>0&&g[0]<=1&&g[1]<=1}mouseClick(u,h,g=0,S=!0){if(u*=this.uiData.dpr,h*=this.uiData.dpr,this.canvas.focus(),this.thumbnailVisible){this.thumbnailVisible=!1,Promise.all([this.loadVolumes(this.deferredVolumes),this.loadMeshes(this.deferredMeshes)]).catch(v=>{throw v});return}if(this.inGraphTile(u,h)){if(!this.graph.plotLTWH)throw new Error("plotLTWH undefined");const v=[(u-this.graph.plotLTWH[0])/this.graph.plotLTWH[2],(h-this.graph.plotLTWH[1])/this.graph.plotLTWH[3]];if(v[0]>0&&v[1]>0&&v[0]<=1&&v[1]<=1){const C=Math.round(v[0]*(this.volumes[0].nFrame4D-1));this.setFrame4D(this.volumes[0].id,C);return}v[0]>.5&&v[1]>1&&this.loadDeferred4DVolumes(this.volumes[0].id).catch(C=>{throw C});return}if(this.inRenderTile(u,h)>=0){this.sliceScroll3D(g),this.drawScene();return}if(!(this.screenSlices.length<1||this.gl.canvas.height<1||this.gl.canvas.width<1))for(let v=0;v<this.screenSlices.length;v++){const C=this.screenSlices[v].axCorSag;if(this.drawPenAxCorSag>=0&&this.drawPenAxCorSag!==C||C>2)continue;const D=this.screenXY2TextureFrac(u,h,v,!1);if(!(D[0]<0)){if(!S){this.scene.crosshairPos[2-C]=g,this.drawScene();return}if(g!==0){let _=1;g<0&&(_=-1);const P=[0,0,0];P[2-C]=_,this.moveCrosshairInVox(P[0],P[1],P[2]),this.drawScene(),this.createOnLocationChange(C);return}if(this.opts.isForceMouseClickToVoxelCenters?this.scene.crosshairPos=clone$1(this.vox2frac(this.frac2vox(D))):this.scene.crosshairPos=clone$1(D),this.opts.drawingEnabled){const _=this.frac2vox(this.scene.crosshairPos),P=this.frac2mm(this.scene.crosshairPos);if(this.opts.clickToSegment){const L=this.opts.clickToSegmentRadius,m=this.opts.clickToSegmentSteps,k=this.opts.clickToSegmentBright?Number.POSITIVE_INFINITY:Number.NEGATIVE_INFINITY;this.drawPenFillPts=[],this.drawPenAxCorSag=C;for(let O=1;O<=m;O++){const q=O/m*2*Math.PI,Q=P[0]+L*Math.cos(q),i0=P[1]+L*Math.sin(q),j=P[2],Y=this.back.mm2vox([Q,i0,j])[0],T=this.back.mm2vox([Q,i0,j])[1],H=this.back.mm2vox([Q,i0,j])[2];this.drawPt(Y,T,H,this.opts.penValue),this.drawPenFillPts.push([Y,T,_[2]]),O===m&&this.drawFloodFill([Y,T,_[2]],0,k,NaN,NaN,this.opts.floodFillNeighbors)}this.drawScene(),this.createOnLocationChange(C);const e=this.getDescriptives(0,[],!0);this.onClickToSegment({mL:e.volumeML,mm3:e.volumeMM3});return}if(!isFinite(this.opts.penValue)||this.opts.penValue<0||Object.is(this.opts.penValue,-0)){isFinite(this.opts.penValue)?this.drawFloodFill(_,Math.abs(this.opts.penValue),this.opts.penValue,NaN,NaN,this.opts.floodFillNeighbors):this.drawFloodFill(_,0,this.opts.penValue,NaN,NaN,this.opts.floodFillNeighbors);return}if(isNaN(this.drawPenLocation[0]))this.drawPenAxCorSag=C,this.drawPenFillPts=[],this.drawPt(..._,this.opts.penValue);else{if(_[0]===this.drawPenLocation[0]&&_[1]===this.drawPenLocation[1]&&_[2]===this.drawPenLocation[2])return;this.drawPenLine(_,this.drawPenLocation,this.opts.penValue)}this.drawPenLocation=_,this.opts.isFilledPen&&this.drawPenFillPts.push(_),this.refreshDrawing(!1)}this.drawScene(),this.createOnLocationChange(C);return}}}drawRuler(){let u=[],h=[];for(let _=0;_<this.screenSlices.length;_++)if(this.screenSlices[_].axCorSag!==4&&this.screenSlices[_].fovMM.length>1){h=this.screenSlices[_].leftTopWidthHeight,u=this.screenSlices[_].fovMM;break}if(h.length<4)return;const S=100/u[0]*h[2],v=h[0]+.5*h[2]-.5*S,C=h[1]+h[3]-2*this.opts.rulerWidth,D=[v,C,v+S,C];this.drawRuler10cm(D)}drawRuler10cm(u){if(!this.lineShader)throw new Error("lineShader undefined");this.gl.bindVertexArray(this.genericVAO),this.lineShader.use(this.gl),this.gl.uniform4fv(this.lineShader.uniforms.lineColor,this.opts.rulerColor),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,this.opts.rulerWidth),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,u),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4);const h=-.1*(u[0]-u[2]),g=u[1],S=g-2*this.opts.rulerWidth,v=g-4*this.opts.rulerWidth;for(let C=0;C<11;C++){const D=u[0]+C*h,_=[D,g,D,S];C%5===0&&(_[3]=v),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,_),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4)}this.gl.bindVertexArray(this.unusedVAO)}screenXY2mm(u,h,g=-1){let S;for(let v=0;v<this.screenSlices.length;v++){let C=v;if(g>=0&&(C=g),this.screenSlices[C].axCorSag>2)continue;const _=this.screenSlices[C].leftTopWidthHeight;if(u<_[0]||h<_[1]||u>_[0]+_[2]||h>_[1]+_[3]||(S=this.screenXY2TextureFrac(u,h,C,!1),S[0]<0))continue;const P=this.frac2mm(S);return fromValues$1(P[0],P[1],P[2],C)}return fromValues$1(NaN,NaN,NaN,NaN)}dragForPanZoom(u){const h=this.screenXY2mm(u[2],u[3]);if(isNaN(h[0]))return;const g=this.screenXY2mm(u[0],u[1],h[3]);if(isNaN(g[0])||isNaN(h[0])||isNaN(h[3]))return;const S=create$1(),v=this.uiData.pan2DxyzmmAtMouseDown[3];sub(S,h,g),this.scene.pan2Dxyzmm[0]=this.uiData.pan2DxyzmmAtMouseDown[0]+v*S[0],this.scene.pan2Dxyzmm[1]=this.uiData.pan2DxyzmmAtMouseDown[1]+v*S[1],this.scene.pan2Dxyzmm[2]=this.uiData.pan2DxyzmmAtMouseDown[2]+v*S[2],this.canvas.focus()}dragForCenterButton(u){this.dragForPanZoom(u)}dragForSlicer3D(u){let h=this.uiData.pan2DxyzmmAtMouseDown[3];const g=u[3]-u[1];h+=g*.01,h=Math.max(h,.1),h=Math.min(h,10);const v=this.scene.pan2Dxyzmm[3]-h;this.opts.yoke3Dto2DZoom&&(this.scene.volScaleMultiplier=h),this.scene.pan2Dxyzmm[3]=h;const C=this.frac2mm(this.scene.crosshairPos);this.scene.pan2Dxyzmm[0]+=v*C[0],this.scene.pan2Dxyzmm[1]+=v*C[1],this.scene.pan2Dxyzmm[2]+=v*C[2]}drawMeasurementTool(u){const h=this.gl;if(h.bindVertexArray(this.genericVAO),h.depthFunc(h.ALWAYS),h.enable(h.BLEND),h.blendFunc(h.SRC_ALPHA,h.ONE_MINUS_SRC_ALPHA),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl),h.uniform4fv(this.lineShader.uniforms.lineColor,this.opts.rulerColor),h.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[h.canvas.width,h.canvas.height]),h.uniform1f(this.lineShader.uniforms.thickness,this.opts.rulerWidth),h.uniform4fv(this.lineShader.uniforms.startXYendXY,u),h.drawArrays(h.TRIANGLE_STRIP,0,4);const g=this.opts.rulerColor;g[3]=1,h.uniform4fv(this.lineShader.uniforms.lineColor,g);const S=this.opts.rulerWidth;h.uniform1f(this.lineShader.uniforms.thickness,S*2);let v=[u[0],u[1]-S,u[0],u[1]+S];h.uniform4fv(this.lineShader.uniforms.startXYendXY,v),h.drawArrays(h.TRIANGLE_STRIP,0,4),v=[u[2],u[3]-S,u[2],u[3]+S],h.uniform4fv(this.lineShader.uniforms.startXYendXY,v),h.drawArrays(h.TRIANGLE_STRIP,0,4);let C=this.canvasPos2frac([u[0],u[1]]),D=this.canvasPos2frac([u[2],u[3]]);if(C[0]>=0&&D[0]>=0){const _=this.frac2mm(C);C=fromValues$2(_[0],_[1],_[2]);const P=this.frac2mm(D);D=fromValues$2(P[0],P[1],P[2]);const L=create$2();sub$1(L,C,D);const m=len(L);let k=2;m>9&&(k=1),m>99&&(k=0);const e=m.toFixed(k);this.drawTextBetween(u,e,1,g)}h.bindVertexArray(this.unusedVAO)}drawRect(u,h=[1,0,0,-1]){if(h[3]<0&&(h=this.opts.crosshairColor),!this.rectShader)throw new Error("rectShader undefined");this.rectShader.use(this.gl),this.gl.enable(this.gl.BLEND),this.gl.uniform4fv(this.rectShader.uniforms.lineColor,h),this.gl.uniform2fv(this.rectShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform4f(this.rectShader.uniforms.leftTopWidthHeight,u[0],u[1],u[2],u[3]),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawCircle(u,h=this.opts.fontColor,g=1){if(!this.circleShader)throw new Error("circleShader undefined");this.circleShader.use(this.gl),this.gl.enable(this.gl.BLEND),this.gl.uniform4fv(this.circleShader.uniforms.circleColor,h),this.gl.uniform2fv(this.circleShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform4f(this.circleShader.uniforms.leftTopWidthHeight,u[0],u[1],u[2],u[3]),this.gl.uniform1f(this.circleShader.uniforms.fillPercent,g),this.gl.uniform4fv(this.circleShader.uniforms.circleColor,h),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawSelectionBox(u){this.drawRect(u,this.opts.selectionBoxColor)}effectiveCanvasHeight(){return this.gl.canvas.height-this.colorbarHeight}effectiveCanvasWidth(){return this.gl.canvas.width-this.getLegendPanelWidth()}getAllLabels(){const S=this.meshes.filter(C=>C.type==="connectome").flatMap(C=>C.nodes).map(C=>C.label).filter(C=>C!==void 0);return[...this.document.labels,...S]}getConnectomeLabels(){const S=this.meshes.filter(D=>D.type==="connectome").flatMap(D=>D.nodes).map(D=>D.label).filter(D=>D!==void 0),v=this.document.labels.filter(D=>D.anchor==null||D.anchor===0),C=new Set(S);for(const D of v)C.add(D);return Array.from(C)}getBulletMarginWidth(){let u=0;const h=this.getConnectomeLabels();if(h.length===0)return 0;const g=h.length===1?h[0].style.bulletScale:h.reduce((C,D)=>C.style.bulletScale>D.style.bulletScale?C:D).style.bulletScale,S=h.length===1?h[0]:h.reduce((C,D)=>{const _=this.opts.textHeight*this.gl.canvas.height*C.style.textScale,P=this.opts.textHeight*this.gl.canvas.height*D.style.textScale;return this.textHeight(_,C.text)>this.textHeight(P,D.text)?C:D}),v=this.opts.textHeight*this.gl.canvas.height*S.style.textScale;return u=this.textHeight(v,S.text)*g,u+=v,u}getLegendPanelWidth(){const u=this.getConnectomeLabels();if(!this.opts.showLegend||u.length===0)return 0;const g=this.opts.textHeight*this.gl.canvas.height*1;let S=0;const v=u.reduce((P,L)=>{const m=this.opts.textHeight*this.gl.canvas.height*P.style.textScale,k=this.opts.textHeight*this.gl.canvas.height*L.style.textScale;return this.textWidth(m,P.text)>this.textWidth(k,L.text)?P:L}),C=this.opts.textHeight*this.gl.canvas.height*v.style.textScale,D=this.textWidth(C,v.text),_=this.getBulletMarginWidth();return D&&(S=_+D,S+=g*2),S>=this.gl.canvas.width?0:S}getLegendPanelHeight(){const u=this.getConnectomeLabels();let h=0;const S=this.opts.textHeight*this.gl.canvas.height*1;for(const v of u){const C=this.opts.textHeight*this.gl.canvas.height*v.style.textScale,D=this.textHeight(C,v.text);h+=D}return h&&(h+=S/2*(u.length+1)),h}reserveColorbarPanel(){let u=Math.max(this.opts.textHeight,.01);u=u*Math.min(this.gl.canvas.height,this.gl.canvas.width);const h=3*u,g=[0,this.gl.canvas.height-h,this.gl.canvas.width,h];return this.colorbarHeight=g[3]+1,g}drawColorbarCore(u=0,h=[0,0,0,0],g=!1,S=0,v=1,C){if(h[2]<=0||h[3]<=0)return;let D=Math.max(this.opts.textHeight,.01);D=D*Math.min(this.gl.canvas.height,this.gl.canvas.width);let _=D;const P=3*D;let L=D;if(h[3]<P){if(h[3]<3)return;_=1,L=h[3]-2}this.gl.disable(this.gl.DEPTH_TEST),this.colorbarHeight=h[3]+1;const m=[h[0]+_,h[1],h[2]-2*_,L],k=[m[0]-1,m[1]-1,m[2]+2,m[3]+2];if(this.drawRect(k,this.opts.crosshairColor),!this.colorbarShader)throw new Error("colorbarShader undefined");this.colorbarShader.use(this.gl),this.gl.activeTexture(TEXTURE1_COLORMAPS),this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST);const e=u;if(this.gl.uniform1f(this.colorbarShader.uniforms.layer,e),this.gl.uniform2fv(this.colorbarShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.disable(this.gl.CULL_FACE),g){const K=[m[0]+m[2],m[1],-m[2],m[3]];this.gl.uniform4fv(this.colorbarShader.uniforms.leftTopWidthHeight,K)}else this.gl.uniform4fv(this.colorbarShader.uniforms.leftTopWidthHeight,m);this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR);let O=0;if(C&&v<0&&g?(O=v,v=0):C&&S>0&&(O=S,S=0),S===v||D<1)return;const q=Math.abs(v-S);let[Q,i0]=tickSpacing(S,v);i0<S&&(i0+=Q);function j(K){return K.toFixed(6).replace(/\.?0*$/,"")}let Y=i0;const T=[0,m[1]+m[3]-D*.5,2,D*.75],H=T[1]+T[3],G=1;for(;Y<=v;){T[0]=m[0]+(Y-S)/q*m[2],this.drawRect(T);const K=j(G*Y);this.drawTextBelow([T[0],H],K),Y+=Q}if(O!==0){const K=[m[0]+(O-S)/q*m[2],m[1]-m[3]*.25,2,m[3]*1.5];this.drawRect(K)}}drawColorbar(){const u=this.colormapLists,h=u.length;if(h<1)return;let g=0;for(let _=0;_<h;_++)u[_].visible&&g++;if(g<1)return;let S=this.reserveColorbarPanel(),v=Math.max(this.opts.textHeight,.01);v=v*Math.min(this.gl.canvas.height,this.gl.canvas.width);const C=3*v;let D=S[2]/g;(S[2]<=0||S[3]<=0)&&(D=this.gl.canvas.width/g,S=[0,this.gl.canvas.height-C,D,C]),S[2]=D;for(let _=0;_<h;_++)u[_].visible&&(this.drawColorbarCore(_,S,u[_].negative,u[_].min,u[_].max,u[_].alphaThreshold),S[0]+=D)}textWidth(u,h){if(!h)return 0;let g=0;const S=new TextEncoder().encode(h);for(let v=0;v<h.length;v++)g+=u*this.fontMets.mets[S[v]].xadv;return g}textHeight(u,h){if(!h)return 0;const g=new Set(Array.from(h)),S=new TextEncoder().encode(Array.from(g).join("")),C=Object.values(this.fontMets.mets).filter((D,_)=>S.includes(_)).reduce((D,_)=>D.lbwh[3]>_.lbwh[3]?D:_).lbwh[3];return u*C}drawChar(u,h,g){if(!this.fontShader)throw new Error("fontShader undefined");const S=this.fontMets.mets[g],v=u[0]+h*S.lbwh[0],C=-(h*S.lbwh[1]),D=h*S.lbwh[2],_=h*S.lbwh[3],P=u[1]+(C-_)+h;return this.gl.uniform4f(this.fontShader.uniforms.leftTopWidthHeight,v,P,D,_),this.gl.uniform4fv(this.fontShader.uniforms.uvLeftTopWidthHeight,S.uv_lbwh),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),h*S.xadv}drawLoadingText(u){if(!this.canvas)throw new Error("canvas undefined");this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.gl.enable(this.gl.CULL_FACE),this.gl.enable(this.gl.BLEND),this.drawTextBelow([this.canvas.width/2,this.canvas.height/2],u,3)}drawText(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;if(!this.fontShader)throw new Error("fontShader undefined");this.fontShader.use(this.gl);const v=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*g;this.gl.enable(this.gl.BLEND),this.gl.uniform2f(this.fontShader.uniforms.canvasWidthHeight,this.gl.canvas.width,this.gl.canvas.height),S===null&&(S=this.opts.fontColor),this.gl.uniform4fv(this.fontShader.uniforms.fontColor,S);let C=v/this.fontMets.size*this.fontMets.distanceRange;C=Math.max(C,1),this.gl.uniform1f(this.fontShader.uniforms.screenPxRange,C);const D=new TextEncoder().encode(h);this.gl.bindVertexArray(this.genericVAO);for(let _=0;_<h.length;_++)u[0]+=this.drawChar(u,v,D[_]);this.gl.bindVertexArray(this.unusedVAO)}drawTextRight(u,h,g=1,S=null){this.opts.textHeight<=0||(u[1]-=.5*this.opts.textHeight*this.gl.canvas.height,this.drawText(u,h,g,S))}drawTextLeft(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;const v=this.opts.textHeight*this.gl.canvas.height*g;u[0]-=this.textWidth(v,h),u[1]-=.5*v,this.drawText(u,h,g,S)}drawTextRightBelow(u,h,g=1,S=null){this.opts.textHeight<=0||this.drawText(u,h,g,S)}drawTextBetween(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;const v=[(u[0]+u[2])*.5,(u[1]+u[3])*.5],C=this.opts.textHeight*this.gl.canvas.height*g,D=this.textWidth(C,h);v[0]-=.5*D,v[1]-=.5*C;const _=[v[0]-1,v[1]-1,D+2,C+2];let P=S;P===null&&(P=this.opts.crosshairColor),P&&P[0]+P[1]+P[2]>.8?P=[0,0,0,.5]:P=[1,1,1,.5],this.drawRect(_,P),this.drawText(v,h,g,S)}drawTextBelow(u,h,g=1,S=null){if(this.opts.textHeight<=0)return;if(!this.canvas)throw new Error("canvas undefined");let v=this.opts.textHeight*this.gl.canvas.height*g,C=this.textWidth(v,h);C>this.canvas.width&&(g*=(this.canvas.width-2)/C,v=this.opts.textHeight*this.gl.canvas.height*g,C=this.textWidth(v,h)),u[0]-=.5*this.textWidth(v,h),u[0]=Math.max(u[0],1),u[0]=Math.min(u[0],this.canvas.width-C-1),this.drawText(u,h,g,S)}updateInterpolation(u,h=!1){let g=this.gl.LINEAR;!h&&this.opts.isNearestInterpolation&&(g=this.gl.NEAREST),u===0?this.gl.activeTexture(TEXTURE0_BACK_VOL):this.gl.activeTexture(TEXTURE2_OVERLAY_VOL),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,g),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,g)}setAtlasOutline(u){this.opts.atlasOutline=u,this.updateGLVolume(),this.drawScene()}setInterpolation(u){this.opts.isNearestInterpolation=u;const h=this.volumes.length;if(!(h<1)){for(let g=0;g<h;g++)this.updateInterpolation(g);this.drawScene()}}calculateMvpMatrix2D(u,h,g,S=1/0,v=0,C=0,D=0,_){this.gl.viewport(u[0],this.gl.canvas.height-(u[1]+u[3]),u[2],u[3]);let L=h[0],m=g[0],k=[L,h[1]],e=[m-L,g[1]-h[1]];_&&(k=[g[0],h[1]],e=[h[0]-g[0],g[1]-h[1]],L=-g[0],m=-h[0]);const O=2*Math.max(Math.abs(h[2]),Math.abs(g[2])),q=create$3();let Q=.01,i0=O*8;if(S!==1/0){let K=_;D===0&&(C===0||C===180)&&(K=!K);let e0=O*1.8-v;K||(e0=O*1.8+v),Q=e0-S,i0=e0+S}ortho(q,L,m,h[1],g[1],Q,i0);const j=create$3();j[0]=-1;const Y=fromValues$2(0,0,-O*1.8);translate(j,j,Y),rotateX(j,j,deg2rad(270-D)),rotateZ(j,j,deg2rad(C-180));const T=create$3();invert(T,j);const H=create$3();transpose(H,T);const G=create$3();return multiply(G,q,j),{modelViewProjectionMatrix:G,modelMatrix:j,normalMatrix:H,leftTopMM:k,fovMM:e}}swizzleVec3MM(u,h){return h===1?u=swizzleVec3(u,[0,2,1]):h===2&&(u=swizzleVec3(u,[1,2,0])),u}screenFieldOfViewVox(u=0){const h=clone$1(this.volumeObject3D.fieldOfViewDeObliqueMM);return this.swizzleVec3MM(h,u)}screenFieldOfViewMM(u=0,h=!1){if(!h&&!this.opts.isSliceMM)return this.screenFieldOfViewVox(u);const g=this.volumeObject3D.extentsMin,S=this.volumeObject3D.extentsMax;let v=fromValues$2(g[0],g[1],g[2]),C=fromValues$2(S[0],S[1],S[2]);v=this.swizzleVec3MM(v,u),C=this.swizzleVec3MM(C,u);const D=create$2();return subtract$1(D,C,v),D}screenFieldOfViewExtendedVox(u=0){const h=this.volumes[0].extentsMinOrtho,g=this.volumes[0].extentsMaxOrtho;let S=fromValues$2(h[0],h[1],h[2]),v=fromValues$2(g[0],g[1],g[2]);const C=create$3();S=this.swizzleVec3MM(S,u),v=this.swizzleVec3MM(v,u);const D=create$2();return subtract$1(D,v,S),{mnMM:S,mxMM:v,rotation:C,fovMM:D}}screenFieldOfViewExtendedMM(u=0){if(!this.volumeObject3D)throw new Error("volumeObject3D undefined");const h=this.volumeObject3D.extentsMin,g=this.volumeObject3D.extentsMax;let S=fromValues$2(h[0],h[1],h[2]),v=fromValues$2(g[0],g[1],g[2]);const C=create$3();S=this.swizzleVec3MM(S,u),v=this.swizzleVec3MM(v,u);const D=create$2();return subtract$1(D,v,S),{mnMM:S,mxMM:v,rotation:C,fovMM:D}}drawSliceOrientationText(u,h,g=[NaN,NaN]){this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height);let S="S";h===0&&(S="A");let v=this.opts.isRadiologicalConvention?"R":"L";if(h===2&&(v=this.opts.sagittalNoseLeft?"A":"P"),this.opts.isCornerOrientationText){this.drawTextRightBelow([u[0],u[1]],v+S);return}let C=!0,D=!0;if(!isNaN(g[0])){const _=this.opts.textHeight*this.gl.canvas.height+2;g[1]>_&&(this.drawTextBelow([u[0]+u[2]*.5,u[1]+g[1]-_],S),C=!1);const P=this.textWidth(_,v)+2;g[0]>P&&(this.drawTextRight([u[0]+g[0]-P,u[1]+u[3]*.5],v),D=!1)}C&&this.drawTextBelow([u[0]+u[2]*.5,u[1]],S),D&&this.drawTextRight([u[0],u[1]+u[3]*.5],v)}xyMM2xyzMM(u,h){let g=2;u===1&&(g=1),u===2&&(g=0);let S=[0,0,0],v=[1,1,0],C=[1,0,1];S[g]=h,v[g]=h,C[g]=h,S=this.frac2mm(S),v=this.frac2mm(v),C=this.frac2mm(C),S=this.swizzleVec3MM(fromValues$2(S[0],S[1],S[2]),u),v=this.swizzleVec3MM(fromValues$2(v[0],v[1],v[2]),u),C=this.swizzleVec3MM(fromValues$2(C[0],C[1],C[2]),u);const D=(v[0]-S[0])*(C[1]-S[1])-(C[0]-S[0])*(v[1]-S[1]);let _=(v[0]-S[0])*(C[2]-S[2])-(C[0]-S[0])*(v[2]-S[2]);_/=D;let P=(v[1]-S[1])*(C[2]-S[2])-(C[1]-S[1])*(v[2]-S[2]);P/=D;const L=[0,0,0,0,0];return L[0]=S[0],L[1]=S[1],L[2]=S[2],L[3]=P,L[4]=_,L}draw2DMain(u,h,g=NaN){let S=this.volumes[0].frac2mm.slice(),v=this.screenFieldOfViewExtendedMM(h),C=create$3();this.opts.isSliceMM||(S=this.volumes[0].frac2mmOrtho.slice(),C=clone$2(this.volumes[0].mm2ortho),v=this.screenFieldOfViewExtendedVox(h));let D=this.opts.isRadiologicalConvention&&h<2;g===1/0||g===-1/0?(D=g!==1/0,h===1&&(D=!D)):this.opts.sagittalNoseLeft&&h===2&&(D=!D);let _=0,P=0;h===2?P=D?90:-90:h===1?P=D?180:0:(P=D?180:0,_=D?-90:90);const L=this.gl;let m=!1;if(u[2]===0||u[3]===0){m=!0;const j=L.canvas.width/v.fovMM[0],Y=L.canvas.height/v.fovMM[1],T=Math.min(j,Y),H=j/T,G=Y/T;v.fovMM[0]*=H,v.fovMM[1]*=G;let K=(v.mnMM[0]+v.mxMM[0])*.5;v.mnMM[0]=K-v.fovMM[0]*.5,v.mxMM[0]=K+v.fovMM[0]*.5,K=(v.mnMM[1]+v.mxMM[1])*.5,v.mnMM[1]=K-v.fovMM[1]*.5,v.mxMM[1]=K+v.fovMM[1]*.5,u=[0,0,L.canvas.width,L.canvas.height]}if(isNaN(g)){const j=this.scene.pan2Dxyzmm,Y=this.swizzleVec3MM(fromValues$2(j[0],j[1],j[2]),h),T=this.scene.pan2Dxyzmm[3];v.mnMM[0]-=Y[0],v.mxMM[0]-=Y[0],v.mnMM[1]-=Y[1],v.mxMM[1]-=Y[1],v.mnMM[0]/=T,v.mxMM[0]/=T,v.mnMM[1]/=T,v.mxMM[1]/=T}let k=2;h===1&&(k=1),h===2&&(k=0);let e=this.scene.crosshairPos[k],O=this.frac2mm(this.scene.crosshairPos);!isNaN(g)&&g!==1/0&&g!==-1/0&&(O=this.frac2mm([.5,.5,.5]),O[k]=g,e=this.mm2frac(O)[k]);const q=O[k];L.clear(L.DEPTH_BUFFER_BIT);let Q=this.calculateMvpMatrix2D(u,v.mnMM,v.mxMM,1/0,0,P,_,D);if(g===1/0||g===-1/0){const j=u.slice();this.draw3D(u,Q.modelViewProjectionMatrix,Q.modelMatrix,Q.normalMatrix,P,_);const Y=this.screenSlices[this.screenSlices.length-1];Y.leftTopWidthHeight=j,Y.axCorSag=h,Y.sliceFrac=1/0,Y.AxyzMxy=this.xyMM2xyzMM(h,e),Y.leftTopMM=Q.leftTopMM,Y.fovMM=Q.fovMM;return}L.enable(L.DEPTH_TEST),L.blendFunc(L.SRC_ALPHA,L.ONE_MINUS_SRC_ALPHA),L.disable(L.BLEND),L.depthFunc(L.GREATER),L.disable(L.CULL_FACE);let i0=this.sliceMMShader;if(this.opts.isV1SliceShader&&(i0=this.sliceV1Shader),!i0)throw new Error("slice Shader undefined");if(i0.use(this.gl),L.uniform1f(i0.uniforms.overlayOutlineWidth,this.overlayOutlineWidth),L.uniform1f(i0.uniforms.overlayAlphaShader,this.overlayAlphaShader),L.uniform1i(i0.uniforms.isAlphaClipDark,this.isAlphaClipDark?1:0),L.uniform1i(i0.uniforms.backgroundMasksOverlays,this.backgroundMasksOverlays),L.uniform1f(i0.uniforms.drawOpacity,this.drawOpacity),L.enable(L.BLEND),L.blendFunc(L.SRC_ALPHA,L.ONE_MINUS_SRC_ALPHA),L.uniform1f(i0.uniforms.opacity,this.volumes[0].opacity),L.uniform1i(i0.uniforms.axCorSag,h),L.uniform1f(i0.uniforms.slice,e),L.uniformMatrix4fv(i0.uniforms.frac2mm,!1,S),L.uniformMatrix4fv(i0.uniforms.mvpMtx,!1,Q.modelViewProjectionMatrix.slice()),L.bindVertexArray(this.genericVAO),L.drawArrays(L.TRIANGLE_STRIP,0,4),L.bindVertexArray(this.unusedVAO),this.screenSlices.push({leftTopWidthHeight:u,axCorSag:h,sliceFrac:e,AxyzMxy:this.xyMM2xyzMM(h,e),leftTopMM:Q.leftTopMM,screen2frac:[],fovMM:Q.fovMM}),isNaN(g)&&this.drawCrosshairs3D(!0,1,Q.modelViewProjectionMatrix,!0,this.opts.isSliceMM),this.opts.meshThicknessOn2D>0){this.opts.meshThicknessOn2D!==1/0&&(Q=this.calculateMvpMatrix2D(u,v.mnMM,v.mxMM,this.opts.meshThicknessOn2D,q,P,_,D));const j=clone$2(Q.modelViewProjectionMatrix);multiply(j,j,C),this.drawMesh3D(!0,1,j,Q.modelMatrix,Q.normalMatrix)}isNaN(g)&&this.drawCrosshairs3D(!1,.15,Q.modelViewProjectionMatrix,!0,this.opts.isSliceMM),m&&this.drawSliceOrientationText(u,h),this.readyForSync=!0}draw2D(u,h,g=NaN,S=[NaN,NaN]){const v=[NaN,NaN];if(isNaN(S[0]))this.draw2DMain(u,h,g);else{const C=u.slice();v[0]=Math.floor(.5*(C[2]-S[0])),v[1]=Math.floor(.5*(C[3]-S[1])),C[0]+=v[0],C[1]+=v[1],C[2]=S[0],C[3]=S[1],this.draw2DMain(C,h,g)}g===1/0||g===-1/0||h===4||u[2]!==0&&u[3]!==0&&this.drawSliceOrientationText(u,h,v)}calculateMvpMatrix(u,h=[0,0,0,0],g,S){(h[2]===0||h[3]===0)&&(h=[0,0,this.gl.canvas.width,this.gl.canvas.height]);const v=h[2]/h[3];let C=this.furthestFromPivot;const D=this.pivot3D,_=create$3();C=.8*C/this.scene.volScaleMultiplier,v<1?ortho(_,-C,C,-C/v,C/v,C*.01,C*8):ortho(_,-C*v,C*v,-C,C,C*.01,C*8);const P=create$3();P[0]=-1;const L=fromValues$2(0,0,-C*1.8);translate(P,P,L),this.position&&translate(P,P,this.position),rotateX(P,P,deg2rad(270-S)),rotateZ(P,P,deg2rad(g-180)),translate(P,P,[-D[0],-D[1],-D[2]]);const m=create$3();invert(m,P);const k=create$3();transpose(k,m);const e=create$3();return multiply(e,_,P),[e,P,k]}calculateModelMatrix(u,h){if(!this.back)throw new Error("back undefined");const g=create$3();if(g[0]=-1,rotateX(g,g,deg2rad(270-h)),rotateZ(g,g,deg2rad(u-180)),this.back.obliqueRAS){const S=clone$2(this.back.obliqueRAS);multiply(g,g,S)}return g}calculateRayDirection(u,h){const g=this.calculateModelMatrix(u,h),S=fromValues$3(1,0,0,0,0,-1,0,0,0,0,-1,0,0,0,0,1),v=create$3();multiply(v,S,g);const C=create$3();invert(C,v);const D=fromValues$1(0,0,-1,1);transformMat4(D,D,C);const _=fromValues$2(D[0],D[1],D[2]);normalize$1(_,_);const P=5e-5;return Math.abs(_[0])<P&&(_[0]=P),Math.abs(_[1])<P&&(_[1]=P),Math.abs(_[2])<P&&(_[2]=P),_}sceneExtentsMinMax(u=!0){let h=fromValues$2(0,0,0),g=fromValues$2(0,0,0);if(this.volumes.length>0){if(!this.volumeObject3D)throw new Error("volumeObject3D undefined");h=fromValues$2(this.volumeObject3D.extentsMin[0],this.volumeObject3D.extentsMin[1],this.volumeObject3D.extentsMin[2]),g=fromValues$2(this.volumeObject3D.extentsMax[0],this.volumeObject3D.extentsMax[1],this.volumeObject3D.extentsMax[2]),u||(h=fromValues$2(this.volumes[0].extentsMinOrtho[0],this.volumes[0].extentsMinOrtho[1],this.volumes[0].extentsMinOrtho[2]),g=fromValues$2(this.volumes[0].extentsMaxOrtho[0],this.volumes[0].extentsMaxOrtho[1],this.volumes[0].extentsMaxOrtho[2]))}if(this.meshes.length>0){if(this.volumes.length<1){const v=this.meshes[0].extentsMin,C=this.meshes[0].extentsMax;h=fromValues$2(v[0],v[1],v[2]),g=fromValues$2(C[0],C[1],C[2])}for(let v=0;v<this.meshes.length;v++){const C=this.meshes[v].extentsMin,D=this.meshes[v].extentsMax,_=fromValues$2(C[0],C[1],C[2]);min(h,h,_);const P=fromValues$2(D[0],D[1],D[2]);max$2(g,g,P)}}const S=create$2();return subtract$1(S,g,h),[h,g,S]}setPivot3D(){const[u,h]=this.sceneExtentsMinMax(),g=create$2();add$1(g,u,h),scale$2(g,g,.5),this.pivot3D=[g[0],g[1],g[2]],subtract$1(g,h,u),this.extentsMin=u,this.extentsMax=h,this.furthestFromPivot=length$1(g)*.5}getMaxVols(){if(this.volumes.length<1)return 0;let u=0;for(let h=0;h<this.volumes.length;h++)u=Math.max(u,this.volumes[h].nFrame4D);return u}detectPartialllyLoaded4D(){if(this.volumes.length<1)return!1;for(let u=0;u<this.volumes.length;u++)if(this.volumes[u].nFrame4D<this.volumes[u].hdr.dims[4])return!0;return!1}drawGraph(){if(this.getMaxVols()<2)return;const u=this.graph;let h=0;if(this.graph.autoSizeMultiplanar&&this.opts.sliceType===3)for(let o0=0;o0<this.screenSlices.length;o0++){const c0=this.screenSlices[o0].axCorSag;if(c0===0&&(h=this.screenSlices[o0].leftTopWidthHeight[1]),c0!==2)continue;const d0=this.screenSlices[o0].leftTopWidthHeight.slice();d0[1]===h?(u.LTWH[0]=d0[0]+d0[2],u.LTWH[1]=d0[1]):(u.LTWH[0]=d0[0],u.LTWH[1]=d0[1]+d0[3]),u.LTWH[2]=d0[2],u.LTWH[3]=d0[2]}if(u.opacity<=0||u.LTWH[2]<=5||u.LTWH[3]<=5||u.LTWH[0]+u.LTWH[2]>this.gl.canvas.width||u.LTWH[1]+u.LTWH[3]>this.gl.canvas.height)return;u.backColor=[.15,.15,.15,u.opacity],u.lineColor=[1,1,1,1],this.opts.backColor[0]+this.opts.backColor[1]+this.opts.backColor[2]>1.5&&(u.backColor=[.95,.95,.95,u.opacity],u.lineColor=[0,0,0,1]),u.textColor=u.lineColor.slice(),u.lineThickness=4,u.lineAlpha=1,u.lines=[];const g=[];if(u.vols.length<1)this.volumes[0]!=null&&g.push(0);else for(let o0=0;o0<u.vols.length;o0++){const c0=u.vols[o0];this.volumes[c0]==null||this.volumes[c0].nFrame4D<2||g.push(c0)}if(g.length<1)return;const S=this.volumes[g[0]].nFrame4D;if(this.graph.selectedColumn=this.volumes[g[0]].frame4D,S<2){log.debug("Unable to generate a graph: Selected volume is 3D not 4D");return}for(let o0=0;o0<g.length;o0++){u.lines[o0]=[];const c0=this.frac2vox(this.scene.crosshairPos),d0=this.volumes[g[o0]];let v0=d0.nFrame4D;v0=Math.min(v0,S);for(let g0=0;g0<v0;g0++){const C0=d0.getValue(c0[0],c0[1],c0[2],g0);u.lines[o0].push(C0)}}u.lineRGB=[[1,0,0],[0,.7,0],[0,0,1],[1,1,0],[1,0,1],[0,1,1],[1,1,1],[0,0,0]];let v=u.lines[0][0],C=u.lines[0][0];for(let o0=0;o0<u.lines.length;o0++)for(let c0=0;c0<u.lines[o0].length;c0++){const d0=u.lines[o0][c0];v=Math.min(d0,v),C=Math.max(d0,C)}if(u.normalizeValues&&C>v){const o0=C-v;for(let c0=0;c0<u.lines.length;c0++)for(let d0=0;d0<u.lines[c0].length;d0++){const v0=u.lines[c0][d0];u.lines[c0][d0]=(v0-v)/o0}v=0,C=1}v>=C&&(C=v+1),this.drawRect(u.LTWH,u.backColor);const[D,_,P]=tickSpacing(v,C),L=Math.max(0,-1*Math.floor(Math.log(D)/Math.log(10)));v=Math.min(_,v),C=Math.max(P,C);function m(o0){return o0.toFixed(6).replace(/\.?0*$/,"")}const e=.07*(Math.min(u.LTWH[2],u.LTWH[3])/(this.fontMets.size*this.uiData.dpr));let O=this.opts.textHeight*this.gl.canvas.height*e;O<16&&(O=0);let q=0,Q=_;if(O>0)for(;Q<=C;){const o0=Q.toFixed(L),c0=this.textWidth(O,o0);q=Math.max(c0,q),Q+=D}const i0=.05,j=Math.abs(u.LTWH[2]),Y=Math.abs(u.LTWH[3]),T=[u.LTWH[0]+i0*j+q,u.LTWH[1]+i0*Y,u.LTWH[2]-q-2*i0*j,u.LTWH[3]-O-2*i0*Y];this.graph.LTWH=u.LTWH,this.graph.plotLTWH=T,this.drawRect(T,this.opts.backColor);const H=C-v,G=T[3]/H,K=T[2]/(u.lines[0].length-1),e0=T[1]+T[3];Q=_+.5*D;const z=u.lineColor.slice();for(z[3]=.25*u.lineColor[3];Q<=C;){const o0=e0-(Q-v)*G;this.drawLine([T[0],o0,T[0]+T[2],o0],.5*u.lineThickness,z),Q+=D}Q=_;const f=.5*u.lineThickness;for(;Q<=C;){const o0=e0-(Q-v)*G;this.drawLine([T[0]-f,o0,T[0]+T[2]+u.lineThickness,o0],u.lineThickness,u.lineColor);const c0=Q.toFixed(L);O>0&&this.drawTextLeft([T[0]-6,o0],c0,e,u.textColor),Q+=D}let f0=1;for(;u.lines[0].length/f0>20;)f0*=5;for(let o0=0;o0<u.lines[0].length;o0+=f0){const c0=o0*K+T[0];let d0=u.lineThickness;if(o0%2===1)d0*=.5,this.drawLine([c0,T[1],c0,T[1]+T[3]],d0,z);else{const v0=m(o0);O>0&&this.drawTextBelow([c0,2+T[1]+T[3]],v0,e,u.textColor),this.drawLine([c0,T[1],c0,T[1]+T[3]],d0,u.lineColor)}}for(let o0=0;o0<u.lines.length;o0++){let c0=[1,0,0,u.lineAlpha];o0<u.lineRGB.length&&(c0=[u.lineRGB[o0][0],u.lineRGB[o0][1],u.lineRGB[o0][2],u.lineAlpha]);for(let d0=1;d0<u.lines[o0].length;d0++){const v0=(d0-1)*K,g0=d0*K,C0=(u.lines[o0][d0-1]-v)*G,x0=(u.lines[o0][d0]-v)*G,M0=[T[0]+v0,T[1]+T[3]-C0,T[0]+g0,T[1]+T[3]-x0];this.drawLine(M0,u.lineThickness,c0)}}if(u.selectedColumn>=0&&u.selectedColumn<u.lines[0].length){const o0=u.selectedColumn*K+T[0];this.drawLine([o0,T[1],o0,T[1]+T[3]],u.lineThickness,[u.lineRGB[3][0],u.lineRGB[3][1],u.lineRGB[3][2],1])}this.detectPartialllyLoaded4D()&&this.drawTextBelow([T[0]+T[2],T[1]+T[3]+O*.5],"...",e,u.textColor)}depthPicker(u,h){if(!this.uiData.mouseDepthPicker)return;this.uiData.mouseDepthPicker=!1;const g=this.gl,S=this.mousePos[0]*u[2]/u[2],v=g.canvas.height-this.mousePos[1]*u[3]/u[3]-1,C=new Uint8Array(4);if(g.readPixels(S,v,1,1,g.RGBA,g.UNSIGNED_BYTE,C),this.selectedObjectId=C[3],this.selectedObjectId===this.VOLUME_ID){this.scene.crosshairPos=new Float32Array(C.slice(0,3)).map(k=>k/255);return}const D=unpackFloatFromVec4i(C);if(D>1)return;const _=(this.mousePos[0]-u[0])/u[2],P=(g.canvas.height-this.mousePos[1]-u[1])/u[3],L=unProject(_,P,D,h),m=this.mm2frac(L,0,!0);m[0]<0||m[0]>1||m[1]<0||m[1]>1||m[2]<0||m[2]>1||(this.scene.crosshairPos=this.mm2frac(L,0,!0))}drawImage3D(u,h,g){if(this.volumes.length===0)return;const S=this.gl,v=this.calculateRayDirection(h,g),C=this.volumeObject3D;if(C){S.enable(S.BLEND),S.blendFunc(S.SRC_ALPHA,S.ONE_MINUS_SRC_ALPHA),S.enable(S.CULL_FACE),S.cullFace(S.FRONT);let D=this.renderShader;if(this.uiData.mouseDepthPicker&&(D=this.pickingImageShader),D.use(this.gl),S.uniform1i(D.uniforms.backgroundMasksOverlays,this.backgroundMasksOverlays),this.gradientTextureAmount>0){S.activeTexture(TEXTURE6_GRADIENT),S.bindTexture(S.TEXTURE_3D,this.gradientTexture);const _=this.calculateModelMatrix(h,g),P=create$3();invert(P,_);const L=create$3();transpose(L,P),S.uniformMatrix4fv(D.uniforms.normMtx,!1,L)}this.drawBitmap&&this.drawBitmap.length>8?S.uniform2f(D.uniforms.renderDrawAmbientOcclusionXY,this.renderDrawAmbientOcclusion,this.drawOpacity):S.uniform2f(D.uniforms.renderDrawAmbientOcclusionXY,this.renderDrawAmbientOcclusion,0),S.uniformMatrix4fv(D.uniforms.mvpMtx,!1,u),S.uniformMatrix4fv(D.uniforms.matRAS,!1,this.back.matRAS),S.uniform3fv(D.uniforms.rayDir,v),this.gradientTextureAmount<0?S.uniform4fv(D.uniforms.clipPlane,[this.scene.crosshairPos[0],this.scene.crosshairPos[1],this.scene.crosshairPos[2],30]):S.uniform4fv(D.uniforms.clipPlane,this.scene.clipPlane),S.uniform1f(D.uniforms.drawOpacity,1),S.bindVertexArray(C.vao),S.drawElements(C.mode,C.indexCount,S.UNSIGNED_SHORT,0),S.bindVertexArray(this.unusedVAO)}}drawOrientationCube(u,h=0,g=0){if(!this.opts.isOrientCube)return;const S=.05*Math.min(u[2],u[3]);if(S<5)return;const v=this.gl;v.enable(v.CULL_FACE),v.cullFace(v.BACK),this.orientCubeShader.use(this.gl),v.bindVertexArray(this.orientCubeShaderVAO);const C=create$3(),D=create$3();ortho(D,0,v.canvas.width,0,v.canvas.height,-10*S,10*S);let _=0;u[1]===0&&(_=v.canvas.height-this.effectiveCanvasHeight()),translate(C,C,[1.8*S+u[0],_+1.8*S+u[1],0]),scale$3(C,C,[S,S,S]),rotateX(C,C,deg2rad(270-g)),rotateZ(C,C,deg2rad(-h));const P=create$3();multiply(P,D,C),v.uniformMatrix4fv(this.orientCubeShader.uniforms.u_matrix,!1,P),v.drawArrays(v.TRIANGLE_STRIP,0,168),v.bindVertexArray(this.unusedVAO),this.gl.disable(this.gl.CULL_FACE)}createOnLocationChange(u=NaN){const[h,g,S]=this.sceneExtentsMinMax(!0),v=Math.max(Math.max(S[0],S[1]),S[2]);function C(k){return Math.max(0,-Math.ceil(Math.log10(Math.abs(k))))}let D=C(v*.001);const _=this.frac2mm(this.scene.crosshairPos,0,!0);function P(k,e=0){return parseFloat(k.toFixed(e))}let L=P(_[0],D)+"×"+P(_[1],D)+"×"+P(_[2],D);if(this.volumes.length>0&&this.volumes[0].nFrame4D>0&&(L+="×"+P(this.volumes[0].frame4D)),this.volumes.length>0){let k=" = ";for(let q=0;q<this.volumes.length;q++){const Q=this.volumes[q].mm2vox(_);let i0=this.volumes[q].getValue(Q[0],Q[1],Q[2],this.volumes[q].frame4D);if(D=3,this.volumes[q].colormapLabel!==null){const j=Math.round(i0);j>=0&&j<this.volumes[q].colormapLabel.labels.length?k+=this.volumes[q].colormapLabel.labels[j]:k+="undefined("+P(i0,D)+")"}else k+=P(i0,D);this.volumes[q].imaginary&&(i0=this.volumes[q].getValue(Q[0],Q[1],Q[2],this.volumes[q].frame4D,!0),i0>=0&&(k+="+"),k+=P(i0,D)),k+="   "}L+=k;const e=this.back.dimsRAS,O=e[1]*e[2]*e[3];if(this.drawBitmap&&this.drawBitmap.length===O){const q=this.frac2vox(this.scene.crosshairPos),Q=q[0]+q[1]*e[1]+q[2]*e[1]*e[2];L+=" "+this.drawLut.labels[this.drawBitmap[Q]]}}const m={mm:this.frac2mm(this.scene.crosshairPos,0,!0),axCorSag:u,vox:this.frac2vox(this.scene.crosshairPos),frac:this.scene.crosshairPos,xy:[this.mousePos[0],this.mousePos[1]],values:this.volumes.map(k=>{const e=this.frac2mm(this.scene.crosshairPos,0,!0),O=k.mm2vox(e),q=k.getValue(O[0],O[1],O[2],k.frame4D);return{name:k.name,value:q,id:k.id,mm:e,vox:O}}),string:L};this.onLocationChange(m)}addLabel(u,h,g,S,v){const C={textColor:this.opts.legendTextColor,textScale:1,textAlignment:"left",lineWidth:0,lineColor:this.opts.legendTextColor,lineTerminator:"none",bulletScale:0,bulletColor:this.opts.legendTextColor},D=h?{...C,...h}:{...C},_=new NVLabel3D(u,{...D},g,S,v);return this.document.labels.push(_),_}calculateScreenPoint(u,h,g){const S=create$1();return transformMat4(S,[...u,1],h),S[3]!==0&&(S[0]=(S[0]/S[3]+1)*.5*g[2],S[1]=(1-S[1]/S[3])*.5*g[3],S[2]/=S[3],S[0]+=g[0],S[1]+=g[1]),S}getLabelAtPoint(u){const g=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1,S=this.opts.textHeight*this.gl.canvas.height*1;for(const L of this.document.labels){if(L.anchor==null||L.anchor===0)continue;const m=this.opts.textHeight*this.gl.canvas.height*L.style.textScale,k=this.textHeight(m,L.text),e=this.textWidth(m,L.text);if(!(L.anchor&1&&u[0]>e)&&!(L.anchor&2&&(u[0]<(this.gl.canvas.width-e)/2||u[0]>(this.gl.canvas.width+e)/2))&&!(L.anchor&4&&u[0]<this.gl.canvas.width-e)&&!(L.anchor&8&&(u[1]<S/2||u[1]>k+S/2))&&!(L.anchor&16&&(u[1]<(this.gl.canvas.height-k-S)/2||u[1]>(this.gl.canvas.height+k-S/2)/2))&&!(L.anchor&32&&(u[1]<this.gl.canvas.height-k-S||u[1]>this.gl.canvas.height-S/2)))return L}log.debug("screenPoint",u);const v=this.getLegendPanelHeight(),C=this.getLegendPanelWidth(),D=this.gl.canvas.width-C;let _=(this.canvas.height-v)/2;if(log.debug("panelrect",D,_,D+C,_+v),u[0]<D||u[1]<_||u[0]>D+C||u[1]>_+v)return null;const P=this.getConnectomeLabels();for(const L of P){const m=this.opts.textHeight*this.gl.canvas.height*L.style.textScale,k=this.textHeight(m,L.text);if(u[1]>=_&&u[1]<=_+k+g/2)return L;_+=k,_+=g/2}return null}drawLabelLine(u,h,g,S,v=!1){const C=Array.isArray(u.points)&&Array.isArray(u.points[0])?u.points:[u.points];for(const D of C){const _=this.calculateScreenPoint(D,g,S);v?this.drawDottedLine([...h,_[0],_[1]],u.style.lineWidth,u.style.lineColor):this.draw3DLine(h,[_[0],_[1],_[2]],u.style.lineWidth,u.style.lineColor)}}draw3DLabel(u,h,g,S,v,C,D){const _=u.text,P=h[0],L=h[1],m=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1,k=this.textHeight(u.style.textScale,_)*m;if(u.style.lineWidth>0&&Array.isArray(u.points)&&this.drawLabelLine(u,[P,L+k],g,S,D),u.style.bulletScale){const O=u.style.bulletScale*k,q=k-O,Q=L+q/2+O/2,i0=P+(v-O)/2;this.drawCircle([i0,Q,O,O],u.style.bulletColor)}let e=P;if(C)if(u.style.textAlignment!=="left"){const O=this.textWidth(u.style.textScale,u.text)*m;if(u.style.textAlignment==="right")e=P+C-m*1.5-O;else{const q=C-(v||m);e+=(q-O)/2}}else e+=v;this.drawText([e,L],_,u.style.textScale,u.style.textColor)}draw3DLabels(u,h,g=!1){const S=this.getConnectomeLabels();if(!this.opts.showLegend||S.length===0)return;if(!this.canvas)throw new Error("canvas undefined");const v=this.gl;v.disable(v.CULL_FACE),v.viewport(0,0,this.canvas.width,this.canvas.height);const D=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1,_=this.getBulletMarginWidth(),P=this.getLegendPanelHeight(),L=this.getLegendPanelWidth(),m=v.canvas.width-L;let k=(this.canvas.height-P)/2;this.drawRect([v.canvas.width-L,k,L-D,P],this.opts.legendBackgroundColor);const e=v.getParameter(v.BLEND),O=v.getParameter(v.DEPTH_FUNC);g||(v.disable(v.BLEND),v.depthFunc(v.GREATER));for(const q of S){this.draw3DLabel(q,[m,k],u,h,_,L,g);const Q=this.opts.textHeight*this.gl.canvas.height*q.style.textScale,i0=this.textHeight(Q,q.text);k+=i0,k+=D/2}g||(v.depthFunc(O),e&&v.enable(v.BLEND))}drawAnchoredLabels(){const u=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1,h=this.document.labels.filter(g=>g.anchor!=null&&g.anchor!==0);for(const g of h){const S=g.text,v=this.textHeight(g.style.textScale,S)*u,C=this.textWidth(g.style.textScale,S)*u;let D,_;const L=this.opts.textHeight*this.gl.canvas.height*1,m=L;let k=L/4,e=0,O=0;g.anchor&1&&(D=0),g.anchor&4&&(D=this.canvas.width-C,e-=L/4),g.anchor&2&&(D=(this.canvas.width-C)/2,e-=L/4,k+=L/4),g.anchor&8&&(_=0),g.anchor&16&&(_=(this.canvas.height-v-L)/2,O-=L/4),g.anchor&32&&(_=this.canvas.height-v-L,O-=L/4),this.drawRect([D+e,_+O,C+k,v+m],g.style.backgroundColor),this.draw3DLabel(g,[D,_])}}draw3D(u=[0,0,0,0],h=null,g=null,S=null,v=null,C=0){const D=v!==null;this.setPivot3D(),D||(v=this.scene.renderAzimuth,C=this.scene.renderElevation);const _=this.gl;h===null&&([h,g,S]=this.calculateMvpMatrix(null,u,v,C));let P=[...u];if(u[2]===0||u[3]===0?(u=[0,0,_.canvas.width,_.canvas.height],P=[...u],this.screenSlices.push({leftTopWidthHeight:u,axCorSag:4,sliceFrac:0,AxyzMxy:[],leftTopMM:[],fovMM:[isRadiological(g),0]})):(this.screenSlices.push({leftTopWidthHeight:u.slice(),axCorSag:4,sliceFrac:0,AxyzMxy:[],leftTopMM:[],fovMM:[isRadiological(g),0]}),u[1]=_.canvas.height-u[3]-u[1]),_.enable(_.DEPTH_TEST),_.depthFunc(_.ALWAYS),_.depthMask(!0),_.clearDepth(0),this.draw3DLabels(h,P,!1),_.viewport(u[0],u[1],u[2],u[3]),this.volumes.length>0&&(this.updateInterpolation(0,!0),this.updateInterpolation(1,!0),this.drawImage3D(h,v,C)),this.updateInterpolation(0),this.updateInterpolation(1),D||this.drawCrosshairs3D(!0,1,h),this.drawMesh3D(!0,1,h,g,S),this.uiData.mouseDepthPicker){this.depthPicker(u,h),this.createOnLocationChange(),this.draw3D(u,h,g,S,v,C);return}this.opts.meshXRay>0&&this.drawMesh3D(!1,this.opts.meshXRay,h,g,S),this.draw3DLabels(h,P,!1),_.viewport(u[0],u[1],u[2],u[3]),D||this.drawCrosshairs3D(!1,.15,h),_.viewport(0,0,_.canvas.width,_.canvas.height),this.drawOrientationCube(u,v,C);const L="azimuth: "+this.scene.renderAzimuth.toFixed(0)+" elevation: "+this.scene.renderElevation.toFixed(0);return this.readyForSync=!0,this.sync(),this.draw3DLabels(h,P,!0),L}drawMesh3D(u=!0,h=1,g,S,v){if(this.meshes.length<1)return;const C=this.gl;g||([g,S,v]=this.calculateMvpMatrix(this.volumeObject3D,void 0,this.scene.renderAzimuth,this.scene.renderElevation)),C.enable(C.DEPTH_TEST),C.blendFunc(C.SRC_ALPHA,C.ONE_MINUS_SRC_ALPHA),C.disable(C.BLEND),C.depthFunc(C.GREATER),C.disable(C.CULL_FACE),u?(C.disable(C.BLEND),C.depthFunc(C.GREATER)):(C.enable(C.BLEND),C.depthFunc(C.ALWAYS),C.enable(C.CULL_FACE)),C.cullFace(C.BACK);let D=this.meshShaders[0].shader,_=!1;for(let P=0;P<this.meshes.length;P++)if(this.meshes[P].visible!==!1&&(D=this.meshShaders[this.meshes[P].meshShaderIndex].shader,this.uiData.mouseDepthPicker&&(D=this.pickingMeshShader),D.use(this.gl),C.uniformMatrix4fv(D.uniforms.mvpMtx,!1,g),C.uniformMatrix4fv(D.uniforms.normMtx,!1,v),C.uniform1f(D.uniforms.opacity,h),!(this.meshes[P].indexCount<3))){if(this.meshes[P].offsetPt0&&(this.meshes[P].fiberSides<3||this.meshes[P].fiberRadius<=0)){_=!0;continue}D.isMatcap&&(C.activeTexture(TEXTURE5_MATCAP),C.bindTexture(C.TEXTURE_2D,this.matCapTexture)),C.bindVertexArray(this.meshes[P].vao),C.drawElements(C.TRIANGLES,this.meshes[P].indexCount,C.UNSIGNED_INT,0),C.bindVertexArray(this.unusedVAO)}if(!_){C.enable(C.BLEND),C.depthFunc(C.ALWAYS);return}D=this.fiberShader,D.use(this.gl),C.uniformMatrix4fv(D.uniforms.mvpMtx,!1,g),C.uniform1f(D.uniforms.opacity,h);for(let P=0;P<this.meshes.length;P++)this.meshes[P].indexCount<3||this.meshes[P].offsetPt0&&(this.meshes[P].fiberSides>=3&&this.meshes[P].fiberRadius>0||(C.bindVertexArray(this.meshes[P].vaoFiber),C.drawElements(C.LINE_STRIP,this.meshes[P].indexCount,C.UNSIGNED_INT,0),C.bindVertexArray(this.unusedVAO)));C.enable(C.BLEND),C.depthFunc(C.ALWAYS),this.readyForSync=!0}drawCrosshairs3D(u=!0,h=1,g=null,S=!1,v=!0){if(!this.opts.show3Dcrosshair&&!S||this.opts.crosshairWidth<=0&&S)return;const C=this.gl,D=this.frac2mm(this.scene.crosshairPos,0,v);if(this.crosshairs3D===null||this.crosshairs3D.mm[0]!==D[0]||this.crosshairs3D.mm[1]!==D[1]||this.crosshairs3D.mm[2]!==D[2]){this.crosshairs3D!==null&&(C.deleteBuffer(this.crosshairs3D.indexBuffer),C.deleteBuffer(this.crosshairs3D.vertexBuffer));const[L,m,k]=this.sceneExtentsMinMax(v);let e=1;if(this.volumes.length>0){if(!this.back)throw new Error("back undefined");e=.5*Math.min(Math.min(this.back.pixDims[1],this.back.pixDims[2]),this.back.pixDims[3])}else(k[0]<50||k[0]>1e3)&&(e=k[0]*.02);e*=this.opts.crosshairWidth,this.crosshairs3D=NiivueObject3D.generateCrosshairs(this.gl,1,D,L,m,e,20,this.opts.crosshairGap),this.crosshairs3D.mm=D}if(!this.surfaceShader)throw new Error("surfaceShader undefined");const _=this.surfaceShader;_.use(this.gl),g==null&&([g]=this.calculateMvpMatrix(this.crosshairs3D,void 0,this.scene.renderAzimuth,this.scene.renderElevation)),C.uniformMatrix4fv(_.uniforms.mvpMtx,!1,g),C.bindBuffer(C.ELEMENT_ARRAY_BUFFER,this.crosshairs3D.indexBuffer),C.enable(C.DEPTH_TEST);const P=[...this.opts.crosshairColor];u?(C.disable(C.BLEND),C.depthFunc(C.GREATER)):(C.enable(C.BLEND),C.blendFunc(C.SRC_ALPHA,C.ONE_MINUS_SRC_ALPHA),C.depthFunc(C.ALWAYS)),P[3]=h,C.uniform4fv(_.uniforms.surfaceColor,P),C.bindVertexArray(this.crosshairs3D.vao),C.drawElements(C.TRIANGLES,this.crosshairs3D.indexCount,C.UNSIGNED_INT,0),C.bindVertexArray(this.unusedVAO)}mm2frac(u,h=0,g=!1){if(this.volumes.length<1){const S=fromValues$2(.1,.5,.5),[v,C,D]=this.sceneExtentsMinMax();return S[0]=(u[0]-v[0])/D[0],S[1]=(u[1]-v[1])/D[1],S[2]=(u[2]-v[2])/D[2],isFinite(S)||(isFinite(S[0])||(S[0]=.5),isFinite(S[1])||(S[1]=.5),isFinite(S[2])||(S[2]=.5),this.meshes.length<1&&log.error("mm2frac() not finite: objects not (yet) loaded.")),S}return this.volumes[h].convertMM2Frac(u,g||this.opts.isSliceMM)}vox2frac(u,h=0){return this.volumes[h].convertVox2Frac(u)}frac2vox(u,h=0){return this.volumes.length<=h?[0,0,0]:this.volumes[h].convertFrac2Vox(u)}moveCrosshairInVox(u,h,g){const S=this.frac2vox(this.scene.crosshairPos);S[0]+=u,S[1]+=h,S[2]+=g,S[0]=clamp(S[0],0,this.volumes[0].dimsRAS[1]-1),S[1]=clamp(S[1],0,this.volumes[0].dimsRAS[2]-1),S[2]=clamp(S[2],0,this.volumes[0].dimsRAS[3]-1),this.scene.crosshairPos=this.vox2frac(S),this.createOnLocationChange(),this.drawScene()}frac2mm(u,h=0,g=!1){const S=fromValues$1(u[0],u[1],u[2],1);if(this.volumes.length>0)return this.volumes[h].convertFrac2MM(u,g||this.opts.isSliceMM);{const[v,C]=this.sceneExtentsMinMax(),D=(_,P,L)=>_*(1-L)+P*L;S[0]=D(v[0],C[0],u[0]),S[1]=D(v[1],C[1],u[1]),S[2]=D(v[2],C[2],u[2])}return S}screenXY2TextureFrac(u,h,g,S=!0){const v=fromValues$2(-1,-1,-1),C=this.screenSlices[g].axCorSag;if(C>2)return v;const D=this.screenSlices[g].leftTopWidthHeight.slice();let _=!1;D[2]<0&&(_=!0,D[0]+=D[2],D[2]=-D[2]);let P=(u-D[0])/D[2];_&&(P=1-P);const L=1-(h-D[1])/D[3];if(P<0||P>1||L<0||L>1||this.screenSlices[g].AxyzMxy.length<4)return v;let m=fromValues$2(0,0,0);m[0]=this.screenSlices[g].leftTopMM[0]+P*this.screenSlices[g].fovMM[0],m[1]=this.screenSlices[g].leftTopMM[1]+L*this.screenSlices[g].fovMM[1];const k=this.screenSlices[g].AxyzMxy;m[2]=k[2]+k[4]*(m[1]-k[1])-k[3]*(m[0]-k[0]),C===1&&(m=swizzleVec3(m,[0,2,1])),C===2&&(m=swizzleVec3(m,[2,0,1]));const e=this.mm2frac(m);return S&&(e[0]<0||e[0]>1||e[1]<0||e[1]>1||e[2]<0||e[2]>1)?v:e}canvasPos2frac(u){for(let h=0;h<this.screenSlices.length;h++){const g=this.screenXY2TextureFrac(u[0],u[1],h);if(g[0]>=0)return g}return[-1,-1,-1]}scaleSlice(u,h,g=0,S=0){const v=this.effectiveCanvasWidth()-g,C=this.effectiveCanvasHeight()-S;let D=v/u;h*D>C&&(D=C/h);const _=u*D,P=h*D;return[(v-_)*.5,(C-P)*.5,_,P,D]}drawThumbnail(){if(!this.bmpShader)throw new Error("bmpShader undefined");this.bmpShader.use(this.gl),this.gl.uniform2f(this.bmpShader.uniforms.canvasWidthHeight,this.gl.canvas.width,this.gl.canvas.height);let u=this.gl.canvas.height,h=this.gl.canvas.height*this.bmpTextureWH;h>this.gl.canvas.width&&(u=this.gl.canvas.width/this.bmpTextureWH,h=this.gl.canvas.width),this.gl.uniform4f(this.bmpShader.uniforms.leftTopWidthHeight,0,0,h,u),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawLine(u,h=1,g=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl),g[3]<0&&(g=this.opts.crosshairColor),this.gl.uniform4fv(this.lineShader.uniforms.lineColor,g),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,h),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,u),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}draw3DLine(u,h,g=1,S=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.line3DShader)throw new Error("line3DShader undefined");this.line3DShader.use(this.gl),S[3]<0&&(S=this.opts.crosshairColor),this.gl.uniform4fv(this.line3DShader.uniforms.lineColor,S),this.gl.uniform2fv(this.line3DShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.line3DShader.uniforms.thickness,g),this.gl.uniform2fv(this.line3DShader.uniforms.startXY,u),this.gl.uniform3fv(this.line3DShader.uniforms.endXYZ,h),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawDottedLine(u,h=1,g=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl);const S=g[3]<0?[...this.opts.crosshairColor]:[...g];S[3]=.3;const v=fromValues(u[2]-u[0],u[3]-u[1]),C=length(v);normalize(v,v);const _=this.opts.textHeight*Math.min(this.gl.canvas.height,this.gl.canvas.width)*1;scale(v,v,_/2);const P=length(v);let L=Math.floor(C/P);C%P&&L++;const m=[u[0],u[1]];this.gl.uniform4fv(this.lineShader.uniforms.lineColor,S),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,h);for(let k=0;k<L-1;k++){if(k%2){m[0]+=v[0],m[1]+=v[1];continue}const e=[m[0],m[1],m[0]+v[0],m[1]+v[1]];this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,e),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),m[0]+=v[0],m[1]+=v[1]}this.gl.bindVertexArray(this.unusedVAO)}drawGraphLine(u,h=[1,0,0,.5],g=2){this.drawLine(u,g,h)}drawCrossLinesMM(u,h,g,S,v){if(u<0||this.screenSlices.length<=u)return;const C=this.screenSlices[u];let D=C.sliceFrac;D===1/0&&log.warn("Rendering approximate cross lines in world view mode"),D===1/0&&(D=.5);let P=S.slice(),L=v.slice();const m=Math.max(1,this.opts.crosshairWidth);h===1&&(P=g.slice()),h===2&&(P=g.slice(),L=S.slice());function k(e){const O=fromValues(0,0);return O[0]=C.leftTopWidthHeight[0]+(e[0]-C.leftTopMM[0])/C.fovMM[0]*C.leftTopWidthHeight[2],O[1]=C.leftTopWidthHeight[1]+C.leftTopWidthHeight[3]-(e[1]-C.leftTopMM[1])/C.fovMM[1]*C.leftTopWidthHeight[3],O}if(P.length>0&&h===0){const e=D,O=1;for(let q=0;q<P.length;q++){const Q=this.frac2mm([.5,.5,.5]);Q[O]=P[q];let i0=this.mm2frac(Q);i0=i0[O];let j=this.frac2mm([0,i0,e]);j=swizzleVec3(j,[0,1,2]);let Y=this.frac2mm([1,i0,e]);Y=swizzleVec3(Y,[0,1,2]),j=k(j),Y=k(Y),this.drawLine([j[0],j[1],Y[0],Y[1]],m)}}if(P.length>0&&h===1){const e=D,O=2;for(let q=0;q<P.length;q++){const Q=this.frac2mm([.5,.5,.5]);Q[O]=P[q];let i0=this.mm2frac(Q);i0=i0[O];let j=this.frac2mm([0,e,i0]);j=swizzleVec3(j,[0,2,1]);let Y=this.frac2mm([1,e,i0]);Y=swizzleVec3(Y,[0,2,1]),j=k(j),Y=k(Y),this.drawLine([j[0],j[1],Y[0],Y[1]],m)}}if(P.length>0&&h===2){const e=D,O=2;for(let q=0;q<P.length;q++){const Q=this.frac2mm([.5,.5,.5]);Q[O]=P[q];let i0=this.mm2frac(Q);i0=i0[O];let j=this.frac2mm([e,0,i0]);j=swizzleVec3(j,[1,2,0]);let Y=this.frac2mm([e,1,i0]);Y=swizzleVec3(Y,[1,2,0]),j=k(j),Y=k(Y),this.drawLine([j[0],j[1],Y[0],Y[1]],m)}}if(L.length>0&&h===0){const e=D,O=0;for(let q=0;q<L.length;q++){const Q=this.frac2mm([.5,.5,.5]);Q[O]=L[q];let i0=this.mm2frac(Q);i0=i0[O];let j=this.frac2mm([i0,0,e]);j=swizzleVec3(j,[0,1,2]);let Y=this.frac2mm([i0,1,e]);Y=swizzleVec3(Y,[0,1,2]),j=k(j),Y=k(Y),this.drawLine([j[0],j[1],Y[0],Y[1]],m)}}if(L.length>0&&h===1){const e=D,O=0;for(let q=0;q<L.length;q++){const Q=this.frac2mm([.5,.5,.5]);Q[O]=L[q];let i0=this.mm2frac(Q);i0=i0[O];let j=this.frac2mm([i0,e,0]);j=swizzleVec3(j,[0,2,1]);let Y=this.frac2mm([i0,e,1]);Y=swizzleVec3(Y,[0,2,1]),j=k(j),Y=k(Y),this.drawLine([j[0],j[1],Y[0],Y[1]],m)}}if(L.length>0&&h===2){const e=D,O=1;for(let q=0;q<L.length;q++){const Q=this.frac2mm([.5,.5,.5]);Q[O]=L[q];let i0=this.mm2frac(Q);i0=i0[O];let j=this.frac2mm([e,i0,0]);j=swizzleVec3(j,[1,2,0]);let Y=this.frac2mm([e,i0,1]);Y=swizzleVec3(Y,[1,2,0]),j=k(j),Y=k(Y),this.drawLine([j[0],j[1],Y[0],Y[1]],m)}}}drawCrossLines(u,h,g,S,v){if(u<0||this.screenSlices.length<=u)return;if(this.opts.isSliceMM)return this.drawCrossLinesMM(u,h,g,S,v);if(this.screenSlices[u].sliceFrac===1/0)return this.drawCrossLinesMM(u,h,g,S,v);const C=this.screenSlices[u];let D=S.slice(),_=v.slice();if(h===1&&(D=g.slice()),h===2&&(D=g.slice(),_=S.slice()),D.length>0){const P=C.leftTopWidthHeight.slice();let L=2;h===0&&(L=1);const m=this.frac2mm([.5,.5,.5]);for(let k=0;k<D.length;k++){m[L]=D[k];const e=this.mm2frac(m);this.drawRect([P[0],P[1]+P[3]-e[L]*P[3],P[2],1])}}if(_.length>0){const P=C.leftTopWidthHeight.slice(),L=C.fovMM[0]<0;let m=0;h===2&&(m=1);const k=this.frac2mm([.5,.5,.5]);for(let e=0;e<_.length;e++){k[m]=_[e];const O=this.mm2frac(k);L?this.drawRect([P[0]+(P[2]-O[m]*P[2]),P[1],1,P[3]]):this.drawRect([P[0]+O[m]*P[2],P[1],1,P[3]])}}}drawMosaic(u){if(this.volumes.length===0){log.debug("Unable to draw mosaic until voxel-based image is loaded");return}this.screenSlices=[];const h=this.screenFieldOfViewMM(0,!0),g=this.screenFieldOfViewMM(0);u=u.replaceAll(";"," ;").trim();const S=[],v=[],C=[],D=u.split(/\s+/);let _=1;const P=this.opts.textHeight;let L=0,m=0;for(let k=0;k<2;k++){let e=!1,O=!1;e=!1;let q=0,Q=0,i0=0,j=0,Y=!1,T=0;for(let K=0;K<D.length;K++){const e0=D[K];if(e0.includes("X")){O=!0;continue}if(e0.includes("L")){Y=!e0.includes("-");continue}if(e0.includes("V")||e0.includes("H")){K++;continue}e0.includes("A")&&(T=0),e0.includes("C")&&(T=1),e0.includes("S")&&(T=2),e0.includes("R")&&(e=!0),e0.includes(";")&&(i0+=q,j=Math.max(j,Q),q=0,Q=0);const z=parseFloat(e0);if(isNaN(z))continue;let f=0,f0=0,o0=g;if(e&&(o0=h),T===2?f=o0[1]:f=o0[0],T===0?f0=o0[1]:f0=o0[2],k===0)e||(T===0&&S.push(z),T===1&&v.push(z),T===2&&C.push(z));else{const c0=[L+_*Q,m+_*i0,_*f,_*f0];if(this.opts.textHeight=Y?P:0,e){let d0=z<0?-1/0:1/0;Object.is(z,-0)&&(d0=-1/0),this.draw2D(c0,T,d0)}else this.draw2D(c0,T,z);O&&this.drawCrossLines(this.screenSlices.length-1,T,S,v,C),e=!1,O=!1}Q+=f,q=Math.max(q,f0)}if(i0+=q,j=Math.max(j,Q),j<=0||i0<=0)break;const H=this.gl.canvas.width/j,G=this.effectiveCanvasHeight()/i0;_=Math.min(H,G),this.opts.centerMosaic&&(L=Math.floor(.5*(this.gl.canvas.width-j*_)),m=Math.floor(.5*(this.effectiveCanvasHeight()-i0*_)))}this.opts.textHeight=P}drawSceneCore(){if(!this.initialized)return;if(this.colorbarHeight=0,this.gl.clearColor(this.opts.backColor[0],this.opts.backColor[1],this.opts.backColor[2],this.opts.backColor[3]),this.gl.clear(this.gl.COLOR_BUFFER_BIT|this.gl.DEPTH_BUFFER_BIT),this.bmpTexture&&this.thumbnailVisible){this.drawThumbnail();return}let u="";if(this.volumes.length===0||typeof this.volumes[0].dims>"u"){if(this.meshes.length>0){this.screenSlices=[],this.opts.sliceType=4,this.draw3D(),this.opts.isColorbar&&this.drawColorbar();return}this.drawLoadingText(this.loadingText);return}if(this.back===null)return;if(this.uiData.isDragging&&this.scene.clipPlaneDepthAziElev[0]<1.8&&this.inRenderTile(this.uiData.dragStart[0],this.uiData.dragStart[1])>=0){const v=this.uiData.dragStart[0]-this.uiData.dragEnd[0],C=this.uiData.dragStart[1]-this.uiData.dragEnd[1],D=this.uiData.dragClipPlaneStartDepthAziElev.slice();if(D[1]-=v,D[1]=D[1]%360,D[2]+=C,D[1]!==this.scene.clipPlaneDepthAziElev[1]||D[2]!==this.scene.clipPlaneDepthAziElev[2])return this.scene.clipPlaneDepthAziElev=D,this.setClipPlane(this.scene.clipPlaneDepthAziElev)}if(this.sliceMosaicString.length<1&&this.opts.sliceType===4){this.opts.isColorbar&&this.reserveColorbarPanel(),this.screenSlices=[],this.draw3D(),this.opts.isColorbar&&this.drawColorbar();return}this.opts.isColorbar&&this.reserveColorbarPanel();const h=this.getMaxVols(),g=this.opts.sliceType===3&&h>1&&this.graph.autoSizeMultiplanar&&this.graph.opacity>0;if(this.sliceMosaicString.length>0)this.drawMosaic(this.sliceMosaicString);else if(this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.screenSlices=[],this.opts.sliceType===0)this.draw2D([0,0,0,0],0);else if(this.opts.sliceType===1)this.draw2D([0,0,0,0],1);else if(this.opts.sliceType===2)this.draw2D([0,0,0,0],2);else{let v=!1;this.opts.multiplanarForceRender?(v=!0,this.opts.multiplanarForceRender?this.opts.multiplanarShowRender=1:this.opts.multiplanarShowRender=2,delete this.opts.multiplanarForceRender):this.opts.multiplanarShowRender===1&&(v=!0);const C=isFinite(this.drawPenLocation[0])&&this.opts.drawingEnabled,{volScale:D}=this.sliceScale(),_=D.slice();this.opts.multiplanarEqualSize&&(D[0]=1,D[1]=1,D[2]=1),typeof this.opts.multiplanarPadPixels!="number"&&log.debug("multiplanarPadPixels must be numeric");const P=parseFloat(`${this.opts.multiplanarPadPixels}`),L=this.scaleSlice(D[0]+D[1],D[1]+D[2],P*1,P*1),m=Math.max(Math.max(D[1],D[2]),D[0]),k=this.scaleSlice(D[0]+D[0]+D[1],Math.max(D[1],D[2]),P*2),e=this.scaleSlice(D[0]+D[0]+D[1]+m,Math.max(D[1],D[2]),P*3),O=this.scaleSlice(m,D[1]+D[2]+D[2],0,P*2),q=this.scaleSlice(m,D[1]+D[2]+D[2]+m,0,P*3);let Q=!C&&(h<2||!g),i0=!1,j=!1,Y=!1;this.opts.multiplanarLayout===1?i0=!0:this.opts.multiplanarLayout===2?j=!0:this.opts.multiplanarLayout===3?Y=!0:O[4]>k[4]&&O[4]>L[4]?i0=!0:k[4]>L[4]?Y=!0:j=!0;let T=L;i0?(T=O,v||this.opts.multiplanarShowRender===2&&q[4]>=O[4]?T=q:Q=!1):Y&&(T=k,v||this.opts.multiplanarShowRender===2&&e[4]>=k[4]?T=e:Q=!1);const H=D[0]*T[4],G=D[1]*T[4],K=D[2]*T[4],e0=_[0]*T[4],z=_[1]*T[4],f=_[2]*T[4];if(i0){if(this.draw2D([T[0],T[1],H,G],0,NaN,[e0,z]),this.draw2D([T[0],T[1]+G+P,H,K],1,NaN,[e0,f]),this.draw2D([T[0],T[1]+G+P+K+P,G,K],2,NaN,[z,f]),Q){const f0=m*T[4];this.draw3D([T[0],T[1]+G+K+K+P*3,f0,f0])}}else if(Y){if(this.draw2D([T[0],T[1],H,G],0,NaN,[e0,z]),this.draw2D([T[0]+H+P,T[1],H,K],1,NaN,[e0,f]),this.draw2D([T[0]+H+H+P*2,T[1],G,K],2,NaN,[z,f]),Q){const f0=m*T[4];this.draw3D([T[0]+H+H+G+P*3,T[1],f0,f0])}}else j&&(v||(Q=!1),this.opts.multiplanarShowRender===2&&(Q=!0),this.draw2D([T[0],T[1]+K+P,H,G],0,NaN,[e0,z]),this.draw2D([T[0],T[1],H,K],1,NaN,[e0,f]),this.draw2D([T[0]+H+P,T[1],G,K],2,NaN,[z,f]),Q&&this.draw3D([T[0]+H+P,T[1]+K+P,G,G]))}if(this.opts.isRuler&&this.drawRuler(),this.opts.isColorbar&&this.drawColorbar(),g&&this.drawGraph(),this.uiData.isDragging){if(this.uiData.mouseButtonCenterDown){this.dragForCenterButton([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.opts.dragMode===4){this.dragForSlicer3D([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.opts.dragMode===3){this.dragForPanZoom([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.inRenderTile(this.uiData.dragStart[0],this.uiData.dragStart[1])>=0)return;if(this.opts.dragMode===2){this.drawMeasurementTool([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}const v=Math.abs(this.uiData.dragStart[0]-this.uiData.dragEnd[0]),C=Math.abs(this.uiData.dragStart[1]-this.uiData.dragEnd[1]);this.drawSelectionBox([Math.min(this.uiData.dragStart[0],this.uiData.dragEnd[0]),Math.min(this.uiData.dragStart[1],this.uiData.dragEnd[1]),v,C])}if(this.opts.clickToSegment){const v=this.mousePos[0],C=this.mousePos[1],D=this.tileIndex(v,C);if(D>-1){const _=this.screenSlices[D].fovMM,L=this.screenSlices[D].leftTopWidthHeight[2]/_[0],m=this.opts.crosshairColor,k=[m[0],m[1],m[2],.4],e=this.opts.clickToSegmentRadius*L;this.drawCircle([v-e,C-e,e*2,e*2],k,1)}}const S=this.frac2mm([this.scene.crosshairPos[0],this.scene.crosshairPos[1],this.scene.crosshairPos[2]]);return u=S[0].toFixed(2)+"×"+S[1].toFixed(2)+"×"+S[2].toFixed(2),this.readyForSync=!0,this.sync(),this.drawAnchoredLabels(),u}drawScene(){if(this.isBusy){this.needsRefresh=!0;return}this.isBusy=!1,this.needsRefresh=!1;let u=this.drawSceneCore();return this._gl!==null&&this.gl.finish(),this.needsRefresh&&(u=this.drawScene()),u}get gl(){if(!this._gl)throw new Error("unable to get WebGL context. Maybe the browser doesn't support WebGL2.");return this._gl}set gl(u){this._gl=u}},Dcm2niix=class{constructor(){this.worker=null}init(){return this.worker=new Worker(new URL(""+new URL("worker-BxHQgUvF.js",import.meta.url).href,import.meta.url),{type:"module"}),new Promise((w,u)=>{this.worker.onmessage=h=>{h.data&&h.data.type==="ready"&&w(!0)},this.worker.onerror=h=>{u(new Error(`Worker failed to load: ${h.message}`))}})}conformFileList(w){return Array.from(w).map(h=>({file:h,webkitRelativePath:h.webkitRelativePath||h._webkitRelativePath||""}))}input(w){const u=this.conformFileList(w);return new Processor({worker:this.worker,fileList:u})}inputFromWebkitDirectory(w){const u=this.conformFileList(w);return new Processor({worker:this.worker,fileList:u})}inputFromDropItems(w){const u=this.conformFileList(w);return new Processor({worker:this.worker,fileList:u})}},Processor=class{constructor({worker:w,fileList:u}){this.worker=w,this.fileList=u,this.commands=[]}_addCommand(w,...u){return this.commands.push(w,...u.map(String)),this}version(){return this._addCommand("--version")}compressionLevel(w){return this._addCommand(`-${w}`)}a(w){return this._addCommand("-a",w)}adjacent(w){return this.a(w)}b(w){return this._addCommand("-b",w)}bids(w){return this.b(w)}ba(w){return this._addCommand("-ba",w)}bidsAnonymize(w){return this.ba(w)}c(w){return this._addCommand("-c",w)}comment(w){return this.c(w)}d(w){return this._addCommand("-d",w)}directorySearchDepth(w){return this.d(w)}e(w){return this._addCommand("-e",w)}exportFormat(w){return this.e(w)}f(w){return this._addCommand("-f",w)}filenameformat(w){return this.f(w)}i(w){return this._addCommand("-i",w)}ignoreDerived(w){return this.i(w)}l(w){return this._addCommand("-l",w)}losslessScale(w){return this.l(w)}m(w){return this._addCommand("-m",w)}merge2DSlices(w){return this.m(w)}n(w){return this._addCommand("-n",w)}seriesCRC(w){return this.n(w)}p(w){return this._addCommand("-p",w)}philipsPreciseFloat(w){return this.p(w)}q(w){return this._addCommand("-q",w)}searchDirectory(w){return this.q(w)}r(w){return this._addCommand("-r",w)}renameOnly(w){return this.r(w)}s(w){return this._addCommand("-s",w)}singleFileMode(w){return this.s(w)}v(w){return this._addCommand("-v",w)}verbose(w){return this.v(w)}w(w){return this._addCommand("-w",w)}writeBehavior(w){return this.w(w)}x(w){return this._addCommand("-x",w)}crop(w){return this.x(w)}z(w){return this._addCommand("-z",w)}gzip(w){return this.z(w)}bigEndian(w){return this._addCommand("--big-endian",w)}ignoreTriggerTimes(){return this._addCommand("--ignore_trigger_times")}terse(){return this._addCommand("--terse")}xml(){return this._addCommand("--xml")}async run(){return new Promise((w,u)=>{this.worker.onmessage=g=>{if(g.data.type==="error")u(new Error(g.data.message));else{const{convertedFiles:S,exitCode:v}=g.data;v===0||v===3?w(S):u(new Error(`dcm2niix processing failed with exit code ${v}`))}};const h=[...this.commands];this.worker===null&&u(new Error("Worker not initialized. Did you await the init() method?")),this.worker.postMessage({fileList:this.fileList,cmd:h})})}};const nv=new Niivue({dragAndDropEnabled:!1});let resultFileList=[],conversionTime=0,downloadFile=null;const handleSaveButtonClick=()=>{let w=URL.createObjectURL(downloadFile);const u=document.createElement("a");u.href=w,u.download=downloadFile.name,u.click()},showSaveButton=()=>{document.getElementById("saveButton").classList.remove("hidden")},hideSaveButton=()=>{document.getElementById("saveButton").classList.add("hidden")},showLoadingCircle=()=>{loadingCircle.classList.remove("hidden")},hideLoadingCircle=()=>{loadingCircle.classList.add("hidden")},hideFileSelect=()=>{fileSelect.classList.add("hidden")},showFileSelect=()=>{fileSelect.classList.remove("hidden")},handleLocationChange=w=>{document.getElementById("intensity").innerHTML=w.string},showText=w=>{document.getElementById("intensity").innerHTML=w},removeAllVolumes=()=>{const w=nv.volumes;for(let u=0;u<w.length;u++)nv.removeVolume(w[u])},handleFileSelectChange=async w=>{if(resultFileList.length===0){console.log("No files to select from");return}const u=parseInt(w.target.value);if(u===-1)return;const h=resultFileList[u];if(downloadFile=h,h.name.endsWith(".nii")){removeAllVolumes(),console.log(h);const g=await NVImage.loadFromFile({file:h,name:h.name});await nv.addVolume(g)}showSaveButton()},removeSelectItems=()=>{const w=document.getElementById("fileSelect");for(;w.firstChild;)w.removeChild(w.firstChild)},updateSelectItems=w=>{removeSelectItems();const u=document.getElementById("fileSelect");u.innerHTML="";for(let g=0;g<w.length;g++){const S=document.createElement("option");S.value=g,S.text=w[g].name,u.appendChild(S)}const h=document.createElement("option");h.value=-1,h.text="Select a file",h.selected=!0,u.appendChild(h)},runDcm2niix=async w=>{try{hideSaveButton(),showLoadingCircle();const u=new Dcm2niix;await u.init();const h=Date.now();resultFileList=await u.input(w).run(),conversionTime=(Date.now()-h)/1e3,showText(`Conversion time: ${conversionTime} seconds`),updateSelectItems(resultFileList),console.log(resultFileList),hideLoadingCircle(),showFileSelect(),fileSelect.value=0;const S=new Event("change");fileSelect.dispatchEvent(S)}catch(u){console.error(u),resultFileList=[],hideLoadingCircle(),hideFileSelect(),showText("Error converting files. Check the console for more information.")}},ensureObjectOfObjects=w=>w.length?w:{0:w};async function handleDrop(w){w.preventDefault();const u=w.dataTransfer.items;try{showLoadingCircle();const h=[];for(let v=0;v<u.length;v++){const C=u[v].webkitGetAsEntry();C&&await traverseFileTree(C,"",h)}const g=new Dcm2niix;await g.init(),resultFileList=await g.inputFromDropItems(h).run(),resultFileList=resultFileList.filter(v=>v.name.endsWith(".nii")),updateSelectItems(resultFileList),console.log(resultFileList),hideLoadingCircle(),showFileSelect(),fileSelect.value=0;const S=new Event("change");fileSelect.dispatchEvent(S),showText("")}catch(h){console.error(h),hideLoadingCircle(),hideFileSelect(),showText("Error converting files. Check the console for more information.")}}async function traverseFileTree(w,u="",h){return new Promise(g=>{if(w.isFile)w.file(S=>{S.fullPath=u+S.name,S._webkitRelativePath=u+S.name,h.push(S),g()});else if(w.isDirectory){const S=w.createReader(),v=()=>{S.readEntries(C=>{if(C.length>0){const D=[];for(const _ of C)D.push(traverseFileTree(_,u+w.name+"/",h));Promise.all(D).then(v)}else g()})};v()}})}async function main(){fileInput.addEventListener("change",async u=>{if(u.target.files.length===0){console.log("No files selected");return}console.log("Selected files:",u.target.files);const h=u.target.files,g=ensureObjectOfObjects(h);await runDcm2niix(g)}),fileSelect.onchange=handleFileSelectChange,dropTarget.ondrop=handleDrop,dropTarget.ondragover=u=>{u.preventDefault()},saveButton.onclick=handleSaveButtonClick,nv.onLocationChange=handleLocationChange;const w=document.getElementById("gl");nv.attachToCanvas(w),nv.opts.yoke3Dto2DZoom=!0,nv.opts.crosshairGap=5,nv.setInterpolation(!0),nv.setMultiplanarLayout(MULTIPLANAR_TYPE.GRID),nv.setSliceType(SLICE_TYPE.MULTIPLANAR),nv.opts.multiplanarShowRender=SHOW_RENDER.ALWAYS,nv.opts.dragMode=DRAG_MODE.slicer3D}main();
diff --git a/index.html b/index.html
index 16288c0..e90e20a 100644
--- a/index.html
+++ b/index.html
@@ -5,7 +5,7 @@
   <meta charset="UTF-8" />
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
   <title>NiiVue + dcm2niix WASM</title>
-  <script type="module" crossorigin src="./assets/index-pvyZ93tw.js"></script>
+  <script type="module" crossorigin src="./assets/index-BpgbaWPX.js"></script>
   <link rel="stylesheet" crossorigin href="./assets/index-BhMGqCQj.css">
 </head>
 
@@ -32,7 +32,7 @@
       <li>
         <!-- optional: save nii file in the niivue canvas from conversion -->
         <label for="saveButton" id="saveButtonLabel">Optional: save the nifti file you are viewing</label>
-        <button id="saveButton" class="hidden">Save nifti</button>
+        <button id="saveButton" class="hidden">Save selected file</button>
       </li>
     </ol>