diff --git a/NF.jsonld b/NF.jsonld new file mode 100644 index 00000000..1f224757 --- /dev/null +++ b/NF.jsonld @@ -0,0 +1,15048 @@ +{ + "@context": { + "bts": "http://schema.biothings.io/", + "rdf": "http://www.w3.org/1999/02/22-rdf-syntax-ns#", + "rdfs": "http://www.w3.org/2000/01/rdf-schema#", + "schema": "http://schema.org/", + "xsd": "http://www.w3.org/2001/XMLSchema#" + }, + "@graph": [ + { + "@id": "schema:Text", + "@type": [ + "schema:DataType", + "rdfs:Class" + ], + "rdfs:comment": "Data type: Text.", + "rdfs:label": "Text" + }, + { + "@id": "schema:Number", + "@type": [ + "schema:DataType", + "rdfs:Class" + ], + "rdfs:comment": "Data type: Number.", + "rdfs:label": "Number" + }, + { + "@id": "schema:Integer", + "@type": "rdfs:Class", + "rdfs:comment": "Data type: Integer.", + "rdfs:label": "Integer", + "rdfs:subClassOf": { + "@id": "schema:Number" + } + }, + { + "@id": "schema:Thing", + "@type": "rdfs:Class", + "rdfs:comment": "Thing", + "rdfs:label": "Thing", + "schema:isPartOf": { + "@id": "http://schema.org" + } + }, + { + "@id": "bts:BiologicalEntity", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "BiologicalEntity", + "rdfs:subClassOf": { + "@id": "schema:Thing" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:OntologyClass", + "@type": "rdfs:Class", + "rdfs:comment": "a concept or class in an ontology, vocabulary or thesaurus", + "rdfs:label": "OntologyClass", + "rdfs:subClassOf": { + "@id": "schema:Thing" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:RelationshipType", + "@type": "rdfs:Class", + "rdfs:comment": "An OWL property used as an edge label", + "rdfs:label": "RelationshipType", + "rdfs:subClassOf": { + "@id": "bts:OntologyClass" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:GeneOntologyClass", + "@type": "rdfs:Class", + "rdfs:comment": "an ontology class that describes a functional aspect of a gene, gene prodoct or complex", + "rdfs:label": "GeneOntologyClass", + "rdfs:subClassOf": { + "@id": "bts:OntologyClass" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:OrganismTaxon", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "OrganismTaxon", + "rdfs:subClassOf": { + "@id": "bts:OntologyClass" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:OrganismalEntity", + "@type": "rdfs:Class", + "rdfs:comment": "A named entity that is either a part of an organism, a whole organism, population or clade of organisms, excluding molecular entities", + "rdfs:label": "OrganismalEntity", + "rdfs:subClassOf": { + "@id": "bts:BiologicalEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:IndividualOrganism", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "IndividualOrganism", + "rdfs:subClassOf": { + "@id": "bts:OrganismalEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Case", + "@type": "rdfs:Class", + "rdfs:comment": "An individual organism that has a patient role in some clinical context.", + "rdfs:label": "Case", + "rdfs:subClassOf": { + "@id": "bts:IndividualOrganism" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:PopulationOfIndividualOrganisms", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "PopulationOfIndividualOrganisms", + "rdfs:subClassOf": { + "@id": "bts:OrganismalEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Biosample", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "Biosample", + "rdfs:subClassOf": { + "@id": "bts:OrganismalEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:DiseaseOrPhenotypicFeature", + "@type": "rdfs:Class", + "rdfs:comment": "Either one of a disease or an individual phenotypic feature. Some knowledge resources such as Monarch treat these as distinct, others such as MESH conflate.", + "rdfs:label": "DiseaseOrPhenotypicFeature", + "rdfs:subClassOf": { + "@id": "bts:BiologicalEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Disease", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "Disease", + "rdfs:subClassOf": { + "@id": "bts:DiseaseOrPhenotypicFeature" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:PhenotypicFeature", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "PhenotypicFeature", + "rdfs:subClassOf": { + "@id": "bts:DiseaseOrPhenotypicFeature" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Environment", + "@type": "rdfs:Class", + "rdfs:comment": "A feature of the environment of an organism that influences one or more phenotypic features of that organism, potentially mediated by genes", + "rdfs:label": "Environment", + "rdfs:subClassOf": { + "@id": "bts:BiologicalEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:InformationContentEntity", + "@type": "rdfs:Class", + "rdfs:comment": "a piece of information that typically describes some piece of biology or is used as support.", + "rdfs:label": "InformationContentEntity", + "rdfs:subClassOf": { + "@id": "schema:Thing" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:ConfidenceLevel", + "@type": "rdfs:Class", + "rdfs:comment": "Level of confidence in a statement", + "rdfs:label": "ConfidenceLevel", + "rdfs:subClassOf": { + "@id": "bts:InformationContentEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:EvidenceType", + "@type": "rdfs:Class", + "rdfs:comment": "Class of evidence that supports an association", + "rdfs:label": "EvidenceType", + "rdfs:subClassOf": { + "@id": "bts:InformationContentEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Publication", + "@type": "rdfs:Class", + "rdfs:comment": "Any published piece of information. Can refer to a whole publication, or to a part of it (e.g. a figure, figure legend, or section highlighted by NLP). The scope is intended to be general and include information published on the web as well as journals.", + "rdfs:label": "Publication", + "rdfs:subClassOf": { + "@id": "bts:InformationContentEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:MolecularEntity", + "@type": "rdfs:Class", + "rdfs:comment": "A gene, gene product, small molecule or macromolecule (including protein complex)", + "rdfs:label": "MolecularEntity", + "rdfs:subClassOf": { + "@id": "bts:BiologicalEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:ChemicalSubstance", + "@type": "rdfs:Class", + "rdfs:comment": "May be a chemical entity or a formulation with a chemical entity as active ingredient, or a complex material with multiple chemical entities as part", + "rdfs:label": "ChemicalSubstance", + "rdfs:subClassOf": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Drug", + "@type": "rdfs:Class", + "rdfs:comment": "A substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease", + "rdfs:label": "Drug", + "rdfs:subClassOf": { + "@id": "bts:ChemicalSubstance" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Metabolite", + "@type": "rdfs:Class", + "rdfs:comment": "Any intermediate or product resulting from metabolism. Includes primary and secondary metabolites.", + "rdfs:label": "Metabolite", + "rdfs:subClassOf": { + "@id": "bts:ChemicalSubstance" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:AnatomicalEntity", + "@type": "rdfs:Class", + "rdfs:comment": "A subcellular location, cell type or gross anatomical part", + "rdfs:label": "AnatomicalEntity", + "rdfs:subClassOf": { + "@id": "bts:OrganismalEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:LifeStage", + "@type": "rdfs:Class", + "rdfs:comment": "A stage of development or growth of an organism, including post-natal adult stages", + "rdfs:label": "LifeStage", + "rdfs:subClassOf": { + "@id": "bts:OrganismalEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:PlanetaryEntity", + "@type": "rdfs:Class", + "rdfs:comment": "Any entity or process that exists at the level of the whole planet", + "rdfs:label": "PlanetaryEntity", + "rdfs:subClassOf": { + "@id": "schema:Thing" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:EnvironmentalProcess", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "EnvironmentalProcess", + "rdfs:subClassOf": { + "@id": "bts:PlanetaryEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:EnvironmentalFeature", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "EnvironmentalFeature", + "rdfs:subClassOf": { + "@id": "bts:PlanetaryEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:ClinicalEntity", + "@type": "rdfs:Class", + "rdfs:comment": "Any entity or process that exists in the clinical domain and outside the biological realm. Diseases are placed under biological entities", + "rdfs:label": "ClinicalEntity", + "rdfs:subClassOf": { + "@id": "schema:Thing" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:ClinicalTrial", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "ClinicalTrial", + "rdfs:subClassOf": { + "@id": "bts:ClinicalEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:ClinicalIntervention", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "ClinicalIntervention", + "rdfs:subClassOf": { + "@id": "bts:ClinicalEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Device", + "@type": "rdfs:Class", + "rdfs:comment": "A thing made or adapted for a particular purpose, especially a piece of mechanical or electronic equipment", + "rdfs:label": "Device", + "rdfs:subClassOf": { + "@id": "schema:Thing" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:GenomicEntity", + "@type": "rdfs:Class", + "rdfs:comment": "an entity that can either be directly located on a genome (gene, transcript, exon, regulatory region) or is encoded in a genome (protein)", + "rdfs:label": "GenomicEntity", + "rdfs:subClassOf": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Genome", + "@type": "rdfs:Class", + "rdfs:comment": "A genome is the sum of genetic material within a cell or virion.", + "rdfs:label": "Genome", + "rdfs:subClassOf": { + "@id": "bts:GenomicEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Transcript", + "@type": "rdfs:Class", + "rdfs:comment": "An RNA synthesized on a DNA or RNA template by an RNA polymerase", + "rdfs:label": "Transcript", + "rdfs:subClassOf": { + "@id": "bts:GenomicEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Exon", + "@type": "rdfs:Class", + "rdfs:comment": "A region of the transcript sequence within a gene which is not removed from the primary RNA transcript by RNA splicing", + "rdfs:label": "Exon", + "rdfs:subClassOf": { + "@id": "bts:GenomicEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:CodingSequence", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "CodingSequence", + "rdfs:subClassOf": { + "@id": "bts:GenomicEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:MacromolecularMachine", + "@type": "rdfs:Class", + "rdfs:comment": "A union of gene, gene product, and macromolecular complex. These are the basic units of function in a cell. They either carry out individual biological activities, or they encode molecules which do this.", + "rdfs:label": "MacromolecularMachine", + "rdfs:subClassOf": { + "@id": "bts:GenomicEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:GeneOrGeneProduct", + "@type": "rdfs:Class", + "rdfs:comment": "a union of genes or gene products. Frequently an identifier for one will be used as proxy for another", + "rdfs:label": "GeneOrGeneProduct", + "rdfs:subClassOf": { + "@id": "bts:MacromolecularMachine" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Gene", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "Gene", + "rdfs:subClassOf": { + "@id": "bts:GeneOrGeneProduct" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:GeneProduct", + "@type": "rdfs:Class", + "rdfs:comment": "The functional molecular product of a single gene. Gene products are either proteins or functional RNA molecules", + "rdfs:label": "GeneProduct", + "rdfs:subClassOf": { + "@id": "bts:GeneOrGeneProduct" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Protein", + "@type": "rdfs:Class", + "rdfs:comment": "A gene product that is composed of a chain of amino acid sequences and is produced by ribosome-mediated translation of mRNA", + "rdfs:label": "Protein", + "rdfs:subClassOf": { + "@id": "bts:GeneProduct" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:GeneProductIsoform", + "@type": "rdfs:Class", + "rdfs:comment": "This is an abstract class that can be mixed in with different kinds of gene products to indicate that the gene product is intended to represent a specific isoform rather than a canonical or reference or generic product. The designation of canonical or reference may be arbitrary, or it may represent the superclass of all isoforms.", + "rdfs:label": "GeneProductIsoform", + "rdfs:subClassOf": { + "@id": "bts:GeneProduct" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:ProteinIsoform", + "@type": "rdfs:Class", + "rdfs:comment": "Represents a protein that is a specific isoform of the canonical or reference protein. See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114032/", + "rdfs:label": "ProteinIsoform", + "rdfs:subClassOf": { + "@id": "bts:Protein" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:RnaProduct", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "RnaProduct", + "rdfs:subClassOf": { + "@id": "bts:GeneProduct" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:RnaProductIsoform", + "@type": "rdfs:Class", + "rdfs:comment": "Represents a protein that is a specific isoform of the canonical or reference RNA", + "rdfs:label": "RnaProductIsoform", + "rdfs:subClassOf": { + "@id": "bts:RnaProduct" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:NoncodingRnaProduct", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "NoncodingRnaProduct", + "rdfs:subClassOf": { + "@id": "bts:RnaProduct" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Microrna", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "Microrna", + "rdfs:subClassOf": { + "@id": "bts:NoncodingRnaProduct" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:MacromolecularComplex", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "MacromolecularComplex", + "rdfs:subClassOf": { + "@id": "bts:MacromolecularMachine" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:GeneFamily", + "@type": "rdfs:Class", + "rdfs:comment": "any grouping of multiple genes or gene products related by common descent", + "rdfs:label": "GeneFamily", + "rdfs:subClassOf": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Genotype", + "@type": "rdfs:Class", + "rdfs:comment": "An information content entity that describes a genome by specifying the total variation in genomic sequence and/or gene expression, relative to some extablished background", + "rdfs:label": "Genotype", + "rdfs:subClassOf": { + "@id": "bts:GenomicEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Haplotype", + "@type": "rdfs:Class", + "rdfs:comment": "A set of zero or more Alleles on a single instance of a Sequence[VMC]", + "rdfs:label": "Haplotype", + "rdfs:subClassOf": { + "@id": "bts:GenomicEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:SequenceVariant", + "@type": "rdfs:Class", + "rdfs:comment": "An allele that varies in its sequence from what is considered the reference allele at that locus.", + "rdfs:label": "SequenceVariant", + "rdfs:subClassOf": { + "@id": "bts:GenomicEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:DrugExposure", + "@type": "rdfs:Class", + "rdfs:comment": "A drug exposure is an intake of a particular chemical substance", + "rdfs:label": "DrugExposure", + "rdfs:subClassOf": { + "@id": "bts:Environment" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Treatment", + "@type": "rdfs:Class", + "rdfs:comment": "A treatment is targeted at a disease or phenotype and may involve multiple drug 'exposures'", + "rdfs:label": "Treatment", + "rdfs:subClassOf": { + "@id": "bts:Environment" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:GeographicLocation", + "@type": "rdfs:Class", + "rdfs:comment": "a location that can be described in lat/long coordinates", + "rdfs:label": "GeographicLocation", + "rdfs:subClassOf": { + "@id": "bts:PlanetaryEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:GeographicLocationAtTime", + "@type": "rdfs:Class", + "rdfs:comment": "a location that can be described in lat/long coordinates, for a particular time", + "rdfs:label": "GeographicLocationAtTime", + "rdfs:subClassOf": { + "@id": "bts:GeographicLocation" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Occurrent", + "@type": "rdfs:Class", + "rdfs:comment": "A processual entity", + "rdfs:label": "Occurrent", + "rdfs:subClassOf": { + "@id": "schema:Thing" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:BiologicalProcessOrActivity", + "@type": "rdfs:Class", + "rdfs:comment": "Either an individual molecular activity, or a collection of causally connected molecular activities", + "rdfs:label": "BiologicalProcessOrActivity", + "rdfs:subClassOf": { + "@id": "bts:BiologicalEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:MolecularActivity", + "@type": "rdfs:Class", + "rdfs:comment": "An execution of a molecular function carried out by a gene product or macromolecular complex.", + "rdfs:label": "MolecularActivity", + "rdfs:subClassOf": { + "@id": "bts:BiologicalProcessOrActivity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:ActivityAndBehavior", + "@type": "rdfs:Class", + "rdfs:comment": "Activity or behavior of any independent integral living, organization or mechanical actor in the world", + "rdfs:label": "ActivityAndBehavior", + "rdfs:subClassOf": { + "@id": "bts:Occurrent" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Procedure", + "@type": "rdfs:Class", + "rdfs:comment": "A series of actions conducted in a certain order or manner", + "rdfs:label": "Procedure", + "rdfs:subClassOf": { + "@id": "bts:Occurrent" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Phenomenon", + "@type": "rdfs:Class", + "rdfs:comment": "a fact or situation that is observed to exist or happen, especially one whose cause or explanation is in question", + "rdfs:label": "Phenomenon", + "rdfs:subClassOf": { + "@id": "bts:Occurrent" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:BiologicalProcess", + "@type": "rdfs:Class", + "rdfs:comment": "One or more causally connected executions of molecular functions", + "rdfs:label": "BiologicalProcess", + "rdfs:subClassOf": { + "@id": "bts:BiologicalProcessOrActivity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Pathway", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "Pathway", + "rdfs:subClassOf": { + "@id": "bts:BiologicalProcess" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:PhysiologicalProcess", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "PhysiologicalProcess", + "rdfs:subClassOf": { + "@id": "bts:BiologicalProcess" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:CellularComponent", + "@type": "rdfs:Class", + "rdfs:comment": "A location in or around a cell", + "rdfs:label": "CellularComponent", + "rdfs:subClassOf": { + "@id": "bts:AnatomicalEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:Cell", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "Cell", + "rdfs:subClassOf": { + "@id": "bts:AnatomicalEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:CellLine", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "CellLine", + "rdfs:subClassOf": { + "@id": "bts:Biosample" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + "@id": "bts:GrossAnatomicalStructure", + "@type": "rdfs:Class", + "rdfs:comment": null, + "rdfs:label": "GrossAnatomicalStructure", + "rdfs:subClassOf": { + "@id": "bts:AnatomicalEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + } + }, + { + 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"rdfs:comment": "Refseq ID for gene, protein or transcript", + "rdfs:label": "refseq", + "schema:domainIncludes": [ + { + "@id": "bts:Transcript" + } + ], + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "schema:Text" + } + }, + { + "@id": "bts:omim", + "@type": "rdf:Property", + "rdfs:comment": "Refseq ID for gene, protein or transcript", + "rdfs:label": "omim", + "schema:domainIncludes": [ + { + "@id": "bts:Disease" + } + ], + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "schema:Integer" + } + }, + { + "@id": "bts:umls", + "@type": "rdf:Property", + "rdfs:comment": "Refseq ID for gene, protein or transcript", + "rdfs:label": "umls", + "schema:domainIncludes": { + "@id": "bts:Disease" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "schema:Text" + } + }, + { + "@id": "bts:homologousTo", + "@type": "rdf:Property", + 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Examples include epistasis and synthetic lethality.", + "rdfs:label": "geneticallyInteractsWith", + "schema:domainIncludes": { + "@id": "bts:Gene" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:Gene" + } + }, + { + "@id": "bts:affectsAbundanceOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one changes the amount of the other within a system of interest", + "rdfs:label": "affectsAbundanceOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:increasesAbundanceOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one increases the amount of the other within a system of interest", + "rdfs:label": "increasesAbundanceOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:decreasesAbundanceOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one decreases the amount of the other within a system of interest", + "rdfs:label": "decreasesAbundanceOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:affectsActivityOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one changes the activity of the other within a system of interest", + "rdfs:label": "affectsActivityOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:increasesActivityOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one increases the activity of the other within a system of interest", + "rdfs:label": "increasesActivityOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:decreasesActivityOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one decreases the activity of the other within a system of interest", + "rdfs:label": "decreasesActivityOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:affectsExpressionOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one changes the level of expression of the other within a system of interest", + "rdfs:label": "affectsExpressionOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:GenomicEntity" + } + }, + { + "@id": "bts:increasesExpressionOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one increases the level of expression of the other within a system of interest", + "rdfs:label": "increasesExpressionOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:GenomicEntity" + } + }, + { + "@id": "bts:decreasesExpressionOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one decreases the level of expression of the other within a system of interest", + "rdfs:label": "decreasesExpressionOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:GenomicEntity" + } + }, + { + "@id": "bts:affectsFoldingOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one changes the rate or quality of folding of the other ", + "rdfs:label": "affectsFoldingOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:increasesFoldingOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one increases the rate or quality of folding of the other ", + "rdfs:label": "increasesFoldingOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:decreasesFoldingOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one decreases the rate or quality of folding of the other ", + "rdfs:label": "decreasesFoldingOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:affectsLocalizationOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one changes the localization of the other within a system of interest", + "rdfs:label": "affectsLocalizationOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:increasesLocalizationOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one increases the proper localization of the other within a system of interest", + "rdfs:label": "increasesLocalizationOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:decreasesLocalizationOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one decreases the proper localization of the other within a system of interest", + "rdfs:label": "decreasesLocalizationOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:affectsMetabolicProcessingOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one impacts the metabolic processing of the other within a system of interest", + "rdfs:label": "affectsMetabolicProcessingOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:increasesMetabolicProcessingOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one increases the rate of metabolic processing of the other within a system of interest", + "rdfs:label": "increasesMetabolicProcessingOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:decreasesMetabolicProcessingOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one decreases the rate of metabolic processing of the other within a system of interest", + "rdfs:label": "decreasesMetabolicProcessingOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:affectsMolecularModificationOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one leads changes in the molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)", + "rdfs:label": "affectsMolecularModificationOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:increasesMolecularModificationOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one leads to increased molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)", + "rdfs:label": "increasesMolecularModificationOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:decreasesMolecularModificationOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one leads to decreased molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)", + "rdfs:label": "decreasesMolecularModificationOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:affectsSynthesisOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one impacts the rate of chemical synthesis of the other", + "rdfs:label": "affectsSynthesisOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:increasesSynthesisOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one increases the rate of chemical synthesis of the other", + "rdfs:label": "increasesSynthesisOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:decreasesSynthesisOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one decreases the rate of chemical synthesis of the other", + "rdfs:label": "decreasesSynthesisOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:affectsDegradationOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one impacts the rate of degradation of the other within a system of interest", + "rdfs:label": "affectsDegradationOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:increasesDegradationOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one increases the rate of degradation of the other within a system of interest", + "rdfs:label": "increasesDegradationOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:decreasesDegradationOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one decreases the rate of degradation of the other within a system of interest", + "rdfs:label": "decreasesDegradationOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:affectsMutationRateOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between a molecular entity and a genomic entity where the action or effect of the molecular entity impacts the rate of mutation of the genomic entity within a system of interest", + "rdfs:label": "affectsMutationRateOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:GenomicEntity" + } + }, + { + "@id": "bts:increasesMutationRateOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between a molecular entity and a genomic entity where the action or effect of the molecular entity increases the rate of mutation of the genomic entity within a system of interest", + "rdfs:label": "increasesMutationRateOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:GenomicEntity" + } + }, + { + "@id": "bts:decreasesMutationRateOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between a molecular entity and a genomic entity where the action or effect of the molecular entity decreases the rate of mutation of the genomic entity within a system of interest", + "rdfs:label": "decreasesMutationRateOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:GenomicEntity" + } + }, + { + "@id": "bts:affectsResponseTo", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one impacts the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine, biological or pathological process) to the other", + "rdfs:label": "affectsResponseTo", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:increasesResponseTo", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one increases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine, biological or pathological process) to the other", + "rdfs:label": "increasesResponseTo", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:decreasesResponseTo", + "@type": "rdf:Property", + "rdfs:comment": "holds between two molecular entities where the action or effect of one decreases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine, biological or pathological process) to the other", + "rdfs:label": "decreasesResponseTo", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:MolecularEntity" + } + }, + { + "@id": "bts:affectsSplicingOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between a molecular entity and an mRNA where the action or effect of the molecular entity impacts the splicing of the mRNA", + "rdfs:label": "affectsSplicingOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:Transcript" + } + }, + { + "@id": "bts:increasesSplicingOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between a molecular entity and an mRNA where the action or effect of the molecular entity increases the proper splicing of the mRNA", + "rdfs:label": "increasesSplicingOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + "schema:isPartOf": { + "@id": "http://schema.biothings.io" + }, + "schema:rangeIncludes": { + "@id": "bts:Transcript" + } + }, + { + "@id": "bts:decreasesSplicingOf", + "@type": "rdf:Property", + "rdfs:comment": "holds between a molecular entity and an mRNA where the action or effect of the molecular entity decreases the proper splicing of the mRNA", + "rdfs:label": "decreasesSplicingOf", + "schema:domainIncludes": { + "@id": "bts:MolecularEntity" + }, + 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