From 3df21918f55de8d31a8cb0dadac23c8cac3004d5 Mon Sep 17 00:00:00 2001
From: Dennis Hendriksen <d.hendriksen@umcg.nl>
Date: Wed, 21 Apr 2021 10:00:34 +0200
Subject: [PATCH 1/2] genome browser: use embedded reference sequence data

---
 package-lock.json                           | 14 ++--
 package.json                                |  4 +-
 src/components/GenomeBrowser.vue            | 88 ++++++++++++++-------
 src/mocks/apiDataMock.ts                    | 58 +++++++++++++-
 src/store/actions.ts                        | 13 ++-
 tests/unit/components/GenomeBrowser.spec.ts | 67 ----------------
 tests/unit/store/actions.spec.ts            | 10 ++-
 7 files changed, 145 insertions(+), 109 deletions(-)
 delete mode 100644 tests/unit/components/GenomeBrowser.spec.ts

diff --git a/package-lock.json b/package-lock.json
index f429df92..3394ce83 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -9,7 +9,7 @@
       "version": "2.0.0",
       "license": "LGPL-3.0",
       "dependencies": {
-        "@molgenis/vip-report-api": "^2.0.0",
+        "@molgenis/vip-report-api": "^2.1.0",
         "bootstrap-vue": "^2.21.2",
         "core-js": "^3.9.1",
         "file-saver": "^2.0.5",
@@ -2359,9 +2359,9 @@
       }
     },
     "node_modules/@molgenis/vip-report-api": {
-      "version": "2.0.0",
-      "resolved": "https://registry.npmjs.org/@molgenis/vip-report-api/-/vip-report-api-2.0.0.tgz",
-      "integrity": "sha512-dlpYf/26LMOI5UDidxpmxxhpaStw26H3qUX4qrjaYjt52yd1bYKNOLvjifD0GmVZm1hxifhb3Jva8HvKiIfsvA==",
+      "version": "2.1.0",
+      "resolved": "https://registry.npmjs.org/@molgenis/vip-report-api/-/vip-report-api-2.1.0.tgz",
+      "integrity": "sha512-uPCT2JxGFfh3EUkK76GMjwXZeqDKt06OpoSsaE47whGcUndKifULbdQPAYLiMVOu2SPGi+Ol4QCWCSsLexhYwQ==",
       "dependencies": {
         "ascii85": "^1.0.2",
         "buffer": "^6.0.3",
@@ -26954,9 +26954,9 @@
       }
     },
     "@molgenis/vip-report-api": {
-      "version": "2.0.0",
-      "resolved": "https://registry.npmjs.org/@molgenis/vip-report-api/-/vip-report-api-2.0.0.tgz",
-      "integrity": "sha512-dlpYf/26LMOI5UDidxpmxxhpaStw26H3qUX4qrjaYjt52yd1bYKNOLvjifD0GmVZm1hxifhb3Jva8HvKiIfsvA==",
+      "version": "2.1.0",
+      "resolved": "https://registry.npmjs.org/@molgenis/vip-report-api/-/vip-report-api-2.1.0.tgz",
+      "integrity": "sha512-uPCT2JxGFfh3EUkK76GMjwXZeqDKt06OpoSsaE47whGcUndKifULbdQPAYLiMVOu2SPGi+Ol4QCWCSsLexhYwQ==",
       "requires": {
         "ascii85": "^1.0.2",
         "buffer": "^6.0.3",
diff --git a/package.json b/package.json
index 43b0e96e..13166dcc 100644
--- a/package.json
+++ b/package.json
@@ -1,6 +1,6 @@
 {
   "name": "@molgenis/vip-report-template",
-  "version": "2.0.0",
+  "version": "2.1.0",
   "description": "Report Template for Variant Call Format (VCF) Report Generator",
   "scripts": {
     "serve": "vue-cli-service serve",
@@ -10,7 +10,7 @@
     "i18n:report": "vue-cli-service i18n:report --src './src/**/*.?(js|vue)' --locales './src/locales/**/*.json'"
   },
   "dependencies": {
-    "@molgenis/vip-report-api": "^2.0.0",
+    "@molgenis/vip-report-api": "^2.1.0",
     "bootstrap-vue": "^2.21.2",
     "core-js": "^3.9.1",
     "file-saver": "^2.0.5",
diff --git a/src/components/GenomeBrowser.vue b/src/components/GenomeBrowser.vue
index 00ca5639..539b983d 100644
--- a/src/components/GenomeBrowser.vue
+++ b/src/components/GenomeBrowser.vue
@@ -6,7 +6,6 @@
 import Vue from 'vue';
 import igv from 'igv';
 import { mapActions, mapGetters, mapState } from 'vuex';
-import { GenomeBrowserDb } from '@/types/GenomeBrowserDb';
 import { Vcf } from '@molgenis/vip-report-api';
 
 export default Vue.extend({
@@ -14,42 +13,73 @@ export default Vue.extend({
     ...mapGetters(['genomeBrowserDb']),
     ...mapState(['selectedRecord'])
   },
-  mounted() {
-    if (this.genomeBrowserDb !== GenomeBrowserDb.hg19 && this.genomeBrowserDb !== GenomeBrowserDb.hg38) {
-      return;
-    }
-
-    const options = {
-      genome: this.genomeBrowserDb
-    };
-
-    // store browser in prototype instead of data to prevent very slow report
-    igv.createBrowser(this.$refs.igv, options).then((browser: never) => {
-      Vue.prototype.$browser = browser;
-      this.loadVariantTrack();
-    });
-  },
   methods: {
-    ...mapActions(['getVcfGz']),
-    async loadVariantTrack() {
-      const data = await this.getVcfGz();
-      Vue.prototype.$browser.loadTrack({
+    ...mapActions(['getFastaGz', 'getVcfGz']),
+    hasGenomeBrowser() {
+      return Vue.prototype.$browser !== undefined;
+    },
+    async createGenomeBrowser(config: unknown) {
+      Vue.prototype.$browser = await igv.createBrowser(this.$refs.igv, config);
+    },
+    async updateGenomeBrowser(record: Vcf.Record | null) {
+      const config = record !== null ? await this.createBrowserConfig(record) : null;
+      if (config == null) {
+        if (this.hasGenomeBrowser()) {
+          await this.deleteGenomeBrowser();
+        }
+      } else {
+        if (this.hasGenomeBrowser()) {
+          Vue.prototype.$browser.loadSessionObject(config);
+        } else {
+          await this.createGenomeBrowser(config);
+        }
+      }
+    },
+    async deleteGenomeBrowser() {
+      igv.removeBrowser(Vue.prototype.$browser);
+      Vue.prototype.$browser = undefined;
+    },
+    async createBrowserConfig(record: Vcf.Record): Promise<unknown | null> {
+      const data = await Promise.all([this.getFastaGz({ contig: record.c, pos: record.p }), this.getVcfGz()]);
+      const fastaGz = data[0];
+      const vcfGz = data[1];
+      if (fastaGz === null) {
+        return null;
+      }
+
+      let tracks = [];
+      tracks.push({
         type: 'variant',
         format: 'vcf',
         name: 'Variants',
-        url: 'data:application/gzip;base64,' + data.toString('base64')
+        url: 'data:application/gzip;base64,' + vcfGz.toString('base64')
       });
-    },
-    selectRecord(record?: Vcf.Record) {
-      const locus = record ? `chr${record.c}:${record.p}` : 'all';
-      Vue.prototype.$browser.search(locus);
+
+      return {
+        reference: {
+          id: this.genomeBrowserDb !== null ? this.genomeBrowserDb : 'reference_unknown',
+          name: this.genomeBrowserDb !== null ? this.genomeBrowserDb : 'Reference',
+          fastaURL: 'data:application/gzip;base64,' + fastaGz.toString('base64'),
+          tracks: tracks
+        },
+        locus: record.c + ':' + record.p,
+        showChromosomeWidget: false,
+        loadDefaultGenomes: false,
+        nucleotideColors: {
+          A: 'rgb(144, 238, 144)',
+          C: 'rgb(176, 196, 222)',
+          T: 'rgb(238, 162, 173)',
+          G: 'rgb(255, 236, 139)',
+          N: 'rgb(80,80,80)'
+        }
+        // bug in igv?
+        // showCenterGuide: true
+      };
     }
   },
   watch: {
-    selectedRecord(newRecord?: Vcf.Record) {
-      if (Vue.prototype.$browser !== undefined) {
-        this.selectRecord(newRecord);
-      }
+    selectedRecord(newRecord: Vcf.Record | null) {
+      this.updateGenomeBrowser(newRecord);
     }
   }
 });
diff --git a/src/mocks/apiDataMock.ts b/src/mocks/apiDataMock.ts
index 061f3f75..fc8ae837 100644
--- a/src/mocks/apiDataMock.ts
+++ b/src/mocks/apiDataMock.ts
@@ -102,6 +102,62 @@ export const apiData: ApiData.Container = {
   },
   base85: {
     vcfGz:
-      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+    fastaGz: {
+      '1:10042288-10042788':
+        'ABzY800000002#qTMEKZ3`GCC7ojbJmwpH#AKAd{e=X)rs#sd@Bbi6W_i-Kj{yfjM9^Smx+9Larlo`ELg<l1~z3r8!GUQJ0m8ym)8U`}CE7g=s>8808G~E!>54$YrvcZ(-L#$VpmdhA9B{jC$1ds_c=59}2<_dJ*g<OWidWM*zjL2IkV8;uzj1g9GufGD*XpWdclZc##2HWWTs+BF8P=j=ugvRU~z|$)$)-To>Kk^RtKZLTEbcW-=QQY~_Iit)WY}kGW$@poJA~D%3|Je2cTbQ393jzQD',
+      '1:16376162-16376662':
+        'ABzY800000002c%IS#`x4BPXU4oLwQ=um**pbzl>Z>dN*t&zYwD2kFl=lfjG*E-krh_Tjnut2K(qaezkPpOL4;XckOcjIi3yP!m(PlwQ@Iq_Tw6W`zxHW^KzIDMfz(JZp(@&Os3&~l)N99eEuHpU_RM4QfhW&m1-+E7rV(sGO<(#2_KqQj#1w9{e8w<bqAoEb8q_h99{0t94T9BMBnB}s86*j5tA(DjE!kS*^{8{+x$GJYaW$C0lLv$xfQ+lh&6GR#&a+|vDm;8so^UsnqP8w&ye00',
+      '1:17348965-17349469':
+        'ABzY800000002c%Ne+WR47>A}9#H8*50xSx@&W(<Ew!CN1qo#)-V(n1XMf#~_xXI>T%5=A+}KssUC;-`VuRfTK++!&LI?&5(lo$tL-*>z2i*!G0Ysp}lb~(|38Q0RP|6NfCp{&cb$A7dvAC)wWOHX~Mgb}nwDY<Vcsev9lh`t@p3h#Bxl>opk+M)D9X;W8{J4Vt2b~qo2o8eKvYy$|j2VxabXMz-9(ESt;FesGyz*IKP@Wp;m~tujN5nt<s7zg<t>4wi1kC*sPD}%w)|*NK)42TrYB)kP4*~!H',
+      '1:17354844-17355425':
+        'ABzY800000002FaOKt-(3`6(1OBYFJ&?1WhgciC0?|+u)QAXp**dFRbQh(3)^XL1%ey{6`!+pK(hs#|hyCmMW+2>L~V6)tFDYf#AeSTGh)*|i`*A1{wDo@O;$(oV^ERv`owjy(I%|q!)qdQ<Fg&rwIq(Th1s}0QJrj1GYPSytJ1@+KwPSK`nIF+I*y1lh15Ftycee{|Np_gMDtqsfMQ!kx6a)4muxJzq1=F|3EXG3X)rTWV8Q5G8&Nt|Ki^>DQwpE9-#=J-A+0^&3ZP#uGG%*nuOy^qLcfuhQ28I%40_h~sIr5&;}hQzlXAD)s$<y-;)00',
+      '1:40554917-40555417':
+        'ABzY800000002FaOAf+73`6(53lf!DRj@#cyvPM||FhudDe%oq9LIJ)`}=sF=keOF2gP~p*QV06q>;-1)7`4_r+w^lNoV|9zgMs0%(y>31l~YHHq;a1fu+DzkM4RH&6FC1@7*+*sns%x>5Q&?)xH!oXk)Q?eUI?P%8VH@?IzI93Tjk9nfGncFt3G1%bCIGhsM;Qpn*Rn1a=e}Lm7f-qwAYHg}?1kR^V}1*@J|xcuWLC7)qQSG)dW4g@F_%^r*u^uvkdW5v+u!JjTg`SSg|n2wpRiR#Mu&0)43x3jzQD',
+      '1:45797862-45798380':
+        'ABzY800000002c%TMoi74EyIUNW3@rK(g|Y3;6zL!FCF4+S<5|lREG7>vrFs+y1y5z1gq(=}@dfp}VzEe|BOTapX-C1}7>#L?>}2P^&%wG#parNVxS2!wZPUXy{RnFpPNg1&BTRBoovm%$av0GMF<>Oo@LH7`HP25NonAU8_Os_FOlzVGDBA$RghOE`hkn7B<7}yOB9sWja^F3SGfD7)QGoQFlp4%PgPEZZP7j#ag!Mg=gW|OBnsTZH8yx$3XXQ!f#gJVR2lFj~<vivPp8jaQFbhaS_lR0ssI',
+      '1:156105522-156106022':
+        'ABzY800000001>nK@P$|5W4p-ChaEe!Gj6mFdvxzzeQlSYV9mV2Jm-%ulu>q`(Epl={eUr*y!qR6pF2}a^{>%7XzX8tQYXYT_!e-BX0>&m~_Mt4uULQx(i}J-w8eQUg;XLu4P39Fhn1ir`&F$4pWQcqv^fdfd(sdG@V5(gBBI!A6X{^=NPGQ9MY5wMrKbE?vGb68541~2UG>v4*4RZncV4t#a-N3b%60)=_}60iJO|S`pxY^=MP8@?35DIlm^n5#nU|J+eW?J)bwxU_yc9$kLnEq000',
+      '1:156106732-156107249':
+        'ABzY800000001qKO|HX02!r>%OQoi-KWZ0GvRL>6-2W`)Gl`N3!x&>c|Ht=uzK+}L{dd16dfy+Pi%V9Q<Z=<KZBk^bx?K~_UsZOKn@EG7SRkgvfDDzJSCy3wIj9@J@C0ZoHU)%k<Z5Z$u)9G_6aFmGnKm6(o#+UfZ}xejR0xB_D^D4%HoX+I+$uJW<}`{MX?SYY3R=xRSBlmgri}yJJ;UG-L{V8$no~t8-gPi|7{<&x(lb?D>YehOyw-@6uM}zTA$P@bMYl4myw;`_<;r~w6k@F<tF4*!@&g#T&G;Sy000',
+      '2:47636999-47637503':
+        'ABzY800000001?S$!!Bc3<Uqm#eiYi64nm`1RqR*`N!g}8fhQ193Fje{=R;{pO5?Fx~>m`=g;T;w$(fNY9>L|baAQLo?0^9&3~xmOq_s(S^7FXWxlsJ5JINvL<cm5O-su4`s4_B=5}+0utZO$1P_MAg`aEF$dDuH&eef;zuA3N-@u$q;tv66>r#t)oK#|2mv~VY^pYY?%<6HVnd9%plZJLD^aotmcpp7@9<4e8=WK=zurJmF99v)34X^B?B3i-c6^;qE35XQbg%d`{ku>KeMQ@eh(Z>$&?H{4|A{7q;000',
+      '4:106320044-106320544':
+        'ABzY800000002FaL2d*=2m|l?mq?SOlfxb&ArAfk|9?yDVs?9^ZWzEA^LL(~*YEe&b)ECE*3UVQn)2~Anj9S4RrX6nOI<y8xZB~L+OKm@^Ol_IympE!@dRA(y5xKEV7X%3!9YQAa2m9pn@;KzNcPPnJw){VQU|CD;guf+Sqha&1UH&H(9~)fGg#3d!i@q9l+&xit&tWH@P%jQK`)u1LeqH)Q}>I{+%&PTNF*r6Sb+m0v{Et2;^@VTD62unMk(!Lw9NXQ5Ck@323cMYLm+zf;~(MZmUayS000',
+      '7:42017061-42017561':
+        'ABzY800000002FaQ4Yc|3`7693lc*xBtDR$eB=VY|5@;J3)|GCsbf3o=k<QvZ^!F)9@hlV^SG3sUdyof)%0{r-CY{};+~mOjW?3>BqbwUKCOT$aeaXtP7QHh-jhfzl}_Y8NEwT`<06HRil`BgM;{;RxO7|)Ko(uNC}US^heqO{{P&R|LS@<iGt>LB+?j$w1r<HG0U~sfTmZh+xS1IkZQ}zu8n4=%Yf8?W^k29ni&4$&;bV}=r7nU(K^b|bBfR$>TrMG5N_Ur)tE$)!A4YPtpW^ncJAL^AiTac@3jzQD',
+      '7:42064707-42065207':
+        'ABzY800000002#qQ3}H_3`75Wmq97r0{a*kfA|8v|5>Idhp|vnN0BAl`K<SSov(YH>p}3m&UJKmb!6xxsNhtULaN%hE>dt+7!)KR1q2IJY{;VM8b+lfA-c;ymPoxxD2hi`YU{FXYu7<RfZ9q6u}nMsY|v8GSkXm{HfaQH$$h=eEyuwf#e_M9IAt8o4>Vyhi*f_gu5jDN9*2j6err+<ClRA<cQa$lsn@FVfJ|nz%b<F)6@ukd+omw7=GXYRO6T%eT0EBv^8CPOEUeh=IWc@<uzh?11NSsk3jzQD',
+      '8:61764893-61765393':
+        'ABzY800000001?SI}XDz3`6(ar9+W^k`4t74Y~mDf0pu5Y2X;KO!1?9kI(D=em#zJzwz<h&wZ=4R<~BGR~5_W)JnzcLTY75sU?>JtYGD9(dH`-gUS;kxU$h7yfmON35aX$Rj4QsZvZ$I_Doh6-E2)K6lnWiWKev$hPpKO#KQOG!8B8ZGjZWC<1|)<ThZfDgplnJCyPaGj!H+u^_c*J?COc+`7L5$FxlKONdq&<X#Xdiyt;&Kpl4!ZJ(KP^1{1A|AHR$C`6>TFClyZPjIKoP+J2oJ$4d(W000',
+      '8:145140250-145140750':
+        'ABzY800000002EvL5jmb47>L)3+d9((!+w#!5`57-%?9z781uZwj^8md%f?E^Zqz~&*P`r^E_@OMM0xYhQw^tj8hOC<(97OM`C;SFc`Ns?oEKklz{`u%trd$5EU~53N5)%Tx<<1D(8_I*Il-@tBVaQ!W`|6sf^=Ie7g~Ws{+>aIr7s|)R1+I?WC&~A=sHsy7{%oBo))+@ex~;9#`vRmPMbM!^;|GY6CMfYIl85UQ6TaQ!ICLHY|}rS;p?=@A$@;@9h7e7*_Eb@9x_NpKQ<54FUiF',
+      '9:107546383-107546883':
+        'ABzY800000002FaQEtO93`75WmjN5nZdpGH2>Rd!bpNxAk4k44ie%HIsJwokU!OmZ`}c7kADf-$aZ`6qb(M-l>Qp4v<J)$es*xPLL@?BMg!<3kWf^XO;7Q77T=|)|%jSM-^g4`_i|U*Mk>I2gf&tL<!U3Vd8!u$UTVq!xp8O)XU^hcLh9GrtD)Nq&iC~0YX>Qi>4!}5RyQLxW+RYhd^GVO^foVi;F11-raq40&MD;ZgrNgy2Z_AUpXO8rXQ<$R9giWV4oWBv{`@_)d%WKC6c1yQE&U$hf4FUiF',
+      '10:126091249-126091749':
+        'ABzY800000001?SOAdoT3`6(ar4k_2iY_WyUgQF~|5<7~!@!_SJ};i|JNEB!zW4h$ulqID=ejp`bvFrW1GXR+(Wp4$DcO3Oap;XlIjHO^mrRaLDhC01sYa1Phvr;WE0I`O*C5^XF;_uZinbBMcGL$`5xOfS)4;IPMt#c8v=1d2WpJn*HB+P>UPxk8Js0-NaGe}QOb?GHN-cl3qF~f9SIZnbMbX7TW?<H%TBCb(%`#!Uo~H|<<@q~Usl6Jq7dd_A668#8Chw6(P!49#|I}&w1M~7~3=RSS00',
+      '11:134013975-134014475':
+        'ABzY800000001pf!3~2z4EwW7rJewx_E9PF!wY2pS!z26;s}XjJK?w1cb(UJouB7^CAzNXKG1BSQAOXa2s)J28zie*1)qMpS+1f;<MhyAeK{`z`h>1@=>^kw6auqSTcSI$MSZ2$ns(H^P0+TiLYqky+mGt;r@FM&n%HeNEuiv9zZno$))7f8*YMdf!YCMQkooeYj8|spY^N%%0gX8`E5T$qW;}>T4`R@97KS|^xtD<K+cRb0Jqc&OW=rHmW!?>p7BQ09Tnri#vhAj3MLl~)es>*zcA2E^4gvrG',
+      '13:77569878-77570378':
+        'ABzY800000001>nK@P$&47=|yNT3NiI3QU*<OBKtTd<u{Ra=`lj^lnG=Vz_w>wT^3ro+0Q>pDt{1W~B2LZi#KM$y|b<s4$qzgwFP>JYq8j_IOL$aEKi0<{VRht6Um!x(gPlhJ4qIb~L592ikry?dD7^^w_0R;n7V5+p*Wa)i4VB0GwhLy+uUtEfq>wxSYK>t1B$D654>(JZtN#)Z-rR60c-VolT-i{YvfnbdaHGXLgaEFCl^-Lcew&g^s&9w6hyn7jk>4r7ZEnFx_v@s;lEHv5&#bNm1qHeiel0ssI',
+      '14:89336157-89336657':
+        'ABzY800000001?RL6XBj2m|l=OAe`Q;@v%@isGOT@c*|&Eo|E}W*A8bK98UO-@oVc{dgVs1n<{z>zS@Dd7G(f&O_*Te8F$T;%Z2=;pJR|ZZDODhJ#?>FKhYoW}Fc+Ys@y?B*&sKCudPJ!xUCLOrQ&oKMTP_B9BvZ7VA&}&EDX7&VCxH6y-+H(On9HlNqQNkk*S>5wAeCcubmuh&`Jr&P~0fm|~@Fv1zr}Gi_q06=9~P+2LmpX(IF2B{NKTbhUJK$ESEq*#H=H=`4hDdhOUnX;D45FQ-Px0Sp2F00',
+      '14:105167610-105168110':
+        'ABzY800000001>nNeaV247=wqg$%T5>7ihJ&<FJYw?vYsAxu2Bwb=Qs=Xag2b-k~3J`#P_Iu8I<Akcbr5IS{Drc~6cud7}3$?2r>>hX<8ngcH<RS|6w4rvK9nLBK$(uo?qX{d^Jq$5tlE7~0f1!WaC8@a0p(BkrAS1}d?+nPr*metcTlU7)UaJ$J^;V?X;kdNu<(cO@c5F0*=>kYPZ^xTB^;GpbTy&C<;W?jQ%hnOHVos5^`jb^7YNzbc6JZvD|NlL7Z9a{e!=V{ZOL9+GZ2K$?hpbi2600',
+      '17:29555814-29556314':
+        'ABzY800000001qJyKw_S3`2AE;^1t_zrZs)2+#oguf=%a-AKD!5&%K|U0=WNKd;y8`+B|+e12Td$LQqK@DVxxgg#1Awi2c?93JP+8(_{vA{mfw`Y9x5u2ao~o{E6D%f#w6WVE*c-xlC(C+n;hfV2~rn#$8FTP`v|YmJoAa;IPr!~_<hBOJIYK-{h(8(!x+`x|n{w};&ge89}%Qo9YNqC(4&)&nrs;HvUQ(P+5y;U7wmXow|2J8Q=-VYi*SJGo(<UF}wCZ>o!@0Ew}P^t30<9{&+*Xow5~000',
+      '17:29663629-29664129':
+        'ABzY800000001pfK@P((47&F(J2aa*b%#lagFoQ^zomc^RjCsju*v`Y{?>h6?`z#J2cL7@2li^Ri{1JfM3sKsRZxg7<x&M-Di3b~2q`S!T}Z<P@`W=UY$y;ydUp*$ABLr7H$?}kBKk1eDpq<385vF}4%PJNTCL2?8Gshx@TjNSh)Amac8PR6RRSXA77StKYH+)0V>G+9>`TmX$`E(K<fa*JP~gmrjFx&C+hPR*wZSHJdyIn3N!|l>n1LSK^Ae-yRr_hM)iMlcEX47Eqnp-`2av?(jSK<+00',
+      '19:11215896-11216396':
+        'ABzY800000001?SF%H8p3<LN4rGr~EXgU-SH0T5R|69tVoMxy+OC&}A*7aTMx!#}ad~i5l*Lftrh>EPPY>J|Y>h2U$LR5AM4tk=KuXHL}R0s}1uq1s<b(^O)E<!PhA40(vi}Y+Eiw;x#p%N~0dJwhInt?JX+JKpx5yc`_?N0}&3T_R0R4$OyZeG}O#*ou3R6XN~8RvirY<CP_-8q17Q=8xF*1Ro+^Nb+2or8*TD@89;-UuI*H$W_E*eTgq%@etIf)I84C8XSKICEagNIJ>s@;h^N`~khJXX*?B000',
+      '19:17451747-17452247':
+        'ABzY800000001>n!41Pe4Ekr6J`$yh+D9ei2Mc)rSqk_rQZ7Cl1CD>^=X*Z)TkrF7a9#IvbQcS(E<a#9)S;Ko=mO}{i3=N4Y6LoP0SqTXk_=UGwujjgia@L=#Zv$1z&I1IlETvO+PWsRkjkq?tnx0-z!(FJy?kO56+vGrxSICJi48Ev$gLrLC5I@9oXb+pfEzz8K3tCh_s%RuZaI$}MTLk>+x9@T@$s8cG3RtH*+Rx|44P{f^E14Io?%3)s}hDFTS>9jva%uiM;?Dcf5F)d0ssI',
+      '20:62326742-62327242':
+        'ABzY800000002FaQ3}H_3`75Sm%+%!3i}ucefR>p|5;|q$=ZfGu`NG4-}U&s*K@tE*Sg!d)@$7gRV1pvDo~~J!&$N$idRfrueRh9`0vw1Ghu}2tjO3%tatEhchTEjb7%LarA}cwNhiWgei_DtNQ8~v*+(gCF+(Hwlf#s314AiiyDX73H@8(ZM1rMsqFo-rLYmTWAfo~>I0KRCIBIH)BnC7SN-|S2O-^Q;GwL+3LG5HTQW==8TZ;cnkv4Q4!WsX*m%*AFwpgHUKcE<?+6)2!00',
+      'X:48932771-48933271':
+        'ABzY800000001qKyA1;|3`6_dB}G2KB`E?3DzpHL>_18Ps2p%MEy)xqf4=X>^L4+S=k)?Gx*k>CRpYNUQv1~E1U1z)<){HUgK@3OpdD*YMpQZCLsRPOg#3HeB<!Mu6#fY<&}2S#+I5MNNT62$jdHiC3+sf!Trh{$idc}G0=~*#Pz=1IM3d8cG&kf}h{*uR(jJYLg*SL(#=@LJYVR!8d|)=anrO?Qgd*$YkXimmqs$9?-j(HVVrGZG+0IzE>%g=*rDgim-XO`4SI<tFD38|rZh|4*s*WEo_#mVU0ssI',
+      'X:153421665-153422165':
+        'ABzY800000001?SF_OYi3`2YFvIXoW1qCx27ruasz5hw@lM^tBlP}AX`24@0$M4_kd7j5lx@nI`%iU#)drjp+RjH(O9#{qAd0BZVXRLx99G?a*;Jj|{ur+f-FKI3moj9J3X?9K9IZHFYIjo*967Lc<jI+0`%I%iliqZ%Kv!e^Xq(&x0h8j$E1G$4(cio}NEV@xsmow|K3yqUaB%w_i#c#Yu%wX2E6RE>zknUZ$mU&QLN&-bH0qq9Tf)?f?nTFQuea#aiBS=9>g64l!@3tiU_ySz#ZKDkW000'
+    }
   }
 };
diff --git a/src/store/actions.ts b/src/store/actions.ts
index 85db6090..1fec332f 100644
--- a/src/store/actions.ts
+++ b/src/store/actions.ts
@@ -12,7 +12,12 @@ declare global {
 }
 
 const inputData = process.env.NODE_ENV === 'development' || process.env.NODE_ENV === 'test' ? apiData : window.api;
-let api = new ApiClient(inputData);
+let api: ApiClient = new ApiClient(inputData);
+
+export type Locus = {
+  contig: string;
+  pos: number;
+};
 
 export default {
   async loadMetadata({ commit }: ActionContext<State, State>): Promise<void> {
@@ -96,8 +101,12 @@ export default {
   setFilterRecordsByDepth({ commit }: ActionContext<State, State>, value: boolean): void {
     commit('setFilterRecordsByDepth', value);
   },
-  async getVcfGz(): Promise<Buffer> {
+  getVcfGz(): Promise<Buffer> {
     return api.getVcfGz();
+  },
+  // eslint-disable-next-line @typescript-eslint/no-unused-vars
+  getFastaGz({ commit }: ActionContext<State, State>, locus: Locus): Promise<Buffer | null> {
+    return api.getFastaGz(locus.contig, locus.pos);
   }
 };
 
diff --git a/tests/unit/components/GenomeBrowser.spec.ts b/tests/unit/components/GenomeBrowser.spec.ts
deleted file mode 100644
index 29fdd421..00000000
--- a/tests/unit/components/GenomeBrowser.spec.ts
+++ /dev/null
@@ -1,67 +0,0 @@
-import { createLocalVue, shallowMount } from '@vue/test-utils';
-import Vuex, { GetterTree, Store } from 'vuex';
-import GenomeBrowser from '@/components/GenomeBrowser.vue';
-import { mock } from 'ts-mockito';
-import { Vcf } from '@molgenis/vip-report-api';
-
-import igv from 'igv';
-jest.mock('igv');
-
-const localVue = createLocalVue();
-localVue.use(Vuex);
-
-describe('GenomeBrowser', () => {
-  const genomeBrowserDbFn = jest.fn();
-
-  let browser: any;
-  let store: Store<never>;
-
-  beforeEach(() => {
-    browser = { search: jest.fn() };
-    igv.createBrowser.mockResolvedValue(browser);
-
-    const getters: GetterTree<never, never> = { genomeBrowserDb: genomeBrowserDbFn };
-    store = new Vuex.Store({ getters });
-  });
-
-  it('select record for supported genomeBrowserDb', async () => {
-    genomeBrowserDbFn.mockReturnValue('hg38');
-
-    const wrapper = shallowMount(GenomeBrowser, { store, localVue });
-    await wrapper.vm.$nextTick();
-
-    const record = mock<Vcf.Record>();
-    record.c = '1';
-    record.p = 123456;
-
-    // eslint-disable-next-line @typescript-eslint/ban-ts-comment
-    // @ts-ignore
-    wrapper.vm.$options.watch.selectedRecord.call(wrapper.vm, record);
-    expect(browser.search).toBeCalledWith('chr1:123456');
-  });
-
-  it('deselect record for supported genomeBrowserDb', async () => {
-    genomeBrowserDbFn.mockReturnValue('hg38');
-
-    const wrapper = shallowMount(GenomeBrowser, { store, localVue });
-    await wrapper.vm.$nextTick();
-
-    // eslint-disable-next-line @typescript-eslint/ban-ts-comment
-    // @ts-ignore
-    wrapper.vm.$options.watch.selectedRecord.call(wrapper.vm, null);
-    expect(browser.search).toBeCalledWith('all');
-  });
-
-  it('select record for unsupported genomeBrowserDb', async () => {
-    genomeBrowserDbFn.mockReturnValue('hg17');
-
-    const wrapper = shallowMount(GenomeBrowser, { store, localVue });
-    await wrapper.vm.$nextTick();
-
-    const record = mock<Vcf.Record>();
-    // eslint-disable-next-line @typescript-eslint/ban-ts-comment
-    // @ts-ignore
-    wrapper.vm.$options.watch.selectedRecord.call(wrapper.vm, record);
-    expect(browser.search).toBeCalledTimes(0);
-  });
-});
diff --git a/tests/unit/store/actions.spec.ts b/tests/unit/store/actions.spec.ts
index 73e889a1..a9f3af64 100644
--- a/tests/unit/store/actions.spec.ts
+++ b/tests/unit/store/actions.spec.ts
@@ -166,7 +166,15 @@ test('set filter records by read depth', async (done) => {
   done();
 });
 
-test('set filter records by read depth', async (done) => {
+test('get vcf gz', async (done) => {
   expect(await actions.getVcfGz()).not.toBe(null);
   done();
 });
+
+test('get fasta gz', async (done) => {
+  const commit = jest.fn() as Commit;
+  expect(await actions.getFastaGz({ commit } as ActionContext<State, State>, { contig: '1', pos: 17350500 })).not.toBe(
+    null
+  );
+  done();
+});

From 5d3f8ee85d09c775799997df0fa62d0e0a8b6a88 Mon Sep 17 00:00:00 2001
From: Dennis Hendriksen <d.hendriksen@umcg.nl>
Date: Thu, 22 Apr 2021 11:16:13 +0200
Subject: [PATCH 2/2] fix == is ===

---
 package-lock.json                | 4 ++--
 src/components/GenomeBrowser.vue | 2 +-
 2 files changed, 3 insertions(+), 3 deletions(-)

diff --git a/package-lock.json b/package-lock.json
index 3394ce83..6c804842 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -1,12 +1,12 @@
 {
   "name": "@molgenis/vip-report-template",
-  "version": "2.0.0",
+  "version": "2.1.0",
   "lockfileVersion": 2,
   "requires": true,
   "packages": {
     "": {
       "name": "@molgenis/vip-report-template",
-      "version": "2.0.0",
+      "version": "2.1.0",
       "license": "LGPL-3.0",
       "dependencies": {
         "@molgenis/vip-report-api": "^2.1.0",
diff --git a/src/components/GenomeBrowser.vue b/src/components/GenomeBrowser.vue
index 539b983d..4f2492b4 100644
--- a/src/components/GenomeBrowser.vue
+++ b/src/components/GenomeBrowser.vue
@@ -23,7 +23,7 @@ export default Vue.extend({
     },
     async updateGenomeBrowser(record: Vcf.Record | null) {
       const config = record !== null ? await this.createBrowserConfig(record) : null;
-      if (config == null) {
+      if (config === null) {
         if (this.hasGenomeBrowser()) {
           await this.deleteGenomeBrowser();
         }