diff --git a/mist/main.py b/mist/main.py
index 1e32e03..47acc05 100755
--- a/mist/main.py
+++ b/mist/main.py
@@ -97,6 +97,9 @@ def main(args):
 if __name__ == "__main__":
     set_warning_levels()
     args = get_main_args()
+    if not args.overwrite:
+        assert not os.path.exists(os.path.join(args.results, "results.csv")), \
+                "Results folder already contains a previous run. Enable --overwrite to overwrite the previous run"
 
     if args.loss in ["bl", "hdl", "gsl"]:
         args.use_dtm = True
diff --git a/mist/runtime/args.py b/mist/runtime/args.py
index e28b1fd..63321e2 100755
--- a/mist/runtime/args.py
+++ b/mist/runtime/args.py
@@ -60,6 +60,7 @@ def get_main_args():
     p.arg("--master-port", type=str, default="12355", help="Master port for multi-gpu training")
     p.arg("--seed_val", type=non_negative_int, default=42, help="Random seed")
     p.boolean_flag("--tta", default=False, help="Enable test time augmentation")
+    p.boolean_flag("--overwrite", default=False, help="Overwrites previous run at specified results folder")
 
     # Output
     p.arg("--results", type=str, help="Path to output of MIST pipeline")