diff --git a/NAMESPACE b/NAMESPACE
index 314a32e8..6c09f664 100644
--- a/NAMESPACE
+++ b/NAMESPACE
@@ -76,6 +76,7 @@ S3method(print,bbi_nmboot_summary)
 S3method(print,bbi_nonmem_summary)
 S3method(print,bbi_process)
 S3method(print,model_tree_static)
+S3method(print,nmtran_process)
 S3method(print_model_files,default)
 S3method(submit_model,bbi_base_model)
 S3method(submit_model,bbi_nmboot_model)
@@ -194,6 +195,7 @@ export(replace_model_field)
 export(replace_note)
 export(replace_tag)
 export(run_log)
+export(run_nmtran)
 export(setup_bootstrap_run)
 export(submit_model)
 export(submit_models)
diff --git a/man/execute_nmtran.Rd b/man/execute_nmtran.Rd
new file mode 100644
index 00000000..50d578df
--- /dev/null
+++ b/man/execute_nmtran.Rd
@@ -0,0 +1,19 @@
+% Generated by roxygen2: do not edit by hand
+% Please edit documentation in R/run-nmtran.R
+\name{execute_nmtran}
+\alias{execute_nmtran}
+\title{Execute NMTRAN in a given directory}
+\usage{
+execute_nmtran(nmtran_exe, mod_path, dir = NULL)
+}
+\arguments{
+\item{nmtran_exe}{Path to \code{NMTRAN} executable.}
+
+\item{mod_path}{Path of a model to evaluate. Should be relative to \code{dir}.}
+
+\item{dir}{Directory in which to execute the command.}
+}
+\description{
+Execute NMTRAN in a given directory
+}
+\keyword{internal}
diff --git a/man/locate_nmtran.Rd b/man/locate_nmtran.Rd
new file mode 100644
index 00000000..a1aeb357
--- /dev/null
+++ b/man/locate_nmtran.Rd
@@ -0,0 +1,23 @@
+% Generated by roxygen2: do not edit by hand
+% Please edit documentation in R/run-nmtran.R
+\name{locate_nmtran}
+\alias{locate_nmtran}
+\title{Search for and validate existence of an \code{NMTRAN} executable}
+\usage{
+locate_nmtran(.mod = NULL, .config_path = NULL, nmtran_exe = NULL)
+}
+\arguments{
+\item{.mod}{a \code{bbr} model object}
+
+\item{.config_path}{Path to a bbi configuration file. If \code{NULL}, the
+default, will attempt to use a \code{bbi.yaml} in the same directory as the
+model.}
+
+\item{nmtran_exe}{Path to an \code{NMTRAN} executable. If \code{NULL}, will look for a
+\code{bbi.yaml} file in the same directory as the model.}
+}
+\description{
+If \code{nmtran_exe = NULL}, this will look for a \code{bbi.yaml} file in the same
+directory as the model.
+}
+\keyword{internal}
diff --git a/man/print_bbi.Rd b/man/print_bbi.Rd
index bc312230..50ee3fe8 100644
--- a/man/print_bbi.Rd
+++ b/man/print_bbi.Rd
@@ -6,6 +6,7 @@
 \alias{print.bbi_model}
 \alias{print.bbi_nonmem_summary}
 \alias{print.bbi_nmboot_summary}
+\alias{print.nmtran_process}
 \alias{print.model_tree_static}
 \title{Print methods for bbr objects}
 \usage{
@@ -17,6 +18,8 @@
 
 \method{print}{bbi_nmboot_summary}(x, .digits = 3, .nrow = 10, ...)
 
+\method{print}{nmtran_process}(x, ...)
+
 \method{print}{model_tree_static}(x, newpage = is.null(vp), vp = NULL, ...)
 }
 \arguments{
@@ -59,6 +62,8 @@ will make for prettier formatting, especially of table outputs.
 
 \item \code{print(bbi_nmboot_summary)}: Prints a high level summary of a model from a \code{bbi_nmboot_summary} object
 
+\item \code{print(nmtran_process)}: Prints the \code{NMTRAN} evaluation of a \code{bbi_model} model
+
 \item \code{print(model_tree_static)}: Draw model tree as a static plot
 
 }}
diff --git a/man/run_nmtran.Rd b/man/run_nmtran.Rd
new file mode 100644
index 00000000..f6e71ea7
--- /dev/null
+++ b/man/run_nmtran.Rd
@@ -0,0 +1,34 @@
+% Generated by roxygen2: do not edit by hand
+% Please edit documentation in R/run-nmtran.R
+\name{run_nmtran}
+\alias{run_nmtran}
+\title{Run NMTRAN on a model object}
+\usage{
+run_nmtran(.mod, .config_path = NULL, nmtran_exe = NULL, delete_on_exit = TRUE)
+}
+\arguments{
+\item{.mod}{a \code{bbr} model object}
+
+\item{.config_path}{Path to a bbi configuration file. If \code{NULL}, the
+default, will attempt to use a \code{bbi.yaml} in the same directory as the
+model.}
+
+\item{nmtran_exe}{Path to an \code{NMTRAN} executable. If \code{NULL}, will look for a
+\code{bbi.yaml} file in the same directory as the model.}
+
+\item{delete_on_exit}{Logical. If \code{FALSE}, don't delete the temporary folder
+containing the \code{NMTRAN} run.}
+}
+\description{
+Run NMTRAN on a model object
+}
+\examples{
+\dontrun{
+mod <- read_model(file.path(MODEL_DIR, 1))
+run_nmtran(mod)
+
+# Set the path to an NMTRAN executable
+run_nmtran(mod, nmtran_exe = "/opt/NONMEM/nm75/tr/NMTRAN.exe")
+}
+
+}
diff --git a/tests/testthat/test-workflow-bbi.R b/tests/testthat/test-workflow-bbi.R
index 9ab8f683..afb31811 100644
--- a/tests/testthat/test-workflow-bbi.R
+++ b/tests/testthat/test-workflow-bbi.R
@@ -305,5 +305,103 @@ withr::with_options(list(
     run_times <- model_summaries(mods) %>% check_run_times(.wait = FALSE) %>% suppressWarnings()
     expect_equal(dim(run_times), c(3, 3))
   })
+
+  describe("run_nmtran", {
+    it("locate_nmtran", {
+      mod1 <- read_model(file.path(MODEL_DIR_BBI, "1"))
+      # Using model object, looks for bbi.yaml
+      nmtran_exe <- locate_nmtran(mod1)
+      # Confirm executable
+      expect_equal(as.character(nmtran_exe), "/opt/NONMEM/nm74gf/tr/NMTRAN.exe")
+      # Confirm NONMEM version
+      expect_equal(attr(nmtran_exe, "nonmem_version"), "nm74gf")
+
+      # Passed executable
+      nmtran_exe <- locate_nmtran(mod1, nmtran_exe = "/opt/NONMEM/nm74gf/tr/NMTRAN.exe")
+      # Confirm executable
+      expect_equal(as.character(nmtran_exe), "/opt/NONMEM/nm74gf/tr/NMTRAN.exe")
+      # Confirm NONMEM version
+      expect_true(is.null(attr(nmtran_exe, "nonmem_version")))
+
+      # Passed config_path
+      nmtran_exe <- locate_nmtran(.config_path = file.path(MODEL_DIR_BBI, "bbi.yaml"))
+      # Confirm executable
+      expect_equal(as.character(nmtran_exe), "/opt/NONMEM/nm74gf/tr/NMTRAN.exe")
+      # Confirm NONMEM version
+      expect_equal(attr(nmtran_exe, "nonmem_version"), "nm74gf")
+
+      # Wrong nmtran_exe path passed
+      expect_error(
+        locate_nmtran(mod1, nmtran_exe = "/opt/NONMEM/nm74gf/tr/NMTRAN2.exe"),
+        "Could not find an NMTRAN executable"
+      )
+
+      # no configuration file found
+      expect_error(
+        locate_nmtran(.config_path = file.path(tempdir(), "bbi.yaml")),
+        "No bbi configuration was found"
+      )
+    })
+
+    it("execute_nmtran", {
+      # Execute in subdirectory to avoid messing with other tests
+      nmtran_dir <- file.path(MODEL_DIR_BBI, "nmtran")
+      fs::dir_create(nmtran_dir)
+      on.exit(fs::dir_delete(nmtran_dir), add = TRUE)
+
+      # Copy model file into new model dir
+      fs::file_copy(CTL_TEST_FILE, nmtran_dir, overwrite = TRUE)
+      mod1 <- new_model(file.path(nmtran_dir, "1"), .overwrite = TRUE)
+
+      # create new bbi.yaml
+      bbi_init(
+        nmtran_dir,
+        .nonmem_dir = Sys.getenv("BBR_TESTS_NONMEM_DIR", "/opt/NONMEM"),
+        .nonmem_version = Sys.getenv("BBR_TESTS_NONMEM_VERSION", "nm74gf"),
+        .bbi_args = list(mpi_exec_path = get_mpiexec_path())
+      )
+
+      nmtran_exe <- locate_nmtran(mod1)
+      nmtran_results <- execute_nmtran(
+        nmtran_exe, mod_path = basename(get_model_path(mod1)), dir = nmtran_dir
+      )
+
+      # Check attributes
+      expect_equal(nmtran_dir, nmtran_results$run_dir)
+      expect_equal(nmtran_results$status_val, 0)
+      expect_equal(nmtran_results$status, "NMTRAN successful")
+
+      # Test failure
+      data_path <- "test/this/path/data.csv"
+      modify_data_path_ctl(mod1, data_path)
+
+      nmtran_results <- execute_nmtran(
+        nmtran_exe, mod_path = basename(get_model_path(mod1)), dir = nmtran_dir
+      )
+
+      # Check attributes
+      expect_equal(nmtran_results$status_val, 4)
+      expect_equal(nmtran_results$status, "NMTRAN failed. See errors.")
+    })
+
+    it("run_nmtran", {
+      # create model
+      mod1 <- read_model(file.path(MODEL_DIR_BBI, "1"))
+
+      nmtran_results <- run_nmtran(mod1, delete_on_exit = FALSE)
+      on.exit(fs::dir_delete(nmtran_results$run_dir))
+
+      # Check attributes
+      expect_equal(get_model_path(mod1), nmtran_results$absolute_model_path)
+      expect_equal(
+        file.path(nmtran_results$run_dir, basename(get_model_path(mod1))),
+        nmtran_results$nmtran_model
+      )
+      expect_equal(nmtran_results$nonmem_version, "nm74gf")
+      expect_equal(nmtran_results$status_val, 0)
+      expect_equal(nmtran_results$status, "NMTRAN successful")
+    })
+  })
+
 }) # closing withr::with_options