refactor(app): create drug inhibitor utils

hpi-dhc · Dec 6, 2024 · 6fda75f · 6fda75f
1 parent c89f418
commit 6fda75f
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Showing 3 changed files with 111 additions and 115 deletions.
diff --git a/app/lib/common/models/drug/drug_inhibitors.dart b/app/lib/common/models/drug/drug_inhibitors.dart
@@ -5,10 +5,6 @@
 
 // structure: gene symbol -> drug name -> overwriting lookupkey
 
-import 'package:collection/collection.dart';
-
-import '../../module.dart';
-
 // Inhibit phenotype for gene by overwriting with poor metabolizer
 const Map<String, Map<String, String>> strongDrugInhibitors = {
   'CYP2D6': {
@@ -33,118 +29,7 @@ const Map<String, Map<String, double>> moderateDrugInhibitors = {
   },
 };
 
-// Private helper functions
-
-final _drugInhibitorsPerGene = {
-  for (final gene in inhibitableGenes) gene: [
-    ...?strongDrugInhibitors[gene]?.keys,
-    ...?moderateDrugInhibitors[gene]?.keys,
-  ]
-};
-
-List<String> _inhibitorsFor(String gene) {
-  return _drugInhibitorsPerGene[gene] ?? [];
-}
-
-bool _isInhibitorOfType(
-  String drugName,
-  Map<String, Map<String, dynamic>> inhibitorDefinition
-) {
-  final influencingDrugs = inhibitorDefinition.keys.flatMap(
-    (gene) => inhibitorDefinition[gene]!.keys);
-  return influencingDrugs.contains(drugName);
-}
-
-// Public helper functions
-
-bool isModerateInhibitor(String drugName) {
-  return _isInhibitorOfType(drugName, moderateDrugInhibitors);
-}
-
-List<String> activeInhibitorsFor(String gene, { required String? drug }) {
-  return UserData.instance.activeDrugNames == null
-    ? <String>[]
-    : UserData.instance.activeDrugNames!.filter(
-        (activeDrug) =>
-          _inhibitorsFor(gene).contains(activeDrug) &&
-          activeDrug != drug
-      ).toList();
-}
-
 final inhibitableGenes = List<String>.from(<String>{
   ...strongDrugInhibitors.keys,
   ...moderateDrugInhibitors.keys,
 });
-
-bool isInhibitor(String drugName) {
-  var drugIsInhibitor = false;
-  for (final gene in _drugInhibitorsPerGene.keys) {
-    final influencingDrugs = _drugInhibitorsPerGene[gene];
-    // WARNING: this does not work for non-unique genes, such as HLA-B
-    final originalLookup = UserData.lookupFor(
-      gene,
-      drug: drugName,
-      useOverwrite: false,
-    );
-    if (influencingDrugs!.contains(drugName) && originalLookup != '0.0') {
-      drugIsInhibitor = true;
-      break;
-    }
-  }
-  return drugIsInhibitor;
-}
-
-bool isInhibited(
-    GenotypeResult genotypeResult,
-    { required String? drug }
-) {
-  final activeInhibitors = activeInhibitorsFor(
-    genotypeResult.gene,
-    drug: drug,
-  );
-  final originalPhenotype = genotypeResult.phenotype;
-  final phenotypeCanBeInhibited =
-    originalPhenotype?.toLowerCase() != overwritePhenotype.toLowerCase();
-  return activeInhibitors.isNotEmpty && phenotypeCanBeInhibited;
-}
-
-List<String> inhibitedGenes(Drug drug) {
-  return _drugInhibitorsPerGene.keys.filter(
-    (gene) => _drugInhibitorsPerGene[gene]!.contains(drug.name)
-  ).toList();
-}
-
-MapEntry<String, String>? getOverwrittenLookup (
-  String gene,
-  { required String? drug }
-) {
-  final inhibitors = strongDrugInhibitors[gene];
-  if (inhibitors == null) return null;
-  final lookup = inhibitors.entries.firstWhereOrNull((entry) {
-    final isActiveInhibitor =
-      UserData.instance.activeDrugNames?.contains(entry.key) ?? false;
-    final wouldInhibitItself = drug == entry.key;
-    return isActiveInhibitor && !wouldInhibitItself;
-  });
-  if (lookup == null) return null;
-  return lookup;
-}
-
-String possiblyAdaptedPhenotype(
-  BuildContext context,
-  GenotypeResult genotypeResult,
-  { required String? drug }
-) {
-  final originalPhenotype = genotypeResult.phenotypeDisplayString(context);
-  if (!isInhibited(genotypeResult, drug: drug)) {
-    return originalPhenotype;
-  }
-  final overwrittenLookup = getOverwrittenLookup(
-    genotypeResult.gene,
-    drug: drug,
-  );
-  if (overwrittenLookup == null) {
-    return '$originalPhenotype$drugInteractionIndicator';
-  }
-  return '$overwritePhenotype$drugInteractionIndicator';
-}
diff --git a/app/lib/common/utilities/drug_inhibitors.dart b/app/lib/common/utilities/drug_inhibitors.dart
@@ -0,0 +1,110 @@
+import 'package:collection/collection.dart';
+
+import '../module.dart';
+
+final _drugInhibitorsPerGene = {
+  for (final gene in inhibitableGenes) gene: [
+    ...?strongDrugInhibitors[gene]?.keys,
+    ...?moderateDrugInhibitors[gene]?.keys,
+  ]
+};
+
+List<String> _inhibitorsFor(String gene) {
+  return _drugInhibitorsPerGene[gene] ?? [];
+}
+
+bool _isInhibitorOfType(
+  String drugName,
+  Map<String, Map<String, dynamic>> inhibitorDefinition
+) {
+  final influencingDrugs = inhibitorDefinition.keys.flatMap(
+    (gene) => inhibitorDefinition[gene]!.keys);
+  return influencingDrugs.contains(drugName);
+}
+
+bool isModerateInhibitor(String drugName) {
+  return _isInhibitorOfType(drugName, moderateDrugInhibitors);
+}
+
+List<String> activeInhibitorsFor(String gene, { required String? drug }) {
+  return UserData.instance.activeDrugNames == null
+    ? <String>[]
+    : UserData.instance.activeDrugNames!.filter(
+        (activeDrug) =>
+          _inhibitorsFor(gene).contains(activeDrug) &&
+          activeDrug != drug
+      ).toList();
+}
+
+bool isInhibitor(String drugName) {
+  var drugIsInhibitor = false;
+  for (final gene in _drugInhibitorsPerGene.keys) {
+    final influencingDrugs = _drugInhibitorsPerGene[gene];
+    // WARNING: this does not work for non-unique genes, such as HLA-B
+    final originalLookup = UserData.lookupFor(
+      gene,
+      drug: drugName,
+      useOverwrite: false,
+    );
+    if (influencingDrugs!.contains(drugName) && originalLookup != '0.0') {
+      drugIsInhibitor = true;
+      break;
+    }
+  }
+  return drugIsInhibitor;
+}
+
+bool isInhibited(
+    GenotypeResult genotypeResult,
+    { required String? drug }
+) {
+  final activeInhibitors = activeInhibitorsFor(
+    genotypeResult.gene,
+    drug: drug,
+  );
+  final originalPhenotype = genotypeResult.phenotype;
+  final phenotypeCanBeInhibited =
+    originalPhenotype?.toLowerCase() != overwritePhenotype.toLowerCase();
+  return activeInhibitors.isNotEmpty && phenotypeCanBeInhibited;
+}
+
+List<String> inhibitedGenes(Drug drug) {
+  return _drugInhibitorsPerGene.keys.filter(
+    (gene) => _drugInhibitorsPerGene[gene]!.contains(drug.name)
+  ).toList();
+}
+
+MapEntry<String, String>? getOverwrittenLookup (
+  String gene,
+  { required String? drug }
+) {
+  final inhibitors = strongDrugInhibitors[gene];
+  if (inhibitors == null) return null;
+  final lookup = inhibitors.entries.firstWhereOrNull((entry) {
+    final isActiveInhibitor =
+      UserData.instance.activeDrugNames?.contains(entry.key) ?? false;
+    final wouldInhibitItself = drug == entry.key;
+    return isActiveInhibitor && !wouldInhibitItself;
+  });
+  if (lookup == null) return null;
+  return lookup;
+}
+
+String possiblyAdaptedPhenotype(
+  BuildContext context,
+  GenotypeResult genotypeResult,
+  { required String? drug }
+) {
+  final originalPhenotype = genotypeResult.phenotypeDisplayString(context);
+  if (!isInhibited(genotypeResult, drug: drug)) {
+    return originalPhenotype;
+  }
+  final overwrittenLookup = getOverwrittenLookup(
+    genotypeResult.gene,
+    drug: drug,
+  );
+  if (overwrittenLookup == null) {
+    return '$originalPhenotype$drugInteractionIndicator';
+  }
+  return '$overwritePhenotype$drugInteractionIndicator';
+}
diff --git a/app/lib/common/utilities/module.dart b/app/lib/common/utilities/module.dart
@@ -1,5 +1,6 @@
 export 'color_utils.dart';
 export 'contact.dart';
+export 'drug_inhibitors.dart';
 export 'drug_utils.dart';
 export 'genome_data.dart';
 export 'material_colors.dart';