diff --git a/education/HADDOCK24/HADDOCK24-antibody-antigen-basic/index.md b/education/HADDOCK24/HADDOCK24-antibody-antigen-basic/index.md index 96886956..7cfa2b79 100644 --- a/education/HADDOCK24/HADDOCK24-antibody-antigen-basic/index.md +++ b/education/HADDOCK24/HADDOCK24-antibody-antigen-basic/index.md @@ -515,7 +515,7 @@ Are the active residues at the interface in the different clusters? How is the r


-## BONUS 2: Does the antibody bind to a known interface of interleukin? ARCTIC-3D analysis +## BONUS 1: Does the antibody bind to a known interface of interleukin? ARCTIC-3D analysis Gevokizumab is a highly specific antibody that targets an allosteric site of Interleukin-1β (IL-1β) in PDB file *4G6M*, thus reducing its binding affinity for its substrate, interleukin-1 receptor type I (IL-1RI). Canakinumab, another antibody binding to IL-1β, has a different mode of action, as it competes directly with IL-1RI's binding site (in PDB file *4G6J*). For more details please check [this article](https://www.sciencedirect.com/science/article/abs/pii/S0022283612007863?via%3Dihub){:target="\_blank"}.