diff --git a/README.md b/README.md
index ad1e26d4eb4..8889ccd7be5 100644
--- a/README.md
+++ b/README.md
@@ -4,6 +4,34 @@ Source code for React Native's debugger frontend, based on Chrome DevTools. This
 
 This repository is a fork of [ChromeDevTools/devtools-frontend](https://github.com/ChromeDevTools/devtools-frontend).
 
+## Development
+
+### Initial setup
+
+1. Install [`depot_tools`](https://commondatastorage.googleapis.com/chrome-infra-docs/flat/depot_tools/docs/html/depot_tools_tutorial.html#_setting_up) (ensuring your `PATH` is updated).
+
+2. This repository must be located inside a gclient workspace directory. Run the `setup.sh` script to perform this one-time step (which will relocate the repo folder).
+
+    ```sh
+    # Using `source` will enable the script to change dir in your shell
+    source setup.sh
+    ```
+
+### Build and run
+
+```sh
+npm run build
+# or npm run build-release
+```
+
+This can then be served from a static web server to test locally:
+
+```sh
+python3 -m http.server 8000 --directory out/Default/gen/front_end
+```
+
+The frontend will be available at `http://localhost:8000/inspector.html` (or `http://localhost:8000/rn_inspector.html` for the RN-specific entry point).
+
 ## Contributing
 
 ### Project documentation
diff --git a/setup.sh b/setup.sh
new file mode 100755
index 00000000000..3ac8d056aa9
--- /dev/null
+++ b/setup.sh
@@ -0,0 +1,32 @@
+#!/bin/bash
+# Copyright (c) Meta Platforms, Inc. and affiliates.
+# Copyright 2019 The Chromium Authors. All rights reserved.
+# Use of this source code is governed by a BSD-style license that can be
+# found in the LICENSE file.
+
+PROJECT_NAME=rn-chrome-devtools-frontend
+WORKSPACE_DIR="${PROJECT_NAME}__workspace"
+
+if [ "$(basename "$(dirname "$PWD")")" = "$WORKSPACE_DIR" ]; then
+  echo "[setup] Error: Already in workspace directory"
+  exit 1
+fi
+
+STARTING_DIR=$PWD
+
+echo "[setup] Creating workspace directory at $(dirname "$PWD")/$WORKSPACE_DIR/"
+cd ..
+mkdir $WORKSPACE_DIR
+
+echo "[setup] Moving repo folder into workspace"
+mv $STARTING_DIR "$WORKSPACE_DIR/$PROJECT_NAME"
+
+echo "[setup] Syncing gclient workspace"
+cd $WORKSPACE_DIR
+gclient config --unmanaged $PROJECT_NAME --name $PROJECT_NAME
+gclient sync --no-history
+
+echo "[setup] Moving to project folder"
+cd $PROJECT_NAME
+
+echo "[setup] Success: Repo ready at $PWD/"