diff --git a/eng/pipelines/common/platform-matrix.yml b/eng/pipelines/common/platform-matrix.yml
index cb3c8b2d0a65e..2dc00a29da5d3 100644
--- a/eng/pipelines/common/platform-matrix.yml
+++ b/eng/pipelines/common/platform-matrix.yml
@@ -294,6 +294,25 @@ jobs:
         helixQueueGroup: ${{ parameters.helixQueueGroup }}
         ${{ insert }}: ${{ parameters.jobParameters }}
 
+- ${{ if containsValue(parameters.platforms, 'linux_musl_x64_dev_innerloop') }}:
+  - template: xplat-setup.yml
+    parameters:
+      jobTemplate: ${{ parameters.jobTemplate }}
+      helixQueuesTemplate: ${{ parameters.helixQueuesTemplate }}
+      variables: ${{ parameters.variables }}
+      osGroup: linux
+      osSubgroup: _musl
+      archType: x64
+      targetRid: linux-musl-x64
+      platform: linux_musl_x64
+      shouldContinueOnError: ${{ parameters.shouldContinueOnError }}
+      container: linux_musl_x64_dev_innerloop
+      jobParameters:
+        runtimeFlavor: ${{ parameters.runtimeFlavor }}
+        buildConfig: ${{ parameters.buildConfig }}
+        helixQueueGroup: ${{ parameters.helixQueueGroup }}
+        ${{ insert }}: ${{ parameters.jobParameters }}
+
 # GCC Linux x64 Build
 
 - ${{ if containsValue(parameters.platforms, 'gcc_linux_x64') }}:
diff --git a/eng/pipelines/common/templates/pipeline-with-resources.yml b/eng/pipelines/common/templates/pipeline-with-resources.yml
index e5e821f60fbc0..3c9fc538c4845 100644
--- a/eng/pipelines/common/templates/pipeline-with-resources.yml
+++ b/eng/pipelines/common/templates/pipeline-with-resources.yml
@@ -68,6 +68,9 @@ extends:
       linux_x64_dev_innerloop:
         image: mcr.microsoft.com/dotnet-buildtools/prereqs:ubuntu-22.04
 
+      linux_musl_x64_dev_innerloop:
+        image: mcr.microsoft.com/dotnet-buildtools/prereqs:alpine-3.19-WithNode
+
       # We use a CentOS Stream 8 image here to test building from source on CentOS Stream 8.
       SourceBuild_centos_x64:
         image: mcr.microsoft.com/dotnet-buildtools/prereqs:centos-stream8
diff --git a/eng/pipelines/global-build.yml b/eng/pipelines/global-build.yml
index 2e70a2448cd9d..d7302fe253b6b 100644
--- a/eng/pipelines/global-build.yml
+++ b/eng/pipelines/global-build.yml
@@ -1,6 +1,6 @@
-# The purpose of this pipeline is to exercise local developer workflow in the consolidated
-# runtime repo. In particular, it is supposed to run the root "build" script just like any
-# normal developer normally would and monitor regressions w.r.t. this fundamental scenario.
+# The purpose of this pipeline is to exercise various developer workflows in the repo.
+# Primarily, it is meant to cover local (non-cross) build scenarios and
+# source-build scenarios that commonly cause build breaks.
 
 trigger: none
 
@@ -41,28 +41,6 @@ extends:
     - stage: Build
       jobs:
 
-      #
-      # Build with Release config and Debug runtimeConfiguration
-      #
-      - template: /eng/pipelines/common/platform-matrix.yml
-        parameters:
-          jobTemplate: /eng/pipelines/common/global-build-job.yml
-          buildConfig: release
-          platforms:
-          - windows_x86
-          - osx_x64
-          - osx_arm64
-          jobParameters:
-            testGroup: innerloop
-            nameSuffix: Runtime_Debug
-            buildArgs: -c release -runtimeConfiguration debug
-            timeoutInMinutes: 120
-            condition:
-              or(
-                eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_coreclr.containsChange'], true),
-                eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_non_mono_and_wasm.containsChange'], true),
-                eq(variables['isRollingBuild'], true))
-
       #
       # Build with Release config and runtimeConfiguration with MSBuild generator
       #
@@ -83,26 +61,6 @@ extends:
                 eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_non_mono_and_wasm.containsChange'], true),
                 eq(variables['isRollingBuild'], true))
 
-      #
-      # Build with Debug config and Release runtimeConfiguration
-      #
-      - template: /eng/pipelines/common/platform-matrix.yml
-        parameters:
-          jobTemplate: /eng/pipelines/common/global-build-job.yml
-          buildConfig: debug
-          platforms:
-          - linux_x64_dev_innerloop
-          jobParameters:
-            testGroup: innerloop
-            nameSuffix: Runtime_Release
-            buildArgs: -c debug -runtimeConfiguration release
-            timeoutInMinutes: 120
-            condition:
-              or(
-                eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_coreclr.containsChange'], true),
-                eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_non_mono_and_wasm.containsChange'], true),
-                eq(variables['isRollingBuild'], true))
-
       #
       # Build with RuntimeFlavor only. This exercise code paths where only RuntimeFlavor is
       # specified. Catches cases where we depend on Configuration also being specified
@@ -124,38 +82,37 @@ extends:
                 eq(variables['isRollingBuild'], true))
 
       #
-      # Build Mono + Libraries. This exercises the code path where we build libraries without
-      # first building CoreCLR
+      # Build Libraries AllConfigurations. This exercises the code path where we build libraries for all
+      # configurations on a non Windows operating system.
       #
       - template: /eng/pipelines/common/platform-matrix.yml
         parameters:
           jobTemplate: /eng/pipelines/common/global-build-job.yml
           buildConfig: debug
           platforms:
-          - windows_x64
+          - linux_x64_dev_innerloop
           jobParameters:
-            testGroup: innerloop
-            nameSuffix: Mono_Libraries
-            buildArgs: -subset mono+libs /p:RuntimeFlavor=Mono
+            nameSuffix: Libraries_AllConfigurations
+            buildArgs: -subset libs -allconfigurations
             timeoutInMinutes: 120
             condition:
               or(
-                eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_non_wasm.containsChange'], true),
+                eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_non_mono_and_wasm.containsChange'], true),
                 eq(variables['isRollingBuild'], true))
 
       #
-      # Build Libraries AllConfigurations. This exercises the code path where we build libraries for all
-      # configurations on a non Windows operating system.
+      # Build native assets on Alpine. This exercises more modern musl libc changes that have a tendendy to break source-build.
+      # We don't add this as a source-build job as the repo source-build infrastructure isn't set up to run on alpine effectively.
       #
       - template: /eng/pipelines/common/platform-matrix.yml
         parameters:
           jobTemplate: /eng/pipelines/common/global-build-job.yml
-          buildConfig: debug
+          buildConfig: release
           platforms:
-          - linux_x64_dev_innerloop
+          - linux_musl_x64_dev_innerloop
           jobParameters:
-            nameSuffix: Libraries_AllConfigurations
-            buildArgs: -subset libs -allconfigurations
+            nameSuffix: Musl_Validation
+            buildArgs: -subset clr.native+libs.native+host.native -c $(_BuildConfig)
             timeoutInMinutes: 120
             condition:
               or(