diff --git a/README.md b/README.md
index 44de01a..1926514 100644
--- a/README.md
+++ b/README.md
@@ -13,11 +13,6 @@ A ready-to-use docker image is available to download.
 
     docker pull b3rse/granite:<version>
 
-To run locally, install the following libraries:
-
-    pip install numpy pysam bitarray h5py matplotlib
-    pip install --user pytabix
-
 Additional software needs to be available in the environment:
 
   - [*samtools*](http://www.htslib.org/ "samtools documentation")
diff --git a/poetry.lock b/poetry.lock
index f5e51e7..972e3de 100644
--- a/poetry.lock
+++ b/poetry.lock
@@ -2,7 +2,7 @@
 name = "atomicwrites"
 version = "1.4.0"
 description = "Atomic file writes."
-category = "main"
+category = "dev"
 optional = false
 python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*"
 
@@ -10,7 +10,7 @@ python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*"
 name = "attrs"
 version = "21.4.0"
 description = "Classes Without Boilerplate"
-category = "main"
+category = "dev"
 optional = false
 python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
 
@@ -22,7 +22,7 @@ tests_no_zope = ["coverage[toml] (>=5.0.2)", "hypothesis", "pympler", "pytest (>
 
 [[package]]
 name = "bitarray"
-version = "2.4.0"
+version = "2.4.1"
 description = "efficient arrays of booleans -- C extension"
 category = "main"
 optional = false
@@ -40,7 +40,7 @@ python-versions = "*"
 name = "colorama"
 version = "0.4.4"
 description = "Cross-platform colored terminal text."
-category = "main"
+category = "dev"
 optional = false
 python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
 
@@ -73,7 +73,7 @@ numpy = [
 name = "importlib-metadata"
 version = "4.8.3"
 description = "Read metadata from Python packages"
-category = "main"
+category = "dev"
 optional = false
 python-versions = ">=3.6"
 
@@ -90,7 +90,7 @@ testing = ["pytest (>=6)", "pytest-checkdocs (>=2.4)", "pytest-flake8", "pytest-
 name = "iniconfig"
 version = "1.1.1"
 description = "iniconfig: brain-dead simple config-ini parsing"
-category = "main"
+category = "dev"
 optional = false
 python-versions = "*"
 
@@ -130,7 +130,7 @@ python-versions = ">=3.6"
 name = "packaging"
 version = "21.3"
 description = "Core utilities for Python packages"
-category = "main"
+category = "dev"
 optional = false
 python-versions = ">=3.6"
 
@@ -149,7 +149,7 @@ python-versions = ">=3.6"
 name = "pluggy"
 version = "1.0.0"
 description = "plugin and hook calling mechanisms for python"
-category = "main"
+category = "dev"
 optional = false
 python-versions = ">=3.6"
 
@@ -164,7 +164,7 @@ testing = ["pytest", "pytest-benchmark"]
 name = "py"
 version = "1.11.0"
 description = "library with cross-python path, ini-parsing, io, code, log facilities"
-category = "main"
+category = "dev"
 optional = false
 python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
 
@@ -181,7 +181,7 @@ diagrams = ["jinja2", "railroad-diagrams"]
 
 [[package]]
 name = "pysam"
-version = "0.18.0"
+version = "0.19.0"
 description = "pysam"
 category = "main"
 optional = false
@@ -199,7 +199,7 @@ python-versions = "*"
 name = "pytest"
 version = "7.0.1"
 description = "pytest: simple powerful testing with Python"
-category = "main"
+category = "dev"
 optional = false
 python-versions = ">=3.6"
 
@@ -240,7 +240,7 @@ python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*"
 name = "tomli"
 version = "1.2.3"
 description = "A lil' TOML parser"
-category = "main"
+category = "dev"
 optional = false
 python-versions = ">=3.6"
 
@@ -248,7 +248,7 @@ python-versions = ">=3.6"
 name = "typing-extensions"
 version = "4.1.1"
 description = "Backported and Experimental Type Hints for Python 3.6+"
-category = "main"
+category = "dev"
 optional = false
 python-versions = ">=3.6"
 
@@ -256,7 +256,7 @@ python-versions = ">=3.6"
 name = "zipp"
 version = "3.6.0"
 description = "Backport of pathlib-compatible object wrapper for zip files"
-category = "main"
+category = "dev"
 optional = false
 python-versions = ">=3.6"
 
@@ -267,7 +267,7 @@ testing = ["pytest (>=4.6)", "pytest-checkdocs (>=2.4)", "pytest-flake8", "pytes
 [metadata]
 lock-version = "1.1"
 python-versions = "^3.6"
-content-hash = "014cb39b961033980d0624e14d4ee1922e18f509cdfce986a6036b96522bca63"
+content-hash = "b6e8b81ee1c0d5e9e28c359042778d40ae84b8d8d4906b3c362d71075722463e"
 
 [metadata.files]
 atomicwrites = [
@@ -279,78 +279,78 @@ attrs = [
     {file = "attrs-21.4.0.tar.gz", hash = "sha256:626ba8234211db98e869df76230a137c4c40a12d72445c45d5f5b716f076e2fd"},
 ]
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 pytabix = [
     {file = "pytabix-0.1.tar.gz", hash = "sha256:0774f1687ebd41811fb07a0e50951b6be72d7cc7e22ed2b18972eaf7482eb7d1"},
diff --git a/tests/test_novoCaller.py b/tests/test_novoCaller.py
index e7babe0..8089d36 100644
--- a/tests/test_novoCaller.py
+++ b/tests/test_novoCaller.py
@@ -8,14 +8,7 @@
                             main as main_novoCaller
                             )
 
-
-#################################################################
-#   Tests
-#################################################################
-# this tests may fail because of differences in float handling
-# e.g. novoCaller=1.4030838153054451e-05 Vs novoCaller=1.403083815305445e-05
-# depending on the machine
-
+# define flexible assert function to compare vcf files
 def assert_(tfile, ofile, test=False):
     ''' '''
     # Creating Vcf object
@@ -75,6 +68,12 @@ def assert_(tfile, ofile, test=False):
             except ValueError as e:
                 assert str(e) == '\nERROR in GENOTYPES identifiers, PSC-01-003 identifier is missing in VCF\n'
 
+#################################################################
+#   Tests
+#################################################################
+# this tests may fail because of differences in float handling
+# e.g. novoCaller=1.4030838153054451e-05 Vs novoCaller=1.403083815305445e-05
+# depending on the machine
 def test_run_novoCaller_rck_all():
     ''' '''
     # Variables