diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index f80b3c5382..11dfc3acdb 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -6,6 +6,12 @@ cgap-portal
 Change Log
 ----------
 
+15.6.0
+=======
+* 2024-10-11/dmichaels
+* Updated dcicutils version (8.16.1) for vulnerabilities.
+
+
 15.5.0
 ======
 * Use snovault search modules rather than the local ones (in the src/encoded/search directory).
diff --git a/poetry.lock b/poetry.lock
index efe7b84332..a0f165d94d 100644
--- a/poetry.lock
+++ b/poetry.lock
@@ -87,17 +87,17 @@ requests = ">=0.14.0"
 
 [[package]]
 name = "awscli"
-version = "1.34.31"
+version = "1.35.5"
 description = "Universal Command Line Environment for AWS."
 optional = false
 python-versions = ">=3.8"
 files = [
-    {file = "awscli-1.34.31-py3-none-any.whl", hash = "sha256:9cb9eede9d09678a6b57477cb8aa1cbb11e3761dfd15f21b3471e8e4f2fcc580"},
-    {file = "awscli-1.34.31.tar.gz", hash = "sha256:6f1d3073b00a4702b678d207fc61f73e4a895cd472a64f171d988c31cad4c90a"},
+    {file = "awscli-1.35.5-py3-none-any.whl", hash = "sha256:cf826082e7e1b6f8163f6a67e34431342ba7a933bcb54bcdd03a7d86a0ead75c"},
+    {file = "awscli-1.35.5.tar.gz", hash = "sha256:e3a1801bbb5772423549dfce2bd55395292fc84dcfaf115a7268463462a6c3af"},
 ]
 
 [package.dependencies]
-botocore = "1.35.31"
+botocore = "1.35.39"
 colorama = ">=0.2.5,<0.4.7"
 docutils = ">=0.10,<0.17"
 PyYAML = ">=3.10,<6.1"
@@ -258,17 +258,17 @@ files = [
 
 [[package]]
 name = "boto3"
-version = "1.35.31"
+version = "1.35.39"
 description = "The AWS SDK for Python"
 optional = false
 python-versions = ">=3.8"
 files = [
-    {file = "boto3-1.35.31-py3-none-any.whl", hash = "sha256:2e9af74d10d8af7610a8d8468d2914961f116912a024fce17351825260385a52"},
-    {file = "boto3-1.35.31.tar.gz", hash = "sha256:8c593af260c4ea3eb6f079c09908f94494ca2222aa4e40a7ff490fab1cee8b39"},
+    {file = "boto3-1.35.39-py3-none-any.whl", hash = "sha256:5970b62c1ec8177501e02520f0d41839ca5fc549b30bac4e8c0c0882ae776217"},
+    {file = "boto3-1.35.39.tar.gz", hash = "sha256:670f811c65e3c5fe4ed8c8d69be0b44b1d649e992c0fc16de43816d1188f88f1"},
 ]
 
 [package.dependencies]
-botocore = ">=1.35.31,<1.36.0"
+botocore = ">=1.35.39,<1.36.0"
 jmespath = ">=0.7.1,<2.0.0"
 s3transfer = ">=0.10.0,<0.11.0"
 
@@ -277,8 +277,8 @@ crt = ["botocore[crt] (>=1.21.0,<2.0a0)"]
 
 [[package]]
 name = "boto3-stubs"
-version = "1.35.31"
-description = "Type annotations for boto3 1.35.31 generated with mypy-boto3-builder 8.1.2"
+version = "1.34.143"
+description = "Type annotations for boto3 1.34.143 generated with mypy-boto3-builder 7.25.0"
 optional = false
 python-versions = ">=3.8"
 files = [
@@ -685,13 +685,13 @@ xray = ["mypy-boto3-xray (>=1.35.0,<1.36.0)"]
 
 [[package]]
 name = "botocore"
-version = "1.35.31"
+version = "1.35.39"
 description = "Low-level, data-driven core of boto 3."
 optional = false
 python-versions = ">=3.8"
 files = [
-    {file = "botocore-1.35.31-py3-none-any.whl", hash = "sha256:4cee814875bc78656aef4011d3d6b2231e96f53ea3661ee428201afb579d5c31"},
-    {file = "botocore-1.35.31.tar.gz", hash = "sha256:f7bfa910cf2cbcc8c2307c1cf7b93495d614c2d699883417893e0a337fe4eb63"},
+    {file = "botocore-1.35.39-py3-none-any.whl", hash = "sha256:781c547eb6a79c0e4b0bedd87b81fbfed957816b4841d33e20c8f1989c7c19ce"},
+    {file = "botocore-1.35.39.tar.gz", hash = "sha256:cb7f851933b5ccc2fba4f0a8b846252410aa0efac5bfbe93b82d10801f5f8e90"},
 ]
 
 [package.dependencies]
@@ -703,7 +703,7 @@ urllib3 = [
 ]
 
 [package.extras]
-crt = ["awscrt (==0.21.5)"]
+crt = ["awscrt (==0.22.0)"]
 
 [[package]]
 name = "botocore-stubs"
@@ -1170,48 +1170,52 @@ yaml = ["pyyaml (>=3.10,<7.0)"]
 
 [[package]]
 name = "cryptography"
-version = "39.0.2"
+version = "43.0.1"
 description = "cryptography is a package which provides cryptographic recipes and primitives to Python developers."
 optional = false
-python-versions = ">=3.6"
+python-versions = ">=3.7"
 files = [
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-    {file = "cryptography-39.0.2-cp36-abi3-macosx_10_12_x86_64.whl", hash = "sha256:23df8ca3f24699167daf3e23e51f7ba7334d504af63a94af468f468b975b7dd7"},
-    {file = "cryptography-39.0.2-cp36-abi3-manylinux_2_17_aarch64.manylinux2014_aarch64.manylinux_2_24_aarch64.whl", hash = "sha256:eb40fe69cfc6f5cdab9a5ebd022131ba21453cf7b8a7fd3631f45bbf52bed612"},
-    {file = "cryptography-39.0.2-cp36-abi3-manylinux_2_17_aarch64.manylinux2014_aarch64.whl", hash = "sha256:bc0521cce2c1d541634b19f3ac661d7a64f9555135e9d8af3980965be717fd4a"},
-    {file = "cryptography-39.0.2-cp36-abi3-manylinux_2_17_x86_64.manylinux2014_x86_64.whl", hash = "sha256:ffd394c7896ed7821a6d13b24657c6a34b6e2650bd84ae063cf11ccffa4f1a97"},
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-    {file = "cryptography-39.0.2-pp39-pypy39_pp73-macosx_10_12_x86_64.whl", hash = "sha256:e944fe07b6f229f4c1a06a7ef906a19652bdd9fd54c761b0ff87e83ae7a30354"},
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+    {file = "cryptography-43.0.1-pp39-pypy39_pp73-manylinux_2_28_aarch64.whl", hash = "sha256:9d3cdb25fa98afdd3d0892d132b8d7139e2c087da1712041f6b762e4f807cc96"},
+    {file = "cryptography-43.0.1-pp39-pypy39_pp73-manylinux_2_28_x86_64.whl", hash = "sha256:e710bf40870f4db63c3d7d929aa9e09e4e7ee219e703f949ec4073b4294f6172"},
+    {file = "cryptography-43.0.1-pp39-pypy39_pp73-win_amd64.whl", hash = "sha256:7c05650fe8023c5ed0d46793d4b7d7e6cd9c04e68eabe5b0aeea836e37bdcec2"},
+    {file = "cryptography-43.0.1.tar.gz", hash = "sha256:203e92a75716d8cfb491dc47c79e17d0d9207ccffcbcb35f598fbe463ae3444d"},
 ]
 
 [package.dependencies]
-cffi = ">=1.12"
+cffi = {version = ">=1.12", markers = "platform_python_implementation != \"PyPy\""}
 
 [package.extras]
 docs = ["sphinx (>=5.3.0)", "sphinx-rtd-theme (>=1.1.1)"]
-docstest = ["pyenchant (>=1.6.11)", "sphinxcontrib-spelling (>=4.0.1)", "twine (>=1.12.0)"]
-pep8test = ["black", "check-manifest", "mypy", "ruff", "types-pytz", "types-requests"]
-sdist = ["setuptools-rust (>=0.11.4)"]
+docstest = ["pyenchant (>=1.6.11)", "readme-renderer", "sphinxcontrib-spelling (>=4.0.1)"]
+nox = ["nox"]
+pep8test = ["check-sdist", "click", "mypy", "ruff"]
+sdist = ["build"]
 ssh = ["bcrypt (>=3.1.5)"]
-test = ["hypothesis (>=1.11.4,!=3.79.2)", "iso8601", "pretend", "pytest (>=6.2.0)", "pytest-benchmark", "pytest-cov", "pytest-shard (>=0.1.2)", "pytest-subtests", "pytest-xdist", "pytz"]
+test = ["certifi", "cryptography-vectors (==43.0.1)", "pretend", "pytest (>=6.2.0)", "pytest-benchmark", "pytest-cov", "pytest-xdist"]
 test-randomorder = ["pytest-randomly"]
-tox = ["tox"]
 
 [[package]]
 name = "cycler"
@@ -1379,13 +1383,13 @@ xlrd = ">=1.0.0,<2.0.0"
 
 [[package]]
 name = "dcicutils"
-version = "8.14.3"
+version = "8.16.1"
 description = "Utility package for interacting with the 4DN Data Portal and other 4DN resources"
 optional = false
 python-versions = "<3.13,>=3.8.1"
 files = [
-    {file = "dcicutils-8.14.3-py3-none-any.whl", hash = "sha256:685bca11f6d0ad69876b15b4a3a9a3338810e4ffb6e5bb0a479e5ee3e42238a8"},
-    {file = "dcicutils-8.14.3.tar.gz", hash = "sha256:3f238c5245faa5cf6b49ffedb6db9d9a6c9b8a457146c3769a1073f2fb4e5caa"},
+    {file = "dcicutils-8.16.1-py3-none-any.whl", hash = "sha256:6bd36178154b18b29ab1a10cedeaae695af6ccd4ee807233bc7e1a2874529ec5"},
+    {file = "dcicutils-8.16.1.tar.gz", hash = "sha256:9f588cf39081e46e6f47f2762b50d25eb85907dff121bedf6f6aace99b8d752d"},
 ]
 
 [package.dependencies]
@@ -1394,6 +1398,7 @@ aws-requests-auth = ">=0.4.2,<1"
 boto3 = ">=1.34.147,<2.0.0"
 botocore = ">=1.34.147,<2.0.0"
 chardet = ">=5.2.0,<6.0.0"
+cryptography = ">=43.0.1,<44.0.0"
 docker = ">=7.1.0,<8.0.0"
 elasticsearch = "7.13.4"
 gitpython = ">=3.1.2,<4.0.0"
@@ -1402,7 +1407,7 @@ jsonschema = ">=4.22.0,<5.0.0"
 openpyxl = ">=3.1.2,<4.0.0"
 opensearch-py = ">=2.0.1,<3.0.0"
 PyJWT = ">=2.6.0,<3.0.0"
-pyOpenSSL = ">=23.1.1,<24.0.0"
+pyopenssl = ">=24.2.1,<25.0.0"
 pyperclip = ">=1.8.2,<2.0.0"
 pyramid = "1.10.8"
 pytz = ">=2020.4"
@@ -2322,46 +2327,30 @@ description = "Python plotting package"
 optional = false
 python-versions = ">=3.9"
 files = [
-    {file = "matplotlib-3.9.2-cp310-cp310-macosx_10_12_x86_64.whl", hash = "sha256:9d78bbc0cbc891ad55b4f39a48c22182e9bdaea7fc0e5dbd364f49f729ca1bbb"},
-    {file = "matplotlib-3.9.2-cp310-cp310-macosx_11_0_arm64.whl", hash = "sha256:c375cc72229614632c87355366bdf2570c2dac01ac66b8ad048d2dabadf2d0d4"},
-    {file = "matplotlib-3.9.2-cp310-cp310-manylinux_2_17_aarch64.manylinux2014_aarch64.whl", hash = "sha256:1d94ff717eb2bd0b58fe66380bd8b14ac35f48a98e7c6765117fe67fb7684e64"},
-    {file = "matplotlib-3.9.2-cp310-cp310-manylinux_2_17_x86_64.manylinux2014_x86_64.whl", hash = "sha256:ab68d50c06938ef28681073327795c5db99bb4666214d2d5f880ed11aeaded66"},
-    {file = "matplotlib-3.9.2-cp310-cp310-musllinux_1_2_x86_64.whl", hash = "sha256:65aacf95b62272d568044531e41de26285d54aec8cb859031f511f84bd8b495a"},
-    {file = "matplotlib-3.9.2-cp310-cp310-win_amd64.whl", hash = "sha256:3fd595f34aa8a55b7fc8bf9ebea8aa665a84c82d275190a61118d33fbc82ccae"},
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 ]
 
 [[package]]
@@ -4843,4 +4824,4 @@ test = ["zope.testing"]
 [metadata]
 lock-version = "2.0"
 python-versions = ">=3.9,<3.13"
-content-hash = "004eb2055f1a4d70be81d361fc62be9fb64b3ecb1b4610561d6882c9556d9b61"
+content-hash = "e160ce903cf53de7ea5ae1ad2e2a7190bc5765c10d2b01e651be7fdff95047f7"
diff --git a/pyproject.toml b/pyproject.toml
index dcabca0e4d..bdd4e263f1 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,7 +1,7 @@
 [tool.poetry]
 # Note: Various modules refer to this system as "encoded", not "cgap-portal".
 name = "encoded"
-version = "15.5.0"
+version = "15.6.0"
 description = "Computational Genome Analysis Platform"
 authors = ["4DN-DCIC Team <support@4dnucleome.org>"]
 license = "MIT"
@@ -49,11 +49,12 @@ codeguru-profiler-agent = "^1.2.4"
 # At least on Mac M1 if cryptography package is later than 39.x.x (i.e. 40.x.x and up)
 # we get odd 'pyo3_runtime.PanicException: Python API call failed' error on import
 # of cryptography.hazmat.bindings._rust in cryptography package. 2023-04-21.
-cryptography = "39.0.2"
+# cryptography = "39.0.2"
+cryptography = "^43.0.1"
 colorama = "0.3.3"
 dcicpyvcf = "^3.1.0"
-dcicsnovault = "^11.22.0"
-dcicutils = "^8.13.3"
+dcicsnovault = "^11.18.0"
+dcicutils = "^8.16.1"
 elasticsearch = "7.13.4"
 execnet = "1.4.1"
 future = ">=0.18.2,<1"