diff --git a/config/config.example.yml b/config/config.example.yml
index 6c3c900f6ab..ebe1b2ff9b6 100644
--- a/config/config.example.yml
+++ b/config/config.example.yml
@@ -516,3 +516,8 @@ liveRegion:
   messageTimeOutDurationMs: 30000
   # The visibility of the live region. Setting this to true is only useful for debugging purposes.
   isVisible: false
+
+# Configuration for storing accessibility settings, used by the AccessibilitySettingsService
+accessibility:
+  # The duration in days after which the accessibility settings cookie expires
+  cookieExpirationDuration: 7
diff --git a/src/app/accessibility/accessibility-settings.config.ts b/src/app/accessibility/accessibility-settings.config.ts
new file mode 100644
index 00000000000..1852579c3d3
--- /dev/null
+++ b/src/app/accessibility/accessibility-settings.config.ts
@@ -0,0 +1,11 @@
+import { Config } from '../../config/config.interface';
+
+/**
+ * Configuration interface used by the AccessibilitySettingsService
+ */
+export class AccessibilitySettingsConfig implements Config {
+  /**
+   * The duration in days after which the accessibility settings cookie expires
+   */
+  cookieExpirationDuration: number;
+}
diff --git a/src/app/accessibility/accessibility-settings.service.spec.ts b/src/app/accessibility/accessibility-settings.service.spec.ts
new file mode 100644
index 00000000000..26cf488450e
--- /dev/null
+++ b/src/app/accessibility/accessibility-settings.service.spec.ts
@@ -0,0 +1,386 @@
+import {
+  fakeAsync,
+  flush,
+} from '@angular/core/testing';
+import { of } from 'rxjs';
+
+import { AuthService } from '../core/auth/auth.service';
+import { EPersonDataService } from '../core/eperson/eperson-data.service';
+import { EPerson } from '../core/eperson/models/eperson.model';
+import { CookieService } from '../core/services/cookie.service';
+import { CookieServiceMock } from '../shared/mocks/cookie.service.mock';
+import {
+  createFailedRemoteDataObject$,
+  createSuccessfulRemoteDataObject$,
+} from '../shared/remote-data.utils';
+import { AuthServiceStub } from '../shared/testing/auth-service.stub';
+import {
+  ACCESSIBILITY_COOKIE,
+  ACCESSIBILITY_SETTINGS_METADATA_KEY,
+  AccessibilitySetting,
+  AccessibilitySettings,
+  AccessibilitySettingsService,
+} from './accessibility-settings.service';
+
+
+describe('accessibilitySettingsService', () => {
+  let service: AccessibilitySettingsService;
+  let cookieService: CookieServiceMock;
+  let authService: AuthServiceStub;
+  let ePersonService: EPersonDataService;
+
+  beforeEach(() => {
+    cookieService = new CookieServiceMock();
+    authService = new AuthServiceStub();
+
+    ePersonService = jasmine.createSpyObj('ePersonService', {
+      createPatchFromCache: of([{
+        op: 'add',
+        value: null,
+      }]),
+      patch: of({}),
+    });
+
+    service = new AccessibilitySettingsService(
+      cookieService as unknown as CookieService,
+      authService as unknown as AuthService,
+      ePersonService,
+    );
+  });
+
+  describe('getALlAccessibilitySettingsKeys', () => {
+    it('should return an array containing all accessibility setting names', () => {
+      const settingNames: AccessibilitySetting[] = [
+        AccessibilitySetting.NotificationTimeOut,
+        AccessibilitySetting.LiveRegionTimeOut,
+      ];
+
+      expect(service.getAllAccessibilitySettingKeys()).toEqual(settingNames);
+    });
+  });
+
+  describe('get', () => {
+    it('should return the setting if it is set', () => {
+      const settings: AccessibilitySettings = {
+        notificationTimeOut: '1000',
+      };
+
+      service.getAll = jasmine.createSpy('getAll').and.returnValue(of(settings));
+
+      service.get(AccessibilitySetting.NotificationTimeOut, 'default').subscribe(value =>
+        expect(value).toEqual('1000'),
+      );
+    });
+
+    it('should return the default value if the setting is not set', () => {
+      const settings: AccessibilitySettings = {
+        notificationTimeOut: '1000',
+      };
+
+      service.getAll = jasmine.createSpy('getAll').and.returnValue(of(settings));
+
+      service.get(AccessibilitySetting.LiveRegionTimeOut, 'default').subscribe(value =>
+        expect(value).toEqual('default'),
+      );
+    });
+  });
+
+  describe('getAsNumber', () => {
+    it('should return the setting as number if the value for the setting can be parsed to a number', () => {
+      service.get = jasmine.createSpy('get').and.returnValue(of('1000'));
+
+      service.getAsNumber(AccessibilitySetting.NotificationTimeOut).subscribe(value =>
+        expect(value).toEqual(1000),
+      );
+    });
+
+    it('should return the default value if no value is set for the setting', () => {
+      service.get = jasmine.createSpy('get').and.returnValue(of(null));
+
+      service.getAsNumber(AccessibilitySetting.NotificationTimeOut, 123).subscribe(value =>
+        expect(value).toEqual(123),
+      );
+    });
+
+    it('should return the default value if the value for the setting can not be parsed to a number', () => {
+      service.get = jasmine.createSpy('get').and.returnValue(of('text'));
+
+      service.getAsNumber(AccessibilitySetting.NotificationTimeOut, 123).subscribe(value =>
+        expect(value).toEqual(123),
+      );
+    });
+  });
+
+  describe('getAll', () => {
+    it('should attempt to get the settings from metadata first', () => {
+      service.getAllSettingsFromAuthenticatedUserMetadata =
+        jasmine.createSpy('getAllSettingsFromAuthenticatedUserMetadata').and.returnValue(of({ }));
+
+      service.getAll().subscribe();
+      expect(service.getAllSettingsFromAuthenticatedUserMetadata).toHaveBeenCalled();
+    });
+
+    it('should attempt to get the settings from the cookie if the settings from metadata are empty', () => {
+      service.getAllSettingsFromAuthenticatedUserMetadata =
+        jasmine.createSpy('getAllSettingsFromAuthenticatedUserMetadata').and.returnValue(of({ }));
+
+      service.getAllSettingsFromCookie = jasmine.createSpy('getAllSettingsFromCookie').and.returnValue({ });
+
+      service.getAll().subscribe();
+      expect(service.getAllSettingsFromCookie).toHaveBeenCalled();
+    });
+
+    it('should not attempt to get the settings from the cookie if the settings from metadata are not empty', () => {
+      const settings: AccessibilitySettings = {
+        notificationTimeOut: '1000',
+      };
+
+      service.getAllSettingsFromAuthenticatedUserMetadata =
+        jasmine.createSpy('getAllSettingsFromAuthenticatedUserMetadata').and.returnValue(of(settings));
+
+      service.getAllSettingsFromCookie = jasmine.createSpy('getAllSettingsFromCookie').and.returnValue({ });
+
+      service.getAll().subscribe();
+      expect(service.getAllSettingsFromCookie).not.toHaveBeenCalled();
+    });
+
+    it('should return an empty object if both are empty', () => {
+      service.getAllSettingsFromAuthenticatedUserMetadata =
+        jasmine.createSpy('getAllSettingsFromAuthenticatedUserMetadata').and.returnValue(of({ }));
+
+      service.getAllSettingsFromCookie = jasmine.createSpy('getAllSettingsFromCookie').and.returnValue({ });
+
+      service.getAll().subscribe(value => expect(value).toEqual({}));
+    });
+  });
+
+  describe('getAllSettingsFromCookie', () => {
+    it('should retrieve the settings from the cookie', () => {
+      cookieService.get = jasmine.createSpy();
+
+      service.getAllSettingsFromCookie();
+      expect(cookieService.get).toHaveBeenCalledWith(ACCESSIBILITY_COOKIE);
+    });
+  });
+
+  describe('getAllSettingsFromAuthenticatedUserMetadata', () => {
+    it('should retrieve all settings from the user\'s metadata', () => {
+      const settings = { 'liveRegionTimeOut': '1000' };
+
+      const user = new EPerson();
+      user.setMetadata(ACCESSIBILITY_SETTINGS_METADATA_KEY, null, JSON.stringify(settings));
+
+      authService.getAuthenticatedUserFromStoreIfAuthenticated =
+        jasmine.createSpy('getAuthenticatedUserFromStoreIfAuthenticated').and.returnValue(of(user));
+
+      service.getAllSettingsFromAuthenticatedUserMetadata().subscribe(value =>
+        expect(value).toEqual(settings),
+      );
+    });
+  });
+
+  describe('set', () => {
+    it('should correctly update the chosen setting', () => {
+      service.updateSettings = jasmine.createSpy('updateSettings');
+
+      service.set(AccessibilitySetting.LiveRegionTimeOut, '500');
+      expect(service.updateSettings).toHaveBeenCalledWith({ liveRegionTimeOut: '500' });
+    });
+  });
+
+  describe('setSettings', () => {
+    beforeEach(() => {
+      service.setSettingsInCookie = jasmine.createSpy('setSettingsInCookie');
+    });
+
+    it('should attempt to set settings in metadata', () => {
+      service.setSettingsInAuthenticatedUserMetadata =
+        jasmine.createSpy('setSettingsInAuthenticatedUserMetadata').and.returnValue(of(false));
+
+      const settings: AccessibilitySettings = {
+        notificationTimeOut: '1000',
+      };
+
+      service.setSettings(settings).subscribe();
+      expect(service.setSettingsInAuthenticatedUserMetadata).toHaveBeenCalledWith(settings);
+    });
+
+    it('should set settings in cookie if metadata failed', () => {
+      service.setSettingsInAuthenticatedUserMetadata =
+        jasmine.createSpy('setSettingsInAuthenticatedUserMetadata').and.returnValue(of(false));
+
+      const settings: AccessibilitySettings = {
+        notificationTimeOut: '1000',
+      };
+
+      service.setSettings(settings).subscribe();
+      expect(service.setSettingsInCookie).toHaveBeenCalled();
+    });
+
+    it('should not set settings in cookie if metadata succeeded', () => {
+      service.setSettingsInAuthenticatedUserMetadata =
+        jasmine.createSpy('setSettingsInAuthenticatedUserMetadata').and.returnValue(of(true));
+
+      const settings: AccessibilitySettings = {
+        notificationTimeOut: '1000',
+      };
+
+      service.setSettings(settings).subscribe();
+      expect(service.setSettingsInCookie).not.toHaveBeenCalled();
+    });
+
+    it('should return \'metadata\' if settings are stored in metadata', () => {
+      service.setSettingsInAuthenticatedUserMetadata =
+        jasmine.createSpy('setSettingsInAuthenticatedUserMetadata').and.returnValue(of(true));
+
+      const settings: AccessibilitySettings = {
+        notificationTimeOut: '1000',
+      };
+
+      service.setSettings(settings).subscribe(value =>
+        expect(value).toEqual('metadata'),
+      );
+    });
+
+    it('should return \'cookie\' if settings are stored in cookie', () => {
+      service.setSettingsInAuthenticatedUserMetadata =
+        jasmine.createSpy('setSettingsInAuthenticatedUserMetadata').and.returnValue(of(false));
+
+      const settings: AccessibilitySettings = {
+        notificationTimeOut: '1000',
+      };
+
+      service.setSettings(settings).subscribe(value =>
+        expect(value).toEqual('cookie'),
+      );
+    });
+  });
+
+  describe('updateSettings', () => {
+    it('should call setSettings with the updated settings', () => {
+      const beforeSettings: AccessibilitySettings = {
+        notificationTimeOut: '1000',
+      };
+
+      service.getAll = jasmine.createSpy('getAll').and.returnValue(of(beforeSettings));
+      service.setSettings = jasmine.createSpy('setSettings').and.returnValue(of('cookie'));
+
+      const newSettings: AccessibilitySettings = {
+        liveRegionTimeOut: '2000',
+      };
+
+      const combinedSettings: AccessibilitySettings = {
+        notificationTimeOut: '1000',
+        liveRegionTimeOut: '2000',
+      };
+
+      service.updateSettings(newSettings).subscribe();
+      expect(service.setSettings).toHaveBeenCalledWith(combinedSettings);
+    });
+  });
+
+  describe('setSettingsInAuthenticatedUserMetadata', () => {
+    beforeEach(() => {
+      service.setSettingsInMetadata = jasmine.createSpy('setSettingsInMetadata').and.returnValue(of(null));
+    });
+
+    it('should store settings in metadata when the user is authenticated', fakeAsync(() => {
+      const user = new EPerson();
+      authService.getAuthenticatedUserFromStoreIfAuthenticated = jasmine.createSpy().and.returnValue(of(user));
+
+      service.setSettingsInAuthenticatedUserMetadata({}).subscribe();
+      flush();
+
+      expect(service.setSettingsInMetadata).toHaveBeenCalled();
+    }));
+
+    it('should emit false when the user is not authenticated', fakeAsync(() => {
+      authService.getAuthenticatedUserFromStoreIfAuthenticated = jasmine.createSpy().and.returnValue(of(null));
+
+      service.setSettingsInAuthenticatedUserMetadata({})
+        .subscribe(value => expect(value).toBeFalse());
+      flush();
+
+      expect(service.setSettingsInMetadata).not.toHaveBeenCalled();
+    }));
+  });
+
+  describe('setSettingsInMetadata', () => {
+    const ePerson = new EPerson();
+
+    beforeEach(() => {
+      ePerson.setMetadata = jasmine.createSpy('setMetadata');
+      ePerson.removeMetadata = jasmine.createSpy('removeMetadata');
+    });
+
+    it('should set the settings in metadata', () => {
+      service.setSettingsInMetadata(ePerson, { [AccessibilitySetting.LiveRegionTimeOut]: '500' }).subscribe();
+      expect(ePerson.setMetadata).toHaveBeenCalled();
+    });
+
+    it('should remove the metadata when the settings are emtpy', () => {
+      service.setSettingsInMetadata(ePerson, {}).subscribe();
+      expect(ePerson.setMetadata).not.toHaveBeenCalled();
+      expect(ePerson.removeMetadata).toHaveBeenCalled();
+    });
+
+    it('should create a patch with the metadata changes', () => {
+      service.setSettingsInMetadata(ePerson, { [AccessibilitySetting.LiveRegionTimeOut]: '500' }).subscribe();
+      expect(ePersonService.createPatchFromCache).toHaveBeenCalled();
+    });
+
+    it('should send the patch request', () => {
+      service.setSettingsInMetadata(ePerson, { [AccessibilitySetting.LiveRegionTimeOut]: '500' }).subscribe();
+      expect(ePersonService.patch).toHaveBeenCalled();
+    });
+
+    it('should emit true when the update succeeded', fakeAsync(() => {
+      ePersonService.patch = jasmine.createSpy().and.returnValue(createSuccessfulRemoteDataObject$({}));
+
+      service.setSettingsInMetadata(ePerson, { [AccessibilitySetting.LiveRegionTimeOut]: '500' })
+        .subscribe(value => {
+          expect(value).toBeTrue();
+        });
+
+      flush();
+    }));
+
+    it('should emit false when the update failed', fakeAsync(() => {
+      ePersonService.patch = jasmine.createSpy().and.returnValue(createFailedRemoteDataObject$());
+
+      service.setSettingsInMetadata(ePerson, { [AccessibilitySetting.LiveRegionTimeOut]: '500' })
+        .subscribe(value => {
+          expect(value).toBeFalse();
+        });
+
+      flush();
+    }));
+  });
+
+  describe('setSettingsInCookie', () => {
+    beforeEach(() => {
+      cookieService.set = jasmine.createSpy('set');
+      cookieService.remove = jasmine.createSpy('remove');
+    });
+
+    it('should store the settings in a cookie', () => {
+      service.setSettingsInCookie({ [AccessibilitySetting.LiveRegionTimeOut]: '500' });
+      expect(cookieService.set).toHaveBeenCalled();
+    });
+
+    it('should remove the cookie when the settings are empty', () => {
+      service.setSettingsInCookie({});
+      expect(cookieService.set).not.toHaveBeenCalled();
+      expect(cookieService.remove).toHaveBeenCalled();
+    });
+  });
+
+  describe('getInputType', () => {
+    it('should correctly return the input type', () => {
+      expect(service.getInputType(AccessibilitySetting.NotificationTimeOut)).toEqual('number');
+      expect(service.getInputType(AccessibilitySetting.LiveRegionTimeOut)).toEqual('number');
+      expect(service.getInputType('unknownValue' as AccessibilitySetting)).toEqual('text');
+    });
+  });
+
+});
diff --git a/src/app/accessibility/accessibility-settings.service.stub.ts b/src/app/accessibility/accessibility-settings.service.stub.ts
new file mode 100644
index 00000000000..b3fc40d1b3b
--- /dev/null
+++ b/src/app/accessibility/accessibility-settings.service.stub.ts
@@ -0,0 +1,35 @@
+import { of } from 'rxjs';
+
+import { AccessibilitySettingsService } from './accessibility-settings.service';
+
+export function getAccessibilitySettingsServiceStub(): AccessibilitySettingsService {
+  return new AccessibilitySettingsServiceStub() as unknown as AccessibilitySettingsService;
+}
+
+export class AccessibilitySettingsServiceStub {
+  getAllAccessibilitySettingKeys = jasmine.createSpy('getAllAccessibilitySettingKeys').and.returnValue([]);
+
+  get = jasmine.createSpy('get').and.returnValue(of(null));
+
+  getAsNumber = jasmine.createSpy('getAsNumber').and.returnValue(of(0));
+
+  getAll = jasmine.createSpy('getAll').and.returnValue(of({}));
+
+  getAllSettingsFromCookie = jasmine.createSpy('getAllSettingsFromCookie').and.returnValue({});
+
+  getAllSettingsFromAuthenticatedUserMetadata = jasmine.createSpy('getAllSettingsFromAuthenticatedUserMetadata')
+    .and.returnValue(of({}));
+
+  set = jasmine.createSpy('setSettings').and.returnValue(of('cookie'));
+
+  updateSettings = jasmine.createSpy('updateSettings').and.returnValue(of('cookie'));
+
+  setSettingsInAuthenticatedUserMetadata = jasmine.createSpy('setSettingsInAuthenticatedUserMetadata')
+    .and.returnValue(of(false));
+
+  setSettingsInMetadata = jasmine.createSpy('setSettingsInMetadata').and.returnValue(of(false));
+
+  setSettingsInCookie = jasmine.createSpy('setSettingsInCookie');
+
+  getInputType = jasmine.createSpy('getInputType').and.returnValue('text');
+}
diff --git a/src/app/accessibility/accessibility-settings.service.ts b/src/app/accessibility/accessibility-settings.service.ts
new file mode 100644
index 00000000000..6ff19be9bb0
--- /dev/null
+++ b/src/app/accessibility/accessibility-settings.service.ts
@@ -0,0 +1,239 @@
+import { Injectable } from '@angular/core';
+import cloneDeep from 'lodash/cloneDeep';
+import {
+  Observable,
+  of,
+  switchMap,
+} from 'rxjs';
+import {
+  map,
+  take,
+} from 'rxjs/operators';
+
+import { environment } from '../../environments/environment';
+import { AuthService } from '../core/auth/auth.service';
+import { EPersonDataService } from '../core/eperson/eperson-data.service';
+import { EPerson } from '../core/eperson/models/eperson.model';
+import { CookieService } from '../core/services/cookie.service';
+import { getFirstCompletedRemoteData } from '../core/shared/operators';
+import {
+  hasValue,
+  isNotEmpty,
+  isNotEmptyOperator,
+} from '../shared/empty.util';
+
+/**
+ * Name of the cookie used to store the settings locally
+ */
+export const ACCESSIBILITY_COOKIE = 'dsAccessibilityCookie';
+
+/**
+ * Name of the metadata field to store settings on the ePerson
+ */
+export const ACCESSIBILITY_SETTINGS_METADATA_KEY = 'dspace.accessibility.settings';
+
+/**
+ * Enum containing all possible accessibility settings.
+ * When adding new settings, the {@link AccessibilitySettingsService#getInputType} method and the i18n keys for the
+ * accessibility settings page should be updated.
+ */
+export enum AccessibilitySetting {
+  NotificationTimeOut = 'notificationTimeOut',
+  LiveRegionTimeOut = 'liveRegionTimeOut',
+}
+
+export type AccessibilitySettings = { [key in AccessibilitySetting]?: any };
+
+/**
+ * Service handling the retrieval and configuration of accessibility settings.
+ *
+ * This service stores the configured settings in either a cookie or on the user's metadata depending on whether
+ * the user is authenticated.
+ */
+@Injectable({
+  providedIn: 'root',
+})
+export class AccessibilitySettingsService {
+
+  constructor(
+    protected cookieService: CookieService,
+    protected authService: AuthService,
+    protected ePersonService: EPersonDataService,
+  ) {
+  }
+
+  getAllAccessibilitySettingKeys(): AccessibilitySetting[] {
+    return Object.entries(AccessibilitySetting).map(([_, val]) => val);
+  }
+
+  /**
+   * Get the stored value for the provided {@link AccessibilitySetting}. If the value does not exist or if it is empty,
+   * the provided defaultValue is emitted instead.
+   */
+  get(setting: AccessibilitySetting, defaultValue: string = null): Observable<string> {
+    return this.getAll().pipe(
+      map(settings => settings[setting]),
+      map(value => isNotEmpty(value) ? value : defaultValue),
+    );
+  }
+
+  /**
+   * Get the stored value for the provided {@link AccessibilitySetting} as a number. If the stored value
+   * could not be converted to a number, the value of the defaultValue parameter is emitted instead.
+   */
+  getAsNumber(setting: AccessibilitySetting, defaultValue: number = null): Observable<number> {
+    return this.get(setting).pipe(
+      map(value => hasValue(value) ? parseInt(value, 10) : NaN),
+      map(number => !isNaN(number) ? number : defaultValue),
+    );
+  }
+
+  /**
+   * Get all currently stored accessibility settings
+   */
+  getAll(): Observable<AccessibilitySettings> {
+    return this.getAllSettingsFromAuthenticatedUserMetadata().pipe(
+      map(value => isNotEmpty(value) ? value : this.getAllSettingsFromCookie()),
+      map(value => isNotEmpty(value) ? value : {}),
+    );
+  }
+
+  /**
+   * Get all settings from the accessibility settings cookie
+   */
+  getAllSettingsFromCookie(): AccessibilitySettings {
+    return this.cookieService.get(ACCESSIBILITY_COOKIE);
+  }
+
+  /**
+   * Attempts to retrieve all settings from the authenticated user's metadata.
+   * Returns an empty object when no user is authenticated.
+   */
+  getAllSettingsFromAuthenticatedUserMetadata(): Observable<AccessibilitySettings> {
+    return this.authService.getAuthenticatedUserFromStoreIfAuthenticated().pipe(
+      take(1),
+      map(user => hasValue(user) && hasValue(user.firstMetadataValue(ACCESSIBILITY_SETTINGS_METADATA_KEY)) ?
+        JSON.parse(user.firstMetadataValue(ACCESSIBILITY_SETTINGS_METADATA_KEY)) :
+        {},
+      ),
+    );
+  }
+
+  /**
+   * Set a single accessibility setting value, leaving all other settings unchanged.
+   * When setting all values, {@link AccessibilitySettingsService#setSettings} should be used.
+   * When updating multiple values, {@link AccessibilitySettingsService#updateSettings} should be used.
+   *
+   * Returns 'cookie' when the changes were stored in the cookie.
+   * Returns 'metadata' when the changes were stored in metadata.
+   */
+  set(setting: AccessibilitySetting, value: string): Observable<'cookie' | 'metadata'> {
+    return this.updateSettings({ [setting]: value });
+  }
+
+  /**
+   * Set all accessibility settings simultaneously.
+   * This method removes existing settings if they are missing from the provided {@link AccessibilitySettings} object.
+   * Removes all settings if the provided object is empty.
+   *
+   * Returns 'cookie' when the changes were stored in the cookie.
+   * Returns 'metadata' when the changes were stored in metadata.
+   */
+  setSettings(settings: AccessibilitySettings): Observable<'cookie' | 'metadata'> {
+    return this.setSettingsInAuthenticatedUserMetadata(settings).pipe(
+      take(1),
+      map((succeeded) => {
+        if (!succeeded) {
+          this.setSettingsInCookie(settings);
+          return 'cookie';
+        } else {
+          return 'metadata';
+        }
+      }),
+    );
+  }
+
+  /**
+   * Update multiple accessibility settings simultaneously.
+   * This method does not change the settings that are missing from the provided {@link AccessibilitySettings} object.
+   *
+   * Returns 'cookie' when the changes were stored in the cookie.
+   * Returns 'metadata' when the changes were stored in metadata.
+   */
+  updateSettings(settings: AccessibilitySettings): Observable<'cookie' | 'metadata'> {
+    return this.getAll().pipe(
+      take(1),
+      map(currentSettings => Object.assign({}, currentSettings, settings)),
+      switchMap(newSettings => this.setSettings(newSettings)),
+    );
+  }
+
+  /**
+   * Attempts to set the provided settings on the currently authorized user's metadata.
+   * Emits false when no user is authenticated or when the metadata update failed.
+   * Emits true when the metadata update succeeded.
+   */
+  setSettingsInAuthenticatedUserMetadata(settings: AccessibilitySettings): Observable<boolean> {
+    return this.authService.getAuthenticatedUserFromStoreIfAuthenticated().pipe(
+      take(1),
+      switchMap(user => {
+        if (hasValue(user)) {
+          // EPerson has to be cloned, otherwise the EPerson's metadata can't be modified
+          const clonedUser = cloneDeep(user);
+          return this.setSettingsInMetadata(clonedUser, settings);
+        } else {
+          return of(false);
+        }
+      }),
+    );
+  }
+
+  /**
+   * Attempts to set the provided settings on the user's metadata.
+   * Emits false when the update failed, true when the update succeeded.
+   */
+  setSettingsInMetadata(
+    user: EPerson,
+    settings: AccessibilitySettings,
+  ): Observable<boolean> {
+    if (isNotEmpty(settings)) {
+      user.setMetadata(ACCESSIBILITY_SETTINGS_METADATA_KEY, null, JSON.stringify(settings));
+    } else {
+      user.removeMetadata(ACCESSIBILITY_SETTINGS_METADATA_KEY);
+    }
+
+    return this.ePersonService.createPatchFromCache(user).pipe(
+      take(1),
+      isNotEmptyOperator(),
+      switchMap(operations => this.ePersonService.patch(user, operations)),
+      getFirstCompletedRemoteData(),
+      map(rd => rd.hasSucceeded),
+    );
+  }
+
+  /**
+   * Sets the provided settings in a cookie
+   */
+  setSettingsInCookie(settings: AccessibilitySettings) {
+    if (isNotEmpty(settings)) {
+      this.cookieService.set(ACCESSIBILITY_COOKIE, settings, { expires: environment.accessibility.cookieExpirationDuration });
+    } else {
+      this.cookieService.remove(ACCESSIBILITY_COOKIE);
+    }
+  }
+
+  /**
+   * Returns the input type that a form should use for the provided {@link AccessibilitySetting}
+   */
+  getInputType(setting: AccessibilitySetting): string {
+    switch (setting) {
+      case AccessibilitySetting.NotificationTimeOut:
+        return 'number';
+      case AccessibilitySetting.LiveRegionTimeOut:
+        return 'number';
+      default:
+        return 'text';
+    }
+  }
+
+}
diff --git a/src/app/core/auth/auth.service.ts b/src/app/core/auth/auth.service.ts
index cd773b68cfa..1e32fc308c3 100644
--- a/src/app/core/auth/auth.service.ts
+++ b/src/app/core/auth/auth.service.ts
@@ -60,6 +60,7 @@ import {
 import {
   getAllSucceededRemoteDataPayload,
   getFirstCompletedRemoteData,
+  getFirstSucceededRemoteDataPayload,
 } from '../shared/operators';
 import { PageInfo } from '../shared/page-info.model';
 import {
@@ -261,6 +262,23 @@ export class AuthService {
     );
   }
 
+  /**
+   * Returns an observable which emits the currently authenticated user from the store,
+   * or null if the user is not authenticated.
+   */
+  public getAuthenticatedUserFromStoreIfAuthenticated(): Observable<EPerson> {
+    return this.store.pipe(
+      select(getAuthenticatedUserId),
+      switchMap((id: string) => {
+        if (hasValue(id)) {
+          return this.epersonService.findById(id).pipe(getFirstSucceededRemoteDataPayload());
+        } else {
+          return observableOf(null);
+        }
+      }),
+    );
+  }
+
   /**
    * Checks if token is present into browser storage and is valid.
    */
diff --git a/src/app/footer/footer.component.html b/src/app/footer/footer.component.html
index 4841674852b..f715945e3c2 100644
--- a/src/app/footer/footer.component.html
+++ b/src/app/footer/footer.component.html
@@ -80,6 +80,10 @@ <h5 class="text-uppercase">Footer Content</h5>
           <a class="btn text-white"
              routerLink="info/feedback">{{ 'footer.link.feedback' | translate}}</a>
         </li>
+        <li>
+          <a class="text-white"
+             routerLink="info/accessibility">{{ 'footer.link.accessibility' | translate }}</a>
+        </li>
       </ul>
     </div>
     <div *ngIf="coarLdnEnabled$ | async" class="notify-enabled text-white">
diff --git a/src/app/info/accessibility-settings/accessibility-settings.component.html b/src/app/info/accessibility-settings/accessibility-settings.component.html
new file mode 100644
index 00000000000..6550c6a2880
--- /dev/null
+++ b/src/app/info/accessibility-settings/accessibility-settings.component.html
@@ -0,0 +1,26 @@
+<div class="container">
+  <h2>{{ 'info.accessibility-settings.title' | translate }}</h2>
+
+  <form>
+    <div *ngFor="let setting of accessibilitySettingsOptions" class="form-group row">
+      <label [for]="setting + 'Input'" class="col-sm-2 col-form-label">
+        {{ 'info.accessibility-settings.' + setting + '.label' | translate }}
+      </label>
+
+      <div class="col-sm-10">
+        <input [type]="getInputType(setting)" [id]="setting + 'Input'" class="form-control"
+               [(ngModel)]="formValues[setting]" [ngModelOptions]="{ standalone: true }"
+               [attr.aria-describedby]="setting + 'Hint'">
+
+        <small [id]="setting + 'Hint'" class="form-text text-muted">
+          {{ 'info.accessibility-settings.' + setting + '.hint' | translate }}
+        </small>
+      </div>
+    </div>
+
+    <button type="submit" (click)="saveSettings()" class="btn btn-primary">
+      {{ 'info.accessibility-settings.submit' | translate }}
+    </button>
+  </form>
+
+</div>
diff --git a/src/app/info/accessibility-settings/accessibility-settings.component.spec.ts b/src/app/info/accessibility-settings/accessibility-settings.component.spec.ts
new file mode 100644
index 00000000000..10147960d6c
--- /dev/null
+++ b/src/app/info/accessibility-settings/accessibility-settings.component.spec.ts
@@ -0,0 +1,86 @@
+import { NO_ERRORS_SCHEMA } from '@angular/core';
+import {
+  ComponentFixture,
+  TestBed,
+  waitForAsync,
+} from '@angular/core/testing';
+import { TranslateModule } from '@ngx-translate/core';
+import { of } from 'rxjs';
+
+import {
+  AccessibilitySetting,
+  AccessibilitySettingsService,
+} from '../../accessibility/accessibility-settings.service';
+import { getAccessibilitySettingsServiceStub } from '../../accessibility/accessibility-settings.service.stub';
+import { AuthService } from '../../core/auth/auth.service';
+import { NotificationsService } from '../../shared/notifications/notifications.service';
+import { AuthServiceStub } from '../../shared/testing/auth-service.stub';
+import { NotificationsServiceStub } from '../../shared/testing/notifications-service.stub';
+import { AccessibilitySettingsComponent } from './accessibility-settings.component';
+
+
+describe('AccessibilitySettingsComponent', () => {
+  let component: AccessibilitySettingsComponent;
+  let fixture: ComponentFixture<AccessibilitySettingsComponent>;
+
+  let authService: AuthServiceStub;
+  let settingsService: AccessibilitySettingsService;
+  let notificationsService: NotificationsServiceStub;
+
+  beforeEach(waitForAsync(() => {
+    authService = new AuthServiceStub();
+    settingsService = getAccessibilitySettingsServiceStub();
+    notificationsService = new NotificationsServiceStub();
+
+    TestBed.configureTestingModule({
+      imports: [TranslateModule.forRoot()],
+      providers: [
+        { provide: AuthService, useValue: authService },
+        { provide: AccessibilitySettingsService, useValue: settingsService },
+        { provide: NotificationsService, useValue: notificationsService },
+      ],
+      schemas: [NO_ERRORS_SCHEMA],
+    }).compileComponents();
+  }));
+
+  beforeEach(() => {
+    fixture = TestBed.createComponent(AccessibilitySettingsComponent);
+    component = fixture.componentInstance;
+    fixture.detectChanges();
+  });
+
+  it('should create', () => {
+    expect(component).toBeTruthy();
+  });
+
+  describe('On Init', () => {
+    it('should retrieve all accessibility settings options', () => {
+      expect(settingsService.getAllAccessibilitySettingKeys).toHaveBeenCalled();
+    });
+
+    it('should retrieve the current settings', () => {
+      expect(settingsService.getAll).toHaveBeenCalled();
+    });
+  });
+
+  describe('getInputType', () => {
+    it('should retrieve the input type for the setting from the service', () => {
+      component.getInputType(AccessibilitySetting.LiveRegionTimeOut);
+      expect(settingsService.getInputType).toHaveBeenCalledWith(AccessibilitySetting.LiveRegionTimeOut);
+    });
+  });
+
+  describe('saveSettings', () => {
+    it('should save the settings in the service', () => {
+      settingsService.setSettings = jasmine.createSpy('setSettings').and.returnValue(of('cookie'));
+      component.saveSettings();
+      expect(settingsService.setSettings).toHaveBeenCalled();
+    });
+
+    it('should give the user a notification mentioning where the settings were saved', () => {
+      settingsService.setSettings = jasmine.createSpy('setSettings').and.returnValue(of('cookie'));
+      component.saveSettings();
+      expect(notificationsService.success).toHaveBeenCalled();
+    });
+  });
+});
diff --git a/src/app/info/accessibility-settings/accessibility-settings.component.ts b/src/app/info/accessibility-settings/accessibility-settings.component.ts
new file mode 100644
index 00000000000..dca94c67c1d
--- /dev/null
+++ b/src/app/info/accessibility-settings/accessibility-settings.component.ts
@@ -0,0 +1,62 @@
+import { CommonModule } from '@angular/common';
+import {
+  Component,
+  OnInit,
+} from '@angular/core';
+import { FormsModule } from '@angular/forms';
+import {
+  TranslateModule,
+  TranslateService,
+} from '@ngx-translate/core';
+import { take } from 'rxjs';
+
+import {
+  AccessibilitySetting,
+  AccessibilitySettings,
+  AccessibilitySettingsService,
+} from '../../accessibility/accessibility-settings.service';
+import { AuthService } from '../../core/auth/auth.service';
+import { NotificationsService } from '../../shared/notifications/notifications.service';
+
+@Component({
+  selector: 'ds-accessibility-settings',
+  templateUrl: './accessibility-settings.component.html',
+  imports: [
+    CommonModule,
+    TranslateModule,
+    FormsModule,
+  ],
+  standalone: true,
+})
+export class AccessibilitySettingsComponent implements OnInit {
+
+  protected accessibilitySettingsOptions: AccessibilitySetting[];
+
+  protected formValues: AccessibilitySettings = { };
+
+  constructor(
+    protected authService: AuthService,
+    protected settingsService: AccessibilitySettingsService,
+    protected notificationsService: NotificationsService,
+    protected translateService: TranslateService,
+  ) {
+  }
+
+  ngOnInit() {
+    this.accessibilitySettingsOptions = this.settingsService.getAllAccessibilitySettingKeys();
+    this.settingsService.getAll().pipe(take(1)).subscribe(currentSettings => {
+      this.formValues = currentSettings;
+    });
+  }
+
+  getInputType(setting: AccessibilitySetting): string {
+    return this.settingsService.getInputType(setting);
+  }
+
+  saveSettings() {
+    this.settingsService.setSettings(this.formValues).pipe(take(1)).subscribe(location => {
+      this.notificationsService.success(null, this.translateService.instant('info.accessibility-settings.save-notification.' + location));
+    });
+  }
+
+}
diff --git a/src/app/info/info-routes.ts b/src/app/info/info-routes.ts
index 8d70ac740fc..4b7decb49c5 100644
--- a/src/app/info/info-routes.ts
+++ b/src/app/info/info-routes.ts
@@ -8,9 +8,11 @@ import { i18nBreadcrumbResolver } from '../core/breadcrumbs/i18n-breadcrumb.reso
 import { notifyInfoGuard } from '../core/coar-notify/notify-info/notify-info.guard';
 import { feedbackGuard } from '../core/feedback/feedback.guard';
 import { hasValue } from '../shared/empty.util';
+import { AccessibilitySettingsComponent } from './accessibility-settings/accessibility-settings.component';
 import { ThemedEndUserAgreementComponent } from './end-user-agreement/themed-end-user-agreement.component';
 import { ThemedFeedbackComponent } from './feedback/themed-feedback.component';
 import {
+  ACCESSIBILITY_SETTINGS_PATH,
   COAR_NOTIFY_SUPPORT,
   END_USER_AGREEMENT_PATH,
   FEEDBACK_PATH,
@@ -28,6 +30,12 @@ export const ROUTES: Routes = [
     data: { title: 'info.feedback.title', breadcrumbKey: 'info.feedback' },
     canActivate: [feedbackGuard],
   },
+  {
+    path: ACCESSIBILITY_SETTINGS_PATH,
+    component: AccessibilitySettingsComponent,
+    resolve: { breadcrumb: i18nBreadcrumbResolver },
+    data: { title: 'info.accessibility-settings.title', breadcrumbKey: 'info.accessibility-settings' },
+  },
   environment.info.enableEndUserAgreement ? {
     path: END_USER_AGREEMENT_PATH,
     component: ThemedEndUserAgreementComponent,
diff --git a/src/app/info/info-routing-paths.ts b/src/app/info/info-routing-paths.ts
index cd42dd9c1d4..6aa4bfbc721 100644
--- a/src/app/info/info-routing-paths.ts
+++ b/src/app/info/info-routing-paths.ts
@@ -4,6 +4,7 @@ export const END_USER_AGREEMENT_PATH = 'end-user-agreement';
 export const PRIVACY_PATH = 'privacy';
 export const FEEDBACK_PATH = 'feedback';
 export const COAR_NOTIFY_SUPPORT = 'coar-notify-support';
+export const ACCESSIBILITY_SETTINGS_PATH = 'accessibility';
 
 export function getEndUserAgreementPath() {
   return getSubPath(END_USER_AGREEMENT_PATH);
@@ -21,6 +22,10 @@ export function getCOARNotifySupportPath(): string {
   return getSubPath(COAR_NOTIFY_SUPPORT);
 }
 
+export function getAccessibilitySettingsPath() {
+  return getSubPath(ACCESSIBILITY_SETTINGS_PATH);
+}
+
 function getSubPath(path: string) {
   return `${getInfoModulePath()}/${path}`;
 }
diff --git a/src/app/profile-page/profile-page.component.html b/src/app/profile-page/profile-page.component.html
index b5703c47a31..6b0dd8e6d60 100644
--- a/src/app/profile-page/profile-page.component.html
+++ b/src/app/profile-page/profile-page.component.html
@@ -29,10 +29,18 @@ <h1>{{'profile.title' | translate}}</h1>
         ></ds-profile-page-security-form>
       </div>
     </div>
-    <div class="col-12 text-right pr-0">
+    <div class="col-12 text-right pr-0 mb-4">
       <button class="btn btn-primary" (click)="updateProfile()"><i class="fas fa-edit"></i> {{'profile.form.submit' | translate}}</button>
     </div>
 
+    <div class="card mb-4">
+      <div class="card-header">{{'profile.card.accessibility.header' | translate}}</div>
+      <div class="card-body">
+        <div class="mb-1">{{'profile.card.accessibility.content' | translate}}</div>
+        <a [routerLink]="'/info/accessibility'">{{'profile.card.accessibility.link' | translate}}</a>
+      </div>
+    </div>
+
     <ng-container *ngVar="(groupsRD$ | async)?.payload?.page as groups">
       <div *ngIf="groups?.length > 0">
         <h2 class="mt-4">{{'profile.groups.head' | translate}}</h2>
diff --git a/src/app/profile-page/profile-page.component.ts b/src/app/profile-page/profile-page.component.ts
index afa89360b25..673b9856985 100644
--- a/src/app/profile-page/profile-page.component.ts
+++ b/src/app/profile-page/profile-page.component.ts
@@ -8,6 +8,7 @@ import {
   OnInit,
   ViewChild,
 } from '@angular/core';
+import { RouterModule } from '@angular/router';
 import {
   TranslateModule,
   TranslateService,
@@ -65,6 +66,7 @@ import { ProfilePageSecurityFormComponent } from './profile-page-security-form/p
     NgIf,
     NgForOf,
     SuggestionsNotificationComponent,
+    RouterModule,
   ],
   standalone: true,
 })
diff --git a/src/app/root/root.component.spec.ts b/src/app/root/root.component.spec.ts
index 1abc3ffd176..77b39d29088 100644
--- a/src/app/root/root.component.spec.ts
+++ b/src/app/root/root.component.spec.ts
@@ -8,6 +8,8 @@ import { NoopAnimationsModule } from '@angular/platform-browser/animations';
 import { Router } from '@angular/router';
 import { TranslateModule } from '@ngx-translate/core';
 
+import { AccessibilitySettingsService } from '../accessibility/accessibility-settings.service';
+import { AccessibilitySettingsServiceStub } from '../accessibility/accessibility-settings.service.stub';
 import { ThemedAdminSidebarComponent } from '../admin/admin-sidebar/themed-admin-sidebar.component';
 import { ThemedBreadcrumbsComponent } from '../breadcrumbs/themed-breadcrumbs.component';
 import { ThemedFooterComponent } from '../footer/themed-footer.component';
@@ -41,6 +43,7 @@ describe('RootComponent', () => {
         { provide: MenuService, useValue: new MenuServiceStub() },
         { provide: CSSVariableService, useClass: CSSVariableServiceStub },
         { provide: HostWindowService, useValue: new HostWindowServiceStub(800) },
+        { provide: AccessibilitySettingsService, useValue: new AccessibilitySettingsServiceStub() },
       ],
       schemas: [CUSTOM_ELEMENTS_SCHEMA],
     })
diff --git a/src/app/shared/live-region/live-region.service.spec.ts b/src/app/shared/live-region/live-region.service.spec.ts
index 375c0d0d699..60ab2215087 100644
--- a/src/app/shared/live-region/live-region.service.spec.ts
+++ b/src/app/shared/live-region/live-region.service.spec.ts
@@ -1,18 +1,26 @@
 import {
   fakeAsync,
-  flush,
   tick,
 } from '@angular/core/testing';
+import { of } from 'rxjs';
+import { AccessibilitySettingsService } from 'src/app/accessibility/accessibility-settings.service';
+import { getAccessibilitySettingsServiceStub } from 'src/app/accessibility/accessibility-settings.service.stub';
 
 import { UUIDService } from '../../core/shared/uuid.service';
 import { LiveRegionService } from './live-region.service';
 
 describe('liveRegionService', () => {
   let service: LiveRegionService;
+  let accessibilitySettingsService: AccessibilitySettingsService;
 
   beforeEach(() => {
+    accessibilitySettingsService = getAccessibilitySettingsServiceStub();
+
+    accessibilitySettingsService.getAsNumber = jasmine.createSpy('getAsNumber').and.returnValue(of(100));
+
     service = new LiveRegionService(
       new UUIDService(),
+      accessibilitySettingsService,
     );
   });
 
@@ -86,13 +94,16 @@ describe('liveRegionService', () => {
       expect(results[2]).toEqual(['Message One', 'Message Two']);
 
       service.clear();
-      flush();
+      tick(200);
 
       expect(results.length).toEqual(4);
       expect(results[3]).toEqual([]);
     }));
 
     it('should not pop messages added after clearing within timeOut period', fakeAsync(() => {
+      // test expects a clear rate of 30 seconds
+      accessibilitySettingsService.getAsNumber = jasmine.createSpy('getAsNumber').and.returnValue(of(30000));
+
       const results: string[][] = [];
 
       service.getMessages$().subscribe((messages) => {
@@ -119,45 +130,6 @@ describe('liveRegionService', () => {
       expect(results.length).toEqual(5);
       expect(results[4]).toEqual([]);
     }));
-
-    it('should respect configured timeOut', fakeAsync(() => {
-      const results: string[][] = [];
-
-      service.getMessages$().subscribe((messages) => {
-        results.push(messages);
-      });
-
-      expect(results.length).toEqual(1);
-      expect(results[0]).toEqual([]);
-
-      const timeOutMs = 500;
-      service.setMessageTimeOutMs(timeOutMs);
-
-      service.addMessage('Message One');
-      tick(timeOutMs - 1);
-
-      expect(results.length).toEqual(2);
-      expect(results[1]).toEqual(['Message One']);
-
-      tick(1);
-
-      expect(results.length).toEqual(3);
-      expect(results[2]).toEqual([]);
-
-      const timeOutMsTwo = 50000;
-      service.setMessageTimeOutMs(timeOutMsTwo);
-
-      service.addMessage('Message Two');
-      tick(timeOutMsTwo - 1);
-
-      expect(results.length).toEqual(4);
-      expect(results[3]).toEqual(['Message Two']);
-
-      tick(1);
-
-      expect(results.length).toEqual(5);
-      expect(results[4]).toEqual([]);
-    }));
   });
 
   describe('liveRegionVisibility', () => {
diff --git a/src/app/shared/live-region/live-region.service.ts b/src/app/shared/live-region/live-region.service.ts
index 79470240919..c1b889be040 100644
--- a/src/app/shared/live-region/live-region.service.ts
+++ b/src/app/shared/live-region/live-region.service.ts
@@ -1,9 +1,22 @@
 import { Injectable } from '@angular/core';
-import { BehaviorSubject } from 'rxjs';
+import {
+  BehaviorSubject,
+  map,
+  Observable,
+  switchMap,
+  take,
+  timer,
+} from 'rxjs';
 
 import { environment } from '../../../environments/environment';
+import {
+  AccessibilitySetting,
+  AccessibilitySettingsService,
+} from '../../accessibility/accessibility-settings.service';
 import { UUIDService } from '../../core/shared/uuid.service';
 
+export const MIN_MESSAGE_DURATION = 200;
+
 /**
  * The LiveRegionService is responsible for handling the messages that are shown by the {@link LiveRegionComponent}.
  * Use this service to add or remove messages to the Live Region.
@@ -15,6 +28,7 @@ export class LiveRegionService {
 
   constructor(
     protected uuidService: UUIDService,
+    protected accessibilitySettingsService: AccessibilitySettingsService,
   ) {
   }
 
@@ -65,7 +79,12 @@ export class LiveRegionService {
   addMessage(message: string): string {
     const uuid = this.uuidService.generate();
     this.messages.push({ message, uuid });
-    setTimeout(() => this.clearMessageByUUID(uuid), this.messageTimeOutDurationMs);
+
+    this.getConfiguredMessageTimeOutMs().pipe(
+      take(1),
+      switchMap(timeOut => timer(timeOut)),
+    ).subscribe(() => this.clearMessageByUUID(uuid));
+
     this.emitCurrentMessages();
     return uuid;
   }
@@ -116,6 +135,17 @@ export class LiveRegionService {
     this.liveRegionIsVisible = isVisible;
   }
 
+  /**
+   * Gets the user-configured timeOut, or the stored timeOut if the user has not configured a timeOut duration.
+   * Emits {@link MIN_MESSAGE_DURATION} if the configured value is smaller.
+   */
+  getConfiguredMessageTimeOutMs(): Observable<number> {
+    return this.accessibilitySettingsService.getAsNumber(
+      AccessibilitySetting.LiveRegionTimeOut,
+      this.getMessageTimeOutMs(),
+    ).pipe(map(timeOut => Math.max(timeOut, MIN_MESSAGE_DURATION)));
+  }
+
   /**
    * Gets the current message timeOut duration in milliseconds
    */
diff --git a/src/app/shared/notifications/notifications-board/notifications-board.component.spec.ts b/src/app/shared/notifications/notifications-board/notifications-board.component.spec.ts
index 8a4ea204ac0..5fc7ae3ccae 100644
--- a/src/app/shared/notifications/notifications-board/notifications-board.component.spec.ts
+++ b/src/app/shared/notifications/notifications-board/notifications-board.component.spec.ts
@@ -18,6 +18,8 @@ import { cold } from 'jasmine-marbles';
 import uniqueId from 'lodash/uniqueId';
 
 import { INotificationBoardOptions } from '../../../../config/notifications-config.interfaces';
+import { AccessibilitySettingsService } from '../../../accessibility/accessibility-settings.service';
+import { getAccessibilitySettingsServiceStub } from '../../../accessibility/accessibility-settings.service.stub';
 import { AppState } from '../../../app.reducer';
 import { NotificationsServiceStub } from '../../testing/notifications-service.stub';
 import { Notification } from '../models/notification.model';
@@ -48,6 +50,7 @@ describe('NotificationsBoardComponent', () => {
       ],
       providers: [
         { provide: NotificationsService, useClass: NotificationsServiceStub },
+        { provide: AccessibilitySettingsService, useValue: getAccessibilitySettingsServiceStub() },
         ChangeDetectorRef,
       ],
     }).compileComponents();  // compile template and css
diff --git a/src/app/shared/notifications/notifications-board/notifications-board.component.ts b/src/app/shared/notifications/notifications-board/notifications-board.component.ts
index 51d60368ab6..fdb6d2240ea 100644
--- a/src/app/shared/notifications/notifications-board/notifications-board.component.ts
+++ b/src/app/shared/notifications/notifications-board/notifications-board.component.ts
@@ -15,13 +15,19 @@ import {
   select,
   Store,
 } from '@ngrx/store';
+import cloneDeep from 'lodash/cloneDeep';
 import difference from 'lodash/difference';
 import {
   BehaviorSubject,
   Subscription,
+  take,
 } from 'rxjs';
 
 import { INotificationBoardOptions } from '../../../../config/notifications-config.interfaces';
+import {
+  AccessibilitySetting,
+  AccessibilitySettingsService,
+} from '../../../accessibility/accessibility-settings.service';
 import { AppState } from '../../../app.reducer';
 import { INotification } from '../models/notification.model';
 import { NotificationComponent } from '../notification/notification.component';
@@ -61,9 +67,12 @@ export class NotificationsBoardComponent implements OnInit, OnDestroy {
    */
   public isPaused$: BehaviorSubject<boolean> = new BehaviorSubject<boolean>(false);
 
-  constructor(private service: NotificationsService,
-              private store: Store<AppState>,
-              private cdr: ChangeDetectorRef) {
+  constructor(
+    protected service: NotificationsService,
+    protected store: Store<AppState>,
+    protected cdr: ChangeDetectorRef,
+    protected accessibilitySettingsService: AccessibilitySettingsService,
+  ) {
   }
 
   ngOnInit(): void {
@@ -96,7 +105,22 @@ export class NotificationsBoardComponent implements OnInit, OnDestroy {
       if (this.notifications.length >= this.maxStack) {
         this.notifications.splice(this.notifications.length - 1, 1);
       }
-      this.notifications.splice(0, 0, item);
+
+      // It would be a bit better to handle the retrieval of configured settings in the NotificationsService.
+      // Due to circular dependencies this is difficult to implement.
+      this.accessibilitySettingsService.getAsNumber(AccessibilitySetting.NotificationTimeOut, item.options.timeOut)
+        .pipe(take(1)).subscribe(timeOut => {
+          if (timeOut < 0) {
+            timeOut = 0;
+          }
+
+          // Deep clone because the unaltered item is read-only
+          const modifiedNotification = cloneDeep(item);
+          modifiedNotification.options.timeOut = timeOut;
+          this.notifications.splice(0, 0, modifiedNotification);
+          this.cdr.detectChanges();
+        });
+
     } else {
       // Remove the notification from the store
       // This notification was in the store, but not in this.notifications
diff --git a/src/app/shared/testing/auth-service.stub.ts b/src/app/shared/testing/auth-service.stub.ts
index 5a40e05d1db..c844d247545 100644
--- a/src/app/shared/testing/auth-service.stub.ts
+++ b/src/app/shared/testing/auth-service.stub.ts
@@ -59,6 +59,10 @@ export class AuthServiceStub {
     return observableOf(EPersonMock);
   }
 
+  getAuthenticatedUserFromStoreIfAuthenticated(): Observable<EPerson> {
+    return observableOf(EPersonMock);
+  }
+
   public buildAuthHeader(token?: AuthTokenInfo): string {
     return `Bearer ${token ? token.accessToken : ''}`;
   }
diff --git a/src/assets/i18n/en.json5 b/src/assets/i18n/en.json5
index 0ba1f5476b0..54a48032079 100644
--- a/src/assets/i18n/en.json5
+++ b/src/assets/i18n/en.json5
@@ -1900,6 +1900,8 @@
 
   "footer.copyright": "copyright © 2002-{{ year }}",
 
+  "footer.link.accessibility": "Accessibility settings",
+
   "footer.link.dspace": "DSpace software",
 
   "footer.link.lyrasis": "LYRASIS",
@@ -2128,6 +2130,24 @@
 
   "home.top-level-communities.help": "Select a community to browse its collections.",
 
+  "info.accessibility-settings.breadcrumbs": "Accessibility settings",
+
+  "info.accessibility-settings.liveRegionTimeOut.label": "Live region time-out",
+
+  "info.accessibility-settings.liveRegionTimeOut.hint": "The duration in milliseconds after which a message in the live region disappears.",
+
+  "info.accessibility-settings.notificationTimeOut.label": "Notification time-out",
+
+  "info.accessibility-settings.notificationTimeOut.hint": "The duration in milliseconds after which a notification disappears. Set to 0 for notifications to remain indefinitely.",
+
+  "info.accessibility-settings.save-notification.cookie": "Successfully saved settings locally.",
+
+  "info.accessibility-settings.save-notification.metadata": "Successfully saved settings on the user profile.",
+
+  "info.accessibility-settings.submit": "Save accessibility settings",
+
+  "info.accessibility-settings.title": "Accessibility settings",
+
   "info.end-user-agreement.accept": "I have read and I agree to the End User Agreement",
 
   "info.end-user-agreement.accept.error": "An error occurred accepting the End User Agreement",
@@ -3870,6 +3890,12 @@
 
   "profile.breadcrumbs": "Update Profile",
 
+  "profile.card.accessibility.content": "Accessibility settings can be configured on the accessibility settings page.",
+
+  "profile.card.accessibility.header": "Accessibility",
+
+  "profile.card.accessibility.link": "Accessibility Settings Page",
+
   "profile.card.identify": "Identify",
 
   "profile.card.security": "Security",
diff --git a/src/config/app-config.interface.ts b/src/config/app-config.interface.ts
index 7f5f0199582..27763c94184 100644
--- a/src/config/app-config.interface.ts
+++ b/src/config/app-config.interface.ts
@@ -4,6 +4,7 @@ import {
   Type,
 } from '@angular/core';
 
+import { AccessibilitySettingsConfig } from '../app/accessibility/accessibility-settings.config';
 import { AdminNotifyMetricsRow } from '../app/admin/admin-notify-dashboard/admin-notify-metrics/admin-notify-metrics.model';
 import { HALDataService } from '../app/core/data/base/hal-data-service.interface';
 import { LiveRegionConfig } from '../app/shared/live-region/live-region.config';
@@ -66,6 +67,7 @@ interface AppConfig extends Config {
   search: SearchConfig;
   notifyMetrics: AdminNotifyMetricsRow[];
   liveRegion: LiveRegionConfig;
+  accessibility: AccessibilitySettingsConfig;
 }
 
 /**
diff --git a/src/config/default-app-config.ts b/src/config/default-app-config.ts
index 3455ef5f92a..a93bd3a80bd 100644
--- a/src/config/default-app-config.ts
+++ b/src/config/default-app-config.ts
@@ -1,3 +1,4 @@
+import { AccessibilitySettingsConfig } from '../app/accessibility/accessibility-settings.config';
 import { AdminNotifyMetricsRow } from '../app/admin/admin-notify-dashboard/admin-notify-metrics/admin-notify-metrics.model';
 import { RestRequestMethod } from '../app/core/data/rest-request-method';
 import { LiveRegionConfig } from '../app/shared/live-region/live-region.config';
@@ -598,4 +599,9 @@ export class DefaultAppConfig implements AppConfig {
     messageTimeOutDurationMs: 30000,
     isVisible: false,
   };
+
+  // Accessibility settings configuration, used by the AccessibilitySettingsService
+  accessibility: AccessibilitySettingsConfig = {
+    cookieExpirationDuration: 7,
+  };
 }
diff --git a/src/environments/environment.test.ts b/src/environments/environment.test.ts
index c7146dfb078..9ddc40bb8c3 100644
--- a/src/environments/environment.test.ts
+++ b/src/environments/environment.test.ts
@@ -427,4 +427,8 @@ export const environment: BuildConfig = {
     messageTimeOutDurationMs: 30000,
     isVisible: false,
   },
+
+  accessibility: {
+    cookieExpirationDuration: 7,
+  },
 };
diff --git a/src/themes/custom/app/profile-page/profile-page.component.ts b/src/themes/custom/app/profile-page/profile-page.component.ts
index 74a88fdba63..687cf9bc9d5 100644
--- a/src/themes/custom/app/profile-page/profile-page.component.ts
+++ b/src/themes/custom/app/profile-page/profile-page.component.ts
@@ -4,6 +4,7 @@ import {
   NgIf,
 } from '@angular/common';
 import { Component } from '@angular/core';
+import { RouterModule } from '@angular/router';
 import { TranslateModule } from '@ngx-translate/core';
 
 import { SuggestionsNotificationComponent } from '../../../../app/notifications/suggestions-notification/suggestions-notification.component';
@@ -30,6 +31,7 @@ import { VarDirective } from '../../../../app/shared/utils/var.directive';
     NgIf,
     NgForOf,
     SuggestionsNotificationComponent,
+    RouterModule,
   ],
 })
 /**