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首先感谢余老师提供ggmsa这个好用的工具。有一个问题提出如下:
现在ggmsa函数调用了seqmagick的fa_read,而fa_read默认使用了guess_sequence_type函数来猜测序列的类型。 但这个函数在预测时,依赖于计算比对结果中,部分序列的“-”比例,导致对某些同源性较差的比对预测时,即比对结果有很多“-”时,会将AA比对错认为DNA比对。而且目前出现这种问题时没有方便解决的办法。
因此ggmsa可能需要一个选择比对序列类型的参数,或者guess_sequence_type函数需要更加智能一点,谢谢余老师
The text was updated successfully, but these errors were encountered:
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首先感谢余老师提供ggmsa这个好用的工具。有一个问题提出如下:
现在ggmsa函数调用了seqmagick的fa_read,而fa_read默认使用了guess_sequence_type函数来猜测序列的类型。
但这个函数在预测时,依赖于计算比对结果中,部分序列的“-”比例,导致对某些同源性较差的比对预测时,即比对结果有很多“-”时,会将AA比对错认为DNA比对。而且目前出现这种问题时没有方便解决的办法。
因此ggmsa可能需要一个选择比对序列类型的参数,或者guess_sequence_type函数需要更加智能一点,谢谢余老师
The text was updated successfully, but these errors were encountered: