Downloading annotation database ....Failed

[Acetyl-ZHOU]

I want to get gnomad211,and I runannotate_variation.pl -downdb gnomad211 humandb -buildver hg19
but
NOTICE: Web-based checking to see whether ANNOVAR new version is available ... Done NOTICE: Downloading annotation database http://hgdownload.cse.ucsc.edu/goldenPath/hg19/database/gnomad211.txt.gz ... Failed WARNING: Some files cannot be downloaded, including http://hgdownload.cse.ucsc.edu/goldenPath/hg19/database/gnomad211.txt.gz

can you give me some help?

[kaichop]

You can add '-webfrom annovar' to the command line.

…

On Thu, Jan 4, 2024 at 7:26 AM Acetyl-ZHOU ***@***.***> wrote: I want to get gnomad211,and I runannotate_variation.pl -downdb gnomad211 humandb -buildver hg19 but NOTICE: Web-based checking to see whether ANNOVAR new version is available ... Done NOTICE: Downloading annotation database http://hgdownload.cse.ucsc.edu/goldenPath/hg19/database/gnomad211.txt.gz ... Failed WARNING: Some files cannot be downloaded, including http://hgdownload.cse.ucsc.edu/goldenPath/hg19/database/gnomad211.txt.gz can you give me some help? — Reply to this email directly, view it on GitHub <#237>, or unsubscribe <https://github.com/notifications/unsubscribe-auth/ABNG3OH4PWJ6WKUHPCNPLTDYM2NYTAVCNFSM6AAAAABBM3HFGOVHI2DSMVQWIX3LMV43ASLTON2WKOZSGA3DKNJXGE4TONA> . You are receiving this because you are subscribed to this thread.Message ID: ***@***.***>

[mdanzi]

Hello, I am also having this issue and wanted to mention that I think it is because UCSC changed their path from 'hgdownload.cse.ucsc.edu' to 'hgdownload.soe.cse.ucsc.edu'. While I acknowledge that your solution also works for many files, could you potentially update Annovar to look in this new location?

[kaichop]

That particular file for gnomad is compiled and provided in annovar, which is why the '-webfrom annovar' is needed. For UCSC provided files, I will update annovar to look into this new location; also a user-specified URL can be provided in the command line as a temporary fix.

…

On Wed, Feb 7, 2024 at 1:44 PM mdanzi ***@***.***> wrote: Hello, I am also having this issue and wanted to mention that I think it is because UCSC changed their path from 'hgdownload.cse.ucsc.edu' to ' hgdownload.soe.cse.ucsc.edu'. While I acknowledge that your solution also works for many files, could you potentially update Annovar to look in this new location? — Reply to this email directly, view it on GitHub <#237 (comment)>, or unsubscribe <https://github.com/notifications/unsubscribe-auth/ABNG3ODDH6AUK62PGKXL2BTYSPDRFAVCNFSM6AAAAABBM3HFGOVHI2DSMVQWIX3LMV43OSLTON2WKQ3PNVWWK3TUHMYTSMZSGY2TOOJRGA> . You are receiving this because you commented.Message ID: ***@***.***>

[mdanzi]

Thanks! I'll try the user-specified URL approach in the meantime. I didn't know about that.