diff --git a/tests/test_index.py b/tests/test_index.py
index 71dbb766..9a9e07d0 100644
--- a/tests/test_index.py
+++ b/tests/test_index.py
@@ -2,6 +2,7 @@
 
 import ctypes
 import pickle
+import sys
 import tempfile
 import unittest
 from typing import Iterator
@@ -451,6 +452,7 @@ def test_custom_filenames(self) -> None:
         self.assertTrue(len(hits), 10)
         self.assertEqual(hits, [0, 4, 16, 27, 35, 40, 47, 50, 76, 80])
 
+    @pytest.mark.skipif(not sys.maxsize > 2**32, reason="Fails on 32bit systems")
     def test_interleaving(self) -> None:
         """Streaming against a persisted index without interleaving"""