Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

RA-0012822-01 thiophene series #14

Open
qxsml opened this issue Jan 3, 2025 · 0 comments
Open

RA-0012822-01 thiophene series #14

qxsml opened this issue Jan 3, 2025 · 0 comments

Comments

@qxsml
Copy link
Collaborator

qxsml commented Jan 3, 2025

A few thiophene analogues were found to be active against Nsp15 in Sacchettini Lab's FRET assay.
image
Ten analogues and one original hit were synthesized using the route shown below:
image
They were tested, but none showed any activity.
image
By comparing the H NMR spectra of the resynthesized hit and the purchased hit from Enamine, it was discovered that the position of the nitrogen atom in the pyridine ring was different.
image
Further studies are ongoing to determine the exact structure.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

1 participant