diff --git a/Rmd/tgx_ddi.Rmd b/Rmd/tgx_ddi.Rmd index 8f4f7f13..af7c9e28 100644 --- a/Rmd/tgx_ddi.Rmd +++ b/Rmd/tgx_ddi.Rmd @@ -232,7 +232,7 @@ log10ratios <- log2ratios %>% ``` ```{r classifier} -classifier_path <- file.path(params$projectdir, "resources", "Biomarker_TGx-DDI_Li2015_Tk6_with_IDs_PCA_and_training_set.txt") +classifier_path <- file.path(params$projectdir, "resources", "tgx-ddi_biomarker-classifier_Li-2015.txt") classifier <- read.delim(classifier_path, sep = "\t") # Save the classifier IDs for later diff --git a/resources/tgx-ddi_biomarker-classifier_Li-2015.txt b/resources/tgx-ddi_biomarker-classifier_Li-2015.txt index bc33e1b6..c6464c62 100644 --- a/resources/tgx-ddi_biomarker-classifier_Li-2015.txt +++ b/resources/tgx-ddi_biomarker-classifier_Li-2015.txt @@ -1,65 +1,65 @@ -"ID" "GENE_SYMBOL" "ENTREZ_ID" "Genotoxic.score" "Non.Genotoxic.score" "stdev" "PC1" "PC2" "PC.mn" "PC.std" "X5.FU" "AraC" "Bleomycin" "Camptothecin" "Cisp" "Etoposide" "Hydrogen.Peroxide" "Hydroxyurea" "Methotrexate" "MMS" "Potassium.Chromate..VI." "Sodium.Arsenite" "X.ray" "X2.deoxy.D.glucose..2.DG." "Aapicidin" "Antimycin.A" "Cadmium.Chloride" "Colchicine" "Docetaxel" "EtOH.2." "EtOH.4." "HC.toxin" "Heat.Shock" "Oxamflatin" "Paclitaxel" "Thapsigargin" "TSA" "Tunicamysin" "Vinblastin" -"ACTA2" "ACTA2" 59 0.3895 -0.3296 0.198403136 -0.0931217703381756 0.0975621136221921 0.285304546674291 0.435230567526858 0.001926613 0.15453229 0.290304873 0.084226878 0.190019716 0.182649788 0.333947243 0.088884153 0.04201524 0.155649529 0.122013608 0.483750095 0.177082162 -0.051982791 -0.023987106 0.193707982 0.063819649 -0.086609175 0.019175909 0.058031018 -0.093971372 0.029624282 0.037731627 0.040061885 -0.045086879 0.032473665 0.04542313 0.051733543 -0.086475988 -"AEN" "AEN" 64782 0.8952 -0.7575 0.216786892 -0.152348095017392 0.00768685433473227 0.234988312947214 0.688232604030204 0.178590419 0.388652639 0.431461447 0.308173836 0.229341104 0.18617159 0.20786817 0.34063038 0.06624174 0.259343513 0.244738397 0.363514129 0.303085468 0.004654002 -0.290059676 -0.135618103 -0.10567113 -0.039064716 -0.010360068 -0.143382704 0.02364665 -0.209973761 -0.147272586 -0.231406828 -0.008294093 -0.006820003 -0.145746124 0.037081185 -0.048107483 -"ARRDC4" "ARRDC4" 91947 0.554 -0.4688 0.269665846 -0.129126883132508 0.0874491519490443 0.367157037180164 0.650909690571483 0.062890206 0.437841105 0.562620659 0.15453652 0.221790918 0.35340581 0.660171818 0.21670471 -0.025824791 0.015602138 0.276977117 0.106730514 0.29218601 -0.054585572 -0.057408044 0.032062475 -0.033306305 -0.001222829 0.041226573 0 0 0.05049294 0.036194355 0.011657169 0.085931522 0.038014873 -0.170058519 -0.099943812 -0.009454402 -"B3GNT2" "B3GNT2" 10678 -0.513 0.434 0.243409901 0.112949147471718 0.0818901637696086 -0.0192506043527176 0.624611034541117 -0.185059781 -0.076156199 -0.083427855 -0.309204309 -0.324415917 -0.152028014 0.035442252 -0.061849797 -0.159565958 -0.250317906 -0.230571357 0.150203184 -0.139672601 0.183426911 0.121134754 0.430345975 0.395513925 0.01187637 -0.009685783 0.193981701 0.048972436 0.112749465 -0.210545624 0.091060189 -0.046823255 0.054831136 0.045089957 0.166766639 0.029874191 -"BLOC1S2" "BLOC1S2" 282991 0.9074 -0.7678 0.182310618 -0.15376562896466 0.0416924919662887 0.356569761272127 0.56600321176598 0.286160282 0.324303961 0.350870191 0.270117358 0.323284353 0.342281404 0.123548155 0.257937422 0.130926588 0.197239543 0.200450793 0.423659133 0.346799043 -0.019693356 -0.137310906 -0.064866505 -0.055726684 -0.026953512 0.01749299 0.067986003 0.002604668 -0.11351253 -0.071479444 -0.090814342 -0.017738155 0.071094442 -0.023232035 -0.005204823 0.00258358 -"BRMS1L" "BRMS1L" 84312 0.509 -0.4307 0.218519521 -0.125324819137471 0.0289015981756736 0.258705142634513 0.452493347229446 0.162307014 0.311533243 0.336202728 0.196430777 0.174226535 0.219656289 -0.001075049 0.269419377 0.087587139 -0.031322724 0.08439539 0.099344464 0.281434242 -0.09573488 0.040629434 -0.183728898 0.169306245 -0.05486079 0.000304005 0.160673181 0.036326838 0.141594532 -0.091383742 0.078267652 -0.068111044 0.033499354 0.068103068 -0.116220847 -0.050341302 -"BTG2" "BTG2" 7832 0.8538 -0.7224 0.206901972 -0.14048461286332 0.0642748345773671 0.621540348843145 0.628787065258696 0.505451195 0.381445467 0.512381756 0.36064465 0.511788023 0.235598678 0.434196792 0.38363491 0.369698902 0.224611184 0.338167603 0.205071308 0.294563046 -0.124779764 0.221009717 0.040529348 -0.011446282 0.088498218 -0.032237576 0.020498891 -0.08104722 0.140601516 0.038709068 0.130279197 0.01485034 0.048393585 0.01495688 0.027403568 0.132493367 -"C12orf5" "TIGAR" 57103 0.6351 -0.5374 0.225288872 -0.140468178434318 0.098356866679736 0.395070858635696 0.570991078116908 0.351422729 0.399156847 0.459515463 0.291340007 0.254220994 0.294672904 0.070198256 0.372829009 0.053039364 0.143224643 0.196853202 0.236992054 0.348715807 -0.064526826 0.174435876 -0.114888657 -0.133001571 -0.009449433 0.007013043 -0.028208031 -0.01862816 0.158590455 -0.113837388 0.120314066 -0.024653897 -0.038579093 0.029952654 0.000759979 0.031442891 -"CBLB" "CBLB" 868 -0.617 0.5221 0.182955208 0.129353574711447 0.0490001834003111 -0.0743964612708951 0.415886390047415 -0.067954472 -0.079736213 -0.047924416 -0.374783796 -0.133016163 -0.104218115 -0.047789517 -0.106520506 -0.108800128 -0.13561992 -0.222905163 0.005943672 -0.161558274 0.120198961 0.094676855 0.080066408 0.056773648 0.106696325 0.051155134 -0.15548372 -0.058605299 0.044482711 -0.025955311 0.12477765 0.031681625 0.135377856 0.068463463 0.145525698 0.115579581 -"CCP110" "CCP110" 9738 0.6383 -0.5401 0.174623413 -0.151725577882041 0.0208233830613985 0.21369178554441 0.390070282423254 0.181497592 0.281929168 0.273663828 0.211966075 0.212400695 0.150960793 0.111809915 0.257652558 0.070912718 0.156387774 0.049095385 0.13498564 0.146946107 -0.044911405 0.00613919 -0.164900776 -0.050704018 0.044836278 -0.005885903 0.007672015 -0.086350005 -0.010960245 -0.113551657 0.014638716 0.002295587 0.023102579 -0.003643156 -0.00452136 0.012037393 -"CDKN1A" "CDKN1A" 1026 0.7021 -0.5941 0.243437029 -0.120572219476902 0.166341702668956 0.821691620301704 0.67588250324003 0.684382355 0.421079641 0.642638096 0.242379418 0.448744514 0.376752666 0.462066981 0.359344545 0.236830432 0.29133248 0.396423298 0.575848111 0.398466816 0.001304919 0.338958689 0.18451584 0.156909658 0.031325088 0.016881478 0.092337164 0.095796793 0.249268091 0.008674026 0.185471354 -0.043903587 0.108374821 0.184144907 0.060825588 -0.03391326 -"CEBPD" "CEBPD" 1052 0.5021 -0.4249 0.327948833 -0.101000078462626 -0.106939955918536 -0.375292310445741 0.804062011163475 -0.033644459 0.143808435 -0.058362463 0.215244849 0.229126477 -0.059954814 -0.033860207 0.075840115 0.00059665 0.070655185 -0.035494156 0.014528298 -0.211592269 -0.411842894 -0.790452698 -0.387917414 -0.016311534 -0.074822888 -0.068970241 0.009227146 -0.03334026 -0.500548209 -0.070804503 -0.581913181 -0.135200356 0.128093052 -0.271735376 -0.406153226 0.019547906 -"CENPE" "CENPE" 1062 -0.5462 0.4621 0.203300429 0.109798506640863 0.0638296992973986 -0.194358256015209 0.455252241393987 -0.129202835 -0.118066588 -0.067359098 -0.262064803 -0.16317459 -0.08877119 -0.235779592 -0.114240181 -0.402589304 -0.03592301 -0.28537268 -0.071694581 -0.232852079 -0.015500156 0.069248861 -0.088982736 -0.068552654 0.105001762 0.08805321 0.141078537 -0.040673277 0.050997024 -0.039006595 0.085186689 0.014741941 -0.061574834 0.126734552 -0.012542811 0.156158734 -"COIL" "COIL" 8161 0.4245 -0.3592 0.273188589 -0.107318131644414 -0.0177832485474856 -0.284793502058018 0.594620706881246 0.043846146 0.113199515 0.099754268 0.094615319 0.081169641 0.008597844 -0.055108671 0.033983202 -0.094504928 -0.118961683 -0.024483204 0.068144366 0.009849875 0.025599332 -0.568568781 -0.093096633 -0.177931748 -0.088509874 0.012525234 0.029817342 -0.070956313 -0.429523059 -0.158034835 -0.53585547 -0.038237253 -0.179041403 -0.344322034 -0.09704125 -0.033135159 -"DAAM1" "DAAM1" 23002 -0.57 0.4823 0.257656765 0.119380453656819 0.0482125164465678 0.283799935129194 0.627353434474058 -0.106670452 -0.04335161 -0.013325683 -0.208422546 -0.095763315 0.022742676 -0.023693598 -0.073085243 0.051209029 -0.011890218 -0.19502022 0.141230551 -0.094974 0.131190301 0.418240497 0.160369748 0.141057064 0.257973918 0.016834626 0.146005436 0.022855434 0.35910525 -0.101443208 0.454497994 -0.030545278 0.436474042 0.384489745 0.137325803 0.194119761 -"DCP1B" "DCP1B" 196513 0.7629 -0.6455 0.161300043 -0.152553653621101 0.0753275254120734 0.218876980931284 0.407591173676377 0.153805382 0.260946003 0.319268757 0.213285093 0.194528952 0.173191013 0.187297707 0.193198777 0.145978767 0.109145184 -0.019398497 0.205408656 0.233647632 -0.031077622 -0.115125849 -0.009866037 -0.079181703 -0.061037157 0.028268619 0.013297955 -0.021889226 -0.075015328 -0.045839118 -0.015427377 -0.028683255 -0.017777396 0.014612588 0.027481399 -0.042276357 -"DDB2" "DDB2" 1643 0.8717 -0.7376 0.181249754 -0.157039053884665 0.0908286119259457 0.379893460471866 0.515996614938399 0.274425558 0.314640344 0.422502125 0.248327724 0.273141089 0.3813773 0.264294841 0.277977483 0.120826424 0.174271485 0.149947158 0.119173575 0.401941291 -0.062276228 -0.061514673 0.082018981 -0.059005381 -0.012788078 0.027418643 0.055563479 -0.038041529 -0.013142627 0.026692867 -0.04302689 -0.027098816 0.005800499 -0.004285412 0.047157853 -0.029898609 -"DUSP14" "DUSP14" 11072 0.4979 -0.4213 0.18107769 -0.131308391019124 0.0931871016615247 0.329269010695896 0.354337560843073 0.194883497 0.269445905 0.285755115 0.231874779 0.221920863 0.128890646 0.198727704 0.227908558 0.068974133 0.096585566 0.171014318 -0.022312674 0.239944818 -0.028500488 0.075416461 -0.044455152 -0.029913947 0.018025899 -0.005361202 0.025578294 0.17037845 0.071253981 -0.02470609 0.145916757 -0.023295865 0.160523916 0.057259908 -0.04096163 0.033703097 -"E2F7" "E2F7" 144455 0.9433 -0.7982 0.190295356 -0.151189082144493 0.0149622508328152 0.332618552833544 0.570601645538377 0.322092074 0.429676763 0.38955857 0.192282924 0.256418064 0.167667977 0.16882114 0.401125121 0.235377479 0.198106031 0.241196798 0.204184946 0.194634211 -0.144736353 -0.066084233 -0.154292756 0.064579706 -0.052588919 -0.0753555 0.141212096 0.111958536 -0.016048337 0.029669498 -0.05367761 -0.126999469 -0.009863841 -0.009543788 -0.081206196 -0.054448248 -"E2F8" "E2F8" 79733 0.6696 -0.5666 0.236683428 -0.128023349479293 -0.0678593834931921 -0.182058592154623 0.672118988932299 -0.011460452 0.287840319 0.131981457 0.206610139 0.104292863 0.087767234 0.121322885 0.240065256 0.108531645 0.189220175 0.048366083 -0.300104492 -0.01054548 -0.062777694 -0.42742494 -0.314134292 -0.492471197 -0.007118359 -0.002969888 -0.163542081 -0.053786256 -0.287362292 -0.091040743 -0.240792375 0.002833903 -0.230324951 -0.188736039 -0.252560513 0.018972266 -"EI24" "EI24" 9538 0.5449 -0.4611 0.174471691 -0.150531637141215 0.0102658397103505 0.0699458193301052 0.341733297922392 0.075968109 0.142042033 0.217842145 0.180731128 0.179651732 0.150799793 0.047400249 0.110413071 0.02677996 0.035064157 0.048088346 -0.071007439 0.232487993 -0.110758106 -0.05781083 -0.162522998 -0.072881689 -0.004608348 0.033796417 -0.024640378 -0.039871828 -0.044374763 -0.054415092 -0.054790643 -0.037477863 -0.020330318 -0.004906926 -0.098470909 -0.011579102 -"FAM123B" "AMER1" 139285 0.6079 -0.5144 0.223917377 -0.138523645078788 -0.0392109136490018 -0.399255112298826 0.559667448704297 0.034808693 0.184733547 0.116799845 0.134708966 0.023105599 0.132370598 -0.129785998 0.114643128 -0.075720744 -0.108495861 -0.10493294 -0.338171514 0.053666427 -0.241854697 -0.341962446 -0.368112507 -0.29524928 -0.151539997 0.015598791 -0.309734824 -0.219652426 -0.315572573 -0.158012723 -0.291799472 -0.069090331 -0.155001708 -0.213735758 -0.303853817 -0.103601155 -"FBXO22" "FBXO22" 26263 0.695 -0.5881 0.15752166 -0.147279937887125 0.0883684559586124 0.15042446083562 0.368043135007824 0.149285972 0.196339286 0.270224269 0.123160593 0.218667593 0.191969129 0.154382365 0.140253403 0.111213195 0.083195225 -0.030443352 0.031767087 0.264286131 -0.001101956 -0.052368063 -0.017440565 -0.083146013 -0.036014112 -0.006562521 -0.06883262 -0.060535465 -0.011576779 -0.064891945 -0.003539326 -0.040033415 -0.084200012 -0.010068365 -0.006107794 -0.044695976 -"GADD45A" "GADD45A" 1647 0.6457 -0.5464 0.242664719 -0.111311923893582 0.061502752603508 0.867195505436519 0.671866595444874 0.295328331 0.544748325 0.485068287 0.319607133 0.438611549 0.211291165 0.487291221 0.543827332 0.153635833 0.478740151 0.5467591 0.646081343 0.28062162 0.272961728 0.059545374 0.332268161 0.243817503 0.00223626 -0.005341519 0.260812702 0.385547687 0.033966872 0.109081977 0.047544366 -0.065348283 0.156330441 0.012978878 0.269816394 0.022673987 -"GXYLT1" "GXYLT1" 283464 0.3679 -0.3113 0.157334198 -0.116608675176445 0.0984450164611944 0.14838632404134 0.225077409911891 0.209095091 0.126559843 0.109571867 0.08018235 0.010239091 0.109746023 0.025158365 0.154113767 0.057037409 0.034526981 0.076239933 0.124030871 0.135208749 0.009518396 0.00626091 0.002924806 0.075898514 -0.050413285 -0.03392064 0.109430239 0.004834105 0.021296665 -0.020724616 0.0362609 -0.023917942 -0.03170735 -0.00196426 -0.012712531 -0.047380951 -"HIST1H1E" "H1-4" 3008 -0.4708 0.3984 0.311311669 0.0812373013904689 0.273489492965799 -0.424287307869626 0.979993946264671 0.029846075 -0.415433773 -0.006446066 -0.254794346 -0.412010241 -0.21005469 0.049276411 -0.375407297 -0.693419719 -0.547140518 -0.798457687 -0.238960264 -0.061133803 -0.136211112 0.172189696 0.187409822 -0.547603274 -0.089061227 -0.06022232 0.193427463 0.490074835 0.205756319 -0.190235417 0.190402569 -0.112662551 -0.123222894 -0.074150485 0.123181059 0.001090448 -"HIST1H2BB" "H2BC3" 3018 -0.2762 0.2337 0.326182761 0.0758644052296765 0.305726525809145 0.0469577963823845 0.750644871118669 0.577149395 -0.32612867 0.016849205 -0.093690308 -0.136182589 -0.097543631 0.176140498 -0.291922435 -0.482627967 -0.046484664 -0.305516409 -0.025760575 -0.052724065 0.085945399 0.104149731 0.498935623 -0.181140232 -0.063470996 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0.046843093 0.06980163 -0.166874719 -0.063486533 -"SMAD5" "SMAD5" 4090 0.5004 -0.4234 0.211049813 -0.133650967584754 0.0178297643704644 0.192557158378419 0.426352976595706 0.168685315 0.383908541 0.263841098 0.221475073 0.109975597 0.127018084 0.009948434 0.33002983 -0.025401728 0.005142554 0.042745608 0.157183799 0.155979131 -0.001310398 -0.015984058 -0.169878724 0.098576113 0.012916663 -0.012492498 0.105144877 -0.007514598 -0.018852313 -0.076389687 0.027030358 -0.032294184 -0.059266094 -0.002427353 -0.116755504 -3.5e-05 -"TM7SF3" "TM7SF3" 51768 0.607 -0.5136 0.173816425 -0.1444050811503 0.109434417890063 0.177576622828208 0.370280041908875 0.180124122 0.192566242 0.261427621 0.052479718 0.145996392 0.23292862 0.11749602 0.157673558 0.101814946 0.085900835 0.072573079 0.114563654 0.299944949 -0.092773394 0.02979117 -0.050626209 -0.111648997 -0.077821645 -0.017535629 0.031797066 -0.01394714 0.032975955 -0.067624454 0.025349742 0.010247894 -0.047062437 0.013452486 -0.049693654 -0.0801497 -"TNFRSF17" "TNFRSF17" 608 0.5502 -0.4656 0.357411379 -0.110146655107405 -0.00466892849025866 -0.291854019555738 0.942555322353349 0.004151194 0.271007675 0.235866294 0.230109331 0.165917174 0.09866694 -0.151877269 0.249633229 -0.092709598 -0.030597478 0.106492285 0.012088261 0.077703803 -0.197427666 -0.686895614 0.290779241 0.008395037 -0.381773996 -0.061608956 0.06681836 -0.329878295 -0.436909222 -0.515802847 -0.494942226 -0.024369238 -0.160636166 -0.664796072 0.165424646 -0.30067644 -"TOPORS" "TOPORS" 10210 0.4821 -0.4079 0.236195724 -0.118115196575306 -0.0687450976311089 -0.158761867125563 0.506071443176224 -0.030359571 0.186267105 0.071505215 0.178295806 0.132183879 0.033836117 0.016477837 0.098397118 -0.04459666 0.040398341 -0.063802397 0.163631776 -0.043801912 -0.022529918 -0.349207461 -0.262025611 -0.064177487 0.006969551 0.013944028 -0.03431468 -0.047757533 -0.291207959 -0.166755006 -0.437603778 -0.091520893 -0.041277124 -0.214434956 -0.138683967 0.016179699 -"TP53I3" "TP53I3" 9540 0.7029 -0.5947 0.198207248 -0.148250987729792 0.072972440818131 0.211451684571351 0.497665879235453 0.214196383 0.321904578 0.428014027 0.211742951 0.109724887 0.23698868 0.141433884 0.231320981 0.131201702 0.078852956 0.068285328 0.049862138 0.325274157 0.003966025 -0.118358376 0.044003391 -0.083000909 -0.14129202 0.02139048 -0.113098877 -0.035853061 -0.05967546 -0.005469591 -0.078396444 0.002727624 0.043021318 -0.107571787 0.021305218 -0.096554492 -"TRIAP1" "TRIAP1" 51499 0.912 -0.7717 0.231902284 -0.148166405168028 0.0545256314789387 0.13990836731735 0.725272746778085 0.209780846 0.288401224 0.358369074 0.331800505 0.37486561 0.319965433 0.232678898 0.208716713 0.064475699 0.173655029 0.164111371 -0.014457745 0.377721219 -0.444088674 -0.021851977 -0.286940269 -0.227233069 -0.076307702 0.001247418 -0.078626458 0.038257216 -0.016036571 -0.103813028 -0.010288243 -0.086853022 -0.1954901 -0.021566207 -0.258153709 -0.08095764 -"TRIM22" "TRIM22" 10346 0.8468 -0.7165 0.234242743 -0.151716228645138 0.0645594603729571 0.287256406352091 0.705636440244803 0.388742803 0.296407294 0.510299274 0.24759621 0.281050596 0.372247771 0.199920008 0.247723088 0.139842838 0.020273664 0.183846104 0.248464418 0.519064736 -0.062520565 -0.26741266 -0.042028151 -0.108570127 -0.068361305 0.021147071 0.070122651 -0.15808266 -0.205991254 -0.02061349 -0.138620194 0.041029062 -0.025997711 -0.151476929 0.028943616 -0.05933511 -"USP41" "USP41" 373856 0.077237042 0.011720961 0.09086917 -0.0529454040152981 -0.0240115298303933 0.114854091806897 0.291128005627581 0 -0.005701196 0.121978549 0.168330047 0.150166722 -0.038200417 0.131981807 0.044106498 -0.046298761 0.081967934 0.147627607 0 0.070888069 0.062057589 -0.038656778 0.097010878 0.109871399 0 -0.11817354 -0.027720086 -0.028215002 -0.061309968 0.146776688 -0.117505365 -0.051473085 0.164801234 -0.006501467 0.109297648 -0.064445728 +ID GENE_SYMBOL Ensembl_Gene_ID ENTREZ_ID Genotoxic.score Non.Genotoxic.score stdev PC1 PC2 PC.mn PC.std X5.FU AraC Bleomycin Camptothecin Cisp Etoposide Hydrogen.Peroxide Hydroxyurea Methotrexate MMS Potassium.Chromate..VI. Sodium.Arsenite X.ray X2.deoxy.D.glucose..2.DG. Aapicidin Antimycin.A Cadmium.Chloride Colchicine Docetaxel EtOH.2. EtOH.4. HC.toxin Heat.Shock Oxamflatin Paclitaxel Thapsigargin TSA Tunicamysin Vinblastin +ACTA2 ACTA2 ENSG00000107796 59 0.3895 -0.3296 0.198403136 -0.0931217703381756 0.0975621136221921 0.285304546674291 0.435230567526858 0.001926613 0.15453229 0.290304873 0.084226878 0.190019716 0.182649788 0.333947243 0.088884153 0.04201524 0.155649529 0.122013608 0.483750095 0.177082162 -0.051982791 -0.023987106 0.193707982 0.063819649 -0.086609175 0.019175909 0.058031018 -0.093971372 0.029624282 0.037731627 0.040061885 -0.045086879 0.032473665 0.04542313 0.051733543 -0.086475988 +AEN AEN ENSG00000181026 64782 0.8952 -0.7575 0.216786892 -0.152348095017392 0.00768685433473227 0.234988312947214 0.688232604030204 0.178590419 0.388652639 0.431461447 0.308173836 0.229341104 0.18617159 0.20786817 0.34063038 0.06624174 0.259343513 0.244738397 0.363514129 0.303085468 0.004654002 -0.290059676 -0.135618103 -0.10567113 -0.039064716 -0.010360068 -0.143382704 0.02364665 -0.209973761 -0.147272586 -0.231406828 -0.008294093 -0.006820003 -0.145746124 0.037081185 -0.048107483 +ARRDC4 ARRDC4 ENSG00000140450 91947 0.554 -0.4688 0.269665846 -0.129126883132508 0.0874491519490443 0.367157037180164 0.650909690571483 0.062890206 0.437841105 0.562620659 0.15453652 0.221790918 0.35340581 0.660171818 0.21670471 -0.025824791 0.015602138 0.276977117 0.106730514 0.29218601 -0.054585572 -0.057408044 0.032062475 -0.033306305 -0.001222829 0.041226573 0 0 0.05049294 0.036194355 0.011657169 0.085931522 0.038014873 -0.170058519 -0.099943812 -0.009454402 +B3GNT2 B3GNT2 ENSG00000170340 10678 -0.513 0.434 0.243409901 0.112949147471718 0.0818901637696086 -0.0192506043527176 0.624611034541117 -0.185059781 -0.076156199 -0.083427855 -0.309204309 -0.324415917 -0.152028014 0.035442252 -0.061849797 -0.159565958 -0.250317906 -0.230571357 0.150203184 -0.139672601 0.183426911 0.121134754 0.430345975 0.395513925 0.01187637 -0.009685783 0.193981701 0.048972436 0.112749465 -0.210545624 0.091060189 -0.046823255 0.054831136 0.045089957 0.166766639 0.029874191 +BLOC1S2 BLOC1S2 ENSG00000196072 282991 0.9074 -0.7678 0.182310618 -0.15376562896466 0.0416924919662887 0.356569761272127 0.56600321176598 0.286160282 0.324303961 0.350870191 0.270117358 0.323284353 0.342281404 0.123548155 0.257937422 0.130926588 0.197239543 0.200450793 0.423659133 0.346799043 -0.019693356 -0.137310906 -0.064866505 -0.055726684 -0.026953512 0.01749299 0.067986003 0.002604668 -0.11351253 -0.071479444 -0.090814342 -0.017738155 0.071094442 -0.023232035 -0.005204823 0.00258358 +BRMS1L BRMS1L ENSG00000100916 84312 0.509 -0.4307 0.218519521 -0.125324819137471 0.0289015981756736 0.258705142634513 0.452493347229446 0.162307014 0.311533243 0.336202728 0.196430777 0.174226535 0.219656289 -0.001075049 0.269419377 0.087587139 -0.031322724 0.08439539 0.099344464 0.281434242 -0.09573488 0.040629434 -0.183728898 0.169306245 -0.05486079 0.000304005 0.160673181 0.036326838 0.141594532 -0.091383742 0.078267652 -0.068111044 0.033499354 0.068103068 -0.116220847 -0.050341302 +BTG2 BTG2 ENSG00000159388 7832 0.8538 -0.7224 0.206901972 -0.14048461286332 0.0642748345773671 0.621540348843145 0.628787065258696 0.505451195 0.381445467 0.512381756 0.36064465 0.511788023 0.235598678 0.434196792 0.38363491 0.369698902 0.224611184 0.338167603 0.205071308 0.294563046 -0.124779764 0.221009717 0.040529348 -0.011446282 0.088498218 -0.032237576 0.020498891 -0.08104722 0.140601516 0.038709068 0.130279197 0.01485034 0.048393585 0.01495688 0.027403568 0.132493367 +C12orf5 TIGAR ENSG00000078237 57103 0.6351 -0.5374 0.225288872 -0.140468178434318 0.098356866679736 0.395070858635696 0.570991078116908 0.351422729 0.399156847 0.459515463 0.291340007 0.254220994 0.294672904 0.070198256 0.372829009 0.053039364 0.143224643 0.196853202 0.236992054 0.348715807 -0.064526826 0.174435876 -0.114888657 -0.133001571 -0.009449433 0.007013043 -0.028208031 -0.01862816 0.158590455 -0.113837388 0.120314066 -0.024653897 -0.038579093 0.029952654 0.000759979 0.031442891 +CBLB CBLB ENSG00000114423 868 -0.617 0.5221 0.182955208 0.129353574711447 0.0490001834003111 -0.0743964612708951 0.415886390047415 -0.067954472 -0.079736213 -0.047924416 -0.374783796 -0.133016163 -0.104218115 -0.047789517 -0.106520506 -0.108800128 -0.13561992 -0.222905163 0.005943672 -0.161558274 0.120198961 0.094676855 0.080066408 0.056773648 0.106696325 0.051155134 -0.15548372 -0.058605299 0.044482711 -0.025955311 0.12477765 0.031681625 0.135377856 0.068463463 0.145525698 0.115579581 +CCP110 CCP110 ENSG00000103540 9738 0.6383 -0.5401 0.174623413 -0.151725577882041 0.0208233830613985 0.21369178554441 0.390070282423254 0.181497592 0.281929168 0.273663828 0.211966075 0.212400695 0.150960793 0.111809915 0.257652558 0.070912718 0.156387774 0.049095385 0.13498564 0.146946107 -0.044911405 0.00613919 -0.164900776 -0.050704018 0.044836278 -0.005885903 0.007672015 -0.086350005 -0.010960245 -0.113551657 0.014638716 0.002295587 0.023102579 -0.003643156 -0.00452136 0.012037393 +CDKN1A CDKN1A ENSG00000124762 1026 0.7021 -0.5941 0.243437029 -0.120572219476902 0.166341702668956 0.821691620301704 0.67588250324003 0.684382355 0.421079641 0.642638096 0.242379418 0.448744514 0.376752666 0.462066981 0.359344545 0.236830432 0.29133248 0.396423298 0.575848111 0.398466816 0.001304919 0.338958689 0.18451584 0.156909658 0.031325088 0.016881478 0.092337164 0.095796793 0.249268091 0.008674026 0.185471354 -0.043903587 0.108374821 0.184144907 0.060825588 -0.03391326 +CEBPD CEBPD ENSG00000221869 1052 0.5021 -0.4249 0.327948833 -0.101000078462626 -0.106939955918536 -0.375292310445741 0.804062011163475 -0.033644459 0.143808435 -0.058362463 0.215244849 0.229126477 -0.059954814 -0.033860207 0.075840115 0.00059665 0.070655185 -0.035494156 0.014528298 -0.211592269 -0.411842894 -0.790452698 -0.387917414 -0.016311534 -0.074822888 -0.068970241 0.009227146 -0.03334026 -0.500548209 -0.070804503 -0.581913181 -0.135200356 0.128093052 -0.271735376 -0.406153226 0.019547906 +CENPE CENPE ENSG00000138778 1062 -0.5462 0.4621 0.203300429 0.109798506640863 0.0638296992973986 -0.194358256015209 0.455252241393987 -0.129202835 -0.118066588 -0.067359098 -0.262064803 -0.16317459 -0.08877119 -0.235779592 -0.114240181 -0.402589304 -0.03592301 -0.28537268 -0.071694581 -0.232852079 -0.015500156 0.069248861 -0.088982736 -0.068552654 0.105001762 0.08805321 0.141078537 -0.040673277 0.050997024 -0.039006595 0.085186689 0.014741941 -0.061574834 0.126734552 -0.012542811 0.156158734 +COIL COIL ENSG00000121058 8161 0.4245 -0.3592 0.273188589 -0.107318131644414 -0.0177832485474856 -0.284793502058018 0.594620706881246 0.043846146 0.113199515 0.099754268 0.094615319 0.081169641 0.008597844 -0.055108671 0.033983202 -0.094504928 -0.118961683 -0.024483204 0.068144366 0.009849875 0.025599332 -0.568568781 -0.093096633 -0.177931748 -0.088509874 0.012525234 0.029817342 -0.070956313 -0.429523059 -0.158034835 -0.53585547 -0.038237253 -0.179041403 -0.344322034 -0.09704125 -0.033135159 +DAAM1 DAAM1 ENSG00000100592 23002 -0.57 0.4823 0.257656765 0.119380453656819 0.0482125164465678 0.283799935129194 0.627353434474058 -0.106670452 -0.04335161 -0.013325683 -0.208422546 -0.095763315 0.022742676 -0.023693598 -0.073085243 0.051209029 -0.011890218 -0.19502022 0.141230551 -0.094974 0.131190301 0.418240497 0.160369748 0.141057064 0.257973918 0.016834626 0.146005436 0.022855434 0.35910525 -0.101443208 0.454497994 -0.030545278 0.436474042 0.384489745 0.137325803 0.194119761 +DCP1B DCP1B ENSG00000151065 196513 0.7629 -0.6455 0.161300043 -0.152553653621101 0.0753275254120734 0.218876980931284 0.407591173676377 0.153805382 0.260946003 0.319268757 0.213285093 0.194528952 0.173191013 0.187297707 0.193198777 0.145978767 0.109145184 -0.019398497 0.205408656 0.233647632 -0.031077622 -0.115125849 -0.009866037 -0.079181703 -0.061037157 0.028268619 0.013297955 -0.021889226 -0.075015328 -0.045839118 -0.015427377 -0.028683255 -0.017777396 0.014612588 0.027481399 -0.042276357 +DDB2 DDB2 ENSG00000134574 1643 0.8717 -0.7376 0.181249754 -0.157039053884665 0.0908286119259457 0.379893460471866 0.515996614938399 0.274425558 0.314640344 0.422502125 0.248327724 0.273141089 0.3813773 0.264294841 0.277977483 0.120826424 0.174271485 0.149947158 0.119173575 0.401941291 -0.062276228 -0.061514673 0.082018981 -0.059005381 -0.012788078 0.027418643 0.055563479 -0.038041529 -0.013142627 0.026692867 -0.04302689 -0.027098816 0.005800499 -0.004285412 0.047157853 -0.029898609 +DUSP14 DUSP14 ENSG00000276023 11072 0.4979 -0.4213 0.18107769 -0.131308391019124 0.0931871016615247 0.329269010695896 0.354337560843073 0.194883497 0.269445905 0.285755115 0.231874779 0.221920863 0.128890646 0.198727704 0.227908558 0.068974133 0.096585566 0.171014318 -0.022312674 0.239944818 -0.028500488 0.075416461 -0.044455152 -0.029913947 0.018025899 -0.005361202 0.025578294 0.17037845 0.071253981 -0.02470609 0.145916757 -0.023295865 0.160523916 0.057259908 -0.04096163 0.033703097 +E2F7 E2F7 ENSG00000165891 144455 0.9433 -0.7982 0.190295356 -0.151189082144493 0.0149622508328152 0.332618552833544 0.570601645538377 0.322092074 0.429676763 0.38955857 0.192282924 0.256418064 0.167667977 0.16882114 0.401125121 0.235377479 0.198106031 0.241196798 0.204184946 0.194634211 -0.144736353 -0.066084233 -0.154292756 0.064579706 -0.052588919 -0.0753555 0.141212096 0.111958536 -0.016048337 0.029669498 -0.05367761 -0.126999469 -0.009863841 -0.009543788 -0.081206196 -0.054448248 +E2F8 E2F8 ENSG00000129173 79733 0.6696 -0.5666 0.236683428 -0.128023349479293 -0.0678593834931921 -0.182058592154623 0.672118988932299 -0.011460452 0.287840319 0.131981457 0.206610139 0.104292863 0.087767234 0.121322885 0.240065256 0.108531645 0.189220175 0.048366083 -0.300104492 -0.01054548 -0.062777694 -0.42742494 -0.314134292 -0.492471197 -0.007118359 -0.002969888 -0.163542081 -0.053786256 -0.287362292 -0.091040743 -0.240792375 0.002833903 -0.230324951 -0.188736039 -0.252560513 0.018972266 +EI24 EI24 ENSG00000149547 9538 0.5449 -0.4611 0.174471691 -0.150531637141215 0.0102658397103505 0.0699458193301052 0.341733297922392 0.075968109 0.142042033 0.217842145 0.180731128 0.179651732 0.150799793 0.047400249 0.110413071 0.02677996 0.035064157 0.048088346 -0.071007439 0.232487993 -0.110758106 -0.05781083 -0.162522998 -0.072881689 -0.004608348 0.033796417 -0.024640378 -0.039871828 -0.044374763 -0.054415092 -0.054790643 -0.037477863 -0.020330318 -0.004906926 -0.098470909 -0.011579102 +FAM123B AMER1 ENSG00000184675 139285 0.6079 -0.5144 0.223917377 -0.138523645078788 -0.0392109136490018 -0.399255112298826 0.559667448704297 0.034808693 0.184733547 0.116799845 0.134708966 0.023105599 0.132370598 -0.129785998 0.114643128 -0.075720744 -0.108495861 -0.10493294 -0.338171514 0.053666427 -0.241854697 -0.341962446 -0.368112507 -0.29524928 -0.151539997 0.015598791 -0.309734824 -0.219652426 -0.315572573 -0.158012723 -0.291799472 -0.069090331 -0.155001708 -0.213735758 -0.303853817 -0.103601155 +FBXO22 FBXO22 ENSG00000167196 26263 0.695 -0.5881 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