diff --git a/qiskit_ibm_runtime/options/sampler_options.py b/qiskit_ibm_runtime/options/sampler_options.py
index 6b1006dce..8079c6ded 100644
--- a/qiskit_ibm_runtime/options/sampler_options.py
+++ b/qiskit_ibm_runtime/options/sampler_options.py
@@ -21,6 +21,7 @@
 from .options import OptionsV2
 from .utils import primitive_dataclass
 from .dynamical_decoupling_options import DynamicalDecouplingOptions
+from .twirling_options import TwirlingOptions
 
 
 @primitive_dataclass
@@ -36,6 +37,8 @@ class SamplerOptions(OptionsV2):
 
         execution: Execution time options. See :class:`ExecutionOptionsV2` for all available options.
 
+        twirling: Pauli twirling options. See :class:`TwirlingOptions` for all available options.
+
         experimental: Experimental options.
     """
 
@@ -47,4 +50,5 @@ class SamplerOptions(OptionsV2):
     execution: Union[SamplerExecutionOptionsV2, Dict] = Field(
         default_factory=SamplerExecutionOptionsV2
     )
+    twirling: Union[TwirlingOptions, Dict] = Field(default_factory=TwirlingOptions)
     experimental: Union[UnsetType, dict] = Unset
diff --git a/qiskit_ibm_runtime/options/twirling_options.py b/qiskit_ibm_runtime/options/twirling_options.py
index 62d4f579b..d6523a63c 100644
--- a/qiskit_ibm_runtime/options/twirling_options.py
+++ b/qiskit_ibm_runtime/options/twirling_options.py
@@ -32,8 +32,8 @@ class TwirlingOptions:
     Args:
         enable_gates: Whether to apply 2-qubit gate twirling. Default: False.
 
-        enable_measure: Whether to enable twirling of expectation value measurements
-          in Estimator. Default: True.
+        enable_measure: Whether to enable twirling of measurements. Twirling will only be applied to
+         those measurement registers not involved within a conditional logic. Default: True.
 
         num_randomizations: The number of random samples to use when twirling or
             peforming sampled mitigation. If "auto", the value will be chosen automatically
diff --git a/release-notes/unreleased/1557.feat.rst b/release-notes/unreleased/1557.feat.rst
new file mode 100644
index 000000000..f70273d9e
--- /dev/null
+++ b/release-notes/unreleased/1557.feat.rst
@@ -0,0 +1,2 @@
+`SamplerV2` now supports twirling.
+Twirling will only be applied to those measurement registers not involved within a conditional logic.
\ No newline at end of file
diff --git a/test/unit/test_sampler_options.py b/test/unit/test_sampler_options.py
index b9225d1a5..2777a074b 100644
--- a/test/unit/test_sampler_options.py
+++ b/test/unit/test_sampler_options.py
@@ -62,6 +62,7 @@ def test_program_inputs(self):
         environment = {"log_level": "INFO"}
         dynamical_decoupling = {"enable": True, "sequence_type": "XX"}
         execution = {"init_qubits": True, "rep_delay": 0.01}
+        twirling = {"enable_gates": True, "enable_measure": True, "strategy": "active-circuit"}
 
         opt = SamplerOptions(
             max_execution_time=100,
@@ -69,6 +70,7 @@ def test_program_inputs(self):
             simulator=simulator,
             default_shots=1000,
             dynamical_decoupling=dynamical_decoupling,
+            twirling=twirling,
             execution=execution,
             experimental={"foo": "bar", "execution": {"secret": 88}},
         )
@@ -80,6 +82,11 @@ def test_program_inputs(self):
         options = {
             "default_shots": 1000,
             "dynamical_decoupling": dynamical_decoupling,
+            "twirling": {
+                "enable_gates": True,
+                "enable_measure": True,
+                "strategy": "active-circuit",
+            },
             "execution": execution,
             "experimental": {"foo": "bar"},
             "simulator": simulator,
@@ -97,6 +104,7 @@ def test_program_inputs(self):
         {"execution": {"init_qubits": True, "meas_type": "avg_kerneled"}},
         {"dynamical_decoupling": {"enable": True, "sequence_type": "XX"}},
         {"environment": {"log_level": "ERROR"}},
+        {"twirling": {"enable_gates": True, "strategy": "active"}},
     )
     def test_init_options_with_dictionary(self, opts_dict):
         """Test initializing options with dictionaries."""
@@ -117,6 +125,7 @@ def test_init_options_with_dictionary(self, opts_dict):
             "sequence_type": "XX",
             "log_level": "INFO",
         },
+        {"twirling": {"enable_gates": True, "strategy": "active"}},
     )
     def test_update_options(self, new_opts):
         """Test update method."""