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PPAR-gama and intensive pharacogemomics graph 2012-1-20 (phthalate).xml
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PPAR-gama and intensive pharacogemomics graph 2012-1-20 (phthalate).xml
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<edge source="C0166415" target="146" label="STIMULATES" color="#A52A2A" ><sentence id = "15754086.ab.n" text = "METHODS: mRNA expression levels for peroxisome proliferator activated receptor (PPAR) alpha, gamma and delta, PPARgamma co-factor 1 alpha and beta (PGC-1 alpha and beta), 9-cis retinoc-acid-activated receptor alpha, beta and gamma (RXR alpha, beta, gamma), 5'-AMP activated protein kinase (AMPK) alpha1 and alpha2, adiponectin receptor 1 and 2 (AR 1 and AR 2) were measured in heart tissue of neonatal 0-day, 7-day and 21- day old rats."/></edge>
<edge source="C1336636" target="C0122111" label="COEXISTS_WITH" color="#2F4F4F" ><sentence id = "18846339.ab.n" text = "The effect of rosiglitazone as the ligand of peroxisome proliferator-activated receptor gamma (PPARgamma) inhibiting the TLR4 expression in ischemic lobes in partial hepatic ischemia/reperfusion injury (IRI) in BABL/C mice and the action of rosiglitazone inhibiting the TLR4 receptor-mediated inherent immune response were investigated."/></edge>
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<edge source="C0303814" target="C0021760" label="STIMULATES" color="#A52A2A" ><sentence id = "21455100.ab.n" text = "Bisphenol A diglycidyl ether administrated to healthy animals increases serum IL-6 levels.&amp;gt;br /&amp;lt; Conclusions: Rosiglitazone inhibits experimental inflammation; administration of its selective antagonist abolishes this protective influence."/></edge>
<edge source="C0796494" target="C1336636" label="LOCATION_OF" color="#008000" ><sentence id = "18846339.ab.n" text = "As compared with vehicle group, the expression of TLR4 mRNA in ischemic lobes in rosiglitazone group was significantly decreased at 4 h after reperfusion."/><sentence id = "18846339.ab.n" text = "The most intensive expression of TLR4 mRNA was present at 4 h after reperfusion in ischemic lobes in vehicle group."/><sentence id = "18846339.ab.n" text = "After restoration of blood supply, the expression of TLR4 mRNA in ischemic lobes was detected in 0, 2, 4 and 6 h after reperfusion following 1 h ischemia in rosiglitazone group and vehicle group."/><sentence id = "18846339.ab.n" text = "The effect of rosiglitazone as the ligand of peroxisome proliferator-activated receptor gamma (PPARgamma) inhibiting the TLR4 expression in ischemic lobes in partial hepatic ischemia/reperfusion injury (IRI) in BABL/C mice and the action of rosiglitazone inhibiting the TLR4 receptor-mediated inherent immune response were investigated."/></edge>
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<edge source="C0021655" target="C0030305" label="COEXISTS_WITH" color="#2F4F4F" ><sentence id = "12766116.ab.n" text = "FPLD1 subjects also had components of the metabolic syndrome, including hypertension, insulin resistance, and severe hypertriglyceridemia resulting in pancreatitis."/></edge>
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<edge source="C0070099" target="C0166417" label="STIMULATES" color="#A52A2A" ><sentence id = "17724498.ab.n" text = "We have exploited the understanding of these molecular processes to demonstrate the proof-of-principle that by stabilizing the alveolar PTHrP signaling pathway using exogenously administered agonists of peroxisome proliferator-activated receptor-gamma a key target of PTHrP signaling, we can prevent and/or rescue the molecular injuries caused by insults that lead to CLD."/></edge>
<edge source="C0166417" target="146" label="STIMULATES" color="#A52A2A" ><sentence id = "15754086.ab.n" text = "METHODS: mRNA expression levels for peroxisome proliferator activated receptor (PPAR) alpha, gamma and delta, PPARgamma co-factor 1 alpha and beta (PGC-1 alpha and beta), 9-cis retinoc-acid-activated receptor alpha, beta and gamma (RXR alpha, beta, gamma), 5'-AMP activated protein kinase (AMPK) alpha1 and alpha2, adiponectin receptor 1 and 2 (AR 1 and AR 2) were measured in heart tissue of neonatal 0-day, 7-day and 21- day old rats."/></edge>
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