TB results

[KlementineJBS]

31/10/24

WPC and KBS compounds 30102024 with IC50.zip

[KlementineJBS]

IC50 results

Prism had warnings for these two below:

[KlementineJBS]

Raw data

KBS13.csv
KBS19.csv
KBS26.csv
KBS44.csv
KBS52.csv
KBS53.csv

[KlementineJBS]

Graphs

[KlementineJBS]

Summary of results

Code	Core	Pendants	IC50 in uM
KBS13 - 2021	cyclam	2 x adamantane	5.22
KBS13 - 2024	cyclam	2 x adamantane	5.74
KBS19	cyclam	2 x ferrocene	9.94
KBS26	1,6-diaminohexane	2 x adamantane	20.48*
KBS44	1,8-diaminooctane	2 x naphthalene	4.62
KBS53	1,6-diaminohexane	2 x naphthalene	5.79
KBS52	bis-(3-propylamine)	2 x naphthalene	11.75*

IC50s calculated by Prism. Value for KBS13 - 2021 was provided by Diane - presumably was calculated in the same way.

*Warning from Prism: "For at least one parameter, Prism was able to find a best-fit value, but was unable to calculate a complete confidence interval. This best-fit value should be interpreted with caution."

MICs from previous work:
In 2018 paper: lowest is 3.13 uM (naphthalimide), naphthalene pendant is comparable at 6.25 - 12.5 uM