pruebas.py

from random import randint
from telegram.ext import Updater, CommandHandler, CallbackQueryHandler, CallbackContext
from telegram import InlineKeyboardMarkup, InlineKeyboardButton, Update

def start(update: Update, context: CallbackContext):
    a, b = randint(1, 100), randint(1, 100)
    update.message.reply_text('{} + {} = ?'.format(a, b),
        reply_markup = InlineKeyboardMarkup([[
                InlineKeyboardButton(str(s), callback_data = '{} {} {}'.format(a, b, s)) for s in range(a + b - randint(1, 3), a + b + randint(1, 3))
            ]]))

def answer(update: Update, context: CallbackContext):
    a, b, s = [int(x) for x in update.callback_query.data.split()]
    if a + b == s:
        update.callback_query.edit_message_text('你答對了！')
    else:
        update.callback_query.edit_message_text('你答錯囉！')

updater = Updater('1375267822:AAEiFLybctSwv647TOeIQYSLX5TGY_fbFQg',use_context=True)

updater.dispatcher.add_handler(CommandHandler('start', start))
updater.dispatcher.add_handler(CallbackQueryHandler(answer))

updater.start_polling()
updater.idle()