Tool architecture

Tool architecture includes the process of:

• identifying tool modules, sub-modules and various structural elements
• define their relationships
  • visually (Master flow chart)
  • by describing their inputs, functions, and outputs
  • by defining processed data in detail (codebooks, variables, attributes)
• defining and harmonizing a nomenclature by which structural elements are referred to.
• maintaining an overview of code files and other documents

ITHIM-R Modules (workflow)

(workflow here refers to the main, linear flow from inputs to outputs. Think of it as a highly simplified architecture. Or an attempt to explore nomenclature. Also see master flow chart)

ITHIM-R Modules:
Below modules define the ITHIM-R project structure. They may or may not have equivalents in the tool interface structure.

1. Data Sources (user input data, generic data used by the tool, and their various formats, implications)

2. Data localization (adjustments, calibration of international, national data to local settings of ITHIM application)

3. Data harmonization (conversion of various data formats, variable definitions, to generic ITHIM formats)

4. Synthetic "baseline" population (creation of a synthetic sample of 10k individuals, based on all input data)

5. Visualization and Checking of Baseline Data (review and validation of entered data vs. synthetic population produced)

6. Scenario Definition (2 options:)

   1. Manipulation of baseline population through a scenario definition module (interface or code).
   2. creation of a synthetic "scenario" population, based on local data sources, analogous to steps for baseline population. Further: use case definitions, criteria, methodologica parameters, etc.)

7. Visualization and Checking of Scenario Data (review and validation of entered data vs. synthetic population produced)

8. Exposure calculations (adding distributions of various exposure indicators to synth.pop data (baseline and scenario)

   1. pathway specific

9. (Environmental Impacts Calculations)

   1. Carbon emission reductions
   2. Air pollution background concentration
   3. Noise reduction

10. Health Impact pathway calculations (exposures meet epidemiologic literature/evidence)
    Pathways: PA, AP, Noise, Injury
    Impact calculation method: PIF/PAF vs. Disease burden calculation, PMSLT
    Outcome definitions: deaths, dalys etc.

    1. Health Impact calculations for PA
    2. Health Impact calculations for AP
    3. Health impact calculations Noise
    4. Event calculation for injuries
    5. [From events to disease burden injuries]
    6. Comparative Risk Assessment applied to GBD data
    7. Multistate life table

11. Impacts presentations (outcome definitions, level of detail, visualization)

    1. combined pathway results
    2. pathway specific

12. Overarching modules

    1. User interface
    2. Website contents/documentation
    3. Tool Parameters ("is the math being done in miles or km?" A central place for default values, units, constants, assumptions to be called by various tool elements)
    4. Comparison approaches (Impact calculation methods, CRA, lifetables, etc.)

13. Overarching domains

    1. Coding guidelines
    2. Documentation
    3. Scientific publications
    4. Dissemenination
    5. Case studies/applications