diff --git a/CHANGELOG.md b/CHANGELOG.md
index e1404ad..704701f 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -8,6 +8,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ### Added
 
+- manipulation SetComponentActivationAndSetOperatingMode for components and operations
+- manipulation SetAlertActivationAndSetOperatingMode for alerts and operations
 - manipulation TransitionFromCreateStateWithIdentificationToRemoveIdentification for contexts
 - manipulation TransitionFromCreateStateWithIdentificationToChangeIdentification for contexts
 - manipulation TransitionProvideValueToExpressNoValueAvailable for metrics
diff --git a/src/t2iapi/combined/combined_requests.proto b/src/t2iapi/combined/combined_requests.proto
index 6f2334f..865cd14 100644
--- a/src/t2iapi/combined/combined_requests.proto
+++ b/src/t2iapi/combined/combined_requests.proto
@@ -11,6 +11,8 @@ package t2iapi.combined;
 
 import "t2iapi/context/types.proto";
 import "t2iapi/operation/types.proto";
+import "t2iapi/activation_state/types.proto";
+
 
 option java_package = "com.draeger.medical.t2iapi.combined";
 option java_outer_classname = "CombinedRequests";
@@ -21,11 +23,37 @@ Request to create a new or adapt an existing context state with a requested @Con
 set the requested @OperatingMode for the referenced operation.
  */
 message CreateContextStateWithAssociationAndSetOperatingModeRequest {
-    string context_descriptor_handle = 1;  // the context descriptor handle for which the @ContextAssociation value
+    string context_descriptor_handle = 1;  // the context descriptor handle for which the ContextAssociation value
                                            // shall be set
     t2iapi.context.ContextAssociation context_association = 2;  // the requested @ContextAssociation value
                                                                 // of the context state
-    string operation_descriptor_handle = 3; // the operation descriptor handle for which the @OperatingMode value
+    string operation_descriptor_handle = 3; // the operation descriptor handle for which the OperatingMode value
+                                            // shall be set
+    t2iapi.operation.OperatingMode operating_mode = 4;  // the requested OperatingMode value of the operation state
+}
+
+/*
+Request to set the @ActivationState of the component or metric with the given handle to the requested
+ComponentActivation value and to set the @OperatingMode of the operation with the given handle to the requested
+OperatingMode value.
+*/
+message SetComponentActivationAndSetOperatingModeRequest {
+    string component_metric_descriptor_handle = 1; // the component or metric descriptor handle for which
+                                                   // the ActivationState shall be set
+    t2iapi.activation_state.ComponentActivation component_activation= 2; // the requested ComponentActivation value
+    string operation_descriptor_handle = 3; // the operation descriptor handle for which the OperatingMode value
+                                            // shall be set
+    t2iapi.operation.OperatingMode operating_mode = 4; // the requested OperatingMode value of the operation state
+}
+
+/*
+Request to set the @ActivationState of the alert with the given handle to the requested AlertActivation value and
+to set the @OperatingMode of the operation with the given handle to the requested OperatingMode value.
+*/
+message SetAlertActivationAndSetOperatingModeRequest {
+    string alert_descriptor_handle = 1; // alert descriptor handle for which the ActivationState shall be set
+    t2iapi.activation_state.AlertActivation alert_activation= 2; // the requested AlertActivation value
+    string operation_descriptor_handle = 3; // the operation descriptor handle for which the OperatingMode value
                                             // shall be set
-    t2iapi.operation.OperatingMode operating_mode = 4;  // the requested @OperatingMode value of the operation state
+    t2iapi.operation.OperatingMode operating_mode = 4; // the requested OperatingMode value of the operation state
 }
diff --git a/src/t2iapi/combined/service.proto b/src/t2iapi/combined/service.proto
index 0899e8f..328bcc5 100644
--- a/src/t2iapi/combined/service.proto
+++ b/src/t2iapi/combined/service.proto
@@ -11,6 +11,7 @@ package t2iapi.combined;
 
 import "t2iapi/combined/combined_requests.proto";
 import "t2iapi/context/context_responses.proto";
+import "t2iapi/basic_responses.proto";
 
 option java_package = "com.draeger.medical.t2iapi.combined";
 option java_outer_classname = "CombinedApiService";
@@ -29,4 +30,25 @@ service CombinedService {
   rpc CreateContextStateWithAssociationAndSetOperatingMode (
   t2iapi.combined.CreateContextStateWithAssociationAndSetOperatingModeRequest)
       returns (t2iapi.context.CreateContextStateWithAssociationResponse);
+
+  /*
+  Request to set the @ActivationState of the component or metric with the given handle to the requested
+  ComponentActivation value and to set the @OperatingMode of the operation with the given handle to the requested
+  OperatingMode value.
+  The manipulated states shall be persistent until a next manipulation call or an SDC operation invocation.
+  If the device is not able to maintain the static states, it shall return RESULT_NOT_SUPPORTED.
+  */
+  rpc SetComponentActivationAndSetOperatingMode (
+  t2iapi.combined.SetComponentActivationAndSetOperatingModeRequest)
+      returns (BasicResponse);
+
+  /*
+  Request to set the @ActivationState of the alert with the given handle to the requested AlertActivation value and
+  to set the @OperatingMode of the operation with the given handle to the requested OperatingMode value.
+  The manipulated states shall be persistent until a next manipulation call or an SDC operation invocation.
+  If the device is not able to maintain the static states, it shall return RESULT_NOT_SUPPORTED.
+  */
+  rpc SetAlertActivationAndSetOperatingMode (
+  t2iapi.combined.SetAlertActivationAndSetOperatingModeRequest)
+      returns (BasicResponse);
 }