diff --git a/CHANGELOG.md b/CHANGELOG.md
index 594e3e1325..45c6c7e9a2 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -14,6 +14,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 * Fixed the rotation anchor offset of line regions ([#1739](https://github.com/CARTAvis/carta-frontend/issues/1739)).
 * Fixed issue with exporting decimated data instead of full resolution data in spatial profiler ([#1546](https://github.com/CARTAvis/carta-frontend/issues/1546))
 * Fixed larger position errors of projected contours, catalog overlays, and vector overlays near the border ([#1843](https://github.com/CARTAvis/carta-frontend/issues/1843)).
+* Fixed no updating of spatial profile after region deleting ([#1831](https://github.com/CARTAvis/carta-frontend/issues/1831), [#1855](https://github.com/CARTAvis/carta-frontend/issues/1855)).
 
 ## [3.0.0-beta.3]
 
diff --git a/src/stores/AppStore.ts b/src/stores/AppStore.ts
index 0ad45fe29d..8d6ff2560f 100644
--- a/src/stores/AppStore.ts
+++ b/src/stores/AppStore.ts
@@ -699,11 +699,7 @@ export class AppStore {
             const fileId = frame.frameInfo.fileId;
 
             // adjust requirements for stores
-            WidgetsStore.RemoveFrameFromRegionWidgets(this.widgetsStore.statsWidgets, fileId);
-            WidgetsStore.RemoveFrameFromRegionWidgets(this.widgetsStore.histogramWidgets, fileId);
-            WidgetsStore.RemoveFrameFromRegionWidgets(this.widgetsStore.spatialProfileWidgets, fileId);
-            WidgetsStore.RemoveFrameFromRegionWidgets(this.widgetsStore.spectralProfileWidgets, fileId);
-            WidgetsStore.RemoveFrameFromRegionWidgets(this.widgetsStore.stokesAnalysisWidgets, fileId);
+            this.widgetsStore.removeFrameFromRegionWidgets(fileId);
 
             // clear existing requirements for the frame
             this.spectralRequirements.delete(fileId);
@@ -788,11 +784,7 @@ export class AppStore {
             });
             this.frames = [];
             // adjust requirements for stores
-            WidgetsStore.RemoveFrameFromRegionWidgets(this.widgetsStore.statsWidgets);
-            WidgetsStore.RemoveFrameFromRegionWidgets(this.widgetsStore.histogramWidgets);
-            WidgetsStore.RemoveFrameFromRegionWidgets(this.widgetsStore.spatialProfileWidgets);
-            WidgetsStore.RemoveFrameFromRegionWidgets(this.widgetsStore.spectralProfileWidgets);
-            WidgetsStore.RemoveFrameFromRegionWidgets(this.widgetsStore.stokesAnalysisWidgets);
+            this.widgetsStore.removeFrameFromRegionWidgets();
         }
     };
 
@@ -2006,13 +1998,13 @@ export class AppStore {
     @action deleteRegion = (region: RegionStore) => {
         if (region) {
             const frame = this.getFrame(region.fileId);
-            const regionId = region.regionId;
-            WidgetsStore.RemoveRegionFromRegionWidgets(this.widgetsStore.statsWidgets, region.fileId, regionId);
-            WidgetsStore.RemoveRegionFromRegionWidgets(this.widgetsStore.histogramWidgets, region.fileId, regionId);
-            WidgetsStore.RemoveRegionFromRegionWidgets(this.widgetsStore.spectralProfileWidgets, region.fileId, regionId);
-            WidgetsStore.RemoveRegionFromRegionWidgets(this.widgetsStore.stokesAnalysisWidgets, region.fileId, regionId);
+            // adjust requirements for stores
+            this.widgetsStore.removeRegionFromRegionWidgets(region.fileId, region.regionId);
             // delete region
             if (frame) {
+                frame.secondarySpatialImages.forEach(image => {
+                    this.widgetsStore.removeRegionFromRegionWidgets(image.frameInfo.fileId, region.regionId);
+                });
                 frame.regionSet.deleteRegion(region);
             }
         }
diff --git a/src/stores/Frame/FrameStore.ts b/src/stores/Frame/FrameStore.ts
index a2ebf4bccf..a11e90060f 100644
--- a/src/stores/Frame/FrameStore.ts
+++ b/src/stores/Frame/FrameStore.ts
@@ -2110,6 +2110,8 @@ export class FrameStore {
         for (const region of this.frameRegionSet.regions) {
             this.frameRegionSet.deleteRegion(region);
         }
+
+        AppStore.Instance.widgetsStore.removeRegionsFromRegionWidgetsByFrame(this.frameInfo.fileId);
         return true;
     };
 
@@ -2154,6 +2156,8 @@ export class FrameStore {
             this.removeCatalogControlMap(frame);
         });
         this.catalogControlMaps.clear();
+
+        AppStore.Instance.widgetsStore.removeRegionsFromRegionWidgetsByFrame(this.frameInfo.fileId);
     };
 
     @action addSecondarySpatialImage = (frame: FrameStore) => {
diff --git a/src/stores/WidgetsStore.ts b/src/stores/WidgetsStore.ts
index 2202b26152..9f89aa6a43 100644
--- a/src/stores/WidgetsStore.ts
+++ b/src/stores/WidgetsStore.ts
@@ -292,29 +292,47 @@ export class WidgetsStore {
         ]
     ]);
 
-    public static RemoveFrameFromRegionWidgets(storeMap: Map<string, RegionWidgetStore>, fileId: number = ACTIVE_FILE_ID) {
-        if (fileId === ACTIVE_FILE_ID) {
-            storeMap.forEach(widgetStore => {
-                widgetStore.clearRegionMap();
-                widgetStore.setFileId(ACTIVE_FILE_ID);
-            });
-        } else {
-            storeMap.forEach(widgetStore => {
-                widgetStore.clearFrameEntry(fileId);
-                if (widgetStore.fileId === fileId) {
-                    widgetStore.setFileId(ACTIVE_FILE_ID);
+    @action public removeFrameFromRegionWidgets(fileId: number = ACTIVE_FILE_ID) {
+        this.widgetsMap.forEach(widgets => {
+            widgets.forEach(widgetStore => {
+                if (widgetStore instanceof RegionWidgetStore) {
+                    if (fileId === ACTIVE_FILE_ID) {
+                        widgetStore.clearRegionMap();
+                        widgetStore.setFileId(ACTIVE_FILE_ID);
+                    } else {
+                        widgetStore.clearFrameEntry(fileId);
+                        if (widgetStore.fileId === fileId) {
+                            widgetStore.setFileId(ACTIVE_FILE_ID);
+                        }
+                    }
                 }
             });
-        }
+        });
     }
 
-    public static RemoveRegionFromRegionWidgets = (storeMap: Map<string, RegionWidgetStore>, fileId, regionId: number) => {
-        storeMap.forEach(widgetStore => {
-            const selectedRegionId = widgetStore.regionIdMap.get(fileId);
-            // remove entry from map if it matches the deleted region
-            if (isFinite(selectedRegionId) && selectedRegionId === regionId) {
-                widgetStore.clearFrameEntry(fileId);
-            }
+    @action public removeRegionFromRegionWidgets = (fileId: number, regionId: number) => {
+        this.widgetsMap.forEach(widgets => {
+            widgets.forEach(widgetStore => {
+                if (widgetStore instanceof RegionWidgetStore) {
+                    const selectedRegionId = widgetStore.regionIdMap.get(fileId);
+                    // remove entry from map if it matches the deleted region
+                    if (isFinite(selectedRegionId) && selectedRegionId === regionId) {
+                        widgetStore.clearFrameEntry(fileId);
+                    }
+                }
+            });
+        });
+    };
+
+    @action public removeRegionsFromRegionWidgetsByFrame = (fileId: number) => {
+        this.widgetsMap.forEach(widgets => {
+            widgets.forEach(widgetStore => {
+                if (widgetStore instanceof RegionWidgetStore) {
+                    if (widgetStore.regionIdMap.has(fileId)) {
+                        widgetStore.clearFrameEntry(fileId);
+                    }
+                }
+            });
         });
     };