diff --git a/CMakeLists.txt b/CMakeLists.txt
index 64342405..d7197a55 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -104,7 +104,11 @@ endif()
 # Do some tricky things for the python package
 option(PYTHON_PACKAGE "Generate a build for a python package, should be OFF except in setupy.py" OFF)
 if (PYTHON_PACKAGE)
-    set(CMAKE_INSTALL_RPATH "$ORIGIN")
+    if (APPLE)
+        set(CMAKE_INSTALL_RPATH "@loader_path")
+    else()
+        set(CMAKE_INSTALL_RPATH "$ORIGIN")
+    endif()
 endif()
 
 option(WRAP_PYTHON "Generate a pybind11 wrapper" OFF)